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5,054 Results Found

  • Article
  • Open Access
1 Citations
2,655 Views
11 Pages

Cluster Structure of Optimal Solutions in Bipartitioning of Small Worlds

  • Adam Lipowski,
  • António L. Ferreira and
  • Dorota Lipowska

19 November 2020

Using simulated annealing, we examine a bipartitioning of small worlds obtained by adding a fraction of randomly chosen links to a one-dimensional chain or a square lattice. Models defined on small worlds typically exhibit a mean-field behavior, rega...

(This article belongs to the Special Issue Statistical Mechanics of Complex Systems)
  • Article
  • Open Access
33 Citations
5,664 Views
18 Pages

Exploiting Small World Problems in a SIoT Environment

  • Rehman Abdul,
  • Anand Paul,
  • Junaid Gul M.,
  • Won-Hwa Hong and
  • Hyuncheol Seo

10 August 2018

Internet of Things (IoT) has been at the center of attention among researchers for the last two decades. Their aim was to convert each real-world object into a virtual object. Recently, a new idea of integrating the Social Networking concept into the...

  • Article
  • Open Access
2 Citations
2,789 Views
11 Pages

Percolation Distribution in Small-World Quantum Networks

  • Jianxiong Liang,
  • Xiaoguang Chen and
  • Tianyi Wang

11 January 2022

Quantum networks have good prospects for applications in the future. Compared with classical networks, small-world quantum networks have some interesting properties. The topology of the network can be changed through entanglement exchange operations,...

(This article belongs to the Topic Quantum Information and Quantum Computing)
  • Article
  • Open Access
37 Citations
7,052 Views
18 Pages

Large Scale Community Detection Using a Small World Model

  • Ranjan Kumar Behera,
  • Santanu Kumar Rath,
  • Sanjay Misra,
  • Robertas Damaševičius and
  • Rytis Maskeliūnas

15 November 2017

In a social network, small or large communities within the network play a major role in deciding the functionalities of the network. Despite of diverse definitions, communities in the network may be defined as the group of nodes that are more densely...

(This article belongs to the Special Issue Socio-Cognitive and Affective Computing)
  • Article
  • Open Access
6 Citations
3,601 Views
17 Pages

Upregulation of a Small-World Brain Network Improves Inhibitory Control: An fNIRS Neurofeedback Training Study

  • Lingwei Zeng,
  • Chunchen Wang,
  • Kewei Sun,
  • Yue Pu and ,
  • Yuntao Gao,
  • Hui Wang,
  • Xufeng Liu and
  • Zhihong Wen
  • + 3 authors+ 0 author

26 October 2023

The aim of this study was to investigate the inner link between the small-world brain network and inhibitory control. Functional near-infrared spectroscopy (fNIRS) was used to construct a neurofeedback (NF) training system and regulate the frontal sm...

(This article belongs to the Special Issue Executive Functioning Development—Measurements and Promotion in Naturalistic Setups)
  • Article
  • Open Access
5 Citations
2,776 Views
16 Pages

Speeding Up Velocity Consensus Control with Small World Communication Topology for Unmanned Aerial Vehicle Swarms

  • Xiang Ji,
  • Wanpeng Zhang,
  • Shaofei Chen,
  • Junren Luo and ,
  • Lina Lu,
  • Weilin Yuan,
  • Zhenzhen Hu and
  • Jing Chen
  • + 3 authors+ 0 author

18 October 2021

This study addressed a problem of rapid velocity consensus within a swarm of unmanned aerial vehicles. Our analytical framework was based on tools using matrix theory and algebraic graph theory. We established connections between algebraic connectivi...

(This article belongs to the Special Issue Advances in Swarm Intelligence, Data Science and Their Applications)
  • Feature Paper
  • Article
  • Open Access
934 Views
17 Pages

12 April 2025

Linear tight-binding models with long-range interactions and small-world geometry have a broad energy spectrum in the nearest neighbor coupling limit, while the spectrum becomes narrow in the fully connected limit due to the emergence of flat bands....

