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15,334 Results Found

  • Systematic Review
  • Open Access
1 Citations
4,859 Views
16 Pages

Effect of Probiotics on Uric Acid Levels: Meta-Analysis with Subgroup Analysis and Meta-Regression

  • Rym Ben Othman,
  • Mouna Ben Sassi,
  • Syrine Ben Hammamia,
  • Chadli Dziri,
  • Youssef Zanina,
  • Kamel Ben Salem and
  • Henda Jamoussi

29 July 2025

Background: Probiotics can modulate the microbiota and decrease uric acid levels. Objectives: This meta-analysis aimed to assess the effects of probiotics on uric acid levels. Methods: The keywords “probiotics”, “uric acid”, &...

  • Article
  • Open Access
26 Citations
12,977 Views
24 Pages

Effect Sizes, Power, and Biases in Intelligence Research: A Meta-Meta-Analysis

  • Michèle B. Nuijten,
  • Marcel A. L. M. van Assen,
  • Hilde E. M. Augusteijn,
  • Elise A. V. Crompvoets and
  • Jelte M. Wicherts

In this meta-study, we analyzed 2442 effect sizes from 131 meta-analyses in intelligence research, published from 1984 to 2014, to estimate the average effect size, median power, and evidence for bias. We found that the average effect size in intelli...

  • Feature Paper
  • Review
  • Open Access
94 Citations
13,555 Views
13 Pages

Cholesterol and Alzheimer’s Disease Risk: A Meta-Meta-Analysis

  • Olalla Sáiz-Vazquez,
  • Alicia Puente-Martínez,
  • Silvia Ubillos-Landa,
  • Joaquín Pacheco-Bonrostro and
  • Javier Santabárbara

Background: Alzheimer’s disease (AD) is the most common subtype of dementia. In the last ten years, the relationship between cholesterol and AD has been investigated. Evidence suggests that cholesterol is associated with AD and represents promi...

  • Article
  • Open Access
43 Citations
8,103 Views
14 Pages

Deep Brain Stimulation Is Effective for Treatment-Resistant Depression: A Meta-Analysis and Meta-Regression

  • Frederick L. Hitti,
  • Andrew I. Yang,
  • Mario A. Cristancho and
  • Gordon H. Baltuch

30 August 2020

Major depressive disorder (MDD) is a leading cause of disability and a significant cause of mortality worldwide. Approximately 30–40% of patients fail to achieve clinical remission with available pharmacological treatments, a clinical course te...

  • Article
  • Open Access
54 Citations
65,156 Views
28 Pages

22 September 2022

Meta-analysis has started to take place among the most used methodologies in psychological research. Such a technique allows researchers to combine the data sets obtained from several individual studies on the same topic and thus is particularly usef...

  • Systematic Review
  • Open Access
111 Citations
9,822 Views
16 Pages

24 April 2021

Sarcopenia, with risk factors such as poor nutrition and physical inactivity, is becoming prevalent among the older population. The aims of this study were (i) to systematically review the existing data on sarcopenia prevalence in the older Chinese p...

  • Communication
  • Open Access
4 Citations
1,552 Views
19 Pages

27 December 2024

Detecting interactions is a critical aspect of medical research. When interactions are present, it is essential to calculate confidence intervals for both the main effect and the interaction effect. This requires determining the covariance between th...

  • Review
  • Open Access
6 Citations
4,774 Views
15 Pages

Science Mapping of Meta-Analysis in Agricultural Science

  • Weiting Ding,
  • Jialu Li,
  • Heyang Ma,
  • Yeru Wu and
  • Hailong He

11 November 2023

As a powerful statistical method, meta-analysis has been applied increasingly in agricultural science with remarkable progress. However, meta-analysis research reports in the agricultural discipline still need to be systematically combed. Scientometr...

  • Proceeding Paper
  • Open Access
2,537 Views
5 Pages

High and Low Selenium Exposure and Cancer Risk: A Meta-Meta-Analysis

  • Mehmet Emin Arayici,
  • Yasemin Basbinar and
  • Hulya Ellidokuz

Selenium was discovered in the first quarter of the 19th century and classified as a chalcogen belonging to the 16th group, along with oxygen, sulfur, tellurium, and polonium. Selenium plays a crucial role in the activation of antioxidant enzymes in...

