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2,323 Results Found

  • Article
  • Open Access
692 Views
17 Pages

15 September 2025

Although the impact of spatial resolution on river flow simulation has been examined in several studies, unresolved uncertainties remain regarding parameter sensitivity and the applicability of different routing models. This study investigated the re...

  • Article
  • Open Access
2 Citations
2,689 Views
33 Pages

6 March 2025

Exploring the urban spatial pattern and expansion characteristics of African countries under shared socioeconomic pathways (SSPs) is crucial to optimizing urban development in Africa and ensuring ecological sustainability. We use land and socioeconom...

  • Article
  • Open Access
15 Citations
13,103 Views
24 Pages

Designing with Pathways: A Spatial Design Approach for Adaptive and Sustainable Landscapes

  • Mark Zandvoort,
  • Nora Kooijmans,
  • Paul Kirshen and
  • Adri van den Brink

22 January 2019

Despite rising attention to pathways thinking in multiple domains such as climate adaptation, energy supply planning, and flood risk management, their spatial translation is so far understudied. We set out to study how spatial design based on pathway...

  • Article
  • Open Access
31 Citations
7,304 Views
13 Pages

Neuroendocrine prostate carcinoma (NEPC) accounts for less than 1% of prostate neoplasms and has extremely poorer prognosis than the typical androgen receptor pathway-positive adenocarcinoma of the prostate (ARPC). However, very few cases in which de...

  • Article
  • Open Access
25 Citations
7,790 Views
26 Pages

21 April 2020

Spatial population distribution is an important determinant of both drivers of regional environmental change and exposure and vulnerability to it. Spatial projections of population must account for changes in aggregate population, urbanization, and s...

  • Article
  • Open Access
2 Citations
1,154 Views
16 Pages

1 May 2025

The offshore transport of coastal water masses in the East China Sea is vital for maintaining ecological stability. Understanding its spatial-temporal pathways helps clarify material transport and ecological responses. This study used total suspended...

  • Article
  • Open Access
8 Citations
1,672 Views
20 Pages

28 June 2024

The concept of major function-oriented zones is highly compatible with the idea of spatially synergistic carbon reduction. In this study, 2005–2020 is taken as the research period, and 305 counties in the Yangtze River Delta (YRD) region are ta...

  • Article
  • Open Access
1 Citations
822 Views
12 Pages

6 August 2025

A new generation of compact radon detectors with high sensitivity and fine spatial resolution (1–2 cm scale) was used to investigate indoor radon distribution and identify potential entry pathways. Solid-state nuclear track detectors (Kodak-Pat...

  • Article
  • Open Access
1,137 Views
21 Pages

Rural Image Perception and Spatial Optimization Pathways Based on Social Media Data: A Case Study of Baishe Village—A Traditional Village

  • Bingshu Zhao,
  • Zhimin Gao,
  • Meng Jiao,
  • Ruiyao Weng,
  • Tongyu Jia,
  • Chenyu Xu,
  • Xuhui Wang and
  • Yuting Jiang

11 September 2025

The sustainable development of traditional villages faces a core challenge stemming from the disconnect between public perception and spatial planning. To address this issue, this study, taking Baishe Village—a national-level traditional villag...

  • Article
  • Open Access
287 Views
35 Pages

16 January 2026

Promoting the value realization of ecological products is a central issue in practicing the concept that “lucid waters and lush mountains are invaluable assets.” This is particularly urgent for alpine regions, which are vital ecological s...

  • Article
  • Open Access
353 Views
21 Pages

HDCA: Heterogeneous Dual-Path Contrastive Architecture for Action Recognition

  • Shilu Kang,
  • Hua Huo,
  • Lan Ma,
  • Jinxuan Wang and
  • Aokun Mei

30 November 2025

We propose Heterogeneous Dual-path Contrastive Architecture (HDCA) for action recognition. Our model involves a spatial pathway and a temporal pathway; these two pathways employ distinct backbone networks and input formats, tailored to the specific p...

  • Communication
  • Open Access
2 Citations
1,778 Views
8 Pages

19 September 2023

Genome-wide association studies (GWAS) have identified genetic markers associated with type 2 diabetes mellitus (T2DM). Additionally, tissue-specific expression quantitative trait loci (eQTL) studies have revealed regulatory elements influencing gene...

