874 Results Found

Bambara groundnut (Vigna subterranea (L.) Verdc) is a nutritious and drought-tolerant crop that is native to Africa. Currently, it possesses a cosmopolitan distribution across the semi-arid agro-ecologies of Africa and its cultivation has extended to...

This paper studies the convergence of distances between sequences of points and that of sequences of points in metric spaces. This investigation is focused on the iterative processes built with composed self-mappings of a cyclic contraction, which ca...

This paper focuses on dealing with several types of enriched cyclic contractions defined in the union of a set of non-empty closed subsets of normed or metric spaces. In general, any finite number $p\ge 2$ of subsets is permitted in the cyclic arrangem...

Dendritic cells are the only antigen-presenting cells capable of activating naive T cells in humans and mammals and are the most effective antigen-presenting cells. With deepening research, it has been found that dendritic cells have many subsets, an...

Pericytes are increasingly recognized as being important in the control of blood–brain barrier permeability and vascular flow. Research on this important cell type has been hindered by widespread confusion regarding the phenotypic identity and nomenc...

Unsupervised band selection is an essential task to search for representative bands in hyperspectral dimension reduction. Most of existing studies utilize the inherent attribute of hyperspectral image (HSI) and acquire single optimal band subset whil...

This paper focuses on the identification of high-efficiency intensity measures to predict the seismic response of buildings affected by near- and far-fault ground motion records. Near-fault ground motion has received special attention, as it tends to...

Immunotherapy is a beneficial treatment approach for multiple cancers, however, current therapies are effective only in a small subset of patients. Adoptive cell transfer (ACT) is a facet of immunotherapy where T cells targeting the tumor cells are t...

Gamma delta T cells (Tc) are divided according to the type of Vδ and Vγ chains they express, with two major γδ Tc subsets being recognized in humans: Vδ2Vγ9 and Vδ1. Despite many studies in pathological condi...

Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) infection induces elevated levels of inflammatory cytokines, which are mainly produced by the innate response to the virus. The role of NK cells, which are potent producers of IFN-γ and...

Background: Alfalfa, the most economically important forage legume worldwide, features modest genetic progress due to long selection cycles and the extent of the non-additive genetic variance associated with its autotetraploid genome. Methods: To imp...

This review is focused on different subsets of T cells: CD4 and CD8, memory and effector functions, and their role in CAR-T therapy––a cellular adoptive immunotherapy with T cells expressing chimeric antigen receptor. The CAR-T cells recognize tumor...

Limited pre-clinical and clinical data suggest theacrine or theacrine-based supplements modulate biological processes associated with lipid metabolism and aging. Herein, we sought to examine if 12 weeks of daily supplementation with a theacrine-based...

Magic squares have been widely studied, with publications of mathematical interest dating back over 100 years. Most studies construct and analyse specific subsets of magic squares, with some exploring links to puzzles, number theory, and graph theory...

Cancer stem cells (CSCs) are nowadays one of the major focuses in tumor research since this subpopulation was revealed to be a great obstacle for successful treatment. The identification of CSCs in pediatric solid tumors harbors major challenges beca...

The vast majority of studies on T cell biology in tumor immunity have focused on peptide-reactive conventional T cells that are restricted to polymorphic major histocompatibility complex molecules. However, emerging evidence indicated that unconventi...

This study investigates the roles of mucosal-associated invariant T (MAIT) cells and Vα7.2⁺/CD161⁻ T cells in skin diseases, focusing on atopic dermatitis. MAIT cells, crucial for bridging innate and adaptive immunity, were analyzed along...

Semi-supervised classification is one of the core methods to deal with incomplete tag information without manual intervention, which has been widely used in various real problems for its excellent performance. However, the existing algorithms need to...

This study introduces an explainable framework for Automated Fact Verification (AFV) systems, integrating a novel Context-Aware Retrieval and Explanation Generation (CARAG) methodology. CARAG enhances evidence retrieval by leveraging thematic embeddi...

We introduce the Convex Hull of Admissible Modularity Partitions (CHAMP) algorithm to prune and prioritize different network community structures identified across multiple runs of possibly various computational heuristics. Given a set of partitions,...

Maize plant detection was conducted in this study with the goals of target fertilization and reduction of fertilization waste in weed spots and gaps between maize plants. The methods used included two types of color featuring and deep learning (DL)....

Spectroscopic data allows for the obtaining of relevant information about the composition of samples and has been used for research in scientific disciplines such as chemistry, geology, archaeology, Mars research, pharmacy, and medicine, as well as i...

Pancreatic cancer is the fourth-leading cause of cancer-related deaths worldwide. The outcomes in patients with pancreatic cancer remain unsatisfactory. In the current review, we summarize the genetic and epigenetic architecture of metastatic pancrea...

Early life stress (ELS) is linked to an elevated risk of poor health and early mortality, with emerging evidence pointing to the pivotal role of the immune system in long-term health outcomes. While recent research has focused on the impact of ELS on...

The Working Set concept, originally introduced by P. Denning for memory management, defines a dynamic subset of system elements actively in use. Designed to reduce page faults and prevent thrashing, it has proven effective in optimizing memory perfor...

