Background: Evidence on the genetics of functional seizures is scarce, and the purpose of the current scoping systematic review is to examine the existing evidence and propose how to advance the field. Methods: Web of science and MEDLINE were searche...
Numerous potyvirus studies, including virus biology, transmission, viral protein function, as well as virus–host interaction, have greatly benefited from the utilization of reverse genetic techniques. Reverse genetics of RNA viruses refers to t...
Software clustering is usually used for program comprehension. Since it is considered to be the most crucial NP-complete problem, several genetic algorithms have been proposed to solve this problem. In the literature, there exist some objective funct...
The CRISPR/Cas9-based system for targeted mutagenesis has become an indispensable tool for functional genetics in plants. CRISPR/Cas9 allows users to generate loss-of-function alleles in genes of interest with precision and in a simple-to-use system....
Genetic Algorithms are most directly suited to unconstrained optimization. Application of Genetic Algorithms to constrained optimization problems is often a challenging effort. Several methods have been proposed for handling constraints. The most com...
General cognitive (intelligence) function is substantially heritable, and is a major determinant of economic and health-related life outcomes. Cognitive impairments and intelligence decline are core features of schizophrenia which are evident before...
The great mechanical properties, biocompatibility and biodegradability of silk-based materials make them applicable to the biomedical field. Genetic engineering enables the construction of synthetic equivalents of natural silks. Knowledge about the r...
Mild cognitive impairment (MCI) precedes the Alzheimer’s disease (AD) continuum, making it crucial for therapeutic care to identify patients with MCI at risk of progression. We aim to create generalized models to identify patients with MCI who...
There are many algorithms used with different purposes in the area of cryptography. Amongst these, Genetic Algorithms have been used, particularly in the cryptanalysis of block ciphers. Interest in the use of and research on such algorithms has incre...
The functional verification process is one of the most expensive steps in integrated circuit manufacturing. Functional coverage is the most important metric in the entire verification process. By running multiple simulations, different situations of...
Brassica napus L. provides high-quality edible oil and clean energy for humans. For a long time, rapeseed breeders have tried to breed improved varieties through traditional breeding strategies. However, B. napus is an allotetraploid species containi...
In this paper, a new approach to topology optimization using the parameterized level set function and genetic algorithm optimization methods is presented. The impact of a number of parameters describing the level set function in the representation of...
Improving reproductive traits, particularly semen quality and quantity, is crucial for optimizing poultry production and addressing the current limitations in native chicken reproduction. The aim of this study was to develop a genetic model to estima...
This paper presents a method for constructing polynomial Lyapunov functions to analyze the stability of nonlinear dynamical systems. The approach is based on genetic programming, a variant of genetic algorithms where the search space consists of hier...
Recently, balanced Boolean functions with an even number n of variables achieving very good autocorrelation properties have been obtained for
Pax3 and Pax7 transcription factors are paralogs within the Pax gene family that that are expressed in early embryos in partially overlapping expression domains and have distinct functions. Significantly, mammalian development is largely unaffected b...
The calorific value of coal gangue is a critical index for coal waste recycling and the energy industry. To establish an accurate and efficient calorific value forecasting model, a method based on hybrid kernel function–support vector regression and...
Enzymes in the cytochrome P450 4 (CYP4) family are involved in the metabolism of fatty acids, xenobiotics, therapeutic drugs, and signaling molecules, including eicosanoids, leukotrienes, and prostanoids. As CYP4 enzymes play a role in the maintenanc...
In genome-wide association studies (GWAS), efficient incorporation of linkage disequilibria (LD) among densely typed genetic variants into association analysis is a critical yet challenging problem. Functional linear models (FLM), which impose a smoo...
Genetic defects in the TSH receptor (TSHR) can cause poor thyroid differentiation (thyroid dysgenesis) and/or thyroid malfunction (thyroid dyshormonogenesis). The phenotype spectrum is wide: from severe congenital hypothyroidism to mild hyperthyrotro...
The transfer function is an important parameter describing ultrasonic transducers which are designed to operate in various media. The typically high impedance of piezoelectric transducers is matched to a particular loading medium (gas, liquid, biolog...
Aging is associated with motor disorders that decrease the quality of life (QOL). Royal jelly (RJ), used as a dietary supplement, has shown various health benefits and, therefore, it has the potential to improve the QOL during aging. We have previous...
Stream ciphers usually rely on highly secure Boolean functions to ensure safe communication within unsafe channels. However, discovering secure Boolean functions is a non-trivial optimization problem that has been addressed by many optimization techn...
Although healthcare and medical technology have advanced significantly over the past few decades, heart disease continues to be a major cause of mortality globally. Electrocardiography (ECG) is one of the most widely used tools for the detection of h...
Background: Neurodevelopmental disorders (NDDs) like intellectual disability (ID) are highly heritable, but the environment plays an important role. For example, endocrine disrupting chemicals (EDCs), including bisphenol A (BPA) and its analogues, ha...
