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27 Results Found

  • Review
  • Open Access
260 Citations
40,070 Views
22 Pages

Mechanisms Regulating Skin Pigmentation: The Rise and Fall of Complexion Coloration

  • Jody P. Ebanks,
  • R. Randall Wickett and
  • Raymond E. Boissy

15 September 2009

Skin pigmentary abnormalities are seen as aesthetically unfavorable and have led to the development of cosmetic and therapeutic treatment modalities of varying efficacy. Hence, several putative depigmenting agents aimed at modulating skin pigmentatio...

  • Article
  • Open Access
10 Citations
6,937 Views
14 Pages

10 July 2024

Strategies for successful aging, including the use of food supplements, are part of the approach to support skin youthfulness. To demonstrate the efficacy of fermented bilberry extract (FBE) against skin aging and uneven complexion, a clinical trial...

  • Article
  • Open Access
3 Citations
21,260 Views
37 Pages

Skin aging is a complex process influenced by several factors, including UV exposure, environmental stressors, and lifestyle choices. The demand for effective, natural skincare products has driven research into plant-based oils rich in bioactive comp...

  • Review
  • Open Access
28 Citations
25,268 Views
11 Pages

A Fairer Face, a Fairer Tomorrow? A Review of Skin Lighteners

  • Levashni Naidoo,
  • Nokubonga Khoza and
  • Ncoza C. Dlova

7 September 2016

From light-skinned deities depicted in ancient religious tableaux, pearl-swallowing practices in China, turmeric ceremonies in India to clay application in Africa, history has been coloured by our questionable aversion to the darker shades. Complexio...

  • Article
  • Open Access
18 Citations
4,656 Views
14 Pages

An In Vivo Study to Evaluate the Efficacy of Blue Shark (Prionace glauca) Cartilage Collagen as a Cosmetic

  • Wen-Chien Lu,
  • Chien-Shan Chiu,
  • Yung-Jia Chan,
  • Tian-Pin Guo,
  • Ching-Chin Lin,
  • Po-Chun Wang,
  • Po-Yu Lin,
  • Amanda Tresiliana Mulio and
  • Po-Hsien Li

5 October 2022

The “blue shark”, Prionace glauca (class: Chondrichthyes), is a pelagic shark species commonly found in tropical and temperate oceans. This shark is mainly sold in Asian countries as food and as traditional Chinese medicine. According to...

  • Article
  • Open Access
829 Views
15 Pages

Efficacy of a Mesotherapy-Inspired Cosmetic Serum vs. Meso-Injections: Proteomic Insights and Clinical Results

  • Nadège Durand,
  • Sayantani Goswami,
  • Roxane Henry,
  • Aaron Cohen,
  • Jin Namkoong,
  • Joanna Wu,
  • Karima Bourougaa and
  • Lysianne Sanchez-Manoilov

10 December 2025

Aesthetic mesotherapy—the subcutaneous injection of key ingredients for cellular function—has gained popularity as a skin rejuvenation treatment. We developed a cosmetic serum, incorporating 11 ingredients frequently used in meso-injectio...

  • Review
  • Open Access
16 Citations
12,640 Views
15 Pages

Dietary Supplements and the Skin: Focus on Photoprotection and Antioxidant Activity—A Review

  • Thalita Marcílio Cândido,
  • Maíra Bueno Ariede,
  • Fabiana Vieira Lima,
  • Luciana de Souza Guedes,
  • Maria Valéria Robles Velasco,
  • André Rolim Baby and
  • Catarina Rosado

16 March 2022

Skin health is not only significantly affected by ageing, but also by other lifestyle-related factors, such as sun exposure, exercise and eating habits, smoking or alcohol intake. It is known that the cutaneous tissue can exhibit visible signs of sen...

  • Review
  • Open Access
16 Citations
10,725 Views
26 Pages

Mechanism, Formulation, and Efficacy Evaluation of Natural Products for Skin Pigmentation Treatment

  • Xueli Peng,
  • Yuning Ma,
  • Chenxin Yan,
  • Xiaocen Wei,
  • Linlin Zhang,
  • Hehe Jiang,
  • Yuxia Ma,
  • Suohui Zhang,
  • Mengzhen Xing and
  • Yunhua Gao

Skin pigmentation typically arises from the excessive secretion and accumulation of melanin, resulting in a darker complexion compared to normal skin. Currently, the local application of chemical drugs is a first-line strategy for pigmentation disord...

