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465 Results Found

  • Review
  • Open Access
80 Citations
23,169 Views
20 Pages

21 July 2016

Filamentous fungi are well known for their capability of producing antibiotic natural products. Recent studies have demonstrated the potential of antimicrobials with vast chemodiversity from marine fungi. Development of such natural products into lea...

  • Commentary
  • Open Access
6 Citations
5,999 Views
12 Pages

24 June 2017

Normative ethical considerations of growth of the marine biotechnology and aquaculture disciplines in biopharming, food production, and marine products commercialization from a bioethical perspective have been limited. This paucity of information beg...

  • Perspective
  • Open Access
17 Citations
6,097 Views
20 Pages

26 April 2022

As the quest for marine-derived compounds with pharmacological and biotechnological potential upsurges, the importance of following regulations and applying Responsible Research and Innovation (RRI) also increases. This article aims at: (1) presentin...

  • Review
  • Open Access
2 Citations
1,867 Views
20 Pages

19 June 2025

The natural and biological processes of organisms offer significant potential for the removal and remediation of environmental contaminants including organic pollutants such as persistent organic pollutants (POPs) like polychlorinated biphenyls (PCBs...

  • Feature Paper
  • Article
  • Open Access
8 Citations
5,492 Views
26 Pages

Identification of Marine Biotechnology Value Chains with High Potential in the Northern Mediterranean Region

  • Ana Rotter,
  • Antonia Giannakourou,
  • Jesús E. Argente García,
  • Grazia Marina Quero,
  • Charlène Auregan,
  • George Triantaphyllidis,
  • Amalia Venetsanopoulou,
  • Roberta De Carolis,
  • Chrysa Efstratiou and
  • Cristian Chiavetta
  • + 21 authors

22 July 2023

Marine (blue) biotechnology is an emerging field enabling the valorization of new products and processes with massive potential for innovation and economic growth. In the Mediterranean region, this innovation potential is not exploited as well as in...

  • Review
  • Open Access
48 Citations
9,018 Views
45 Pages

Marine Terpenoids from Polar Latitudes and Their Potential Applications in Biotechnology

  • Laura Núñez-Pons,
  • Andrew Shilling,
  • Cinzia Verde,
  • Bill J. Baker and
  • Daniela Giordano

29 July 2020

Polar marine biota have adapted to thrive under one of the ocean’s most inhospitable scenarios, where extremes of temperature, light photoperiod and ice disturbance, along with ecological interactions, have selected species with a unique suite...

  • Article
  • Open Access
34 Citations
9,635 Views
35 Pages

26 January 2021

Biotechnology is an essential tool for the sustainable exploitation of marine resources, although the full development of their potential is complicated by a series of cognitive and technological limitations. Thanks to an innovative systematic approa...

  • Review
  • Open Access
73 Citations
19,054 Views
16 Pages

The Biotechnological Potential of Secondary Metabolites from Marine Bacteria

  • Boris Andryukov,
  • Valery Mikhailov and
  • Nataly Besednova

Marine habitats are a rich source of molecules of biological interest. In particular, marine bacteria attract attention with their ability to synthesize structurally diverse classes of bioactive secondary metabolites with high biotechnological potent...

  • Review
  • Open Access
17 Citations
4,794 Views
20 Pages

Marine Microbial Polysaccharides: An Untapped Resource for Biotechnological Applications

  • Rajesh Jeewon,
  • Aadil Ahmad Aullybux,
  • Daneshwar Puchooa,
  • Nadeem Nazurally,
  • Abdulwahed Fahad Alrefaei and
  • Ying Zhang

24 July 2023

As the largest habitat on Earth, the marine environment harbors various microorganisms of biotechnological potential. Indeed, microbial compounds, especially polysaccharides from marine species, have been attracting much attention for their applicati...

  • Review
  • Open Access
19 Citations
4,876 Views
20 Pages

Advances in the Biotechnological Potential of Brazilian Marine Microalgae and Cyanobacteria

  • Deborah Terra de Oliveira,
  • Ana Alice Farias da Costa,
  • Fabíola Fernandes Costa,
  • Geraldo Narciso da Rocha Filho and
  • Luís Adriano Santos do Nascimento

24 June 2020

Due the worldwide need to improve care for the environment and people, there is a great demand for the development of new renewable, sustainable, and less polluting technologies for food, health, and environmental industries. The marine environment i...

