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328 Results Found

  • Article
  • Open Access
23 Citations
5,480 Views
15 Pages

Accumulation of Microcystin (LR, RR and YR) in Three Freshwater Bivalves in Microcystis aeruginosa Bloom Using Dual Isotope Tracer

  • Min-Seob Kim,
  • Yeon-Jung Lee,
  • Sun-Yong Ha,
  • Baik-Ho Kim,
  • Soon-Jin Hwang,
  • Jung-Taek Kwon,
  • Jong-Woo Choi and
  • Kyung-Hoon Shin

17 July 2017

Abstract: Stable isotope tracers were first applied to evaluate the Microcystis cell assimilation efficiency of Sinanodonta bivalves, since the past identification method has been limited to tracking the changes of each chl-a, clearity, and nutrient....

  • Review
  • Open Access
21 Citations
11,675 Views
55 Pages

16 May 2013

Documentation of contaminant source and dispersal pathways in riverine environments is essential to mitigate the potentially harmful effects of contaminants on human and ecosystem health, and is required from a legal perspective (particularly where t...

  • Article
  • Open Access
30 Citations
12,487 Views
18 Pages

Stable Isotope Tracer Analysis in Isolated Mitochondria from Mammalian Systems

  • Simon-Pierre Gravel,
  • Sylvia Andrzejewski,
  • Daina Avizonis and
  • Julie St-Pierre

10 April 2014

Mitochondria are a focal point in metabolism, given that they play fundamental roles in catabolic, as well as anabolic reactions. Alterations in mitochondrial functions are often studied in whole cells, and metabolomics experiments using 13C-labeled...

  • Article
  • Open Access
35 Citations
7,571 Views
21 Pages

The Role of Faults in Groundwater Circulation before and after Seismic Events: Insights from Tracers, Water Isotopes and Geochemistry

  • Davide Fronzi,
  • Francesco Mirabella,
  • Carlo Cardellini,
  • Stefano Caliro,
  • Stefano Palpacelli,
  • Costanza Cambi,
  • Daniela Valigi and
  • Alberto Tazioli

27 May 2021

The interaction between fluids and tectonic structures such as fault systems is a much-discussed issue. Many scientific works are aimed at understanding what the role of fault systems in the displacement of deep fluids is, by investigating the intera...

  • Article
  • Open Access
1 Citations
1,536 Views
20 Pages

22 December 2023

In this paper, we focused on the initiation of porosity in the anodic alumina under galvanostatic conditions in chromic acid, using an 18O isotope tracer. The general concept of the initiation and growth of porous anodic oxide films on metals has und...

  • Article
  • Open Access
10 Citations
3,363 Views
27 Pages

31 May 2024

Reliance on groundwater is outpacing natural replenishment, a growing imbalance that requires detailed and multi-faceted water resource understanding. This study integrated water-stable isotopes and hydrogeochemical species to examine hydrogeochemica...

  • Article
  • Open Access
2 Citations
1,920 Views
19 Pages

Delineation of the Hydrogeological Functioning of a Karst Aquifer System Using a Combination of Environmental Isotopes and Artificial Tracers: The Case of the Sierra Seca Range (Andalucía, Spain)

  • Antonio Lope Morales-González,
  • Jorge Jódar,
  • Francisco Moral-Martos,
  • Rosario Jiménez-Espinosa,
  • Fernando Gázquez and
  • Antonio González-Ramón

28 September 2024

The Sierra Seca aquifer system is located in the northeast (NE) of the province of Granada, in the Prebetic Domain (Betic Cordillera). It is composed of different aquifer units hosted in the Lower Cretaceous and Upper Cretaceous limestones. The two a...

