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29 Results Found

  • Review
  • Open Access
275 Citations
42,732 Views
22 Pages

Mechanisms Regulating Skin Pigmentation: The Rise and Fall of Complexion Coloration

  • Jody P. Ebanks,
  • R. Randall Wickett and
  • Raymond E. Boissy

15 September 2009

Skin pigmentary abnormalities are seen as aesthetically unfavorable and have led to the development of cosmetic and therapeutic treatment modalities of varying efficacy. Hence, several putative depigmenting agents aimed at modulating skin pigmentatio...

(This article belongs to the Special Issue Inhibitors of Melanogenesis Related Processes: Application to Food and Cosmetic Industry)
  • Article
  • Open Access
17 Citations
8,615 Views
14 Pages

10 July 2024

Strategies for successful aging, including the use of food supplements, are part of the approach to support skin youthfulness. To demonstrate the efficacy of fermented bilberry extract (FBE) against skin aging and uneven complexion, a clinical trial...

(This article belongs to the Section Clinical Nutrition)
  • Article
  • Open Access
6 Citations
41,617 Views
37 Pages

Skin aging is a complex process influenced by several factors, including UV exposure, environmental stressors, and lifestyle choices. The demand for effective, natural skincare products has driven research into plant-based oils rich in bioactive comp...

(This article belongs to the Special Issue Skin Anti-Aging Strategies)
  • Review
  • Open Access
31 Citations
27,439 Views
11 Pages

A Fairer Face, a Fairer Tomorrow? A Review of Skin Lighteners

  • Levashni Naidoo,
  • Nokubonga Khoza and
  • Ncoza C. Dlova

7 September 2016

From light-skinned deities depicted in ancient religious tableaux, pearl-swallowing practices in China, turmeric ceremonies in India to clay application in Africa, history has been coloured by our questionable aversion to the darker shades. Complexio...

(This article belongs to the Special Issue Pigmentation correcting ingredients—Crucial Need for Innovation to Lead the Way)
  • Article
  • Open Access
23 Citations
5,488 Views
14 Pages

An In Vivo Study to Evaluate the Efficacy of Blue Shark (Prionace glauca) Cartilage Collagen as a Cosmetic

  • Wen-Chien Lu,
  • Chien-Shan Chiu,
  • Yung-Jia Chan,
  • Tian-Pin Guo and ,
  • Ching-Chin Lin,
  • Po-Chun Wang,
  • Po-Yu Lin,
  • Amanda Tresiliana Mulio and
  • Po-Hsien Li
  • + 4 authors+ 0 author

5 October 2022

The “blue shark”, Prionace glauca (class: Chondrichthyes), is a pelagic shark species commonly found in tropical and temperate oceans. This shark is mainly sold in Asian countries as food and as traditional Chinese medicine. According to...

(This article belongs to the Special Issue Collagen and Bioactives from Marine By-Products)
  • Article
  • Open Access
3,511 Views
15 Pages

Efficacy of a Mesotherapy-Inspired Cosmetic Serum vs. Meso-Injections: Proteomic Insights and Clinical Results

  • Nadège Durand,
  • Sayantani Goswami,
  • Roxane Henry,
  • Aaron Cohen and ,
  • Jin Namkoong,
  • Joanna Wu,
  • Karima Bourougaa and
  • Lysianne Sanchez-Manoilov
  • + 3 authors+ 0 author

10 December 2025

Aesthetic mesotherapy—the subcutaneous injection of key ingredients for cellular function—has gained popularity as a skin rejuvenation treatment. We developed a cosmetic serum, incorporating 11 ingredients frequently used in meso-injectio...

(This article belongs to the Section Cosmetic Dermatology)
  • Review
  • Open Access
23 Citations
13,880 Views
15 Pages

Dietary Supplements and the Skin: Focus on Photoprotection and Antioxidant Activity—A Review

  • Thalita Marcílio Cândido,
  • Maíra Bueno Ariede,
  • Fabiana Vieira Lima,
  • Luciana de Souza Guedes and ,
  • Maria Valéria Robles Velasco,
  • André Rolim Baby and
  • Catarina Rosado
  • + 2 authors+ 0 author

16 March 2022

Skin health is not only significantly affected by ageing, but also by other lifestyle-related factors, such as sun exposure, exercise and eating habits, smoking or alcohol intake. It is known that the cutaneous tissue can exhibit visible signs of sen...

(This article belongs to the Section Phytochemicals and Human Health)
  • Review
  • Open Access
28 Citations
14,033 Views
26 Pages

Mechanism, Formulation, and Efficacy Evaluation of Natural Products for Skin Pigmentation Treatment

  • Xueli Peng,
  • Yuning Ma,
  • Chenxin Yan,
  • Xiaocen Wei and ,
  • Linlin Zhang,
  • Hehe Jiang,
  • Yuxia Ma,
  • Suohui Zhang,
  • Mengzhen Xing and
  • Yunhua Gao
  • + 5 authors+ 0 author

Skin pigmentation typically arises from the excessive secretion and accumulation of melanin, resulting in a darker complexion compared to normal skin. Currently, the local application of chemical drugs is a first-line strategy for pigmentation disord...