(This article belongs to the Section Statistical Physics)
  • Article
  • Open Access
9 Citations
3,028 Views
28 Pages

Safe and Secure Control of Swarms of Vehicles by Small-World Theory

  • Nicola Roveri,
  • Antonio Carcaterra,
  • Leonardo Molinari and
  • Gianluca Pepe

26 February 2020

The present paper investigates a new paradigm to control a swarm of moving individual vehicles, based on the introduction of a few random long-range communications in a queue dominated by short-range car-following dynamics. The theoretical approach a...

(This article belongs to the Special Issue IoT and Sensor Networks in Industry and Society)
  • Article
  • Open Access
2 Citations
3,198 Views
17 Pages

Electronic Implementation of a Deterministic Small-World Network: Synchronization and Communication

  • Daniel Reyes-De la Cruz,
  • Rodrigo Méndez-Ramírez,
  • Adrian Arellano-Delgado and
  • César Cruz-Hernández

25 April 2023

In this paper, synchronization and encrypted communication transmissions of analog and digital messages in a deterministic small-world network (DSWN) are presented. In the first instance, we use a network with 3 coupled nodes in a nearest-neighbor (N...

(This article belongs to the Special Issue Synchronization in Time-Evolving Complex Networks)
  • Article
  • Open Access
8 Citations
3,196 Views
18 Pages

Evaluating the Alterations Induced by Virtual Reality in Cerebral Small-World Networks Using Graph Theory Analysis with Electroencephalography

  • Shan Yang,
  • Hyeon-Sik Hwang,
  • Bao-Hua Zhu,
  • Jian Chen and ,
  • Ganbold Enkhzaya,
  • Zhi-Ji Wang,
  • Eun-Seong Kim and
  • Nam-Young Kim
  • + 3 authors+ 0 author

28 November 2022

Virtual reality (VR), a rapidly evolving technology that simulates three-dimensional virtual environments for users, has been proven to activate brain functions. However, the continuous alteration pattern of the functional small-world network in resp...

(This article belongs to the Section Computational Neuroscience, Neuroinformatics, and Neurocomputing)
  • Article
  • Open Access
5 Citations
4,008 Views
19 Pages

A Small World Graph Approach for an Efficient Indoor Positioning System

  • Max Lima,
  • Leonardo Guimarães,
  • Eulanda Santos,
  • Edleno Moura and ,
  • Rafael Costa,
  • Marco Levorato and
  • Horácio Oliveira
  • + 2 authors+ 0 author

23 July 2021

The main goal of an Indoor Positioning System (IPS) is to estimate the position of mobile devices in indoor environments. For this purpose, the primary source of information is the signal strength of packets received by a set of routers. The fingerpr...

(This article belongs to the Section Sensor Networks)
  • Article
  • Open Access
10 Citations
4,690 Views
13 Pages

Real-World Outcomes and Treatments Patterns Prior and after the Introduction of First-Line Immunotherapy for the Treatment of Metastatic Non-Small Cell Lung Cancer

  • Valentina Danesi,
  • Ilaria Massa,
  • Flavia Foca,
  • Angelo Delmonte and ,
  • Lucio Crinò,
  • Giuseppe Bronte,
  • Maria Ragonesi,
  • Roberta Maltoni,
  • Silvia Manunta and
  • Mattia Altini
  • + 11 authors+ 6 authors

15 September 2022

Background: This study provides insights into the treatment use and outcomes of metastatic non-small cell lung cancer (NSCLC) patients in a real-world setting prior to and after the availability of immuno-oncology (IO) regimens in the first line (1L)...

(This article belongs to the Section Cancer Immunology and Immunotherapy)
  • Article
  • Open Access
8 Citations
7,461 Views
13 Pages

28 October 2013

The patent cooperation network which enterprises join is a very important network platform for enterprises’ open innovation. However, very limited work has been done to empirically investigate the dynamic change process of the network in China. To ad...

(This article belongs to the Section Information Applications)
  • Article
  • Open Access
1 Citations
1,013 Views
29 Pages

Currently, small moving object detection remains a highly challenging problem, primarily attributable to four critical factors: limited pixel coverage, blurred texture features, indistinguishability from small-object-like background features (i.e., f...