  • Article
  • Open Access
19 Citations
8,216 Views
18 Pages

Oral Gavage Delivery of Stable Isotope Tracer for In Vivo Metabolomics

  • Holden C. Williams,
  • Margaret A. Piron,
  • Grant K. Nation,
  • Adeline E. Walsh,
  • Lyndsay E. A. Young,
  • Ramon C. Sun and
  • Lance A. Johnson

8 December 2020

Stable isotope-resolved metabolomics (SIRM) is a powerful tool for understanding disease. Advances in SIRM techniques have improved isotopic delivery and expanded the workflow from exclusively in vitro applications to in vivo methodologies to study s...

  • Editorial
  • Open Access
15 Citations
7,484 Views
6 Pages

30 October 2014

Environmental tracers continue to provide an important tool for understanding the source, flow and mixing dynamics of water resource systems through their imprint on the system or their sensitivity to alteration within it. However, 60 years or so aft...

  • Article
  • Open Access
19 Citations
13,032 Views
33 Pages

27 March 2014

Stream water quality in areas of the western United States continues to be degraded by acid mine drainage (AMD), a legacy of hard-rock mining. The Rico-Argentine Mine in southwestern Colorado consists of complex multiple-level mine workings connected...

  • Article
  • Open Access
3 Citations
2,456 Views
12 Pages

Preclinical Bioavailability Assessment of a Poorly Water-Soluble Drug, HGR4113, Using a Stable Isotope Tracer

  • Eun Ji Ha,
  • Jeong In Seo,
  • Shaheed Ur Rehman,
  • Hyung Soon Park,
  • Sang-Ku Yoo and
  • Hye Hyun Yoo

Drug solubility limits intravenous dosing for poorly water-soluble medicines, which misrepresents their bioavailability estimation. The current study explored a method using a stable isotope tracer to assess the bioavailability of drugs that are poor...

  • Review
  • Open Access
1,072 Views
15 Pages

8 August 2025

Helium, as a strategic resource with broad applications in industry and science, has drawn increasing global attention due to its scarcity and non-renewable nature. Noble gas isotopes, especially those of helium, neon, and argon, provide unique geoch...

  • Feature Paper
  • Article
  • Open Access
20 Citations
3,984 Views
20 Pages

13 April 2021

Groundwater contamination due to municipal solid waste landfills leachate is a serious environmental threat. During recent years, the use of stable isotopes as environmental tracers to identify groundwater contamination phenomena has found applicatio...

  • Article
  • Open Access
51 Citations
10,329 Views
18 Pages

Submarine Groundwater Discharge at a Single Spot Location: Evaluation of Different Detection Approaches

  • Michael Schubert,
  • Jan Scholten,
  • Axel Schmidt,
  • Jean François Comanducci,
  • Mai Khanh Pham,
  • Ulf Mallast and
  • Kay Knoeller

24 March 2014

Submarine groundwater discharge (SGD) into the ocean is of general interest because it acts as vehicle for the transport of dissolved contaminants and/or nutrients into the coastal sea and because it may be accompanied by the loss of significant volu...

  • Article
  • Open Access
9 Citations
4,892 Views
18 Pages

5 September 2020

Unpredictable climate changes are affecting water resources, especially in karst arid and semiarid areas. In such locations, the need for additional sources of water always arises. The paper gives insight into hydrogeological characteristics of Kazer...

  • Article
  • Open Access
15 Citations
5,112 Views
23 Pages

9 July 2018

Water-stable isotopic (WSI) data are widely used in hydrological modelling investigations. However, the long-term monitoring of these tracers at high-temporal resolution (sub-hourly) remains challenging due to technical and financial limitations. Thu...

  • Article
  • Open Access
4 Citations
2,075 Views
14 Pages

Iron and Molybdenum Isotope Application for Tracing Industrial Contamination in a Highly Polluted River

  • Yu-Hsuan Liang,
  • Po-Chao Wu,
  • Shail Vijeta Ekka,
  • Kuo-Fang Huang and
  • Der-Chuen Lee

5 January 2024

Rivers adjacent to industrial zones usually suffer from severe pollution issues. Industrial wastewater that has undergone sewage treatment processes may be legally discharged into rivers under water quality permits. Previous studies have frequently e...