(This article belongs to the Special Issue Skin Care Products for Healthy and Diseased Skin)
  • Article
  • Open Access
14 Citations
35,976 Views
11 Pages

12 September 2022

Skin dryness, fine lines and wrinkles, red spots, red vasculature, and porphyrin count are common indicators of skin health and beauty. The skincare system in this study contains scientifically validated ingredients such as fermented green tea (Camel...

(This article belongs to the Section Cosmetic Formulations)
  • Article
  • Open Access
9 Citations
10,032 Views
14 Pages

Evaluation of the Efficacy of the 755 nm Picosecond Laser in Eliminating Pigmented Skin Lesions after a Single Treatment Based on Photographic Analysis with Polarised Light

  • Piotr Zawodny,
  • Nicole Wahidi,
  • Paweł Zawodny,
  • Ewa Duchnik and ,
  • Elżbieta Stój,
  • Wiola Rozalia Malec,
  • Monika Kulaszyńska,
  • Karolina Skonieczna-Żydecka and
  • Jerzy Sieńko
  • + 4 authors+ 0 author

5 January 2024

Introduction: Pigmentary changes can be bothersome and affect one’s well-being. Laser therapy has been shown to effectively treat such skin discolouration. We aimed to assess the utility of a 755 nm alexandrite laser in pigmented lesions remova...

(This article belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
  • Article
  • Open Access
1,010 Views
19 Pages

A Preliminary Study Evaluating the Potential of a Topical Hydrating Formulation Enriched with Platelet-Rich Plasma for Improving Skin Texture

  • Cristina-Ionela Stănciulescu,
  • Andreea-Roxana Ungureanu,
  • Virgil Pătrașcu,
  • Cornelia Bejenaru and ,
  • Marilena-Viorica Hovaneţ and
  • Gabi Topor
  • + 1 author+ 0 author

Intrinsic and extrinsic skin aging alter skin structure and function, while hydrating products and regenerative therapies such as platelet-rich plasma (PRP) support the restoration of skin homeostasis and clinical appearance. This in vivo study aimed...

(This article belongs to the Section Cosmetic Dermatology)
  • Article
  • Open Access
7 Citations
4,774 Views
9 Pages

13 January 2023

Pressure injuries (PI) result from pressure-induced damage to the skin and underlying tissues. Currently, Stage I PI are detected using visual skin assessments. However, this visual method is unable to detect skin color changes in persons with darkly...

(This article belongs to the Section Nanosensors)
  • Review
  • Open Access
47 Citations
7,936 Views
21 Pages

A Review of Recent Advances in Computer-Aided Detection Methods Using Hyperspectral Imaging Engineering to Detect Skin Cancer

  • Hung-Yi Huang,
  • Yu-Ping Hsiao,
  • Riya Karmakar,
  • Arvind Mukundan and ,
  • Pramod Chaudhary,
  • Shang-Chin Hsieh and
  • Hsiang-Chen Wang
  • + 2 authors+ 0 author

29 November 2023

Skin cancer, a malignant neoplasm originating from skin cell types including keratinocytes, melanocytes, and sweat glands, comprises three primary forms: basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and malignant melanoma (MM). BCC and...

(This article belongs to the Special Issue New Concepts and Recent Advances in the Management of Skin Cancer)
  • Article
  • Open Access
1 Citations
8,738 Views
11 Pages

25 September 2023

The dietary bacillus natto productive protein (BNPP) is a functional food ingredient that contains Bacillopeptidase F. BNPP is reported to improve blood flow. Based on previous research, we investigated the effect of BNPP on the skin. In vitro tests...

(This article belongs to the Special Issue Bioactive Compounds From Natural Resources Against Skin Aging)
  • Article
  • Open Access
3 Citations
8,795 Views
22 Pages

Effects of Oral Fish Collagen and l-Cystine on Skin Ageing in Mature Women and Skin Imperfections in Young Women: Findings from Two Randomised, Three-Arm, Double-Blind, Placebo-Controlled Studies

  • Fabrice Perin,
  • Christelle Bruno-Bonnet,
  • Jean-Philippe Soulard,
  • Mouna Rahabi and ,
  • Joël Duperray,
  • Kunkanit Suntipraron and
  • Kunyanatt Chalothorn
  • + 2 authors+ 0 author

28 August 2025

Collagen is an essential ingredient in dietary supplements for its anti-ageing benefits, and l-cystine-based supplementation has garnered interest for its ability to improve skin condition. Our study aimed to evaluate the effects of oral supplementat...