(This article belongs to the Special Issue Bionic Vision Applications and Validation)
  • Article
  • Open Access
5 Citations
1,205 Views
25 Pages

9 September 2025

A complex network topology marked by co-competitive relationships between manufacturing enterprises can meaningfully influence low-carbon technology selection, thereby affecting the low-carbon technology diffusion process. This study develops a small...

(This article belongs to the Section Complex Systems and Cybernetics)
  • Article
  • Open Access
1 Citations
2,110 Views
12 Pages

Real-World Comparative Study of Atezolizumab-Based Chemotherapy Regimens in Advanced Non-Small Cell Lung Cancer

  • Ayaka Ohiwa,
  • Tadashi Nishimura,
  • Tadashi Sakaguchi,
  • Hajime Fujimoto and ,
  • Shuji Kodama,
  • Atsushi Fujiwara,
  • Hiroki Nakahara,
  • Taichi Isobe,
  • Takaya Hirai and
  • Tetsu Kobayashi
  • + 14 authors+ 9 authors

12 November 2025

Background/objective: Carboplatin, pemetrexed, and pembrolizumab are established as a key first-line regimen for metastatic non-small cell lung cancer, although selecting the optimal therapy for each patient remains challenging in real-world clinical...

(This article belongs to the Special Issue Clinical Trials and Outcomes for Non-Small Cell Lung Cancer)
  • Article
  • Open Access
12 Citations
5,591 Views
13 Pages

Real-World Outcomes of Crizotinib in ROS1-Rearranged Advanced Non-Small-Cell Lung Cancer

  • Hyeon Hwa Kim,
  • Jae Cheol Lee,
  • In-Jae Oh,
  • Eun Young Kim and ,
  • Seong Hoon Yoon,
  • Shin Yup Lee,
  • Min Ki Lee,
  • Jeong Eun Lee,
  • Chan Kwon Park and
  • Chang-min Choi
  • + 9 authors+ 4 authors

26 January 2024

Real-world data on the use and outcomes of crizotinib in ROS1-rearranged non-small-cell lung cancer (NSCLC) are limited. This study aims to analyze the real-world efficacy of crizotinib in South Korea and explore the utilization of liquid biopsies th...

(This article belongs to the Section Cancer Therapy)
  • Article
  • Open Access
10 Citations
5,004 Views
22 Pages

28 September 2017

There is an increasingly urgent need to reduce carbon emissions. Devising effective carbon tax policies has become an important research topic. It is necessary to explore carbon reduction strategies based on the design of carbon tax elements. In this...

(This article belongs to the Special Issue Carbon Footprint: As an Environmental Sustainability Indicator)
  • Article
  • Open Access
27 Citations
4,846 Views
15 Pages

Anomaly Detection of Wind Turbines Based on Deep Small-World Neural Network

  • Meng Li,
  • Shuangxin Wang,
  • Shanxiang Fang and
  • Juchao Zhao

12 February 2020

Accurate and efficient condition monitoring is the key to enhance the reliability and security of wind turbines. In recent years, an intelligent anomaly detection method based on deep learning networks has been receiving increasing attention. Since a...

  • Article
  • Open Access
5 Citations
7,416 Views
18 Pages

4 March 2023

This article utilizes social network analysis in addition to a measure of genre diversity to quantify the quality and capacity of actors in the Malay language film industry. We built a dataset by collecting data from various websites pertaining to Ma...

(This article belongs to the Topic Complex Systems and Network Science)
  • Article
  • Open Access
4 Citations
4,756 Views
15 Pages

Real-World Treatment Patterns, Clinical Outcomes, and Healthcare Resource Utilization in Early-Stage Non-Small-Cell Lung Cancer

  • Dylan E. O’Sullivan,
  • Devon J. Boyne,
  • Chelsea Ford-Sahibzada,
  • Jessica A. Inskip and ,
  • Christopher J. Smith,
  • Kaushik Sripada,
  • Darren R. Brenner and
  • Winson Y. Cheung
  • + 3 authors+ 0 author

12 January 2024

The prognosis of early non-small-cell lung cancer (eNSCLC) remains poor. An understanding of current therapies and outcomes can provide insights into how novel therapies can be integrated into clinics. We conducted a large, retrospective, population-...