Following unfavorable environmental cues, cells reprogram pathways that govern transcription, translation, and protein degradation systems. This reprogramming is essential to restore homeostasis or commit to cell death. This review focuses on the sec...

We establish a fixed point property for the Lebesgue spaces with variable exponents $L^{p(·)}$, focusing on the scenario where the exponent closely approaches 1. The proof does not impose any additional conditions. In particular, our investigation...

The role of innate lymphoid cells (ILCs) in cancer progression has been uncovered in recent years. ILCs are classified as Type 1, Type 2, and Type 3 ILCs, which are characterized by the transcription factors necessary for their development and the cy...

The interaction between tumor cells and the immune system is considered to be a dynamic process. Dendritic cells (DCs) play a pivotal role in anti-tumor immunity owing to their outstanding T cell activation ability. Their functions and activities are...

Biehl et al. (2021) present some interesting observations on an early formulation of the free energy principle. We use these observations to scaffold a discussion of the technical arguments that underwrite the free energy principle. This discussion f...

We addressed the question of the influence of the molecular polymorphism of cytokines from different T helper subsets on the susceptibility to SARS-CoV-2 infection. From a cohort of 527 samples (collected from 26 May 2020 to 31 March 2022), we focuse...

Cytokine dysregulation is characteristic of systemic lupus erythematosus (SLE), a systemic autoimmune disease of considerable heterogeneity. Insights gained about the cytokine dysregulation in SLE have the potential for identifying patient subsets be...

Spondyloarthritis (SpA) is a subset of seronegative rheumatic-related autoimmune diseases that consist of ankylosing spondylitis (AS), psoriatic spondylitis (PsA), reactive spondylitis (re-SpA), inflammatory bowel disease (IBD)-associated spondylitis...

In recent years, cyclic sulfone compounds, a subset of biologically active heterocyclic compounds, have gained considerable attention due to their potential in the development of novel active pharmaceutical ingredients. This review focuses on identif...

Immunosenescence and inflammaging facilitate the insurgence of chronic diseases. The Mediterranean diet is a non-invasive intervention to improve the chronic low-grade inflammatory status associated with aging. Olive oil oleuropein (OLE) and hydroxyt...

Solar irradiation is influenced by many meteorological features, which results in a complex structure meaning its prediction has low efficiency and accuracy. The existing prediction methods are focused on analyzing the correlation between features an...

Although the overall prognosis of differentiated thyroid cancer (DTC), the most common endocrine malignancy, is favorable, a subset of patients exhibits aggressive features. Therefore, preclinical models that can be utilized to investigate DTC pathog...

Nutraceuticals, including vitamin D, vitamin A, zinc, lactoferrin, polyphenols coenzyme Q, magnesium, and selenium, are implicated in the modulation of the complex molecular pathways involved in the immune response against viral pathogens. A common e...

A proper estimation of anti-epidemic measures related to the influence of the COVID-19 outbreak on air quality has to deal with filtering out the weather influence on pollution concentrations. The goal of this study was to estimate the effect of anti...

Cancer immunotherapy activates the immune system to specifically target malignant cells. Research has often focused on CD8+ cytotoxic T cells, as those have the capacity to eliminate tumor cells after specific recognition upon TCR-MHC class I interac...

Recent years have seen significant efforts in understanding and modulating the immune response in cancer. In this context, immunosuppressive cells, including regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs), have come under int...

We consider the 6D Cascading DGP model, a braneworld model which is a promising candidate to realize the phenomenon of the degravitation of vacuum energy. Focusing on a recently proposed thin limit description of the model, we study solutions where t...

Neuroblastoma is the most common extracranial solid tumor in children. One subset, high-risk neuroblastoma, is very difficult to treat and requires multi-modal therapy. Intensification of therapy has vastly improved survival rates, and research is fo...

The term “cancer stem cells” (CSCs) commonly refers to a subset of tumor cells endowed with stemness features, potentially involved in chemo-resistance and disease relapses. CSCs may present peculiar immunogenic features influencing their homeostasis...

Coumarin is an effective treatment for primary lymphoedema, as well as lymphoedema related to breast cancer radiotherapy or surgery. However, its clinical use is limited in several countries due to the possible occurrence of hepatotoxicity, mainly in...

Since their conception with the smallpox vaccine, vaccines used worldwide have mitigated multiple pandemics, including the recent COVID-19 outbreak. Insightful studies have uncovered the complexities of different functional networks of CD4 T cells (T...

Background: AML with NPM1 mutation is the largest subcategory of AML, representing about 35% of AML cases. It is characterized by CD34 negativity, which suggests a relatively differentiated state of the bulk of leukemic blasts. Notably, a significant...

Reinforcement Learning (RL) is a widely researched area in artificial intelligence that focuses on teaching agents decision-making through interactions with their environment. A key subset includes multi-armed bandit (MAB) and stochastic continuum-ar...

With the aim to advance the understanding of immune regulation in MCL and to identify targetable T-cell subsets, we set out to combine image analysis and spatial omic technology focused on both early and late differentiation stages of T cells. MCL pa...

Sjogren’s syndrome (SS) is an autoimmune disease whose pathogenesis is characterized by an exacerbated T cell infiltration in exocrine glands, markedly associated to the inflammatory and detrimental features as well as the disease progression....