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41,851 Results Found

  • Article
  • Open Access
45 Citations
10,290 Views
20 Pages

15 January 2019

Centrifugal compressor performance is affected by many parameters, optimization of which can lead to superior designs. Recognizing the most important parameters affecting performance helps to reduce the optimization process cost. Of the compressor co...

  • Article
  • Open Access
10 Citations
3,424 Views
15 Pages

Design and Experiment of a Seamless Morphing Trailing Edge

  • Gui Cheng,
  • Tianrui Ma,
  • Jun Yang,
  • Nan Chang and
  • Xiang Zhou

Morphing trailing edge wing as an important morphing wing technology has gained wide attention because of its advantages, such as gust mitigation, improved aerodynamic efficiency, and reduced radar reflective area. However, the key problems such as l...

  • Proceeding Paper
  • Open Access
854 Views
7 Pages

20 September 2023

A virtual experiment conducted using the ICP-MS TuneSim software served as the basis for studies that compared the applicability of the central composite design with the Box–Behnken design in analytical chemistry applications. The insights gath...

  • Article
  • Open Access
27 Citations
6,322 Views
20 Pages

Design of Experiment in the Milling Process of Aluminum Alloys in the Aerospace Industry

  • Aurel Mihail Țîțu,
  • Andrei Victor Sandu,
  • Alina Bianca Pop,
  • Ștefan Țîțu,
  • Dragos Nicolae Frățilă,
  • Costel Ceocea and
  • Alexandru Boroiu

4 October 2020

For many years, surface has quality received a serious attention due to its influence on various mechanical properties. The main contribution made in this scientific paper is the performance of actual experiments, as well as the experimental processi...

  • Article
  • Open Access
6 Citations
5,348 Views
16 Pages

28 December 2022

The smart chemical laboratory has recently emerged as a promising trend for future chemical research, where experiment optimization is of vital importance. The traditional Bayesian optimization (BO) algorithm focuses on exploring the dependent variab...

  • Article
  • Open Access
62 Citations
7,165 Views
17 Pages

Design of Experiment on Concrete Mechanical Properties Prediction: A Critical Review

  • Beng Wei Chong,
  • Rokiah Othman,
  • Ramadhansyah Putra Jaya,
  • Mohd Rosli Mohd Hasan,
  • Andrei Victor Sandu,
  • Marcin Nabiałek,
  • Bartłomiej Jeż,
  • Paweł Pietrusiewicz,
  • Dariusz Kwiatkowski and
  • Mohd Mustafa Al Bakri Abdullah
  • + 1 author

9 April 2021

Concrete mix design and the determination of concrete performance are not merely engineering studies, but also mathematical and statistical endeavors. The study of concrete mechanical properties involves a myriad of factors, including, but not limite...

  • Article
  • Open Access
9 Citations
7,912 Views
23 Pages

Optimization of Capacitive Acoustic Resonant Sensor Using Numerical Simulation and Design of Experiment

  • Rubaiyet Iftekharul Haque,
  • Christophe Loussert,
  • Michelle Sergent,
  • Patrick Benaben and
  • Xavier Boddaert

16 April 2015

Optimization of the acoustic resonant sensor requires a clear understanding of how the output responses of the sensor are affected by the variation of different factors. During this work, output responses of a capacitive acoustic transducer, such as...

  • Article
  • Open Access
713 Views
18 Pages

26 August 2025

The integration of three-dimensional inward-turning inlets with airframes has broad application prospects. This paper develops an integrated design method for the inlet forebody with a controllable incident shock wave shape, aiming at the three-dimen...

  • Feature Paper
  • Article
  • Open Access
7 Citations
5,629 Views
22 Pages

Optimization of Pyrolysis Parameters by Design of Experiment for the Production of Biochar from Sewage Sludge

  • Giacomo Cedrone,
  • Maria Paola Bracciale,
  • Lorenzo Cafiero,
  • Michela Langone,
  • Davide Mattioli,
  • Marco Scarsella and
  • Riccardo Tuffi

24 September 2024

Sewage sludge management is a key concern in today’s world. Improper disposal can lead to various environmental issues including air, water and soil pollution. Among the available technologies, thermal treatments, particularly pyrolysis, are ga...