This study presents an innovative application of genetic algorithms (GAs) for optimizing the Cobb–Douglas production function, a cornerstone of economic modeling that examines the relationship between production output and the inputs of labor a...
Recent fMRI and fTCD studies have found that functional modules for aspects of language, praxis, and visuo-spatial functioning, while typically left, left and right hemispheric respectively, frequently show atypical lateralisation. Studies with incre...
To improve the forming quality of agricultural tractor engine hood and effectively solve the problems of wrinkling and cracking during the drawing forming process, DYNAFORM 5.9 finite element software was used for numerical simulation of the part. Ba...
The ammonium transporter (AMT) family gene is an important transporter involved in ammonium uptake and transfer in plants and is mainly engaged in the uptake and transport of ammonium from the environment by roots and the reabsorption of ammonium in...
A mixed layer-wise (LW) higher-order shear deformation theory (HSDT) is developed for the thermal buckling analysis of simply-supported, functionally graded (FG) beams subjected to a uniform temperature change. The material properties of the FG beam...
Road traffic injuries are a serious concern in emerging economies. Their death toll and economic impact are shocking, with 9 out of 10 deaths occurring in low or middle-income countries; and road traffic crashes representing 3% of their gross domesti...
This research paper explores the relationship between different functionalities of aircraft and investigates the impact of increased air travel on carbon dioxide, nitrous oxide, water vapor, and hydrocarbon emissions. These emissions contribute to bo...
Tree peony (Paeonia section Moutan DC.) is a traditional ornamental flower of China, which has thousands of varieties with different flower colors and types after a long history of natural selection and artificial breeding. However, tree peony is a p...
Forecasting dissolved gas content in power transformers plays a significant role in detecting incipient faults and maintaining the safety of the power system. Though various forecasting models have been developed, there is still room to further impro...
Nowadays, FDM technology permits obtaining functional prototypes or even end parts. The process parameters, such as layer thickness, building orientation, fill density, type of support, etc., have great influence on the quality, functionality and beh...
The rapid development of Cloud Computing (CC) has led to the release of many services in the cloud environment. Service composition awareness of Quality of Service (QoS) is a significant challenge in CC. A single service in the cloud environment cann...
The ultimate goal of rehabilitation engineering is to provide objective assessment tools for the level of injury and/or the degree of neurorehabilitation recovery based on a combination of different sensing technologies that enable the monitoring of...
Genetic generalized epilepsies (GGEs) are a group of seizure syndromes that start in childhood and adolescence. Although generally viewed as benign, large-scale epidemiological studies suggest that a significant proportion of GGE patients suffer from...
Moringa oleifera Lam. (MO) is a fast-growing drought-resistant tree belonging to the family Moringaceae and native to the Indian subcontinent and cultivated and/or naturalized worldwide with a semi-arid climate. MO is also popularly known as a miracl...
The European honey bee is a model organism for studying social behaviors. Comprehensive analyses focusing on the differential expression profiles of genes between the brains of nurse bees and foragers, or in the mushroom bodies—the brain struct...
Common variants strongly influence the risk of human autoimmunity. Two categories of variants contribute substantially to the risk: (i) coding variants of HLA genes and (ii) non-coding variants at the non-HLA loci. We recently developed a novel analy...
Rye is used in some applications in the food and beverage industry and for the preparation of functional foods. It is an interesting raw material in malting and brewing due to its characteristic contribution to the beer’s color, turbidity, foam...
Forests represent one of the most important ecosystems on Earth, covering approximately 30% of the total global land area [...]
This comprehensive literature review assessed the effectiveness of precision medicine approaches in individualizing P2Y12 de-escalation strategies, such as platelet function testing guidance, genetic testing guidance, and uniform de-escalation, for a...
Sarcoidosis is a complex disease that belongs to the vast group of autoinflammatory disorders, but the etiological mechanisms of which are not known. At the crosstalk of environmental, infectious, and genetic factors, sarcoidosis is a multifactorial...
The etiology of hearing impairment following cochlear damage can be caused by many factors, including congenital or acquired onset, ototoxic drugs, noise exposure, and aging. Regardless of the many different etiologies, a common pathologic change is...
SOST encodes the sclerostin protein, which acts as a key extracellular inhibitor of the canonical Wnt pathway in bone, playing a crucial role in skeletal development and bone homeostasis. The objective of this work was to assess the functionality of...
While the central mechanisms of fibromyalgia have gained attention, the causal effects between brain networks and fibromyalgia remain unclear. Two-sample Mendelian randomization and Linkage Disequilibrium Score Regression were performed to investigat...
Background: The vestibular phenotypes of patients with genetic hearing loss are poorly understood. Methods: we performed genetic testing including exome sequencing and vestibular function tests to investigate vestibular phenotypes and functions in pa...
Tourette’s disorder (TD) is a highly heritable childhood-onset neurodevelopmental disorder and is caused by a complex interplay of multiple genetic and environmental factors. Yet, the molecular mechanisms underlying the disorder remain largely...
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