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1,393 Results Found

  • Concept Paper
  • Open Access
131 Citations
8,150 Views
12 Pages

Implementation of Safe-by-Design for Nanomaterial Development and Safe Innovation: Why We Need a Comprehensive Approach

  • Annette Kraegeloh,
  • Blanca Suarez-Merino,
  • Teun Sluijters and
  • Christian Micheletti

14 April 2018

Manufactured nanomaterials (MNMs) are regarded as key components of innovations in various fields with high potential impact (e.g., energy generation and storage, electronics, photonics, diagnostics, theranostics, or drug delivery agents). Widespread...

  • Concept Paper
  • Open Access
14 Citations
5,938 Views
14 Pages

Application of the Safe-by-Design Concept in Crop Breeding Innovation

  • Jan Pieter van der Berg,
  • Gijs A. Kleter,
  • Evy Battaglia,
  • Lianne M. S. Bouwman and
  • Esther J. Kok

The present paper proposes the application of the safe-by-design concept to crop breeding innovation with the aim to accommodate safety considerations for new agricultural food and feed products. Safe-by-design can be implemented in all stages of the...

  • Article
  • Open Access
8 Citations
4,194 Views
18 Pages

10 February 2021

Sustainability of the workforce becomes a crucial issue, of which responsible care for employees can increase job satisfaction and human capital that impact corporate ability to absorb and generate new knowledge. Firms are obligated to provide a heal...

  • Article
  • Open Access
3 Citations
2,467 Views
17 Pages

Adopting Safe-by-Design in Science and Engineering Academia: The Soil May Need Tilling

  • Sam Jan Cees Krouwel,
  • Emma Rianne Dierickx,
  • Sara Heesterbeek and
  • Pim Klaassen

In recent years, Safe-by-Design (SbD) has been launched as a concept that supports science and engineering such that a broad conception of safety is embraced and structurally embedded. The present study explores the extent to which academics in a dis...

  • Article
  • Open Access
34 Citations
9,622 Views
28 Pages

Safe-by-Design in Engineering: An Overview and Comparative Analysis of Engineering Disciplines

  • Pieter van Gelder,
  • Pim Klaassen,
  • Behnam Taebi,
  • Bart Walhout,
  • Ruud van Ommen,
  • Ibo van de Poel,
  • Zoe Robaey,
  • Lotte Asveld,
  • Ruud Balkenende and
  • Frank Hollmann
  • + 9 authors

In this paper, we provide an overview of how Safe-by-Design is conceived and applied in practice in a large number of engineering disciplines. We discuss the differences, commonalities, and possibilities for mutual learning found in those practices a...

  • Article
  • Open Access
8 Citations
2,475 Views
15 Pages

27 January 2023

Industry and scientists develop new nanomaterials and nano-enabled products to make use of the specific properties that the nanoscale can bring. However, the benefit of a nano-enabled product over a conventional product is not always a given. This pa...

  • Article
  • Open Access
1,128 Views
26 Pages

Accessing Alternative Finance in Europe: The Role of SMEs, Innovation, and Digital Platforms

  • Javier Manso Laso,
  • Ismael Moya-Clemente and
  • Gabriela Ribes Giner

Access to business financing in Europe has historically been a challenge for small and medium-sized enterprises (SMEs), which represent a significant share of economic activity and employment in Europe. This issue has been significantly intensified s...

  • Article
  • Open Access
15 Citations
7,383 Views
14 Pages

Technology-Based Innovations in Child Maltreatment Prevention Programs: Examples from SafeCare®

  • Melissa Cowart-Osborne,
  • Matthew Jackson,
  • Elizabeth Chege,
  • Evander Baker,
  • Daniel Whitaker and
  • Shannon Self-Brown

15 August 2014

Each year, hundreds of thousands of children in the U.S. are victims of child maltreatment. Experts recommend behavioral, skill-based parent training programs as a strategy for the prevention of child abuse and neglect. These programs can be enhanced...

  • Essay
  • Open Access
9 Citations
3,910 Views
14 Pages

The purpose of this publication is to provide generalized knowledge of the area of changes that took place over past centuries in relation to health, social and cultural conditions. In Greek mythology, it was necessary to nurture both body and spirit...

  • Article
  • Open Access
2 Citations
2,030 Views
27 Pages

13 June 2025

Forested areas are defined as wooded regions characterized by dense vegetation, largely preserved natural ecosystem features, and availability for recreational use. These areas play a critical role in maintaining ecological balance and are increasing...

