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Open AccessReview

Application-Oriented Marine Isomerases in Biocatalysis

Institute of Biomolecular Chemistry, National Research Council, Via Campi Flegrei, 34, 80078 Pozzuoli, Italy
Mar. Drugs 2020, 18(11), 580; https://doi.org/10.3390/md18110580
Received: 3 November 2020 / Revised: 16 November 2020 / Accepted: 20 November 2020 / Published: 21 November 2020
The class EC 5.xx, a group of enzymes that interconvert optical, geometric, or positional isomers are interesting biocatalysts for the synthesis of pharmaceuticals and pharmaceutical intermediates. This class, named “isomerases,” can transform cheap biomolecules into expensive isomers with suitable stereochemistry useful in synthetic medicinal chemistry, and interesting cases of production of l-ribose, d-psicose, lactulose, and d-phenylalanine are known. However, in two published reports about potential biocatalysts of marine origin, isomerases are hardly mentioned. Therefore, it is of interest to deepen the knowledge of these biocatalysts from the marine environment with this specialized in-depth analysis conducted using a literature search without time limit constraints. In this review, the focus is dedicated mainly to example applications in biocatalysis that are not numerous confirming the general view previously reported. However, from this overall literature analysis, curiosity-driven scientific interest for marine isomerases seems to have been long-standing. However, the major fields in which application examples are framed are placed at the cutting edge of current biotechnological development. Since these enzymes can offer properties of industrial interest, this will act as a promoter for future studies of marine-originating isomerases in applied biocatalysis. View Full-Text
Keywords: marine enzymes; biocatalysis; marine biotechnology marine enzymes; biocatalysis; marine biotechnology
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Trincone, A. Application-Oriented Marine Isomerases in Biocatalysis. Mar. Drugs 2020, 18, 580.

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