  • Article
  • Open Access
14 Citations
3,889 Views
12 Pages

Association between the Phytochemical Index and Overweight/Obesity: A Meta-Analysis

  • Chaojie Wei,
  • Liping Liu,
  • Renli Liu,
  • Wenwen Dai,
  • Weiwei Cui and
  • Dong Li

29 March 2022

Some studies suggest that a higher phytochemical index (PI) is associated with a lower risk of overweight/obesity. This meta-analysis is performed to summarize published studies on the relationship of PI and the risk of overweight/obesity. We searche...

  • Article
  • Open Access
16 Citations
8,002 Views
15 Pages

Characteristics of PSA Bounce after Radiotherapy for Prostate Cancer: A Meta-Analysis

  • Narisa Dewi Maulany Darwis,
  • Takahiro Oike,
  • Nobuteru Kubo,
  • Soehartati A Gondhowiardjo and
  • Tatsuya Ohno

5 August 2020

The rate and characteristics of prostate-specific antigen (PSA) bounce post-radiotherapy remain unclear. To address this issue, we performed a meta-analysis. Reports of PSA bounce post-radiotherapy with a cutoff of 0.2 ng/mL were searched by using Me...

  • Feature Paper
  • Article
  • Open Access
8 Citations
3,332 Views
16 Pages

30 October 2020

Background: Atrophy of grey matter (GM) is observed in the earliest stages of multiple sclerosis (MS) and is associated with cognitive decline and physical disability. Localised GM atrophy in MS can be explored and better understood using magnetic re...

  • Systematic Review
  • Open Access
2,979 Views
20 Pages

25 June 2024

Background: Chemotherapy is the main first-line treatment, but there is a problem of adverse reactions to systemic drugs. Chemotherapeutic agents may cause adverse effects on the body, influencing the prognosis. Whether the clinical application of an...

  • Feature Paper
  • Review
  • Open Access
16 Citations
6,166 Views
15 Pages

Behaviour Change Techniques in Weight Gain Prevention Interventions in Adults of Reproductive Age: Meta-Analysis and Meta-Regression

  • Mamaru Ayenew Awoke,
  • Cheryce L. Harrison,
  • Julie Martin,
  • Marie L. Misso,
  • Siew Lim and
  • Lisa J. Moran

3 January 2022

Weight gain prevention interventions are likely to be more effective with the inclusion of behaviour change techniques. However, evidence on which behaviour change techniques (BCT) are most effective for preventing weight gain and improving lifestyle...

  • Review
  • Open Access
22 Citations
7,663 Views
20 Pages

Parenteral Nutrition in Patients with Inflammatory Bowel Disease Systematic Review, Meta-Analysis and Meta-Regression

  • Jose M. Comeche,
  • Iris Comino,
  • Cesare Altavilla,
  • Jose Tuells,
  • Ana Gutierrez-Hervas and
  • Pablo Caballero

22 November 2019

Inflammatory bowel disease (IBD) is a chronic disease mediated by the immune system and characterized by the inflammation of the gastrointestinal tract. This study is to understand how the use of parenteral nutrition (PN) can affect the adult populat...

  • Systematic Review
  • Open Access
39 Citations
5,737 Views
12 Pages

Prevalence of Hyperhomocysteinemia in China: An Updated Meta-Analysis

  • Yuan Zeng,
  • Fei-Fei Li,
  • Shu-Qian Yuan,
  • Hao-Kai Tang,
  • Jun-Hua Zhou,
  • Quan-Yuan He,
  • Julien S. Baker,
  • Yan-Hui Dong and
  • Yi-De Yang

26 September 2021

We conducted a meta-analysis to systematically assess the prevalence of hyperhomocysteinemia (HHcy) in China, its change over time, and its determinants. Literature searches were conducted using English databases (PubMed, Embase, and Web of Science)...