(This article belongs to the Special Issue Clinical Management and Outcomes of Lung Cancer Patients)
  • Article
  • Open Access
1,619 Views
13 Pages

PD-L1 Negative Advanced Non-Small Cell Lung Cancer: Practice Patterns and Real-World Outcomes

  • Audrey-Ann Bégin,
  • Maude Dubé-Pelletier,
  • Catherine Labbé,
  • Vicky Mai and ,
  • Michaël Maranda-Robitaille and
  • Marie-Hélène Denault
  • + 1 author+ 0 author

28 February 2026

The standard first-line treatment for metastatic non-small cell lung cancer (NSCLC) without oncogenic alterations and programmed death-ligand 1 (PD-L1) expression < 1% is a combination of chemotherapy (CT) and immunotherapy (IO). However, real-wor...

(This article belongs to the Section Thoracic Oncology)
  • Article
  • Open Access
3 Citations
3,317 Views
12 Pages

Real-World Analysis of Survival and Treatment Efficacy in Stage IIIA-N2 Non-Small Cell Lung Cancer

  • Eleni Josephides,
  • Roberta Dunn,
  • Annie-Rose Henry,
  • John Pilling and ,
  • Karen Harrison-Phipps,
  • Akshay Patel,
  • Shahreen Ahmad,
  • Michael Skwarski,
  • James Spicer and
  • Andrea Bille
  • + 10 authors+ 5 authors

2 September 2024

Background: Stage IIIA-N2 non-small cell lung cancer (NSCLC) poses a significant clinical challenge, with low survival rates despite advances in therapy. The lack of a standardised treatment approach complicates patient management. This study utilise...

(This article belongs to the Special Issue The Use of Real World (RW) Data in Oncology)
  • Article
  • Open Access
2 Citations
2,293 Views
23 Pages

Real-World Treatment Patterns and Survival in Patients with Advanced Non-Small Cell Lung Cancer: An Italian Retrospective Cohort Study

  • Angelo Delmonte,
  • Nicola Gentili,
  • Andrea Roncadori,
  • Roberta Maltoni and ,
  • Valentina Danesi,
  • Pooja Hindocha,
  • Cátia Leal,
  • Stavros Oikonomou,
  • Marta Mella and
  • Ilaria Massa
  • + 11 authors+ 6 authors

6 February 2026

Background: Treatment for advanced non-small-cell lung cancer (NSCLC) has evolved substantially over the past decade, necessitating evaluation of real-world treatment patterns and effectiveness before and after the introduction of newer therapies. Me...

(This article belongs to the Section Cancer Epidemiology and Prevention)
  • Article
  • Open Access
4,027 Views
18 Pages

Real-World Treatment Patterns and Survival in Patients with ROS1-Positive Advanced Non-Small Cell Lung Cancer in Canada and Europe

  • Winson Y. Cheung,
  • Adam Lee,
  • Helena Bote de Cabo,
  • Kathrin Burdenski and ,
  • Petros Christopoulos,
  • Bárbara Pinto-Correia,
  • Simon Deshayes,
  • Nicolas Girard,
  • Pooja Hindocha and
  • Christos Chouaid
  • + 19 authors+ 14 authors

Real-world data on patients with ROS1-positive advanced non-small cell lung cancer (NSCLC) remain scarce. In this descriptive observational retrospective cohort study, we describe characteristics, treatments, and real-world progression-free survival...

(This article belongs to the Section Thoracic Oncology)
  • Article
  • Open Access
8 Citations
3,740 Views
13 Pages

Real-World Results of Stereotactic Body Radiotherapy for 399 Medically Operable Patients with Stage I Histology-Proven Non-Small Cell Lung Cancer

  • Hiroshi Onishi,
  • Yoshiyuki Shioyama,
  • Yasuo Matsumoto,
  • Yukinori Matsuo and ,
  • Akifumi Miyakawa,
  • Hideomi Yamashita,
  • Haruo Matsushita,
  • Masahiko Aoki,
  • Keiji Nihei and
  • Masahide Saito
  • + 19 authors+ 14 authors

1 September 2023

Surgery is the standard treatment for stage I non-small cell lung cancer (NSCLC); however, no clear randomized trial demonstrates its superiority to stereotactic body radiotherapy (SBRT) regarding survival. We aimed to retrospectively evaluate the tr...

