Next Article in Journal
Eu-Doped BaTiO3 Powder and Film from Sol-Gel Process with Polyvinylpyrrolidone Additive
Next Article in Special Issue
Evaluation of Depigmenting Activity by 8-Hydroxydaidzein in Mouse B16 Melanoma Cells and Human Volunteers
Previous Article in Journal
Degradability of Polymers for Implantable Biomedical Devices
Previous Article in Special Issue
Variations in IC50 Values with Purity of Mushroom Tyrosinase
Open AccessReview

Mechanisms Regulating Skin Pigmentation: The Rise and Fall of Complexion Coloration

1
Department of Pharmaceutical Sciences, University of Cincinnati College of Pharmacy, 136 Health Professions Building, 3225 Eden Ave., Cincinnati, OH 45267-0004, USA
2
Department of Dermatology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML-0592, Cincinnati, OH 45267-0592, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2009, 10(9), 4066-4087; https://doi.org/10.3390/ijms10094066
Received: 21 August 2009 / Revised: 9 September 2009 / Accepted: 11 September 2009 / Published: 15 September 2009
Skin pigmentary abnormalities are seen as aesthetically unfavorable and have led to the development of cosmetic and therapeutic treatment modalities of varying efficacy. Hence, several putative depigmenting agents aimed at modulating skin pigmentation are currently being researched or sold in commercially available products. In this review we will discuss the regulation of processes that control skin complexion coloration. This includes direct inhibition of tyrosinase and related melanogenic enzymes, regulation of melanocyte homeostasis, alteration of constitutive and facultative pigmentation and down-regulation of melanosome transfer to the keratinocytes. These various processes, in the complex mechanism of skin pigmentation, can be regulated individually or concomitantly to alter complexion coloration and thus ameliorate skin complexion diseases. View Full-Text
Keywords: depigmenting agents; hyperpigmentation; melanin; pigment; tyrosinase depigmenting agents; hyperpigmentation; melanin; pigment; tyrosinase
Show Figures

MDPI and ACS Style

Ebanks, J.P.; Wickett, R.R.; Boissy, R.E. Mechanisms Regulating Skin Pigmentation: The Rise and Fall of Complexion Coloration. Int. J. Mol. Sci. 2009, 10, 4066-4087. https://doi.org/10.3390/ijms10094066

AMA Style

Ebanks JP, Wickett RR, Boissy RE. Mechanisms Regulating Skin Pigmentation: The Rise and Fall of Complexion Coloration. International Journal of Molecular Sciences. 2009; 10(9):4066-4087. https://doi.org/10.3390/ijms10094066

Chicago/Turabian Style

Ebanks, Jody P.; Wickett, R. R.; Boissy, Raymond E. 2009. "Mechanisms Regulating Skin Pigmentation: The Rise and Fall of Complexion Coloration" Int. J. Mol. Sci. 10, no. 9: 4066-4087. https://doi.org/10.3390/ijms10094066

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Search more from Scilit
 
Search
Back to TopTop