  • Review
  • Open Access
43 Citations
8,458 Views
24 Pages

Diversity, Ecological Role and Biotechnological Potential of Antarctic Marine Fungi

  • Stefano Varrella,
  • Giulio Barone,
  • Michael Tangherlini,
  • Eugenio Rastelli,
  • Antonio Dell’Anno and
  • Cinzia Corinaldesi

17 May 2021

The Antarctic Ocean is one of the most remote and inaccessible environments on our planet and hosts potentially high biodiversity, being largely unexplored and undescribed. Fungi have key functions and unique physiological and morphological adaptatio...

  • Review
  • Open Access
9 Citations
6,007 Views
23 Pages

Blue Biotechnology: Marine Bacteria Bioproducts

  • Karina Maldonado-Ruiz,
  • Ruth Pedroza-Islas and
  • Lorena Pedraza-Segura

The ocean is the habitat of a great number of organisms with different characteristics. Compared to terrestrial microorganisms, marine microorganisms also represent a vast and largely unexplored reservoir of bioactive compounds with diverse industria...

  • Review
  • Open Access
44 Citations
5,336 Views
77 Pages

18 November 2021

The marine environment is an underexplored treasure that hosts huge biodiversity of microorganisms. Marine-derived fungi are a rich source of novel metabolites with unique structural features, bioactivities, and biotechnological applications. Marine-...

  • Feature Paper
  • Review
  • Open Access
139 Citations
12,237 Views
30 Pages

Marine Biosurfactants: Biosynthesis, Structural Diversity and Biotechnological Applications

  • Sonja Kubicki,
  • Alexander Bollinger,
  • Nadine Katzke,
  • Karl-Erich Jaeger,
  • Anita Loeschcke and
  • Stephan Thies

9 July 2019

Biosurfactants are amphiphilic secondary metabolites produced by microorganisms. Marine bacteria have recently emerged as a rich source for these natural products which exhibit surface-active properties, making them useful for diverse applications su...

  • Review
  • Open Access
93 Citations
9,072 Views
36 Pages

Enzymes from Marine Polar Regions and Their Biotechnological Applications

  • Stefano Bruno,
  • Daniela Coppola,
  • Guido di Prisco,
  • Daniela Giordano and
  • Cinzia Verde

23 September 2019

The microorganisms that evolved at low temperatures express cold-adapted enzymes endowed with unique catalytic properties in comparison to their mesophilic homologues, i.e., higher catalytic efficiency, improved flexibility, and lower thermal stabili...

  • Review
  • Open Access
33 Citations
7,863 Views
23 Pages

Marine Fungi: Biotechnological Perspectives from Deep-Hypersaline Anoxic Basins

  • Giulio Barone,
  • Stefano Varrella,
  • Michael Tangherlini,
  • Eugenio Rastelli,
  • Antonio Dell’Anno,
  • Roberto Danovaro and
  • Cinzia Corinaldesi

16 July 2019

Deep-sea hypersaline anoxic basins (DHABs) are one of the most hostile environments on Earth. Even though DHABs have hypersaline conditions, anoxia and high hydrostatic pressure, they host incredible microbial biodiversity. Among eukaryotes inhabitin...

  • Article
  • Open Access
3 Citations
3,430 Views
17 Pages

Saccharopolyspora sp. NFXS83 in Marine Biotechnological Applications: From Microalgae Growth Promotion to the Production of Secondary Metabolites

  • Constança D. F. Bertrand,
  • Rodrigo Martins,
  • Francisco Quintas-Nunes,
  • Pedro Reynolds-Brandão,
  • Maria T. B. Crespo and
  • Francisco X. Nascimento

Marine bacteria are a significant source of bioactive compounds for various biotechnological applications. Among these, actinomycetes have been found to produce a wide range of secondary metabolites of interest. Saccharopolyspora is one of the genera...

  • Review
  • Open Access
23 Citations
7,176 Views
30 Pages

Diatom–bacteria interactions evolved during more than 200 million years of coexistence in the same environment. In this time frame, they established complex and heterogeneous cohorts and consortia, creating networks of multiple cell-to-cell mut...