  • Article
  • Open Access
4 Citations
2,193 Views
16 Pages

21 June 2022

This study investigated vertical strain and stress through a dynamic load experiment at the testing area of Ke-Da Road, Pingtung, Taiwan. A thirty-five-ton truck was moved at constant speeds of 40, 60, and 80 km/h to simulate heavy load conditions to...

  • Article
  • Open Access
28 Citations
6,316 Views
23 Pages

1 June 2020

The investigation conducted is aimed at establishing the best operational conditions to obtain the best output of a 5-cell stack Proton Exchange Membrane fuel cell (PEMFC) with three different bipolar plate geometries. The work further explores the b...

  • Article
  • Open Access
2,140 Views
16 Pages

Optimization of In Vitro Transcription by Design of Experiment to Achieve High Self-Amplifying RNA Integrity

  • Chaoying Hu,
  • Haixin Wang,
  • Guanxing Liu,
  • Kelei Li,
  • Xuanxuan Zhang,
  • Lifang Song,
  • Fan Gao,
  • Xing Wu,
  • Qian Wang and
  • Qian He
  • + 7 authors

17 October 2025

Background: Self-amplifying mRNA (saRNA) holds promising application prospects. However, due to the inclusion of a replicase sequence, its extended length leads to premature termination during in vitro transcription (IVT), resulting in poor product i...

  • Review
  • Open Access
14 Citations
8,006 Views
17 Pages

Design of Experiment: A Rational and Still Unexplored Approach to Inorganic Materials’ Synthesis

  • Francesco Lamberti,
  • Chiara Mazzariol,
  • Federico Spolaore,
  • Riccardo Ceccato,
  • Luigi Salmaso and
  • Silvia Gross

6 March 2022

This review was devoted to outlining the use and potential increasing application of the Design of Experiment (DoE) approach to the rational and planned synthesis of inorganic nanomaterials, with a particular focus on polycrystalline nanostructures (...

  • Article
  • Open Access
10 Citations
3,148 Views
17 Pages

In the pharmaceutical industry, the systematic optimization of process variables using a quality-by-design (QbD) approach is highly precise, economic and ensures product quality. The current research presents the implementation of a design-of-experim...

  • Article
  • Open Access
1,034 Views
25 Pages

Design and Experiment of the Codonopsis pilosula Outcrop Film-Laying and Transplanting Machine

  • Jiajia Bai,
  • Wei Sun,
  • Ming Zhao,
  • Luhai Zhang,
  • Juanling Wang and
  • Petru Aurelian Simionescu

A Codonopsis pilosula film-laying and outcrop transplantation machine is developed to solve problems, such as unstable quality of transplanted seedlings, high intensity of manual work, and low efficiency of work in the seedling transplantation of Cod...

  • Article
  • Open Access
360 Views
26 Pages

Design and Experiment of a Handheld Vibration Harvesting Device for Camellia oleifera Fruits

  • Qiaoming Gao,
  • Haoxiang Zeng,
  • Qingqing Xin,
  • Dongxue Wang,
  • Jianyou Huang,
  • Ya Cai,
  • Yuejuan Li,
  • Zepeng Jiang and
  • Zhaofu Dun

14 December 2025

To address the challenges of inefficient Camellia oleifera fruits harvesting in hilly and mountainous regions due to the difficulty of using large machinery, a handheld vibration harvesting device for Camellia oleifera fruits was designed. Based on t...

  • Article
  • Open Access
6 Citations
4,194 Views
12 Pages

23 October 2019

The influence of complex aging processes in water-miscible metalworking fluids on process performance is of high relevance for the metalworking industry. Because of the highly dynamic interactions in the complex “metalworking fluid” ecosy...