  • Article
  • Open Access
8 Citations
383 Views
6 Pages

A Training Paradigm to Enhance Performance and Safe Use of an Innovative Neuroendovascular Device

  • Donald R. Ricci,
  • Thomas R. Marotta,
  • Howard A. Riina,
  • Martina Wan and
  • Joost De Vries

Training has been important to facilitate the safe use of new devices designed to repair vascular structures. This paper outlines the generic elements of a training program for vascular devices and uses as an example the actual training requirements...

  • Article
  • Open Access
4,862 Views
29 Pages

28 June 2025

This paper proposes a technological framework designed to mitigate the inherent risks associated with the deployment of artificial intelligence (AI) in decision-making and task execution within the management processes. The Agreement Validation Inter...

  • Article
  • Open Access
28 Citations
10,299 Views
25 Pages

11 November 2016

Visualising interactions across urban water systems to explore transition and change processes requires the development of methods and models at different scales. This paper contributes a model representing the network interactions of rainwater harve...

  • Article
  • Open Access
11 Citations
2,653 Views
19 Pages

2 July 2021

In order to reach the ambitious decarbonizing goals set by the European Union for 2030, deep renovation of the existing European building stock is a key issue. Within this context, the recently funded H2020 project “e-SAFE” is investigating market-re...

  • Perspective
  • Open Access
2 Citations
1,973 Views
18 Pages

30 April 2025

Background: Artificial intelligence (AI) is increasingly shaping the landscape of emergency surgery by offering real-time decision support, enhancing diagnostic accuracy, and optimizing workflows. However, its implementation raises significant ethica...

  • Review
  • Open Access
95 Citations
13,812 Views
22 Pages

Enhancing Essential Grains Yield for Sustainable Food Security and Bio-Safe Agriculture through Latest Innovative Approaches

  • Ghosoon Albahri,
  • Amal A. Alyamani,
  • Adnan Badran,
  • Akram Hijazi,
  • Mohamad Nasser,
  • Marc Maresca and
  • Elias Baydoun

26 June 2023

A key concern in agriculture is how to feed the expanding population and safeguard the environment from the ill effects of climate change. To feed a growing global population, food production and security are significant problems, as food output may...

  • Article
  • Open Access
4 Citations
3,831 Views
15 Pages

Roadmap for Innovators in the Process of Innovation for Development

  • Thammarat Koottatep,
  • Krisakorn Sukavejworakit and
  • Thanaphol Virasa

23 December 2020

This study aims to provide valuable insights into the process of innovation for development. We selected the “Reinvent the Toilet Challenge”, an initiative of the Gates Foundation, with the objective of creating sustainable sanitation sol...

  • Editorial
  • Open Access
8 Citations
3,238 Views
5 Pages

Editorial for the Special Issue From Nanoinformatics to Nanomaterials Risk Assessment and Governance

  • Iseult Lynch,
  • Antreas Afantitis,
  • Dario Greco,
  • Maria Dusinska,
  • Miguel A. Banares and
  • Georgia Melagraki

7 January 2021

Ensuring the safe and responsible use of nanotechnologies and nanoscale materials is imperative to maximize consumer confidence and drive commercialization of nano-enabled products that underpin innovation and advances in every industrial sector [...]

  • Editorial
  • Open Access
1 Citations
2,007 Views
4 Pages

9 November 2023

The use of lipid-based nanosystems for topical administration represents an innovative “green” approach, being composed of materials, defined as GRAS (generally recognized as safe), characterized by low toxicity, biocompatibility, and bio...

  • Article
  • Open Access
42 Citations
4,366 Views
17 Pages

Influence of Open Innovation Variables on the Competitive Edge of Small and Medium Enterprises

  • Ismael Cristofer Baierle,
  • Guilherme Brittes Benitez,
  • Elpidio Oscar Benitez Nara,
  • Jones Luis Schaefer and
  • Miguel Afonso Sellitto

The purpose of this study is to identify how open innovation variables influence the competitive capability of manufacturing small and medium enterprises (SMEs) in a regional territory in Southern Brazil. The research method is a survey of 67 SMEs in...

  • Article
  • Open Access
74 Citations
11,993 Views
12 Pages

17 October 2017

Earth systems science maintains that there are nine “planetary boundaries” that demarcate a sustainable, safe operating space for humankind for essential global sinks and resources. Respecting these planetary boundaries represents the “strong sustain...