(This article belongs to the Special Issue Stereotactic Body Radiotherapy for Various Cancers: Recent Advances and Future)
  • Article
  • Open Access
467 Views
14 Pages

Real-World Outcomes of Fusion-Directed Targeted Therapy in Advanced Non-Small Cell Lung Cancer Harboring Actionable Gene Fusions

  • Faure Delgado Leon,
  • Suset Almuinas de Armas,
  • Melanie Molina,
  • Eric G. Morales and ,
  • Maria Fernandez-Gomez and
  • Luis Estuardo Raez
  • + 1 author+ 0 author

2 September 2026

Actionable ALK, ROS1, RET, NTRK, and NRG1 fusions define biologically distinct subsets of advanced non-small cell lung cancer (NSCLC), yet real-world data across these rare populations remain limited. We retrospectively evaluated patients with advanc...

(This article belongs to the Special Issue Challenges and Future Perspectives in Treatment for Lung Cancer: 2nd Edition)
  • Article
  • Open Access
664 Views
13 Pages

Real-World Outcomes of First-Line Pembrolizumab-Based Therapy in Advanced Non-Small-Cell Lung Cancer: A Retrospective Single-Center Study

  • Einav Koren,
  • Adar Yaacov,
  • Jamal Zidan,
  • Laila C. Roisman and ,
  • Nir Peled and
  • Noam Asna
  • + 1 author+ 0 author

18 June 2026

Background: Pembrolizumab-based therapy is a standard first-line option for advanced non-small-cell lung cancer (NSCLC), yet pivotal clinical-trial populations may not reflect patients encountered in routine practice. Real-world cohorts enriched for...

(This article belongs to the Section Oncology)
  • Article
  • Open Access
13 Citations
4,763 Views
20 Pages

23 August 2019

Pitch system failures occur primarily because wind turbines typically work in dynamic and variable environments. Conventional monitoring strategies show limitations of continuously identifying faults in most cases, especially when rapidly changing wi...

(This article belongs to the Special Issue Maintenance Management of Wind Turbines)
  • Article
  • Open Access
140 Views
17 Pages

Real-World Treatment Outcomes and Prognostic Factors in Metastatic EGFR-Mutated Non-Small Cell Lung Cancer: A Single-Center Study from a High-Volume Tertiary Chest Hospital

  • Abdülkadir Koçanoğlu,
  • Oktay Ünsal,
  • Fatih Kuş,
  • Nesrin Gürçay and ,
  • Esra Zeynelgil,
  • Yakup Düzköprü and
  • Serdar Karakaya
  • + 2 authors+ 0 author

22 October 2026

Background/Objectives: Epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) is a distinct molecular subgroup responsive to EGFR tyrosine kinase inhibitors (TKIs). This study evaluated real-world treatment outcomes and pr...

(This article belongs to the Section Oncology)
  • Article
  • Open Access
1 Citations
4,218 Views
9 Pages

8 December 2022

Background: In the ATLANTIS study, second-line lurbinectedin/doxorubicin did not improve overall survival (OS), however patients with a chemotherapy-free interval (CTFI) of ≥180 days had an improved progression free survival (PFS). The objective o...

(This article belongs to the Topic Advances in Anti-Cancer Drugs)
  • Article
  • Open Access
12 Citations
4,416 Views
16 Pages

Test-Retest Reliability of Resting Brain Small-World Network Properties across Different Data Processing and Modeling Strategies

  • Qianying Wu,
  • Hui Lei,
  • Tianxin Mao,
  • Yao Deng and ,
  • Xiaocui Zhang,
  • Yali Jiang,
  • Xue Zhong,
  • John A. Detre,
  • Jianghong Liu and
  • Hengyi Rao
  • + 5 authors+ 0 author

Resting-state functional magnetic resonance imaging (fMRI) with graph theoretical modeling has been increasingly applied for assessing whole brain network topological organization, yet its reproducibility remains controversial. In this study, we acqu...