  • Systematic Review
  • Open Access
7 Citations
6,743 Views
17 Pages

Quantifying the Relationship Between Self-Efficacy and Mathematical Creativity: A Meta-Analysis

  • Herianto Herianto,
  • Anastasia Sofroniou,
  • Muh Fitrah,
  • Dadan Rosana,
  • Caly Setiawan,
  • Raden Rosnawati,
  • Widihastuti Widihastuti,
  • Andi Jusmiana and
  • Yudince Marinding

14 November 2024

This study is a meta-analysis to examine the relationship between self-efficacy and mathematical creativity. This meta-analysis included 21 studies with a total sample size of 11,621 participants and 33 effect sizes across the studies. Data analysis...

  • Review
  • Open Access
66 Citations
12,899 Views
15 Pages

Vitamin D and Graves’ Disease: A Meta-Analysis Update

  • Mei-Yan Xu,
  • Bing Cao,
  • Jian Yin,
  • Dong-Fang Wang,
  • Kai-Li Chen and
  • Qing-Bin Lu

21 May 2015

The association between vitamin D levels and Graves’ disease is not well studied. This update review aims to further analyze the relationship in order to provide an actual view of estimating the risk. We searched for the publications on vitamin D and...

  • Article
  • Open Access
23 Citations
9,215 Views
20 Pages

Land Inequality and Economic Growth: A Meta-Analysis

  • Maria Cipollina,
  • Nadia Cuffaro and
  • Giovanna D’Agostino

6 December 2018

Increasing commercial pressure on land may lead to land concentration in developing countries, especially in the context of complex systems of property rights. In this article we review through meta-analysis (MA) the econometric findings of the liter...

  • Article
  • Open Access
128 Citations
27,022 Views
24 Pages

The Economic Value of Mangroves: A Meta-Analysis

  • Marwa E. Salem and
  • D. Evan Mercer

7 March 2012

This paper presents a synthesis of the mangrove ecosystem valuation literature through a meta-regression analysis. The main contribution of this study is that it is the first meta-analysis focusing solely on mangrove forests, whereas previous studies...

  • Review
  • Open Access
27 Citations
5,521 Views
18 Pages

Assessment of the Association of COPD and Asthma with In-Hospital Mortality in Patients with COVID-19. A Systematic Review, Meta-Analysis, and Meta-Regression Analysis

  • Felix M. Reyes,
  • Manuel Hache-Marliere,
  • Dimitris Karamanis,
  • Cesar G. Berto,
  • Rodolfo Estrada,
  • Matthew Langston,
  • George Ntaios,
  • Perminder Gulani,
  • Chirag D. Shah and
  • Leonidas Palaiodimos

13 May 2021

Together, chronic obstructive pulmonary disease (COPD) and asthma account for the most common non-infectious respiratory pathologies. Conflicting preliminary studies have shown varied effect for COPD and asthma as prognostic factors for mortality in...

  • Systematic Review
  • Open Access
4 Citations
11,837 Views
16 Pages

29 October 2024

Background: Emotional Freedom Techniques (EFT) have gained attention as a potential therapy for reducing depressive symptoms. However, the evidence remains inconsistent. This meta-analysis aims to assess the overall efficacy of EFT in treating depres...

  • Article
  • Open Access
5 Citations
3,797 Views
22 Pages

24 January 2022

Previous research showed that employing results from meta-analyses of relevant previous fMRI studies can improve the performance of voxelwise Bayesian second-level fMRI analysis. In this process, prior distributions for Bayesian analysis can be deter...

  • Article
  • Open Access
2,520 Views
30 Pages

6 October 2025

Background: Distal pancreatectomy (DP) is a potentially curative procedure for tumors of the pancreatic body and tail. Minimally invasive DP (MIDP), including laparoscopic and robotic techniques, is increasingly being adopted. This study aimed to eva...

  • Review
  • Open Access
27 Citations
8,464 Views
21 Pages

Enteral Nutrition in Patients with Inflammatory Bowel Disease. Systematic Review, Meta-Analysis, and Meta-Regression

  • Jose M. Comeche,
  • Pablo Caballero,
  • Ana Gutierrez-Hervas,
  • Sofia García-Sanjuan,
  • Iris Comino,
  • Cesare Altavilla and
  • Jose Tuells

4 November 2019

Inflammatory bowel disease (IBD) is a chronic disease mediated by the immune system and is characterized by inflammation of the gastrointestinal tract. One of the possible treatments for this pathology is a change in the type of diet, of which entera...