  • Feature Paper
  • Review
  • Open Access
11 Citations
7,967 Views
20 Pages

Active Ingredients and Carriers in Nutritional Eco-Cosmetics

  • Pierfrancesco Morganti,
  • Alka Lohani,
  • Alessandro Gagliardini,
  • Gianluca Morganti and
  • Maria-Beatrice Coltelli

20 January 2023

Beauty and personal care became a significant part of the global economy for two reasons: (1) The elderly growing in the global population and (2) the desire of women and men to appear younger and more attractive. Thus, both young and old people are...

  • Article
  • Open Access
6 Citations
4,201 Views
16 Pages

This paper examines the role of sustainability as a major driver of innovation, and assesses its affect on firms’ performance. This study was based on companies listed in the Forbes list of 100 most innovative companies and BCG’s 50 most...

  • Editorial
  • Open Access
8 Citations
2,560 Views
3 Pages

22 March 2021

The present water crisis is probable to grow worse in the coming decades, and this has motivated the scientific community to identify innovative, safe, and robust water treatment technologies at a lower cost and with less energy, diminishing the use...

  • Article
  • Open Access
1 Citations
2,006 Views
25 Pages

16 January 2025

Urban Air Mobility (UAM) aims to transform urban transportation through innovative applications of electric Vertical Take-Off and Landing (eVTOL) aircraft. This paper focuses on tilt-wing eVTOLs, which offer significant advantages in energy efficienc...

  • Editorial
  • Open Access
5 Citations
2,206 Views
4 Pages

25 May 2021

The growing demands for affordable and applicable technologies for decentralized safe drinking water provision have instigated technical innovations in the water filtration industry. Adsorptive filtration appears to be the most affordable, resilient,...

  • Article
  • Open Access
9 Citations
2,217 Views
21 Pages

2 June 2023

This publication presents the results of studies of the bottom sediments (sapropels) of lakes in the North Kazakhstan region. The purpose of this study is to identify the possibility of using sapropels from the lakes of the region in obtaining innova...

  • Article
  • Open Access
4 Citations
3,081 Views
9 Pages

Infant Safe Sleep Promotion: Increasing Capacity of Child Protective Services Employees

  • Carolyn R. Ahlers-Schmidt,
  • Christy Schunn,
  • Ashley M. Hervey,
  • Maria Torres,
  • Cherie Sage,
  • Martha Henao and
  • Stephanie Kuhlmann

Sleep-related infant deaths, including Sudden Infant Death Syndrome (SIDS), are the number one cause of death in infants between 28 days and one year of life. Nearly half of families experiencing a sleep-related infant death in Kansas were involved w...

  • Article
  • Open Access
22 Citations
4,204 Views
21 Pages

Model of Evaluation and Selection of Expert Group Members for Smart Cities, Green Transportation and Mobility: From Safe Times to Pandemic Times

  • Miroslav Kelemen,
  • Volodymyr Polishchuk,
  • Beáta Gavurová,
  • Róbert Rozenberg,
  • Juraj Bartok,
  • Ladislav Gaál,
  • Martin Gera and
  • Martin Kelemen

3 June 2021

This paper presents the development of technologies to support the decision-making of local government executives and smart city concept managers in selecting and evaluating the competencies of new members for advisory groups for solving problems tha...

  • Article
  • Open Access
6 Citations
3,184 Views
25 Pages

Toward Smart Air Mobility: Control System Design and Experimental Validation for an Unmanned Light Helicopter

  • Emanuele Luigi de Angelis,
  • Fabrizio Giulietti,
  • Gianluca Rossetti,
  • Matteo Turci and
  • Chiara Albertazzi

25 April 2023

Light helicopters are used for a variety of applications, attracting users from private and public market segments because of their agility and convenient storage capabilities. However, most light helicopters on the market today are designed and manu...

  • Review
  • Open Access
57 Citations
5,427 Views
17 Pages

20 September 2020

This review offers an overview of the most recent research activities on counteracting the biodeterioration process of stone monuments, underlining all those aspects regarding eventual procedural drawbacks and compliance with sustainable criteria. Fo...

  • Review
  • Open Access
13 Citations
5,217 Views
14 Pages

5 June 2024

Minimally invasive spine surgery continues to grow and develop. Over the past 50 years, there has been immense growth within this subspecialty of neurosurgery. A deep understanding of the historical context and future directions of this subspecialty...

