Next Article in Journal
The Bisindole Alkaloid Caulerpin, from Seaweeds of the Genus Caulerpa, Attenuated Colon Damage in Murine Colitis Model
Previous Article in Journal
(+)-Aeroplysinin-1 Modulates the Redox Balance of Endothelial Cells
Previous Article in Special Issue
Pharmacokinetic and Tissue Distribution of Fucoidan from Fucus vesiculosus after Oral Administration to Rats
Article Menu
Issue 9 (September) cover image

Export Article

Open AccessArticle
Mar. Drugs 2018, 16(9), 317; https://doi.org/10.3390/md16090317

Marine Microalgae: Promising Source for New Bioactive Compounds

1
Instituto Universitario de Bio-Orgánica Antonio González (IUBO AG), Centro de Investigaciones Biomédicas de Canarias (CIBICAN), Universidad de La Laguna (ULL), Avenida Astrofísico Francisco Sánchez 2, 38206 Tenerife, Spain
2
Departamento de Química Orgánica, Universidad de La Laguna (ULL), Avenida Astrofísico Francisco Sánchez 2, 38206 Tenerife, Spain
3
Instituto de Productos Naturales y Agrobiología (IPNA), Consejo Superior de Investigaciones Científicas (CSIC), Avenida Astrofísico Francisco Sánchez 2, 38206 Tenerife, Spain
4
Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, P.O. Box 56, University of Helsinki, FI-00014 Helsinki, Finland
5
VTT Technical Research Centre of Finland Ltd., P.O. Box 1000, FI-02044 Espoo, Finland
6
Institut Pluridisciplinaire Hubert Curien, UMR 7178 CRNS, Faculté de Pharmacie, Université de Strasbourg, 67401 Illkirch, France
Current Addresses: Borealis Polymers Oy, P.O. Box 330 (Kilpilahti), 06101 Porvoo, Finland (S.M.L.); Auria Biobank, Kiinamyllynkatu 8, P.O. Box 52, FIN-20521 Turku, Finland (M.P.); Misvik Biology, Karjakatu 35 B, 20520 Turku, Finland (V.H.).
*
Authors to whom correspondence should be addressed.
Received: 1 August 2018 / Revised: 23 August 2018 / Accepted: 4 September 2018 / Published: 6 September 2018
(This article belongs to the Special Issue Marine Bioactive Natural Product Studies in Europe)
Full-Text   |   PDF [5830 KB, uploaded 12 September 2018]   |  

Abstract

The study of marine natural products for their bioactive potential has gained strength in recent years. Oceans harbor a vast variety of organisms that offer a biological and chemical diversity with metabolic abilities unrivalled in terrestrial systems, which makes them an attractive target for bioprospecting as an almost untapped resource of biotechnological applications. Among them, there is no doubt that microalgae could become genuine “cell factories” for the biological synthesis of bioactive substances. Thus, in the course of inter-laboratory collaboration sponsored by the European Union (7th FP) into the MAREX Project focused on the discovery of novel bioactive compounds of marine origin for the European industry, a bioprospecting study on 33 microalgae strains was carried out. The strains were cultured at laboratory scale. Two extracts were prepared for each one (biomass and cell free culture medium) and, thus, screened to provide information on the antimicrobial, the anti-proliferative, and the apoptotic potential of the studied extracts. The outcome of this study provides additional scientific data for the selection of Alexandrium tamarensis WE, Gambierdiscus australes, Prorocentrum arenarium, Prorocentrum hoffmannianum, and Prorocentrum reticulatum (Pr-3) for further investigation and offers support for the continued research of new potential drugs for human therapeutics from cultured microalgae. View Full-Text
Keywords: bioprospecting; blue biotechnology; marine microalgae; bioactive compound; drug discovery; marine natural products bioprospecting; blue biotechnology; marine microalgae; bioactive compound; drug discovery; marine natural products
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

de Vera, C.R.; Díaz Crespín, G.; Hernández Daranas, A.; Montalvão Looga, S.; Lillsunde, K.-E.; Tammela, P.; Perälä, M.; Hongisto, V.; Virtanen, J.; Rischer, H.; Muller, C.D.; Norte, M.; Fernández, J.J.; Souto, M.L. Marine Microalgae: Promising Source for New Bioactive Compounds. Mar. Drugs 2018, 16, 317.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top