  • Article
  • Open Access
9 Citations
31,091 Views
11 Pages

12 September 2022

Skin dryness, fine lines and wrinkles, red spots, red vasculature, and porphyrin count are common indicators of skin health and beauty. The skincare system in this study contains scientifically validated ingredients such as fermented green tea (Camel...

  • Article
  • Open Access
7 Citations
7,691 Views
14 Pages

Evaluation of the Efficacy of the 755 nm Picosecond Laser in Eliminating Pigmented Skin Lesions after a Single Treatment Based on Photographic Analysis with Polarised Light

  • Piotr Zawodny,
  • Nicole Wahidi,
  • Paweł Zawodny,
  • Ewa Duchnik,
  • Elżbieta Stój,
  • Wiola Rozalia Malec,
  • Monika Kulaszyńska,
  • Karolina Skonieczna-Żydecka and
  • Jerzy Sieńko

5 January 2024

Introduction: Pigmentary changes can be bothersome and affect one’s well-being. Laser therapy has been shown to effectively treat such skin discolouration. We aimed to assess the utility of a 755 nm alexandrite laser in pigmented lesions remova...

  • Review
  • Open Access
25 Citations
6,684 Views
21 Pages

A Review of Recent Advances in Computer-Aided Detection Methods Using Hyperspectral Imaging Engineering to Detect Skin Cancer

  • Hung-Yi Huang,
  • Yu-Ping Hsiao,
  • Riya Karmakar,
  • Arvind Mukundan,
  • Pramod Chaudhary,
  • Shang-Chin Hsieh and
  • Hsiang-Chen Wang

29 November 2023

Skin cancer, a malignant neoplasm originating from skin cell types including keratinocytes, melanocytes, and sweat glands, comprises three primary forms: basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and malignant melanoma (MM). BCC and...

  • Article
  • Open Access
6,424 Views
11 Pages

25 September 2023

The dietary bacillus natto productive protein (BNPP) is a functional food ingredient that contains Bacillopeptidase F. BNPP is reported to improve blood flow. Based on previous research, we investigated the effect of BNPP on the skin. In vitro tests...

  • Article
  • Open Access
5,176 Views
22 Pages

Effects of Oral Fish Collagen and l-Cystine on Skin Ageing in Mature Women and Skin Imperfections in Young Women: Findings from Two Randomised, Three-Arm, Double-Blind, Placebo-Controlled Studies

  • Fabrice Perin,
  • Christelle Bruno-Bonnet,
  • Jean-Philippe Soulard,
  • Mouna Rahabi,
  • Joël Duperray,
  • Kunkanit Suntipraron and
  • Kunyanatt Chalothorn

28 August 2025

Collagen is an essential ingredient in dietary supplements for its anti-ageing benefits, and l-cystine-based supplementation has garnered interest for its ability to improve skin condition. Our study aimed to evaluate the effects of oral supplementat...

  • Article
  • Open Access
2 Citations
5,147 Views
14 Pages

Chrono Control Penta is a novel plant derived multifunctional bioactive peptide, which offer a tailored targeted approach to skin health by addressing both pigmentation and aging. Chrono Control Penta inhibits tyrosinase with an IC50 value of 202.8 &...

  • Article
  • Open Access
8,279 Views
15 Pages

Clinical Efficacy of Belight3TM on Dark Spot Pigmentation in Caucasian Subjects

  • Francesco Tursi,
  • Line Pourtau,
  • Gloria Roveda,
  • Ileana De Ponti,
  • David Gaudout,
  • Benjamin Moras,
  • Camille Pouchieu and
  • Vincenzo Nobile

5 February 2025

Belight3TM, a nutricosmetic formulation containing polyphenol-rich extracts, has previously been demonstrated to be safe and effective in brightening skin color and dark spots in a clinical study involving Asian volunteers. The aim of this study was...

  • Article
  • Open Access
7 Citations
5,776 Views
10 Pages

Tooth Shade Relationship with Age, Gender, and Skin Color in a Saudi Population: A Cross-Sectional Study

  • Hussain Alsayed,
  • Razan Alaqeely,
  • Nawaf Almazrouei,
  • Mohammed Alzahrani,
  • Faris Alzahrani,
  • Abdulaziz Bin Oun and
  • Abdulmonem Alshihri

21 June 2022

Objectives: The aim of this study was to assess the relationship between tooth shade among different groups of patients according to their age, gender, and skin color in a Saudi population. Materials and methods: Participants were divided based on ag...

  • Article
  • Open Access
3 Citations
9,263 Views
20 Pages

1 February 2022

It has been previously demonstrated in light microscopic and immunohistochemical studies that ovariectomized rats receiving young coconut juice at 100 mL/kg BW showed much better wound healing and improved skin complexion. Nevertheless, it was found...