  • Article
  • Open Access
1,036 Views
12 Pages

A Pilot Study to Create a Culture of Innovation and Quality: Focus on a Nursing Association, Credentialing Center, and Foundation

  • Marcela Cámpoli,
  • Tanya Mulvey,
  • Olivia Lemberger,
  • Hannah Person,
  • Kasey Bellegarde-Armstrong and
  • Oriana Beaudet

26 August 2025

Background/Objectives: In today’s rapidly evolving healthcare landscape, fostering a culture of innovation and continuous improvement is essential—especially within a nursing association that leads individual and organizational credential...

  • Feature Paper
  • Article
  • Open Access
38 Citations
4,227 Views
22 Pages

A Real-Time Decision Platform for the Management of Structures and Infrastructures

  • Massimo Merenda,
  • Filippo Giammaria Praticò,
  • Rosario Fedele,
  • Riccardo Carotenuto and
  • Francesco Giuseppe Della Corte

17 October 2019

Natural disasters and the poor management of civil engineering structures and infrastructures require timely action and new tools such as specially designed structural health monitoring platforms. This paper proposes an innovative platform based on a...

  • Article
  • Open Access
9 Citations
4,630 Views
23 Pages

Human–robot collaboration (HRC) enables humans and robots to coexist in the same working environment by performing production operations together. HRC systems are used in advanced manufacturing to improve the productivity and efficiency of a ma...

  • Review
  • Open Access
21 Citations
4,542 Views
23 Pages

Antitumor Features of Vegetal Protein-Based Nanotherapeutics

  • Silvia Voci,
  • Agnese Gagliardi,
  • Massimo Fresta and
  • Donato Cosco

The introduction of nanotechnology into pharmaceutical application revolutionized the administration of antitumor drugs through the modulation of their accumulation in specific organs/body compartments, a decrease in their side-effects and their cont...

  • Review
  • Open Access
1 Citations
2,798 Views
8 Pages

A Brief Review of Local Bacteriotherapy for Preventing Respiratory Infections

  • Giorgio Ciprandi,
  • Valerio Damiani,
  • Vittorio Cordara and
  • Maria Angela Tosca

7 November 2022

Recurrent respiratory infections (RRIs) account for relevant economic and social implications and significantly affect family life. Local Bacteriotherapy (LB) represents an innovative option in preventing RRIs. Local bacteriotherapy consists of admin...

  • Review
  • Open Access
4 Citations
3,113 Views
13 Pages

Advances in Intraoperative Glioma Tissue Sampling and Infiltration Assessment

  • Nadeem N. Al-Adli,
  • Jacob S. Young,
  • Katie Scotford,
  • Youssef E. Sibih,
  • Jessica Payne and
  • Mitchel S. Berger

25 November 2023

Gliomas are infiltrative brain tumors that often involve functional tissue. While maximal safe resection is critical for maximizing survival, this is challenged by the difficult intraoperative discrimination between tumor-infiltrated and normal struc...

  • Case Report
  • Open Access
1 Citations
2,914 Views
8 Pages

Embolization of Patent Foramen Ovale Closure Device—Rare Complication and Unique Management Approach

  • Mila Kovacevic,
  • Marko Atanaskovic,
  • Katarina Obradovic,
  • Mirko Todic,
  • Branislav Crnomarkovic,
  • Marija Bjelobrk,
  • Snezana Bjelic,
  • Milenko Cankovic,
  • Aleksandra Milovancev and
  • Ilija Srdanovic

26 April 2024

Percutaneous closure of the patent foramen ovale (PFO) is generally regarded as a safe and effective procedure, indicated in patients with a prior PFO-associated stroke. While it is highly safe, rarely, it could be accompanied by a migration of the d...

  • Perspective
  • Open Access
1,631 Views
14 Pages

Physics at the Cutting Edge: The Essential Science Behind Thoracic Surgery

  • Luca Bertolaccini,
  • Virginia Piva,
  • Antonio Mazzella,
  • Monica Casiraghi,
  • Marco Maria Jacopo Felisi and
  • Lorenzo Spaggiari

9 November 2024

Thoracic surgery is deeply intertwined with the principles of physics, which govern the tools and techniques used in various procedures. A thorough understanding of these principles is essential for the safe and effective use of surgical technology,...