  • Feature Paper
  • Perspective
  • Open Access
17 Citations
4,500 Views
12 Pages

13 September 2024

Marine-derived nutrients and bioactive compounds may offer a myriad of biological benefits, such as anticancer and anti-inflammatory properties, and technological potential, enhancing food quality as additives. Their role in the sustainable developme...

  • Review
  • Open Access
5 Citations
4,724 Views
26 Pages

Marine Microalgae–Microorganism Co-Cultures: An Insight into Nannochloropsis sp. Use and Biotechnological Applications

  • Marta Vala Esteves,
  • Diana M. C. Marques,
  • Joana D. de Almeida,
  • Nuno Torres Faria and
  • Frederico Castelo Ferreira

26 April 2025

The increasing demand for sustainable, economical, and environmentally friendly solutions has positioned microalgae as promising candidates in biotechnology, particularly in food, feed, nutraceutical, pharmaceutical, biofuel, and bioremediation appli...

  • Article
  • Open Access
23 Citations
4,321 Views
22 Pages

Differential Secretome Profiling of Human Osteoarthritic Synoviocytes Treated with Biotechnological Unsulfated and Marine Sulfated Chondroitins

  • Rosita Russo,
  • Valentina Vassallo,
  • Antonietta Stellavato,
  • Mariangela Valletta,
  • Donatella Cimini,
  • Paolo Vincenzo Pedone,
  • Chiara Schiraldi and
  • Angela Chambery

Symptomatic slow-acting drugs (SYSADOA) are increasingly used as effective therapies for osteoarthritis, representing an attractive alternative to analgesics or non-steroidal anti-inflammatory drugs to relieve disease symptoms. Pharmaceutical prepara...

  • Article
  • Open Access
5 Citations
2,427 Views
27 Pages

GC/MS Fatty Acid Profile of Marine-Derived Actinomycetes from Extreme Environments: Chemotaxonomic Insights and Biotechnological Potential

  • Marlene B. Cunha,
  • André F. Jorge,
  • Maria João Nunes,
  • Joana R. Sousa,
  • Maria João Lança,
  • Marco Gomes da Silva and
  • Susana P. Gaudêncio

24 December 2024

This study investigated the fatty acids (FA) profile of 54 actinomycete strains isolated from marine sediments collected off the Portugal continental coast, specifically from the Estremadura Spur pockmarks field, by GC/MS. Fatty acid methyl esters (F...

  • Review
  • Open Access
29 Citations
7,466 Views
27 Pages

Marine-Derived Surface Active Agents: Health-Promoting Properties and Blue Biotechnology-Based Applications

  • Ioannis Anestopoulos,
  • Despina-Evgenia Kiousi,
  • Ariel Klavaris,
  • Monica Maijo,
  • Annabel Serpico,
  • Alba Suarez,
  • Guiomar Sanchez,
  • Karina Salek,
  • Stylliani A. Chasapi and
  • Mihalis I. Panayiotidis
  • + 5 authors

Surface active agents are characterized for their capacity to adsorb to fluid and solid-water interfaces. They can be classified as surfactants and emulsifiers based on their molecular weight (MW) and properties. Over the years, the chemical surfacta...

  • Review
  • Open Access
521 Views
29 Pages

2 January 2026

Marine macroalgae represent a versatile and sustainable platform within blue biotechnology, offering structurally diverse polysaccharides that are making significant contributions to next-generation therapeutical applications. Algae are rich sources...

  • Review
  • Open Access
18 Citations
7,351 Views
25 Pages

29 November 2023

The growing understanding and knowledge of the potential of marine species, as well as the application of “blue biotechnology” have been motivating new innovative solutions in cosmetics. It is widely noted that that marine species are imp...

  • Review
  • Open Access
44 Citations
9,249 Views
30 Pages

Bioinformatics for Marine Products: An Overview of Resources, Bottlenecks, and Perspectives

  • Luca Ambrosino,
  • Michael Tangherlini,
  • Chiara Colantuono,
  • Alfonso Esposito,
  • Mara Sangiovanni,
  • Marco Miralto,
  • Clementina Sansone and
  • Maria Luisa Chiusano

11 October 2019

The sea represents a major source of biodiversity. It exhibits many different ecosystems in a huge variety of environmental conditions where marine organisms have evolved with extensive diversification of structures and functions, making the marine e...