(This article belongs to the Special Issue Feature Papers in Cosmetics in 2025)
  • Article
  • Open Access
63 Views
32 Pages

Concurrent Changes in Facial Skin Parameters, Sleep, and the Salivary Melatonin Day–Night Difference During Topical Use of a Clock-Oriented Six-Botanical Formulation: An Exploratory 4-Week, Single-Arm Pilot Study

  • Miji Yeom,
  • Youngsu Jang,
  • Kyungeun Jeon,
  • Yoon Ji Jeong and ,
  • Soeun Cho,
  • Heetae Kim,
  • Sunhong Moon,
  • De-Hun Ryu,
  • Eunae Cho and
  • Eunsun Jung
  • + 6 authors+ 1 author

4 November 2026

Insufficient sleep can disrupt circadian organization and adversely affect skin condition. Perturbation of the cutaneous clock, which governs skin homeostasis, may contribute to this deterioration. In our study, a six-botanical mixture extract increa...

(This article belongs to the Section Cosmetic Dermatology)
  • Article
  • Open Access
3 Citations
7,351 Views
14 Pages

Chrono Control Penta is a novel plant derived multifunctional bioactive peptide, which offer a tailored targeted approach to skin health by addressing both pigmentation and aging. Chrono Control Penta inhibits tyrosinase with an IC50 value of 202.8 &...

(This article belongs to the Section Cosmetic Dermatology)
  • Article
  • Open Access
11,240 Views
15 Pages

Clinical Efficacy of Belight3TM on Dark Spot Pigmentation in Caucasian Subjects

  • Francesco Tursi,
  • Line Pourtau,
  • Gloria Roveda,
  • Ileana De Ponti and ,
  • David Gaudout,
  • Benjamin Moras,
  • Camille Pouchieu and
  • Vincenzo Nobile
  • + 3 authors+ 0 author

5 February 2025

Belight3TM, a nutricosmetic formulation containing polyphenol-rich extracts, has previously been demonstrated to be safe and effective in brightening skin color and dark spots in a clinical study involving Asian volunteers. The aim of this study was...

  • Essay
  • Open Access
2 Citations
7,189 Views
12 Pages

Their American Dream

  • Danné E. Davis

Centuries before W.E.B. DuBois named the colorline—i.e., racism—as the problem of the 20th century, skin color stratification was a persistent phenomenon. In 1983 Black feminist, scholar, and Pulitzer Prize winning author Alice Walker ter...

(This article belongs to the Special Issue Genealogy and Critical Family History)
  • Article
  • Open Access
9 Citations
7,352 Views
10 Pages

Tooth Shade Relationship with Age, Gender, and Skin Color in a Saudi Population: A Cross-Sectional Study

  • Hussain Alsayed,
  • Razan Alaqeely,
  • Nawaf Almazrouei,
  • Mohammed Alzahrani and ,
  • Faris Alzahrani,
  • Abdulaziz Bin Oun and
  • Abdulmonem Alshihri
  • + 2 authors+ 0 author

21 June 2022

Objectives: The aim of this study was to assess the relationship between tooth shade among different groups of patients according to their age, gender, and skin color in a Saudi population. Materials and methods: Participants were divided based on ag...

(This article belongs to the Special Issue Celebrating Applied Sciences Reaches 20,000 Articles Milestone: Invited Papers in "Applied Dentistry and Oral Sciences" Section)
  • Article
  • Open Access
4 Citations
11,105 Views
20 Pages

1 February 2022

It has been previously demonstrated in light microscopic and immunohistochemical studies that ovariectomized rats receiving young coconut juice at 100 mL/kg BW showed much better wound healing and improved skin complexion. Nevertheless, it was found...

  • Review
  • Open Access
9 Citations
18,302 Views
18 Pages

Polyglutamate: Unleashing the Versatility of a Biopolymer for Cosmetic Industry Applications

  • Mónica Serra,
  • Eduardo Gudina,
  • Cláudia Botelho,
  • José António Teixeira and
  • Ana Novo Barros

Polyglutamic acid (PGA), a biopolymer comprising repeating units of glutamic acid, has garnered significant attention owing to its versatile applications. In recent years, microbial production processes have emerged as promising methods for the large...

(This article belongs to the Special Issue Natural Sources for Cosmetic Ingredients: Challenges and Innovations)
  • Review
  • Open Access
72 Citations
5,822 Views
42 Pages

Photosensitizers-Loaded Nanocarriers for Enhancement of Photodynamic Therapy in Melanoma Treatment

  • Ana Maria Udrea,
  • Adriana Smarandache,
  • Andra Dinache,
  • Catalina Mares and ,
  • Simona Nistorescu,
  • Speranta Avram and
  • Angela Staicu
  • + 2 authors+ 0 author

Malignant melanoma poses a significant global health burden. It is the most aggressive and lethal form of skin cancer, attributed to various risk factors such as UV radiation exposure, genetic modifications, chemical carcinogens, immunosuppression, a...