  • Article
  • Open Access
4 Citations
3,024 Views
22 Pages

Integrating Mental Health Management into Empowerment Group Sessions for Out-of-School Adolescents in Kenyan Informal Settlements: A Process Paper

  • Joan Mutahi,
  • Beth Kangwana,
  • Dorcas Khasowa,
  • Irene Muthoni,
  • Oliver Charo,
  • Alfred Muli and
  • Manasi Kumar

This article presents processes for developing contextualized training procedures to better appreciate partnership, capacity-building experiences, and specific implementation challenges and opportunities for mental and public health teams. The progra...

  • Feature Paper
  • Article
  • Open Access
26 Citations
4,622 Views
15 Pages

Motion Control for Autonomous Navigation in Blue and Narrow Waters Using Switched Controllers

  • Angelo Alessandri,
  • Silvia Donnarumma,
  • Michele Martelli and
  • Stefano Vignolo

Autonomous ships represent one of the new frontiers of technological innovation in marine engineering, which demand the development of innovative control systems to guarantee efficient and safe navigation of vessels. A convenient control system shoul...

  • Article
  • Open Access
26 Citations
4,319 Views
8 Pages

A Road Condition Classification Algorithm for a Tire Acceleration Sensor using an Artificial Neural Network

  • Hyeong-Jun Kim,
  • Jun-Young Han,
  • Suk Lee,
  • Jae-Ryon Kwag,
  • Min-Gu Kuk,
  • In-Hyuk Han and
  • Man-Ho Kim

The automotive industry is experiencing a period of innovation, represented by the term CASE (connected, autonomous, shared, and electric). Among the innovative new technologies for automobiles, intelligent tire (iTire) collects road surface informat...

  • Article
  • Open Access
5 Citations
3,805 Views
19 Pages

19 January 2021

Many of the environment and natural resources that constitute key “safe operating spaces”, as designated by planetary boundaries, are being exploited by a handful of large firms with considerable market share. In this paper, we discuss ho...

  • Article
  • Open Access
989 Views
19 Pages

Development and Evaluation of an Immersive Virtual Reality Application for Road Crossing Training in Older Adults

  • Alina Napetschnig,
  • Wolfgang Deiters,
  • Klara Brixius,
  • Michael Bertram and
  • Christoph Vogel

Background/Objectives: Aging is often accompanied by physical and cognitive decline, affecting older adults’ mobility. Virtual reality (VR) offers innovative opportunities to safely practice everyday tasks, such as street crossing. This study w...

  • Review
  • Open Access
4 Citations
4,070 Views
17 Pages

Anthropo-Mechanical Cradles: A Multidisciplinary Review

  • Maciej Sydor,
  • Jessica Pop,
  • Anna Jasińska and
  • Marek Zabłocki

Domestic cradles are beds that are movable but non-mobile for babies up to five months of age. The “anthropo-mechanical” cradle simulates the physiological movement of the human body. The article reviews scientific literature discussing t...

  • Article
  • Open Access
4 Citations
2,794 Views
21 Pages

17 July 2024

A system has been developed to convert manual wheelchairs into electric wheelchairs, providing assistance to users through the implemented algorithm, which ensures safe driving and obstacle avoidance. While manual wheelchairs are typically controlled...

  • Article
  • Open Access
5 Citations
2,695 Views
16 Pages

20 September 2022

This article aims to explore the relationship between social innovation and opportunities for innovation in public services, focusing on a range of initiatives intended to improve services and infrastructure for pedestrians in the city of São...

  • Article
  • Open Access
1 Citations
2,714 Views
11 Pages

Expansion of MyDispense: A Descriptive Report of Simulation Activities and Assessment in a Certified Pharmacy Technician Training Program

  • Cassandra R. Doyno,
  • Lisa M. Holle,
  • Renee Puente,
  • Sharee Parker,
  • Lauren M. Caldas and
  • Barbara Exum

16 February 2023

Background: Yale New Haven Health (YNHH) implemented a pharmacy technician training program in 2016. The curriculum includes 14 weeks of combined didactic and simulation hours (280 h in total), followed by 360 h of experiential learning. MyDispense,...

  • Review
  • Open Access
52 Citations
5,733 Views
30 Pages

Functional Nanohybrids and Nanocomposites Development for the Removal of Environmental Pollutants and Bioremediation

  • Giulia Rando,
  • Silvia Sfameni,
  • Maurilio Galletta,
  • Dario Drommi,
  • Simone Cappello and
  • Maria Rosaria Plutino

29 July 2022

World population growth, with the consequent consumption of primary resources and production of waste, is progressively and seriously increasing the impact of anthropic activities on the environment and ecosystems. Environmental pollution deriving fr...

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