  • Article
  • Open Access
1,449 Views
26 Pages

17 April 2025

This study investigated the differential impact of two visual dimensions (direction and spatial location) in two spatial Stroop tasks, where the relevant dimension for the response varied. Three studies compared the interactions between spatial compa...

  • Article
  • Open Access
857 Views
37 Pages

31 October 2025

Exploring the dynamic mechanisms of household poverty alleviation is crucial for achieving sustainable poverty reduction and preventing relapse into poverty. However, existing research is often constrained by a static perspective, failing to integrat...

  • Article
  • Open Access
29 Citations
5,527 Views
15 Pages

Atrazine (ATR) is a widely used herbicide that has been implicated as a neurotoxicant. Recent experimental evidence has implicated that ATR exposure also appears to have adverse effects on the hippocampus, which is a critical region for learning and...

  • Article
  • Open Access
690 Views
27 Pages

22 November 2025

This study develops a replicable, data-driven framework for subnational climate action, demonstrated through a case study of Chiang Mai Province, Thailand. The framework integrates a comprehensive greenhouse gas (GHG) inventory with spatial analysis...

  • Article
  • Open Access
4 Citations
3,102 Views
19 Pages

21 February 2025

This study employs various comprehensive research methods to thoroughly analyze the relationship between urban–rural integration and sustainable development, proposing corresponding optimization pathways. First, a literature review method syste...

  • Review
  • Open Access
4 Citations
4,832 Views
22 Pages

Intratumoral immune cytolytic activity (CYT), calculated as the geometric mean of granzyme-A (GZMA) and perforin-1 (PRF1) expression, has emerged as a critical factor in cancer immunotherapy, with significant implications for patient prognosis and tr...

  • Article
  • Open Access
283 Views
29 Pages

21 January 2026

Socio-ecological systems in basin regions characterized by diverse cultural traditions and hierarchical village spatial structure are undergoing profound transformation driven by multifunctional demands and spatial restructuring. This study develops...

  • Review
  • Open Access
19 Citations
7,588 Views
25 Pages

26 December 2023

Panax ginseng C.A. Meyer (P. ginseng) is one of the more common traditional Chinese medicines (TCMs). It contains numerous chemical components and exhibits a range of pharmacological effects. An enormous burden is placed on people’s health and...

  • Review
  • Open Access
422 Views
25 Pages

11 February 2026

Historically, the toxicological evaluation of poorly soluble low toxicity particles (PSLTs), such as titanium dioxide nanoparticles (TiO2 NPs), distinct from conventional pigment-grade TiO2, has focused on carcinogenicity and lung overload, leaving t...

  • Article
  • Open Access
149 Citations
15,450 Views
18 Pages

9 April 2019

This study downscales the population and gross domestic product (GDP) scenarios given under Shared Socioeconomic Pathways (SSPs) into 0.5-degree grids. Our downscale approach has the following features. (i) It explicitly considers spatial and socioec...

  • Article
  • Open Access
1 Citations
1,950 Views
15 Pages

Currently, various types of myoglobins and hemoglobins are widely used in the fields of food additives and biocatalytic applications. However, the limited availability of heme constrains the biosynthesis of these high-activity hemoproteins in microbi...

  • Article
  • Open Access
18 Citations
4,621 Views
16 Pages

Developing an Adaptive Pathway to Mitigate Air Pollution Risk for Vulnerable Groups in South Korea

  • Sugyeong Park,
  • Sea Jin Kim,
  • Hangnan Yu,
  • Chul-Hee Lim,
  • Eunbeen Park,
  • Jiwon Kim and
  • Woo-Kyun Lee

27 February 2020

Air pollution is one of the most significant environmental hazards. The elderly, young, and poor are more vulnerable to air pollution. The risk of air pollution was assessed based on the risk framework published by the Intergovernmental Panel on Clim...

  • Viewpoint
  • Open Access
7 Citations
4,829 Views
6 Pages

7 December 2020

An integrated approach to transport and spatial development has been promoted over the past decades not only in North America and Europe but also in rapidly growing cities in Asia as a means to achieve sustainable urbanization. Some fundamental issue...