  • Article
  • Open Access
18 Citations
4,260 Views
15 Pages

NMR Methods for Determining Lipid Turnover via Stable Isotope Resolved Metabolomics

  • Penghui Lin,
  • Li Dai,
  • Daniel R. Crooks,
  • Leonard M. Neckers,
  • Richard M. Higashi,
  • Teresa W-M. Fan and
  • Andrew N. Lane

29 March 2021

Lipids comprise diverse classes of compounds that are important for the structure and properties of membranes, as high-energy fuel sources and as signaling molecules. Therefore, the turnover rates of these varied classes of lipids are fundamental to...

  • Article
  • Open Access
14 Citations
4,477 Views
12 Pages

17 August 2020

Tropical floodplain wetlands are found in low-lying areas that are periodically inundated. During wet periods, these wetlands can receive large amounts of suspended and dissolved material from the catchment, including many potential pollutants. In th...

  • Article
  • Open Access
15 Citations
6,427 Views
24 Pages

Water–Isotope Capacity Building and Demonstration in a Developing World Context: Isotopic Baseline and Conceptualization of a Lake Malawi Catchment

  • Limbikani C. Banda,
  • Michael O. Rivett,
  • Robert M. Kalin,
  • Anold S.K. Zavison,
  • Peaches Phiri,
  • Laura Kelly,
  • Geoffrey Chavula,
  • Charles C. Kapachika,
  • Macpherson Nkhata and
  • Sydney Kamtukule
  • + 2 authors

10 December 2019

Developing countries such as Malawi require improved access to isotope tracer tools to better characterize and manage water resources threatened by land development, deforestation and climate change. This is the first published study to use an isotop...

  • Feature Paper
  • Article
  • Open Access
17 Citations
7,560 Views
16 Pages

Stable isotopic tracer analysis is a technique used to determine carbon or nitrogen atom incorporation into biological systems. A number of mass spectrometry based approaches have been developed for this purpose, including high-resolution tandem mass...

  • Article
  • Open Access
1,847 Views
9 Pages

12 September 2023

Many non-traditional isotopes, such as chlorine, magnesium, calcium, etc., are widely used as groundwater tracers. A new sample processing protocol of purification and concentration for isotopic analysis is presented to overcome many of the major dra...

  • Article
  • Open Access
1,111 Views
14 Pages

Investigating the Digestibility, Bioavailability and Utilization of Protein Blends in Older Adults Using a Dual Stable Isotope Tracer Technique

  • Jake Cox,
  • Bethan E. Phillips,
  • James Bunce,
  • Thomas Smart,
  • Joshua Wall,
  • Hannah Crossland,
  • Daniel J. Wilkinson,
  • Kenneth Smith and
  • Philip J. Atherton

23 October 2025

Objectives: The impact of combining animal and plant protein sources on digestibility is unclear, despite their increasing clinical use. Using a non-invasive dual stable isotope tracer approach, we assessed the digestibility, bioavailability and util...

  • Feature Paper
  • Article
  • Open Access
22 Citations
4,143 Views
17 Pages

10 March 2020

Karst aquifer recharge areas are usually difficult to identify because of the complexity of these aquifers’ characteristics. On the other hand, their identification is very important in the aim of protecting the groundwater resources that these...

  • Article
  • Open Access
7 Citations
5,538 Views
22 Pages

Environmental isotope tracers were applied in the Upper Crocodile River Basin, Johannesburg, South Africa, to understand the groundwater recharge conditions, flow mechanisms and interactions between surface and subsurface water. Stable isotope analys...

  • Article
  • Open Access
33 Citations
5,994 Views
21 Pages

Dynamic 13C-tracer-based flux analyses of in vivo reaction networks still require a continuous development of advanced quantification methods applying state-of-the-art mass spectrometry platforms. Utilizing alkaline HILIC chromatography, we adapt str...