  • Review
  • Open Access
18 Citations
9,943 Views
21 Pages

Transforming Ocean Conservation: Applying the Genetic Rescue Toolkit

  • Ben J. Novak,
  • Devaughn Fraser and
  • Thomas H. Maloney

18 February 2020

Although oceans provide critical ecosystem services and support the most abundant populations on earth, the extent of damage impacting oceans and the diversity of strategies to protect them is disconcertingly, and disproportionately, understudied. Wh...

  • Review
  • Open Access
93 Citations
10,900 Views
31 Pages

Marine-Derived Polymeric Materials and Biomimetics: An Overview

  • Marion Claverie,
  • Colin McReynolds,
  • Arnaud Petitpas,
  • Martin Thomas and
  • Susana C. M. Fernandes

26 April 2020

The review covers recent literature on the ocean as both a source of biotechnological tools and as a source of bio-inspired materials. The emphasis is on marine biomacromolecules namely hyaluronic acid, chitin and chitosan, peptides, collagen, enzyme...

  • Review
  • Open Access
36 Citations
8,302 Views
24 Pages

Antitumor Potential of Seaweed Derived-Endophytic Fungi

  • Thaiz Rodrigues Teixeira,
  • Gustavo Souza dos Santos,
  • Lorene Armstrong,
  • Pio Colepicolo and
  • Hosana Maria Debonsi

The marine environment presents a high biodiversity and a valuable source of bioactive compounds with therapeutic and biotechnological potential. Among the organisms present in marine environment, the endophytic fungi isolated from seaweed stand out....

  • Project Report
  • Open Access
7 Citations
4,456 Views
12 Pages

A Collaborative European Approach to Accelerating Translational Marine Science

  • Philip Brennecke,
  • Maria I. Ferrante,
  • Ian A. Johnston and
  • David Smith

Marine environments account for over 90% of the biosphere and hold tremendous potential for biotechnological applications and drug discovery. To fully exploit this potential and develop interesting discoveries into useful molecular tools and successf...

  • Review
  • Open Access
98 Citations
17,120 Views
31 Pages

21 September 2017

Microbial symbiotic communities of marine macro-organisms carry functional metabolic profiles different to the ones found terrestrially and within surrounding marine environments. These symbiotic bacteria have increasingly been a focus of microbiolog...

  • Review
  • Open Access
1 Citations
1,587 Views
41 Pages

Microbial Blue Bioprospecting: Exploring the Advances of Compounds Post-Discovery

  • Cristiana Roberta Multisanti,
  • Valeria Celi,
  • Aurora Dibra,
  • Angela Pintus,
  • Rosario Calogero,
  • Carmen Rizzo and
  • Caterina Faggio

17 October 2025

Marine biotechnology is an emerging field of research. There is scientific evidence of the strong potential of a multitude of marine microorganisms in biotechnology, with applications spanning the medical, pharmaceutical, cosmeceutical, nutraceutical...

  • Review
  • Open Access
10 Citations
6,001 Views
25 Pages

Pharmacological Activities of Extracts and Compounds Isolated from Mediterranean Sponge Sources

  • Lorenzo Di Cesare Mannelli,
  • Fortunato Palma Esposito,
  • Enrico Sangiovanni,
  • Ester Pagano,
  • Carmen Mannucci,
  • Beatrice Polini,
  • Carla Ghelardini,
  • Mario Dell’Agli,
  • Angelo Antonio Izzo and
  • Paola Nieri
  • + 1 author

18 December 2021

Marine pharmacology is an exciting and growing discipline that blends blue biotechnology and natural compound pharmacology together. Several sea-derived compounds that are approved on the pharmaceutical market were discovered in sponges, marine organ...

  • Review
  • Open Access
649 Views
24 Pages

Marine Microbial Exopolysaccharides (EPSs): Untapped Bio-Reserves

  • Bilal Aslam,
  • Muhammad Hassan Khalid and
  • Sulaiman F. Aljasir

6 December 2025

Antibiotic discovery occurs at a snail’s pace, coercing researchers to find novel and promising alternatives to tackle antimicrobial resistance (AMR). Marine microbial exopolysaccharides (EPSs) have emerged as one, considering the recent recogn...