  • Article
  • Open Access
1 Citations
2,310 Views
33 Pages

15 October 2022

The objectives of this study were to evaluate and exemplify the potential utility of a climate-sensitive modular-based structural stand density management model (SSDMM) developed for red pine (Pinus resinosa Aiton) in crop planning decision making. F...

  • Review
  • Open Access
46 Citations
14,946 Views
27 Pages

Spatial Regulation of Root Growth: Placing the Plant TOR Pathway in a Developmental Perspective

  • Adam Barrada,
  • Marie-Hélène Montané,
  • Christophe Robaglia and
  • Benoît Menand

19 August 2015

Plant cells contain specialized structures, such as a cell wall and a large vacuole, which play a major role in cell growth. Roots follow an organized pattern of development, making them the organs of choice for studying the spatio-temporal regulatio...

  • Article
  • Open Access
402 Views
27 Pages

24 December 2025

Understanding the pathways through which digital innovation contributes to carbon emission reduction is crucial for designing effective climate policies. Existing studies generally find a negative association between digitalization and carbon emissio...

  • Article
  • Open Access
21 Citations
6,854 Views
16 Pages

Insights from Testing a Modified Dynamic Adaptive Policy Pathways Approach for Spatial Planning at the Municipal Level

  • Christoffer Carstens,
  • Karin Mossberg Sonnek,
  • Riitta Räty,
  • Per Wikman-Svahn,
  • Annika Carlsson-Kanyama and
  • Jonathan Metzger

15 January 2019

The Dynamic Adaptive Policy Pathways (DAPP) approach has successfully been used to manage uncertainties in large infrastructure projects. However, the viability of the DAPP approach for spatial planning in smaller municipal settings is not clear. Thi...

  • Article
  • Open Access
2 Citations
2,168 Views
11 Pages

19 December 2023

While internal aeration in plants is critical for adaptation to waterlogging, there is a gap in understanding the differences in oxygen diffusion gradients from shoots to roots between hypoxia-tolerant and -sensitive species. This study aims to eluci...

  • Article
  • Open Access
1 Citations
1,523 Views
28 Pages

31 January 2025

A comfortable outdoor environment, like its indoor counterpart, can significantly enhance the quality of life and improve the physical and mental health of elderly populations. Urban spatial morphology is one of the key factors influencing outdoor en...

  • Article
  • Open Access
65 Citations
15,578 Views
25 Pages

3 October 2012

In order to incorporate climate adaptation in spatial planning change is required, because climate change impacts the way we live. This implies that spatial planning, as the arranger of the spatial organisation and layout needs to be able to support...

  • Article
  • Open Access
782 Views
20 Pages

Regional Rural Transformation Pathways: A Spatial–Temporal Comparison of Bangladesh, China, Indonesia, and Pakistan

  • Pengfei Shi,
  • Dong Wang,
  • David Shearer,
  • Abedullah,
  • Mohammad Jahangir Alam,
  • Chunlai Chen,
  • Jikun Huang,
  • Abid Hussian,
  • Nunung Nuryartono and
  • Tahlim Sudaryanto

29 November 2025

This paper examines the historical evolution and pathways of rural transformation (RT) at the regional level in four Asian countries—Bangladesh, China, Indonesia, and Pakistan. We conduct a comparative spatial analysis of regional level changes...

  • Article
  • Open Access
13 Citations
6,243 Views
17 Pages

21 February 2022

Accurate and reliable subnational and spatially explicit population projections under shared socioeconomic pathways (SSPs) for China will be helpful for understanding long-term demographic changes and formulating targeted mitigation and adaptation po...

  • Article
  • Open Access
2 Citations
3,625 Views
19 Pages

Downscaling Global Land-Use Scenario Data to the National Level: A Case Study for Belgium

  • Parinaz Rashidi,
  • Sopan D. Patil,
  • Aafke M. Schipper,
  • Rob Alkemade and
  • Isabel Rosa

7 September 2023

Land use change scenarios, and their projected impacts on biodiversity, are highly relevant at local scales but not adequately captured by the coarse spatial resolutions of global land use models. In this study, we used the land use allocation tool o...

