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Meta-Analysis of the Association between Asbestos Exposure and Esophageal Cancer

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Department of Occupational and Environmental Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung City 812, Taiwan
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Department of Surgery, Shin Kong Wu Ho Su Memorial Hospital, Taipei City 111, Taiwan
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Department of Occupational and Environmental Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung City 807, Taiwan
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Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung City 812, Taiwan
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Division of Thoracic Surgery, Department of Surgery, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung City 812, Taiwan
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Division of Pulmonary Medicine, Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung City 812, Taiwan
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Cancer Center, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung City 812, Taiwan
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Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung City 812, Taiwan
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Author to whom correspondence should be addressed.
Academic Editors: Yu-Hsiang Cheng, Elisabete Carolino and Chi-Chi Lin
Int. J. Environ. Res. Public Health 2021, 18(21), 11088; https://doi.org/10.3390/ijerph182111088
Received: 5 September 2021 / Revised: 15 October 2021 / Accepted: 19 October 2021 / Published: 21 October 2021
(This article belongs to the Topic Air Pollution and Occupational Exposure)
Background: We conducted a meta-analysis to quantitatively assess the association between asbestos exposure and esophageal cancer. Methods: We systematically collected articles from three electronic databases and calculated the pooled standardized mortality rate (SMR) from the meta-analysis. Subgroup analysis according to the type of asbestos exposure, follow-up years, sample size, industry classification, sex, and high-dose exposure was conducted. Results: From 242 studies, 34 cohort studies were included in our meta-analysis. Pooled SMR was positively associated with asbestos exposure and esophageal cancer (pooled SMR = 1.28; 95% confidence interval (CI) 1.19–1.38, p < 0.00001). In the subgroup analysis, (1) chrysolite, (2) four groups with follow-up over ten years, (3) the textile industry and shipyard, (4) both male and female, and (5) eight studies on highest asbestos exposure, all the subgroups showed significantly increased pooled SMRs. Conclusion: Asbestos exposure was significantly and positively associated with esophageal cancer, especially chrysolite. Considering the long latency period, we suggest that patients should be followed up for cancer, including esophageal cancer, for over ten years. View Full-Text
Keywords: asbestos exposure; esophageal cancer; carcinogen; occupational medicine; environmental medicine; meta-analysis asbestos exposure; esophageal cancer; carcinogen; occupational medicine; environmental medicine; meta-analysis
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MDPI and ACS Style

Wu, C.-W.; Chuang, H.-Y.; Tsai, D.-L.; Kuo, T.-Y.; Yang, C.-C.; Chen, H.-C.; Kuo, C.-H. Meta-Analysis of the Association between Asbestos Exposure and Esophageal Cancer. Int. J. Environ. Res. Public Health 2021, 18, 11088. https://doi.org/10.3390/ijerph182111088

AMA Style

Wu C-W, Chuang H-Y, Tsai D-L, Kuo T-Y, Yang C-C, Chen H-C, Kuo C-H. Meta-Analysis of the Association between Asbestos Exposure and Esophageal Cancer. International Journal of Environmental Research and Public Health. 2021; 18(21):11088. https://doi.org/10.3390/ijerph182111088

Chicago/Turabian Style

Wu, Chih-Wei, Hung-Yi Chuang, Dong-Lin Tsai, Tzu-Yu Kuo, Chen-Cheng Yang, Huang-Chi Chen, and Chao-Hung Kuo. 2021. "Meta-Analysis of the Association between Asbestos Exposure and Esophageal Cancer" International Journal of Environmental Research and Public Health 18, no. 21: 11088. https://doi.org/10.3390/ijerph182111088

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