  • Article
  • Open Access
11 Citations
6,211 Views
20 Pages

The Holo-Transcriptome of the Zoantharian Protopalythoa variabilis (Cnidaria: Anthozoa): A Plentiful Source of Enzymes for Potential Application in Green Chemistry, Industrial and Pharmaceutical Biotechnology

  • Jean-Étienne R. L. Morlighem,
  • Chen Huang,
  • Qiwen Liao,
  • Paula Braga Gomes,
  • Carlos Daniel Pérez,
  • Álvaro Rossan De Brandão Prieto-da-Silva,
  • Simon Ming-Yuen Lee and
  • Gandhi Rádis-Baptista

13 June 2018

Marine invertebrates, such as sponges, tunicates and cnidarians (zoantharians and scleractinian corals), form functional assemblages, known as holobionts, with numerous microbes. This type of species-specific symbiotic association can be a repository...

  • Review
  • Open Access
3 Citations
1,998 Views
20 Pages

20 September 2024

The alarming pace of species extinction severely threatens terrestrial and aquatic ecosystems, undermining the crucial ecological services vital for environmental sustainability and human well-being. Anthropogenic activities, such as urbanization, ag...

  • Review
  • Open Access
92 Citations
11,905 Views
18 Pages

Marine Natural Products from Microalgae: An -Omics Overview

  • Chiara Lauritano,
  • Maria Immacolata Ferrante and
  • Alessandra Rogato

7 May 2019

Over the last decade, genome sequences and other -omics datasets have been produced for a wide range of microalgae, and several others are on the way. Marine microalgae possess distinct and unique metabolic pathways, and can potentially produce speci...

  • Article
  • Open Access
2 Citations
2,343 Views
17 Pages

Potential of Polar Lipids Isolated from the Marine Sponge Haliclona (Halichoclona) vansoesti against Melanoma

  • Nadia Ruocco,
  • Genoveffa Nuzzo,
  • Serena Federico,
  • Roberta Esposito,
  • Carmela Gallo,
  • Marcello Ziaco,
  • Emiliano Manzo,
  • Angelo Fontana,
  • Marco Bertolino and
  • Maria Costantini
  • + 2 authors

Marine sponges represent a good source of natural metabolites for biotechnological applications in the pharmacological, cosmeceutical, and nutraceutical fields. In the present work, we analyzed the biotechnological potential of the alien species Hali...

  • Feature Paper
  • Article
  • Open Access
1 Citations
5,308 Views
19 Pages

Exploration of Toxins from a Marine Annelid: An Analysis of Phyllotoxins and Accompanying Bioactives

  • Ana P. Rodrigo,
  • Inês Moutinho Cabral,
  • António Alexandre and
  • Pedro M. Costa

16 February 2024

Proteinaceous toxins are peptides or proteins that hold great biotechnological value, evidenced by their ecological role, whether as defense or predation mechanisms. Bioprospecting using bioinformatics and omics may render screening for novel bioacti...

  • Article
  • Open Access
1 Citations
2,957 Views
12 Pages

A Novel, Highly Potent NADPH-Dependent Cytochrome P450 Reductase from Waste Liza klunzingeri Liver

  • Soudeh Bahramian Nasab,
  • Ahmad Homaei,
  • Roberto Fernandez-Lafuente,
  • Jon Del Arco and
  • Jesús Fernández-Lucas

29 January 2023

The use of marine enzymes as catalysts for biotechnological applications is a topical subject. Marine enzymes usually display better operational properties than their animal, plant or bacterial counterparts, enlarging the range of possible biotechnol...

  • Review
  • Open Access
136 Citations
10,725 Views
25 Pages

Exploring the Valuable Carotenoids for the Large-Scale Production by Marine Microorganisms

  • Javier Torregrosa-Crespo,
  • Zaida Montero,
  • Juan Luis Fuentes,
  • Manuel Reig García-Galbis,
  • Inés Garbayo,
  • Carlos Vílchez and
  • Rosa María Martínez-Espinosa

8 June 2018

Carotenoids are among the most abundant natural pigments available in nature. These pigments have received considerable attention because of their biotechnological applications and, more importantly, due to their potential beneficial uses in human he...