(This article belongs to the Special Issue Applications of Nanotechnology for Melanoma Treatment and Diagnosis)
  • Communication
  • Open Access
6 Citations
22,870 Views
10 Pages

The use of low-fluence picosecond (LFPS) 1064 nm neodymium-doped yttrium aluminum garnet (Nd:YAG) lasers, referred to as laser toning, is increasingly acknowledged as an effective treatment for pigmentation disorders in the Asian skin phenotype. This...

(This article belongs to the Special Issue Treatment for Anti-aging and Rejuvenation)
  • Feature Paper
  • Article
  • Open Access
10 Citations
3,670 Views
15 Pages

Elucidating the Role of Santalol as a Potent Inhibitor of Tyrosinase: In Vitro and In Silico Approaches

  • Nabeel Ali,
  • Zainy Zehra,
  • Anas Shamsi,
  • Md. Amjad Beg and ,
  • Zahoor Ahmad Parray,
  • Israil,
  • Md. Ali Imam,
  • Naseem A. Gaur,
  • Md. Imtaiyaz Hassan and
  • Asimul Islam
  • + 9 authors+ 4 authors

15 December 2022

This research work focuses on the potential application of an organic compound, santalol, obtained from santalum album, in the inhibition of the enzyme tyrosinase, which is actively involved in the biosynthesis of melanin pigment. Over-production of...

(This article belongs to the Special Issue Spectroscopic, Thermodynamic and Molecular Docking Studies on Molecular Mechanisms of Drug Binding to Proteins II)
  • Systematic Review
  • Open Access
3 Citations
2,621 Views
25 Pages

Preventive and Therapeutic Interventions in Solar Elastosis and Photoaging: A Comprehensive Systematic Review

  • Francesco Leonforte,
  • Tiziano Pergolizzi,
  • Vito Nicosia,
  • Fabio Nicoli and ,
  • Giovanni Genovese,
  • Cristina Genovese,
  • Kidakorn Kiranantawat,
  • Rosario Perrotta and
  • Antonio Mistretta
  • + 4 authors+ 0 author

11 November 2025

Background/Objectives: Solar elastosis, a key histopathological alteration in skin photodamage, results from chronic UV exposure and photoaging. Clinically, it manifests as deep wrinkles, laxity, and a dull complexion. The growing demand for effectiv...

(This article belongs to the Special Issue Advances in Age-Related Diseases: Molecular Mechanisms, Treatments, and Clinical Implications)
  • Review
  • Open Access
28 Citations
6,697 Views
19 Pages

Immunotherapy for the Treatment of Squamous Cell Carcinoma: Potential Benefits and Challenges

  • Tuba M. Ansary,
  • MD Razib Hossain,
  • Mayumi Komine and
  • Mamitaro Ohtsuki

Melanoma and nonmelanoma skin cancers (NMSCs) are recognized as among the most common neoplasms, mostly in white people, with an increasing incidence rate. Among the NMSCs, squamous cell carcinoma (SCC) is the most prevalent malignancy known to affec...

(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
  • Article
  • Open Access
10 Citations
11,174 Views
15 Pages

Association between Auricular Signals and the Risk Factors of Metabolic Syndrome

  • Lorna Kwai Ping Suen,
  • Chao Hsing Yeh,
  • Simon Kai Wang Yeung,
  • Jojo Yee Mei Kwan and ,
  • Hon Fat Wong,
  • David Chan,
  • Alice Siu Ping Cheung and
  • Vincent Tok Fai Yeung
  • + 3 authors+ 0 author

Objective: This study aims to determine the association between auricular signals and the risk factors of metabolic syndrome (MS). Methods: A case-control study with an equal number of cases and controls matched by age group and gender was conducted....

(This article belongs to the Special Issue Auricular Medicine: Gateway to the Brain in Healing)
  • Article
  • Open Access
4 Citations
1,524 Views
18 Pages

Double-Crosslinked H-PAN/MoS2/PEI Composite Nanofiltration Membrane for Ethanol Systems: Fabrication and Dye Separation Performance

  • Yixin Zhang,
  • Chunli Liu,
  • Lei Zhu,
  • Xin Zhou and ,
  • Miaona Wang and
  • Yongqian Shen
  • + 1 author+ 0 author

23 September 2025

Organic solvent nanofiltration (OSN) is a promising technology for solute removal from organic media, yet developing membranes with stable separation performance remains challenging. This study presents a solvent-resistant double-crosslinked nanofilt...

(This article belongs to the Section Membrane Applications for Water Treatment)