  • Feature Paper
  • Article
  • Open Access
1 Citations
3,375 Views
19 Pages

The Potential of Isotopic Tracers for Precise and Environmentally Clean Stream Discharge Measurements

  • Antoine Picard,
  • Florent Barbecot,
  • Gérard Bardoux,
  • Pierre Agrinier,
  • Marina Gillon,
  • José A. Corcho Alvarado,
  • Vincent Schneider,
  • Jean-François Hélie and
  • Frédérick de Oliveira

23 December 2023

Accurate discharge measurement is mandatory for any hydrological study. While the “velocity” measurement method is adapted to laminar flows, the “dilution” method is more appropriate for turbulent streams. As most low-gradient...

  • Article
  • Open Access
1 Citations
2,266 Views
12 Pages

2 December 2022

In this study, we applied a new methodology that utilized stable isotopic concentrations of water and SF6 concentrations of the air to investigate temporal variations in the spring water mean transit time (MTT) of a forested headwater catchment in Ja...

  • Article
  • Open Access
22 Citations
7,492 Views
18 Pages

Where Does the Chilean Aconcagua River Come from? Use of Natural Tracers for Water Genesis Characterization in Glacial and Periglacial Environments

  • Sebastián Andrés Crespo,
  • Céline Lavergne,
  • Francisco Fernandoy,
  • Ariel A. Muñoz,
  • Leandro Cara and
  • Simón Olfos-Vargas

21 September 2020

The Aconcagua river basin (Chile, 32 °S) has suffered the effects of the megadrought over the last decade. The severe snowfall deficiency drastically modified the water supply to the catchment headwaters. Despite the recognized snowmelt contribution...

  • Article
  • Open Access
3 Citations
3,418 Views
15 Pages

16 May 2021

In this paper, we started from the composition-dependent interdiffusion coefficients with quantified uncertainties in binary alloys by integrating the Matano-based method, distribution functions, and uncertainty propagation approach. After carefully...

  • Article
  • Open Access
2,697 Views
10 Pages

Among the three major global carbon cycle components, the terrestrial one has been the most uncertain because of the complexity of the soil organic carbon (SOC) dynamics. Previous tracer studies, however, have shown that SOC consists of labile and re...

  • Feature Paper
  • Article
  • Open Access
1 Citations
3,409 Views
17 Pages

4 February 2024

Karst aquifers are unique among groundwater systems because of variable permeability and flow-path organization changes resulting from dissolution processes. Over time, changes in flow-path connectivity complicate interpretations of conduit network e...

  • Article
  • Open Access
2 Citations
1,850 Views
16 Pages

9 November 2023

To further our understanding of the change in association between lignin and carbohydrates after kraft pulping, isotope-labeled kraft pulp (KP) was prepared using 13C and D double-isotope-labeled wheat straw, and it was subjected to enzymatic hydroly...

  • Article
  • Open Access
18 Citations
8,170 Views
23 Pages

Environmental Groundwater Vulnerability Assessment in Urban Water Mines (Porto, NW Portugal)

  • Maria José Afonso,
  • Liliana Freitas,
  • Alcides Pereira,
  • Luís Neves,
  • Laura Guimarães,
  • Lúcia Guilhermino,
  • Bernhard Mayer,
  • Fernando Rocha,
  • José Manuel Marques and
  • Helder I. Chaminé

3 November 2016

A multidisciplinary approach was developed to estimate urban groundwater vulnerability to contamination combining hydrogeology, hydrogeochemistry, subterranean hydrogeotechnics, groundwater ecotoxicology and isotope tracers. Paranhos and Salgueiros s...