  • Article
  • Open Access
14 Citations
5,726 Views
20 Pages

Spatial EGFR Dynamics and Metastatic Phenotypes Modulated by Upregulated EphB2 and Src Pathways in Advanced Prostate Cancer

  • Yen-Liang Liu,
  • Aaron M. Horning,
  • Brandon Lieberman,
  • Mirae Kim,
  • Che-Kuang Lin,
  • Chia-Nung Hung,
  • Chih-Wei Chou,
  • Chiou-Miin Wang,
  • Chun-Lin Lin and
  • Chun-Liang Chen
  • + 12 authors

1 December 2019

Advanced prostate cancer is a very heterogeneous disease reflecting in diverse regulations of oncogenic signaling pathways. Aberrant spatial dynamics of epidermal growth factor receptor (EGFR) promote their dimerization and clustering, leading to con...

  • Article
  • Open Access
8 Citations
2,431 Views
12 Pages

24 October 2022

Much research has documented the contagiousness of violence. Some of this work has focused on contagiousness as operationalized by the spread across geographical space, while other work has examined the spread within social networks. While the latter...

  • Article
  • Open Access
2 Citations
2,339 Views
25 Pages

Forecasting Future Vegetation Dynamics under SSP/RCP Pathways under Spatially Changing Climate and Human Activities Conditions

  • Wei Yang,
  • Xinquan Su,
  • Lu Li,
  • Bing Yu,
  • Xiao Chen,
  • Zhibang Luo,
  • Wenyv Chu and
  • Wenting Zhang

19 July 2024

Vegetation dynamics result from the interaction between human activities and climate change. Numerous studies have investigated the contributions of human activities and climate change to vegetation cover dynamics using statistical methods. However,...

  • Article
  • Open Access
525 Views
25 Pages

From EU Just Transition Policy to Local Adaptation: Spatial–Economic Pathways for Coal Microregions in Eastern Europe

  • Iryna Storonyanska,
  • Khrystyna Patytska,
  • Lilia Benovska,
  • Olena Ivashko,
  • Ihor Chulipa and
  • Jerzy Choroszczak

9 December 2025

This study draws on the experience of selected European micro-regions in Germany, Poland, and Romania, representing different stages of a just transition, to identify applicable strategies for the Ukrainian context. The research aims to assess the sp...

  • Article
  • Open Access
6 Citations
2,216 Views
19 Pages

The Spatial Coupling of Fluid Pathways with Gas Hydrates and Shallow Gas Reservoirs: A Case Study in the Qiongdongnan Basin, South China Sea

  • Songlin Wu,
  • Shiguo Wu,
  • Jin Sun,
  • Qingping Li,
  • Junjin Chen,
  • Yuan Chen,
  • Xueqing Zhou and
  • Umair Khan

Shallow gas reservoirs play a crucial role in the gas hydrate system. However, the factors influencing their distribution and their relationship with the gas hydrate system remain poorly understood. In this study, we utilize three-dimensional seismic...

  • Article
  • Open Access
2 Citations
862 Views
22 Pages

23 April 2025

Traditional urban expansion struggles to balance economic and ecological demands. Intensive development planning based on re-naturalization has become the policymakers’ choice. However, planning-oriented land use patterns and re-naturalization...

  • Article
  • Open Access
5 Citations
2,367 Views
16 Pages

6 February 2024

China faces a multi-objective environmental governance dilemma involving achieving fundamental ecological environment improvement, carbon peaking, and carbon neutrality. In this study, we constructed indicators of the level of green finance developme...

  • Article
  • Open Access
14 Citations
6,370 Views
35 Pages

Linking Theories, Past Practices, and Archaeological Remains of Movement through Ontological Reasoning

  • Laure Nuninger,
  • Philip Verhagen,
  • Thérèse Libourel,
  • Rachel Opitz,
  • Xavier Rodier,
  • Clément Laplaige,
  • Catherine Fruchart,
  • Samuel Leturcq and
  • Nathanael Levoguer

24 June 2020

The amount of information available to archaeologists has grown dramatically during the last ten years. The rapid acquisition of observational data and creation of digital data has played a significant role in this “information explosion”...