(This article belongs to the Special Issue Effects of Sleep Deprivation on Cognition, Emotion, and Behavior)
  • Article
  • Open Access
1,993 Views
13 Pages

3 April 2026

Background: Immune checkpoint inhibitor monotherapy targeting the PD-1/PD-L1 axis is a standard first-line treatment option for patients with metastatic non-small cell lung cancer (NSCLC) and high PD-L1 expression. However, comparative real-world dat...

(This article belongs to the Special Issue Immunotherapy in Non-Small Cell Lung Cancers)
  • Article
  • Open Access
1 Citations
951 Views
12 Pages

Real-World Clinical Outcomes and Biopsy Patterns of Older Patients with Unresected Non-Small-Cell Lung Cancer Treated with Primary Stereotactic Body Radiotherapy

  • Pragya Rai,
  • Su Zhang,
  • Yan Song,
  • Chi Gao and ,
  • Anya Jiang,
  • Jiayang Li,
  • Peixi Jiang,
  • James Signorovitch,
  • Ashwini Arunachalam and
  • Megan E. Daly
  • + 7 authors+ 2 authors

4 December 2025

Background/Objectives: We describe the real-world survival and utilization of lung biopsy in Medicare patients with unresected stage I-IIB (N0) non-small-cell lung cancer (NSCLC) receiving primary stereotactic body radiotherapy (SBRT) in the US. Meth...

(This article belongs to the Special Issue Non-Small Cell Lung Cancer (NSCLC): Recent Advances in Clinical Diagnosis and Treatment)
  • Article
  • Open Access
56 Citations
5,502 Views
20 Pages

29 April 2019

The Internet of Things (IoT) is a recent evolutionary technology that has been the primary focus of researchers for the last two decades. In the IoT, an enormous number of objects are connected together using diverse communications protocols. As a re...

(This article belongs to the Special Issue Exploiting the IoT within Cyber Physical Social System)
  • Article
  • Open Access
2 Citations
4,046 Views
16 Pages

Purpose: Extensive-stage small cell lung cancer (ES-SCLC) has poor prognosis. While immune checkpoint inhibitors (ICIs) with chemotherapy show survival benefits in trials, real-world data from Asia are scarce. This study evaluates real-world efficacy...

(This article belongs to the Special Issue Clinical Advances and Therapeutic Challenges in Small-Cell Lung Cancer and Rare Thoracic Cancers)
  • Article
  • Open Access
9 Citations
8,017 Views
13 Pages

Non-Small-Cell Lung Cancer Patients Harboring ROS1 Rearrangement: Real World Testing Practices, Characteristics and Treatment Patterns (ROS1REAL Study)

  • Urska Janzic,
  • Natalie Maimon Rabinovich,
  • Walid Shalata,
  • Waleed Kian and ,
  • Katarzyna Szymczak,
  • Rafal Dziadziuszko,
  • Marko Jakopovic,
  • Giannis Mountzios,
  • Adam Pluzanski and
  • Abed Agbarya
  • + 8 authors+ 3 authors

30 July 2024

ROS1 rearrangements are considered rare in non-small-cell lung cancer (NSCLC). This retrospective real-world study aimed to evaluate first-line treatment with crizotinib, a tyrosine kinase inhibitor (TKI) standard of care vs. new generation ROS1 anti...

(This article belongs to the Section Thoracic Oncology)
  • Article
  • Open Access
9 Citations
4,095 Views
11 Pages

29 July 2021

We aimed at describing treatment pathways, clinical outcomes and healthcare costs of advanced non-small cell lung cancer (NSCLC) patients in Lombardy Region, Italy. Using healthcare administrative data, 37,562 patients with a new diagnosis of lung ca...

(This article belongs to the Section Cancer Therapy)
  • Article
  • Open Access
7 Citations
4,371 Views
14 Pages

A Propensity-Matched Retrospective Comparative Study with Historical Control to Determine the Real-World Effectiveness of Durvalumab after Concurrent Chemoradiotherapy in Unresectable Stage III Non-Small Cell Lung Cancer

  • Cheol-Kyu Park,
  • Nakyung Jeon,
  • Hwa-Kyung Park,
  • Hyung-Joo Oh and ,
  • Young-Chul Kim,
  • Ha-Lim Jeon,
  • Yong-Hyub Kim,
  • Sung-Ja Ahn and
  • In-Jae Oh
  • + 4 authors+ 0 author

5 March 2023

This study aimed to add real-world evidence to the literature regarding the effectiveness and safety of durvalumab consolidation (DC) after concurrent chemoradiotherapy (CCRT) in the treatment of unresectable stage III non-small cell lung cancer (NSC...