  • Communication
  • Open Access
2,077 Views
7 Pages

Regional Variation in the Trophic Ecology of Wahoo (Acanthocybium solandri) in the Western Atlantic Ocean

  • Brendan Gough,
  • Alexandra Prouse,
  • Michael A. Dance,
  • R. J. David Wells and
  • Jay R. Rooker

20 October 2023

Intrinsic tracers, such as stable isotopes of carbon and nitrogen, are common dietary markers that accumulate in the muscle tissue of consumers and can be used to determine the dietary sources and trophic positions of consumers. The aim of this study...

  • Article
  • Open Access
2,950 Views
15 Pages

5 February 2022

Major ions, stable isotopes, and trace elements, including rare earth elements (REEs), are used as natural tracers in the qualitative assessment of potential water sources in lakes and rivers of the upper Yana River basin, between Verkhoyansk and Che...

  • Article
  • Open Access
4 Citations
2,728 Views
18 Pages

20 March 2021

Estuarine freshwater transport has a substantial impact on the near-shore ecosystem and coastal ocean environment away from the estuary. This paper introduces two independent methods to track the Mekong freshwater-induced mass transport by calculatin...

  • Article
  • Open Access
11 Citations
6,034 Views
21 Pages

23 November 2017

Major ions and selected environmental tracers (D, 18O, 3H and chlorofluorocarbons (CFCs)) were employed to determine the source, flow rates, and hydrochemical evolution of groundwater in an alluvial fan along the front of the Qilian Mountains, which...

  • Review
  • Open Access
4 Citations
2,781 Views
12 Pages

Isotopic Tracer for Absolute Quantification of Metabolites of the Pentose Phosphate Pathway in Bacteria

  • Khairunnisa Mohd Kamal,
  • Mohd Hafidz Mahamad Maifiah,
  • Yan Zhu,
  • Nusaibah Abdul Rahim,
  • Yumi Zuhanis Has-Yun Hashim and
  • Muhamad Shirwan Abdullah Sani

9 November 2022

The pentose phosphate pathway (PPP) plays a key role in many metabolic functions, including the generation of NADPH, biosynthesis of nucleotides, and carbon homeostasis. In particular, the intermediates of PPP have been found to be significantly pert...

  • Article
  • Open Access
1 Citations
811 Views
11 Pages

Cadmium Accumulation and Regulation in the Freshwater Mussel Anodonta woodiana

  • Xiubao Chen,
  • Chao Song,
  • Jiazhen Jiang,
  • Tao Jiang,
  • Junren Xue,
  • Ibrahim Bah,
  • Mengying Gu,
  • Meiyi Wang and
  • Shunlong Meng

30 July 2025

Cadmium (Cd) pollution poses a serious threat to freshwater ecosystems. The freshwater mussel Anodonta woodiana is increasingly used as a bioindicator for monitoring Cd pollution in aquatic environments. However, the primary routes of Cd accumulation...

  • Article
  • Open Access
3 Citations
1,258 Views
15 Pages

Study on the Characteristics and Mechanism of Inorganic Nitrogen Nutrients Preferential Assimilation by Phaeocystis globosa

  • Honghong Guo,
  • Wentao Wang,
  • Jishu Han,
  • Jianan Zhu,
  • Zhongshi Wang,
  • Liyan He,
  • Xiuxian Song and
  • Zhiming Yu

Phaeocystis globosa is an important harmful algal species that is globally distributed. Previous studies have indicated that P. globosa preferentially uptake nitrate, but the underlying mechanism is still unclear. To further verify this preference an...

  • Article
  • Open Access
12 Citations
3,678 Views
20 Pages

A Holistic Approach to Study Groundwater-Surface Water Modifications Induced by Strong Earthquakes: The Case of Campiano Catchment (Central Italy)

  • Elisa Mammoliti,
  • Davide Fronzi,
  • Costanza Cambi,
  • Francesco Mirabella,
  • Carlo Cardellini,
  • Emiliano Patacchiola,
  • Alberto Tazioli,
  • Stefano Caliro and
  • Daniela Valigi

Carbonate aquifers are characterised by strong heterogeneities and their modelling is often a challenging aspect in hydrological studies. Understanding carbonate aquifers can be more complicated in the case of strong seismic events which have been wi...