  • Article
  • Open Access
55 Citations
13,836 Views
15 Pages

22 December 2014

ncreasing evidence has suggested an association between dietary magnesium intake and metabolic syndrome. However, previous research examining dietary magnesium intake and metabolic syndrome has produced mixed results. Our objective was to determine t...

  • Article
  • Open Access
15 Citations
4,825 Views
12 Pages

25 February 2021

Data accumulation in public databases has resulted in extensive use of meta-analysis, a statistical analysis that combines the results of multiple studies. Oxidative stress occurs when there is an imbalance between free radical activity and antioxida...

  • Article
  • Open Access
10 Citations
6,164 Views
19 Pages

A Global Meta-Analysis for Estimating Local Ecosystem Service Value Functions

  • Luiz Magalhães Filho,
  • Peter Roebeling,
  • Maria Isabel Bastos,
  • Waldecy Rodrigues and
  • Giulia Ometto

The Meta-analysis has increasingly been used to synthesize the ecosystem services literature, with some testing of the use of such analyses to transfer benefits. These are typically based on local primary studies. However, meta-analyses associated wi...

  • Article
  • Open Access
3 Citations
4,771 Views
13 Pages

MAGE: An Open-Source Tool for Meta-Analysis of Gene Expression Studies

  • Ioannis A. Tamposis,
  • Georgios A. Manios,
  • Theodosia Charitou,
  • Konstantina E. Vennou,
  • Panagiota I. Kontou and
  • Pantelis G. Bagos

10 June 2022

MAGE (Meta-Analysis of Gene Expression) is a Python open-source software package designed to perform meta-analysis and functional enrichment analysis of gene expression data. We incorporate standard methods for the meta-analysis of gene expression st...

  • Review
  • Open Access
82 Citations
25,236 Views
10 Pages

Coffee Intake and Obesity: A Meta-Analysis

  • Ariel Lee,
  • Woobin Lim,
  • Seoyeon Kim,
  • Hayeong Khil,
  • Eugene Cheon,
  • Soobin An,
  • SungEun Hong,
  • Dong Hoon Lee,
  • Seok-Seong Kang and
  • Chung-Cheng Hsieh
  • + 2 authors

5 June 2019

Many studies have explored the relationship between coffee—one of the most commonly consumed beverages today—and obesity. Despite inconsistent results, the relationship has not been systematically summarized. Thus, we conducted a meta-ana...

  • Systematic Review
  • Open Access
6 Citations
3,142 Views
15 Pages

Systematic Review, Meta-Analysis and Bioinformatic Analysis of Biomarkers for Prognosis of Malignant Pleural Mesothelioma

  • Zhenhua Lu,
  • Wenlong Zhang,
  • Ke Huang,
  • Mucheng Zhu,
  • Xiaoting Gu,
  • Defang Wei,
  • Mingxuan Shi,
  • Yaqiong Chen and
  • Huihui Wang

12 September 2022

In previous studies, non-invasive diagnostic biomarkers showed great benefit in the early-stage diagnosis of malignant pleural mesothelioma (MPM). However, the accuracy of different biomarkers was controversial. In this study, meta-analysis and bioin...

  • Review
  • Open Access
4 Citations
8,610 Views
26 Pages

Background: Nowadays, much research deals with the application of the automated meta-analysis of clinical trials through appropriate machine learning tools to extract the results that can then be applied in daily clinical practice. Methods: The autho...

  • Article
  • Open Access
37 Citations
9,403 Views
11 Pages

Hypoxia is the insufficiency of oxygen in the cell, and hypoxia-inducible factors (HIFs) are central regulators of oxygen homeostasis. In order to obtain functional insights into the hypoxic response in a data-driven way, we attempted a meta-analysis...

  • Systematic Review
  • Open Access
19 Citations
10,615 Views
17 Pages

The Psychosocial Effects of Taekwondo Training: A Meta-Analysis

  • Yu-Jin Kim,
  • Seung-Hui Baek,
  • Jong-Beom Park,
  • Sang-Hwan Choi,
  • Jae-Don Lee and
  • Sang-Seok Nam

Taekwondo is a Korean martial art and international sport, and its psychosocial benefits for its trainees have been studied extensively. This review aims to systematically assess and meta-analyze the effects of Taekwondo training on sociality, charac...