(This article belongs to the Special Issue New Era of Cancer Research: From Large-Scale Cohorts to Big-Data)
  • Article
  • Open Access
12 Citations
9,688 Views
19 Pages

Mobocertinib in Patients with EGFR Exon 20 Insertion-Positive Non-Small Cell Lung Cancer (MOON): An International Real-World Safety and Efficacy Analysis

  • Oliver Illini,
  • Felix Carl Saalfeld,
  • Petros Christopoulos,
  • Michaël Duruisseaux and ,
  • Anders Vikström,
  • Nir Peled,
  • Ingel Demedts,
  • Elizabeth Dudnik,
  • Anna Eisert and
  • Martin Wermke
  • + 43 authors+ 38 authors

EGFR exon 20 (EGFR Ex20) insertion mutations in non-small cell lung cancer (NSCLC) are insensitive to traditional EGFR tyrosine kinase inhibitors (TKIs). Mobocertinib is the only approved TKI specifically designed to target EGFR Ex20. We performed an...

(This article belongs to the Special Issue Lung Cancers: An Update on Molecular Diagnostics and Therapy)
  • Article
  • Open Access
4 Citations
2,482 Views
15 Pages

Real-World Data on Immune-Checkpoint Inhibitors in Elderly Patients with Advanced Non-Small Cell Lung Cancer: A Retrospective Study

  • José del Corral-Morales,
  • Carlos Ayala-de Miguel,
  • Laura Quintana-Cortés,
  • Adrián Sánchez-Vegas and ,
  • Fuensanta Aranda-Bellido,
  • Santiago González-Santiago,
  • José Fuentes-Pradera and
  • Pablo Ayala-de Miguel
  • + 3 authors+ 0 author

29 June 2025

Background/Objectives: Non-small cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer cases, with an increasing incidence in patients over 65 years. Although immune-checkpoint inhibitors (ICIs) have transformed the treatment landsca...

(This article belongs to the Special Issue Pathology, Diagnosis and Treatment in Non-small Cell Lung Cancer)
  • Article
  • Open Access
7 Citations
7,033 Views
19 Pages

22 April 2024

Immunotherapy with PD-1/PD-L1 inhibitors has significantly improved the survival rates of patients with metastatic non-small-cell lung cancer (NSCLC). Results of a real-world data study investigating add-on VA (Viscum album L.) to chemotherapy have s...

(This article belongs to the Special Issue Immune Checkpoint Inhibitors, Targeted Therapies and Adjuvant Treatment of Lung Cancer)
  • Article
  • Open Access
6 Citations
6,651 Views
14 Pages

Real-World Outcomes of Patients with Advanced Epidermal Growth Factor Receptor-Mutated Non-Small Cell Lung Cancer in Canada Using Data Extracted by Large Language Model-Based Artificial Intelligence

  • Ruth Moulson,
  • Jennifer Law,
  • Adrian Sacher,
  • Geoffrey Liu and ,
  • Frances A. Shepherd,
  • Penelope Bradbury,
  • Lawson Eng,
  • Sandra Iczkovitz,
  • Erica Abbie and
  • Natasha B. Leighl
  • + 10 authors+ 5 authors

2 April 2024

Real-world evidence for patients with advanced EGFR-mutated non-small cell lung cancer (NSCLC) in Canada is limited. This study’s objective was to use previously validated DARWENTM artificial intelligence (AI) to extract data from electronic he...

