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Open AccessFeature PaperReview

Cholesterol and Alzheimer’s Disease Risk: A Meta-Meta-Analysis

1
Department of Occupational Therapy, Faculty of Health Science, University of Burgos, C/Villadiego, 1, 09001 Burgos, Spain
2
Department of Social Psychology and Methodology of Behavioral Science, University of the Basque Country, Avenida Tolosa 70, 20018 San Sebastián, Spain
3
Department of Social Psychology, Faculty of Health Science, University of Burgos, C/Villadiego, 1, 09001 Burgos, Spain
4
Department of Applied Economy, Faculty of Economics and Business Sciences, University of Burgos, Pza. De la Infanta Dª Elena, s/n. 09001 Burgos, Spain
5
Department of Microbiology, Pediatrics, Radiology and Public Health, University of Zaragoza, C/Domingo Miral s/n, 50009 Zaragoza, Spain
6
Aragonese Institute of Health Sciences (IIS Aragón), 50009 Zaragoza, Spain
*
Author to whom correspondence should be addressed.
Brain Sci. 2020, 10(6), 386; https://doi.org/10.3390/brainsci10060386
Received: 25 May 2020 / Revised: 7 June 2020 / Accepted: 14 June 2020 / Published: 18 June 2020
(This article belongs to the Special Issue Epidemiology of Alzheimer’s Disease and Other Dementias)
Background: Alzheimer’s disease (AD) is the most common subtype of dementia. In the last ten years, the relationship between cholesterol and AD has been investigated. Evidence suggests that cholesterol is associated with AD and represents promising targets for intervention. However, the causality of these associations is unclear. Therefore, we sought to conduct a meta-meta-analysis to determine the effect of cholesterol on the development AD. Then, we assessed the effect of serum levels of low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC) and triglycerides (TG), on AD risk. Methods: A systematic search of meta-analyses was conducted. Scopus, Web of Science, Science direct, PubMed and Google academic system databases were reviewed. Results: We found 100 primary studies and five meta-analyses to analyze the relationships between cholesterol and AD. The total effect of cholesterol on risk of AD was significant and heterogeneous. Subgroup analysis shows that LDL-C levels influence the development of AD. However, non-significant effects of HDL-C, TC and TG levels on AD were found. Conclusions: These results strengthen the evidence that LDL-C cholesterol levels increase risk for AD. More initiatives to investigate the relationship between cholesterol and AD are needed. View Full-Text
Keywords: Alzheimer’s disease; etiology; cholesterol; risk factors; meta-analysis Alzheimer’s disease; etiology; cholesterol; risk factors; meta-analysis
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MDPI and ACS Style

Sáiz-Vazquez, O.; Puente-Martínez, A.; Ubillos-Landa, S.; Pacheco-Bonrostro, J.; Santabárbara, J. Cholesterol and Alzheimer’s Disease Risk: A Meta-Meta-Analysis. Brain Sci. 2020, 10, 386. https://doi.org/10.3390/brainsci10060386

AMA Style

Sáiz-Vazquez O, Puente-Martínez A, Ubillos-Landa S, Pacheco-Bonrostro J, Santabárbara J. Cholesterol and Alzheimer’s Disease Risk: A Meta-Meta-Analysis. Brain Sciences. 2020; 10(6):386. https://doi.org/10.3390/brainsci10060386

Chicago/Turabian Style

Sáiz-Vazquez, Olalla; Puente-Martínez, Alicia; Ubillos-Landa, Silvia; Pacheco-Bonrostro, Joaquín; Santabárbara, Javier. 2020. "Cholesterol and Alzheimer’s Disease Risk: A Meta-Meta-Analysis" Brain Sci. 10, no. 6: 386. https://doi.org/10.3390/brainsci10060386

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