  • Review
  • Open Access
18 Citations
9,067 Views
50 Pages

Effects of Physiotherapy on Pain and Mouth Opening in Temporomandibular Disorders: An Umbrella and Mapping Systematic Review with Meta-Meta-Analysis

  • Manuel Arribas-Pascual,
  • Sofia Hernández-Hernández,
  • Christian Jiménez-Arranz,
  • Mónica Grande-Alonso,
  • Santiago Angulo-Díaz-Parreño,
  • Roy La Touche and
  • Alba Paris-Alemany

18 January 2023

The aim of this meta-meta-analysis was to assess the current evidence regarding the effect of physical therapy (PT) interventions on pain and functional variables in temporomandibular disorders (TMD). We conducted an umbrella systematic review (SR) a...

  • Article
  • Open Access
33 Citations
6,342 Views
15 Pages

Association between Dietary Inflammatory Index and Sarcopenia: A Meta-Analysis

  • Houze Diao,
  • Feifei Yan,
  • Qingzhen He,
  • Mingyuan Li,
  • Qingzhao Zheng,
  • Qing Zhu,
  • Fang Fang and
  • Weiwei Cui

1 January 2023

Background: The dietary inflammatory index (DII) is thought to be related to many healthy events. However, the association between the DII and sarcopenia remains unclear. Methods: The meta-analysis was conducted to evaluate the effects of the DII on...

  • Systematic Review
  • Open Access
4 Citations
4,046 Views
12 Pages

Hypertension and Dental Implants: A Systematic Review and Meta-Analysis

  • Liljan Hamadé,
  • Salma El-Disoki and
  • Bruno Ramos Chrcanovic

16 January 2024

Purpose: The aim of the present systematic review was to investigate the influence of hypertension on the dental implant failure rate. Methods: An electronic search was undertaken in four databases, plus a manual search of journals. The I2 statistic...

  • Article
  • Open Access
5 Citations
2,955 Views
34 Pages

ESG Strategy and Tax Avoidance: Insights from a Meta-Regression Analysis

  • Maria Mitroulia,
  • Evangelos Chytis,
  • Thomas Kitsantas,
  • Michalis Skordoulis and
  • Petros Kalantonis

This research examines the relationship between environmental, social, and governance (ESG) criteria and tax behavior, with a particular focus on tax avoidance (TA). Despite the extensive literature on ESG and tax behavior, there remains a research g...

  • Article
  • Open Access
8 Citations
6,281 Views
22 Pages

Meta-Analysis of the Association between Asbestos Exposure and Esophageal Cancer

  • Chih-Wei Wu,
  • Hung-Yi Chuang,
  • Dong-Lin Tsai,
  • Tzu-Yu Kuo,
  • Chen-Cheng Yang,
  • Huang-Chi Chen and
  • Chao-Hung Kuo

Background: We conducted a meta-analysis to quantitatively assess the association between asbestos exposure and esophageal cancer. Methods: We systematically collected articles from three electronic databases and calculated the pooled standardized mo...

  • Systematic Review
  • Open Access
75 Citations
15,262 Views
15 Pages

Smoking and Dental Implants: A Systematic Review and Meta-Analysis

  • Abir Dunia Mustapha,
  • Zainab Salame and
  • Bruno Ramos Chrcanovic

27 December 2021

Background and Objectives: Tobacco is today the single most preventable cause of death, being associated with countless diseases, including cancer and neurological, cardiovascular, and respiratory diseases. Smoking also brings negative consequences t...

  • Review
  • Open Access
14 Citations
5,509 Views
16 Pages

Advances in Meta-Analysis of the Effects of Grazing on Grassland Ecosystems in China

  • Xuemin Gong,
  • Yijia Wang,
  • Tianyu Zhan,
  • Chenxu Wang,
  • Changjia Li and
  • Yanxu Liu

Grassland ecosystems are among the largest terrestrial ecosystems in China, and grazing, as an important grassland management method, has direct and indirect impacts on grassland ecosystems. Meta-analyses can be used to systematically evaluate and su...

