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Bioinformatics for Marine Products: An Overview of Resources, Bottlenecks, and Perspectives

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Department of Research Infrastructures for Marine Biological Resources, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy
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Department of Cellular, Computational and Integrative Biology - CIBIO, University of Trento, 38123 Povo, Trento, Italy
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Department of Marine Biotechnology, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy
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Department of Agriculture, University of Naples Federico II, Portici, 80055 Naples, Italy
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Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(10), 576; https://doi.org/10.3390/md17100576
Received: 20 August 2019 / Revised: 1 October 2019 / Accepted: 2 October 2019 / Published: 11 October 2019
(This article belongs to the Special Issue Bioinformatics of Marine Natural Products)
The sea represents a major source of biodiversity. It exhibits many different ecosystems in a huge variety of environmental conditions where marine organisms have evolved with extensive diversification of structures and functions, making the marine environment a treasure trove of molecules with potential for biotechnological applications and innovation in many different areas. Rapid progress of the omics sciences has revealed novel opportunities to advance the knowledge of biological systems, paving the way for an unprecedented revolution in the field and expanding marine research from model organisms to an increasing number of marine species. Multi-level approaches based on molecular investigations at genomic, metagenomic, transcriptomic, metatranscriptomic, proteomic, and metabolomic levels are essential to discover marine resources and further explore key molecular processes involved in their production and action. As a consequence, omics approaches, accompanied by the associated bioinformatic resources and computational tools for molecular analyses and modeling, are boosting the rapid advancement of biotechnologies. In this review, we provide an overview of the most relevant bioinformatic resources and major approaches, highlighting perspectives and bottlenecks for an appropriate exploitation of these opportunities for biotechnology applications from marine resources. View Full-Text
Keywords: bioinformatics; omics; marine resources; biotechnological applications; marine observatories bioinformatics; omics; marine resources; biotechnological applications; marine observatories
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MDPI and ACS Style

Ambrosino, L.; Tangherlini, M.; Colantuono, C.; Esposito, A.; Sangiovanni, M.; Miralto, M.; Sansone, C.; Chiusano, M.L. Bioinformatics for Marine Products: An Overview of Resources, Bottlenecks, and Perspectives. Mar. Drugs 2019, 17, 576.

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