  • Communication
  • Open Access
2,583 Views
10 Pages

Can Isotopes Be Used as Lead Tracers in Shooting-Range Soils?

  • Andrés Rodríguez-Seijo,
  • Knut Endre Sjåstad and
  • Vladislav Chrastný

1 September 2022

Lead isotopes have been widely used to assess the sources of Pb in the soil environment since lead isotopes ratios have a specific signature that allows us to use them as environmental tracers. However, some lead sources are difficult to be identifie...

  • Article
  • Open Access
39 Citations
7,436 Views
23 Pages

31 July 2014

The “Scansano-Magliano in Toscana” area is characterized by a morpho-structure chiefly made-up by sandstone and shelly-calcareous lithologies. Generally, these complexes host minor aquifers in Tuscany, since they have medium to medium-low permeabilit...

  • Article
  • Open Access
28 Citations
5,081 Views
25 Pages

Determination of Physicochemical Water Quality of the Ghis-Nekor Aquifer (Al Hoceima, Morocco) Using Hydrochemistry, Multiple Isotopic Tracers, and the Geographical Information System (GIS)

  • Nordine Nouayti,
  • El Khalil Cherif,
  • Manuel Algarra,
  • Mᵃ Luisa Pola,
  • Sara Fernández,
  • Abderrahim Nouayti,
  • Joaquim C. G. Esteves da Silva,
  • Khattach Driss,
  • Nouha Samlani and
  • Hilali Mohamed
  • + 3 authors

16 February 2022

The chemical characterization of the Ghis-Nekor groundwater has become a concern of many researchers in Morocco. It is a crucial indicator for the environment situation and the socioeconomic development of this Moroccan region. Indeed, it helps decis...

  • Article
  • Open Access
9 Citations
3,128 Views
16 Pages

Use of Lead Isotopic Ratios as Geographical Tracer for Lambrusco PDO Wines

  • Lisa Lancellotti,
  • Simona Sighinolfi,
  • Andrea Marchetti and
  • Lorenzo Tassi

In this study, the lead isotope signature was tested with the aim to verify its potential as geographic tracer for wine production and particularly for the Lambrusco PDO wines of the province of Modena (Italy). A solid phase extraction procedure, for...

  • Article
  • Open Access
9 Citations
5,148 Views
30 Pages

Comparison of Uranium Isotopes and Classical Geochemical Tracers in Karst Aquifer of Ljubljanica River catchment (Slovenia)

  • Leja Rovan,
  • Sonja Lojen,
  • Tea Zuliani,
  • Tjaša Kanduč,
  • Metka Petrič,
  • Barbara Horvat,
  • Simon Rusjan and
  • Marko Štrok

21 July 2020

The karst aquifer of the Ljubljanica River catchment, which has numerous springs and sinks, presents an interesting environment for studying hydrogeological processes. This study aims to explore the behavior of U isotopes and to evaluate their use as...

  • Article
  • Open Access
6 Citations
7,105 Views
12 Pages

17 May 2013

Aquifers recharge mainly by local rainfall, which depend on the air mass humidity and orographic lifting, causing rain. The stable isotopes of the water molecule, i.e., oxygen-18 and deuterium, are useful tracers to determine the water source origin....

  • Article
  • Open Access
2 Citations
4,010 Views
19 Pages

16 July 2019

The isotopic compositions of water fluxes provide valuable insights into the hydrological cycle and are widely used to quantify biosphere–atmosphere exchange processes. However, the combination of water isotope approaches with water flux compon...

  • Article
  • Open Access
5 Citations
2,232 Views
18 Pages

25 September 2022

Soil erosion results in land degradation and desertification in northern China. The Xilingol League of Inner Mongolia is an important part of the “Two Barriers and Three Belts”, and has been given the main function of “a windbreak a...

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