  • Article
  • Open Access
20 Citations
4,705 Views
20 Pages

Human Exposure to Pesticides in Dust from Two Agricultural Sites in South Africa

  • Céline Degrendele,
  • Roman Prokeš,
  • Petr Šenk,
  • Simona Rozárka Jílková,
  • Jiří Kohoutek,
  • Lisa Melymuk,
  • Petra Přibylová,
  • Mohamed Aqiel Dalvie,
  • Martin Röösli and
  • Samuel Fuhrimann
  • + 1 author

21 October 2022

Over the last decades, concern has arisen worldwide about the negative impacts of pesticides on the environment and human health. Exposure via dust ingestion is important for many chemicals but poorly characterized for pesticides, particularly in Afr...

  • Article
  • Open Access
5 Citations
9,660 Views
16 Pages

Room for Sea-Level Rise: Conceptual Perspectives to Keep The Netherlands Safe and Livable in the Long Term as Sea Level Rises

  • Jos van Alphen,
  • Stephan van der Biezen,
  • Matthijs Bouw,
  • Alex Hekman,
  • Bas Kolen,
  • Rob Steijn and
  • Harm Albert Zanting

5 February 2025

An accelerated sea-level rise (SLR) may threaten the future livability of the Netherlands. Three perspectives to anticipate this SLR are elaborated here regarding technical, physical, and spatial aspects: Protect, Advance, and Accommodate. The overal...

  • Article
  • Open Access
1,723 Views
18 Pages

18 November 2024

Background: Rhododendron is a globally distributed and extensive genus, comprising over 1000 species. In the southwestern mountains of China, there exists a remarkable diversity of Rhododendron, with Yunnan Province alone harboring more than 600 spec...

  • Article
  • Open Access
9 Citations
4,963 Views
27 Pages

Assessing Future Agricultural Vulnerability in Kashmir Valley: Mid- and Late-Century Projections Using SSP Scenarios

  • Majid Farooq,
  • Suraj Kumar Singh,
  • Shruti Kanga,
  • Gowhar Meraj,
  • Fayma Mushtaq,
  • Bojan Đurin,
  • Quoc Bao Pham and
  • Julian Hunt

4 September 2024

The fragile environment of the Himalayan region is prone to natural hazards, which are intensified by climate change, leading to food and livelihood insecurity for inhabitants. Therefore, building resilience in the most dominant livelihood sector, i....

  • Article
  • Open Access
18 Citations
6,776 Views
11 Pages

A Spatial Analysis Framework to Monitor and Accelerate Progress towards SDG 3 to End TB in Bangladesh

  • Ente Rood,
  • Ahmadul Hasan Khan,
  • Pronab Kumar Modak,
  • Christina Mergenthaler,
  • Margo Van Gurp,
  • Lucie Blok and
  • Mirjam Bakker

Global efforts to end the tuberculosis (TB) epidemic by 2030 (SDG3.3) through improved TB case detection and treatment have not been effective to significantly reduce the global burden of the TB epidemic. This study presents an analytical framework t...

  • Article
  • Open Access
29 Citations
6,465 Views
21 Pages

Iterative Models for Early Detection of Invasive Species across Spread Pathways

  • Gericke Cook,
  • Catherine Jarnevich,
  • Melissa Warden,
  • Marla Downing,
  • John Withrow and
  • Ian Leinwand

29 January 2019

Species distribution models can be used to direct early detection of invasive species, if they include proxies for invasion pathways. Due to the dynamic nature of invasion, these models violate assumptions of stationarity across space and time. To co...

  • Article
  • Open Access
60 Citations
11,990 Views
18 Pages

Action Video Games Enhance Attentional Control and Phonological Decoding in Children with Developmental Dyslexia

  • Sara Bertoni,
  • Sandro Franceschini,
  • Giovanna Puccio,
  • Martina Mancarella,
  • Simone Gori and
  • Andrea Facoetti

29 January 2021

Reading acquisition is extremely difficult for about 5% of children because they are affected by a heritable neurobiological disorder called developmental dyslexia (DD). Intervention studies can be used to investigate the causal role of neurocognitiv...

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