  • Article
  • Open Access
18 Citations
7,238 Views
15 Pages

Efficiency in Vietnamese Banking: A Meta-Regression Analysis Approach

  • Tin H. Ho,
  • Dat T. Nguyen,
  • Thanh Ngo and
  • Tu D. Q. Le

This study explains the differences and variances in the efficiency scores of the Vietnamese banking sector retrieved from 27 studies published in refereed academic journals under the framework of meta-regression analysis. These scores are mainly bas...

  • Systematic Review
  • Open Access
13 Citations
8,884 Views
20 Pages

Does Lead Have a Connection to Autism? A Systematic Review and Meta-Analysis

  • Aleksandar Stojsavljević,
  • Novak Lakićević and
  • Slađan Pavlović

5 September 2023

Environmental pollutants, particularly toxic trace metals with neurotoxic potential, have been related to the genesis of autism. One of these metals that stands out, in particular, is lead (Pb). We conducted an in-depth systematic review and meta-ana...

  • Article
  • Open Access
8 Citations
3,509 Views
18 Pages

Bayesian Meta-Analysis for Binary Data and Prior Distribution on Models

  • Miguel-Angel Negrín-Hernández,
  • María Martel-Escobar and
  • Francisco-José Vázquez-Polo

In meta-analysis, the structure of the between-sample heterogeneity plays a crucial role in estimating the meta-parameter. A Bayesian meta-analysis for binary data has recently been proposed that measures this heterogeneity by clustering the samples...

  • Feature Paper
  • Article
  • Open Access
5 Citations
8,134 Views
10 Pages

23 September 2022

With increasing public data, a statistical analysis approach called meta-analysis, which combines transcriptome results obtained from multiple studies, has succeeded in providing novel insights into targeted biological processes. Locusts and aphids a...

  • Systematic Review
  • Open Access
8 Citations
22,951 Views
20 Pages

23 September 2024

Background: Eye Movement Desensitization and Reprocessing (EMDR) therapy has gained attention for its potential effectiveness in treating depression beyond its initial use for PTSD. This systematic review and meta-analysis aims to evaluate the effica...

  • Article
  • Open Access
9 Citations
8,107 Views
35 Pages

All-Cause Mortality and Cardiovascular Death between Statins and Omega-3 Supplementation: A Meta-Analysis and Network Meta-Analysis from 55 Randomized Controlled Trials

  • Jeongseon Kim,
  • Tung Hoang,
  • Ji-Myung Kim,
  • So Young Bu,
  • Jeong-Hwa Choi,
  • Eunju Park,
  • Seung-Min Lee,
  • Eunmi Park,
  • Ji Yeon Min and
  • Jee-Young Yeon
  • + 2 authors

20 October 2020

Statins and omega-3 supplementation have shown potential benefits in preventing cardiovascular disease (CVD), but their comparative effects on mortality outcomes, in addition to primary and secondary prevention and mixed population, have not been inv...

  • Article
  • Open Access
31 Citations
11,580 Views
19 Pages

How Is Intelligence Test Performance Associated with Creative Achievement? A Meta-Analysis

  • Maciej Karwowski,
  • Marta Czerwonka,
  • Ewa Wiśniewska and
  • Boris Forthmann

This paper presents a meta-analysis of the links between intelligence test scores and creative achievement. A three-level meta-analysis of 117 correlation coefficients from 30 studies found a correlation of r = .16 (95% CI: .12, .19), closely mirrori...

  • Article
  • Open Access
311 Views
18 Pages

This study conducts a meta-analysis to assess the impact of tourism on employment, synthesizing 401 partial correlation coefficients extracted from 39 empirical studies. Employing partial correlation coefficients (PACs) as the effect size measure, th...

  • Brief Report
  • Open Access
10 Citations
4,532 Views
9 Pages

Meta-Analysis of Studies on the Effects of Digital Therapeutics

  • Young-Chul Seo,
  • Sang Yeol Yong,
  • Won Woo Choi and
  • Sung Hoon Kim

30 January 2024

Digital therapeutics (DTx), novel treatment methods that have the potential to surpass traditional approaches such as pills, have received considerable research attention. Various efforts have been made to explore effective treatment methods that act...

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