  • Feature Paper
  • Review
  • Open Access
5,972 Views
19 Pages

24 October 2024

The quest for sustainable space exploration and colonization is a challenge in its infancy, which faces scarcity of resources and an inhospitable environment. In recent years, advancements in space biotechnology have emerged as potential solutions to...

  • Review
  • Open Access
4 Citations
3,600 Views
10 Pages

Sponge–Microbial Symbiosis and Marine Extremozymes: Current Issues and Prospects

  • Praise Tochukwu Nnaji,
  • H. Ruth Morse,
  • Emmanuel Adukwu and
  • Rachael U. Chidugu-Ogborigbo

7 June 2022

Marine microorganisms have great potential for producing extremozymes. They enter useful relationships like many other organisms in the marine habitat. Sponge–microbial symbiosis enables both sponges and microorganisms to mutually benefit each...

  • Review
  • Open Access
35 Citations
5,658 Views
53 Pages

Secondary Metabolites, Biological Activities, and Industrial and Biotechnological Importance of Aspergillus sydowii

  • Sabrin R. M. Ibrahim,
  • Shaimaa G. A. Mohamed,
  • Baiaan H. Alsaadi,
  • Maryam M. Althubyani,
  • Zainab I. Awari,
  • Hazem G. A. Hussein,
  • Abrar A. Aljohani,
  • Jumanah Faisal Albasri,
  • Salha Atiah Faraj and
  • Gamal A. Mohamed

5 August 2023

Marine-derived fungi are renowned as a source of astonishingly significant and synthetically appealing metabolites that are proven as new lead chemicals for chemical, pharmaceutical, and agricultural fields. Aspergillus sydowii is a saprotrophic, ubi...

  • Article
  • Open Access
62 Citations
9,136 Views
12 Pages

Marine Microalgae: Promising Source for New Bioactive Compounds

  • Caterina R. De Vera,
  • Guillermo Díaz Crespín,
  • Antonio Hernández Daranas,
  • Sofia Montalvão Looga,
  • Katja-Emilia Lillsunde,
  • Päivi Tammela,
  • Merja Perälä,
  • Vesa Hongisto,
  • Johannes Virtanen and
  • María L. Souto
  • + 3 authors

6 September 2018

The study of marine natural products for their bioactive potential has gained strength in recent years. Oceans harbor a vast variety of organisms that offer a biological and chemical diversity with metabolic abilities unrivalled in terrestrial system...

  • Review
  • Open Access
10 Citations
2,534 Views
11 Pages

29 June 2023

Bioprospecting of the marine environment for drug development has gained much attention in recent years owing to its massive chemical and biological diversity. Drugs for the treatment of skin and soft tissue infections have become part of the search,...

  • Review
  • Open Access
1 Citations
2,162 Views
35 Pages

Strategies for Biofouling Control: A Review from an Environmental Perspective of Innovation and Trends

  • Virgínia Rayanne Soares de Souza,
  • Camila Ferreira Alves,
  • Larissa Felix de Lucena,
  • Luana Caroline Costa Silva,
  • Everthon de Albuquerque Xavier,
  • Cláudio José Galdino da Silva Jr.,
  • Attilio Converti,
  • Renata Laranjeiras Gouveia and
  • Leonie Asfora Sarubbo

9 October 2025

Biofouling is the colonization and attachment of sessile organisms on submerged surfaces, whether natural or artificial. The presence of these communities compromises the structural integrity, operational efficiency, and durability of coastal structu...

  • Article
  • Open Access
4 Citations
3,531 Views
16 Pages

Exopolysaccharide Production from Marine-Derived Brevundimonas huaxiensis Obtained from Estremadura Spur Pockmarks Sediments Revealing Potential for Circular Economy

  • Marta Catalão,
  • Mafalda Fernandes,
  • Lorena Galdon,
  • Clara F. Rodrigues,
  • Rita G. Sobral,
  • Susana P. Gaudêncio and
  • Cristiana A. V. Torres

23 July 2023

Marine environments represent an enormous biodiversity reservoir due to their numerous different habitats, being abundant in microorganisms capable of producing biomolecules, namely exopolysaccharides (EPS), with unique physical characteristics and a...

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