(This article belongs to the Topic Artificial Intelligence in Cancer, Biology and Oncology)
  • Article
  • Open Access
7 Citations
3,519 Views
21 Pages

Real-World Treatment Patterns and Survival Outcomes for Patients with Non-Metastatic Non-Small-Cell Lung Cancer in Sweden: A Nationwide Registry Analysis from the I-O Optimise Initiative

  • Gudrun N. Oskarsdottir,
  • Erik Lampa,
  • Anders Berglund,
  • Linda Rosengren and ,
  • Maria Ulvestad,
  • Miklos Boros,
  • Melinda J. Daumont,
  • Caroline Rault,
  • Gabrielle Emanuel and
  • Gunnar Wagenius
  • + 7 authors+ 2 authors

25 April 2024

Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide, with ~40–50% of patients diagnosed with non-metastatic disease (stages IA–IIIC). The treatment landscape is evolving rapidly as immunotherapies and...

(This article belongs to the Section Cancer Epidemiology and Prevention)
  • Article
  • Open Access
498 Views
16 Pages

Long-Term Outcomes and Prognostic Factors in Metastatic ALK-Rearranged Non-Small Cell Lung Cancer Treated with ALK Tyrosine Kinase Inhibitors: Real-World Evidence from a High-Volume Thoracic Diseases Center

  • Abdülkadir Koçanoğlu,
  • Oktay Ünsal,
  • Fatih Kuş,
  • Nesrin Gürçay and ,
  • Esra Zeynelgil,
  • Yakup Düzköprü and
  • Serdar Karakaya
  • + 2 authors+ 0 author

26 August 2026

Background/Objectives: ALK tyrosine kinase inhibitors (TKIs) have improved outcomes in patients with metastatic ALK-rearranged non-small cell lung cancer (NSCLC). However, real-world data on long-term outcomes, prognostic factors, and treatment seque...

(This article belongs to the Section Cancer Survivorship and Quality of Life)
  • Article
  • Open Access
497 Views
34 Pages

A Multi-Criteria Framework for Comparative Topological Regime Characterization in Complex Networks

  • Fabiane de Fatima Carvalho,
  • Ivan Bergier,
  • Silvia Maria Fonseca Silveira Massruhá and
  • Jayme Garcia Arnal Barbedo

Collaboration networks are frequently studied as empirical instances of complex social systems, yet standardized methodological frameworks for consistently identifying heterogeneous mesoscopic structural regimes remain limited. This study proposes an...

(This article belongs to the Topic Computational Complex Networks, 2nd Edition)
  • Article
  • Open Access
9 Citations
5,044 Views
14 Pages

28 February 2019

Conformity is a common phenomenon among people in social networks. In this paper, we focus on customers’ conformity behaviors in a symmetry market where customers are located in a social network. We establish a conformity model and analyze it i...

(This article belongs to the Special Issue Symmetry and Complexity 2019)
  • Article
  • Open Access
59 Citations
2,493 Views
9 Pages

Real-World Benefit of Nivolumab in A Canadian Non-Small-Cell Lung Cancer Cohort

  • R.A. Juergens,
  • C. Mariano,
  • J. Jolivet,
  • N. Finn and ,
  • J. Rothenstein,
  • M.N. Reaume,
  • A. Faghih,
  • C. Labbé,
  • S. Owen and
  • C. Butts
  • + 9 authors+ 4 authors

1 December 2018

Background: Nivolumab was the first immuno-oncology agent available for the treatment of lung cancer in Canada. In the present study, we evaluated the real-world benefit of nivolumab in Canadian patients with lung cancer. Methods: Patients included i...

  • Feature Paper
  • Article
  • Open Access
13 Citations
4,828 Views
12 Pages

On M-Polynomials of Dunbar Graphs in Social Networks

  • Santanu Acharjee,
  • Bijit Bora and
  • Robin I. M. Dunbar

3 June 2020

Topological indices describe mathematical invariants of molecules in mathematical chemistry. M-polynomials of chemical graph theory have freedom about the nature of molecular graphs and they play a role as another topological invariant. Social networ...

(This article belongs to the Special Issue Symmetry and Complexity 2020)
  • Article
  • Open Access
24 Citations
2,992 Views
7 Pages

1 August 2020

Background: Almost half of all patients with non-small-cell lung cancer (nsclc) present with stage iv disease. The objective of the present study was to characterize treatment patterns and survival outcomes in patients with advanced nsclc. Methods: W...

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