  • Review
  • Open Access
5 Citations
13,330 Views
18 Pages

Polyglutamate: Unleashing the Versatility of a Biopolymer for Cosmetic Industry Applications

  • Mónica Serra,
  • Eduardo Gudina,
  • Cláudia Botelho,
  • José António Teixeira and
  • Ana Novo Barros

Polyglutamic acid (PGA), a biopolymer comprising repeating units of glutamic acid, has garnered significant attention owing to its versatile applications. In recent years, microbial production processes have emerged as promising methods for the large...

  • Review
  • Open Access
53 Citations
4,913 Views
42 Pages

Photosensitizers-Loaded Nanocarriers for Enhancement of Photodynamic Therapy in Melanoma Treatment

  • Ana Maria Udrea,
  • Adriana Smarandache,
  • Andra Dinache,
  • Catalina Mares,
  • Simona Nistorescu,
  • Speranta Avram and
  • Angela Staicu

Malignant melanoma poses a significant global health burden. It is the most aggressive and lethal form of skin cancer, attributed to various risk factors such as UV radiation exposure, genetic modifications, chemical carcinogens, immunosuppression, a...

  • Communication
  • Open Access
5 Citations
18,088 Views
10 Pages

The use of low-fluence picosecond (LFPS) 1064 nm neodymium-doped yttrium aluminum garnet (Nd:YAG) lasers, referred to as laser toning, is increasingly acknowledged as an effective treatment for pigmentation disorders in the Asian skin phenotype. This...

  • Feature Paper
  • Article
  • Open Access
8 Citations
3,072 Views
15 Pages

Elucidating the Role of Santalol as a Potent Inhibitor of Tyrosinase: In Vitro and In Silico Approaches

  • Nabeel Ali,
  • Zainy Zehra,
  • Anas Shamsi,
  • Md. Amjad Beg,
  • Zahoor Ahmad Parray,
  • Israil,
  • Md. Ali Imam,
  • Naseem A. Gaur,
  • Md. Imtaiyaz Hassan and
  • Asimul Islam
  • + 4 authors

15 December 2022

This research work focuses on the potential application of an organic compound, santalol, obtained from santalum album, in the inhibition of the enzyme tyrosinase, which is actively involved in the biosynthesis of melanin pigment. Over-production of...

  • Systematic Review
  • Open Access
885 Views
25 Pages

Preventive and Therapeutic Interventions in Solar Elastosis and Photoaging: A Comprehensive Systematic Review

  • Francesco Leonforte,
  • Tiziano Pergolizzi,
  • Vito Nicosia,
  • Fabio Nicoli,
  • Giovanni Genovese,
  • Cristina Genovese,
  • Kidakorn Kiranantawat,
  • Rosario Perrotta and
  • Antonio Mistretta

11 November 2025

Background/Objectives: Solar elastosis, a key histopathological alteration in skin photodamage, results from chronic UV exposure and photoaging. Clinically, it manifests as deep wrinkles, laxity, and a dull complexion. The growing demand for effectiv...

  • Article
  • Open Access
9 Citations
10,400 Views
15 Pages

Association between Auricular Signals and the Risk Factors of Metabolic Syndrome

  • Lorna Kwai Ping Suen,
  • Chao Hsing Yeh,
  • Simon Kai Wang Yeung,
  • Jojo Yee Mei Kwan,
  • Hon Fat Wong,
  • David Chan,
  • Alice Siu Ping Cheung and
  • Vincent Tok Fai Yeung

Objective: This study aims to determine the association between auricular signals and the risk factors of metabolic syndrome (MS). Methods: A case-control study with an equal number of cases and controls matched by age group and gender was conducted....

  • Review
  • Open Access
26 Citations
5,786 Views
19 Pages

Immunotherapy for the Treatment of Squamous Cell Carcinoma: Potential Benefits and Challenges

  • Tuba M. Ansary,
  • MD Razib Hossain,
  • Mayumi Komine and
  • Mamitaro Ohtsuki

Melanoma and nonmelanoma skin cancers (NMSCs) are recognized as among the most common neoplasms, mostly in white people, with an increasing incidence rate. Among the NMSCs, squamous cell carcinoma (SCC) is the most prevalent malignancy known to affec...

  • Article
  • Open Access
916 Views
18 Pages

23 September 2025

Organic solvent nanofiltration (OSN) is a promising technology for solute removal from organic media, yet developing membranes with stable separation performance remains challenging. This study presents a solvent-resistant double-crosslinked nanofilt...