  • Article
  • Open Access
59 Citations
8,046 Views
20 Pages

Design, Fabrication and Experiment of Double U-Beam MEMS Vibration Ring Gyroscope

  • Huiliang Cao,
  • Yu Liu,
  • Zhiwei Kou,
  • Yingjie Zhang,
  • Xingling Shao,
  • Jinyang Gao,
  • Kun Huang,
  • Yunbo Shi,
  • Jun Tang and
  • Jun Liu
  • + 1 author

13 March 2019

This study presents a new microelectromechanical system, a vibration ring gyroscope with a double U-beam (DUVRG), which was designed using a combination of mathematical analysis and the finite element method. First, a ring vibration resonator with ei...

  • Communication
  • Open Access
4 Citations
3,548 Views
16 Pages

Effect of Peak Tracking Methods on FBG Calibration Derived by Factorial Design of Experiment

  • Nazila Safari Yazd,
  • Jennifer Kawakami,
  • Alireza Izaddoost and
  • Patrice Mégret

14 September 2021

We present a calibration procedure for a humidity sensor made of a fiber Bragg grating covered by a polyimide layer. FBGs being intrinsically sensitive to temperature and strain, the calibration should tackle three variables, and, therefore, consists...

  • Article
  • Open Access
19 Citations
4,716 Views
14 Pages

6 March 2023

Plastic collapse and buckling are the key structural failure criteria in 3D concrete printing (3DCP). This study aims to analyze the effect of different geometrical designs and printing factors on the buildability performance of 3DCP structures. Due...

  • Article
  • Open Access
7 Citations
3,964 Views
15 Pages

11 September 2023

Electrical losses are converted into thermal energy in motors, which heats each component. It is a significant factor in decreasing motor mechanical performance. In this paper, the motor cooling characteristics were analyzed according to the design f...

  • Article
  • Open Access
22 Citations
3,603 Views
18 Pages

9 July 2020

Polyvinylpyrrolidone electrospun membranes characterized by randomly, partially, or almost completely oriented nanofibers are prepared using a drum collector in static (i.e., 0 rpm) or rotating (i.e., 250 rpm or 500 rpm) configuration. Besides a prog...

  • Feature Paper
  • Article
  • Open Access
14 Citations
3,694 Views
16 Pages

The Design of Experiment (DoE) technique has been used to investigate the photo-electrochemical removal of diuron (DRN) from wastewater. The process is carried out in a photo-electrochemical flow reactor, in which titania nanotubular electrode is irr...

  • Article
  • Open Access
11 Citations
3,040 Views
24 Pages

Optimal Design of Ferronickel Slag Alkali-Activated Material for High Thermal Load Applications Developed by Design of Experiment

  • Andres Arce,
  • Anastasija Komkova,
  • Jorn Van De Sande,
  • Catherine G. Papanicolaou and
  • Thanasis C. Triantafillou

21 June 2022

The development of an optimal low-calcium alkali-activated binder for high-temperature stability based on ferronickel slag, silica fume, potassium hydroxide, and potassium silicate was investigated based on Mixture Design of Experiment (Mixture DOE)....

  • Article
  • Open Access
9 Citations
2,904 Views
13 Pages

Synthesis Metakaolin-Based Geopolymer Incorporated with SiC Sludge Using Design of Experiment Method

  • Kang-Wei Lo,
  • Wei-Ting Lin,
  • Ya-Wen Lin,
  • Ta-Wui Cheng and
  • Kae-Long Lin

19 August 2022

This study uses metakaolin, sodium hydroxide, sodium metasilicate, and water content as the reaction variables in the application of the design of experiment (DOE) method. At the same time, the various component factors and their interactions were an...

  • Article
  • Open Access
17 Citations
5,338 Views
17 Pages

Mathematical Model for Scaling up Bioprocesses Using Experiment Design Combined with Buckingham Pi Theorem

  • Leidy Rendón-Castrillón,
  • Margarita Ramírez-Carmona,
  • Carlos Ocampo-López and
  • Luis Gómez-Arroyave

30 November 2021

Scaling up bioprocesses from the experimental to the pilot or industrial scale involves heuristics and scale relationships that are far from the specific phenomena and are usually not connected to the experimental data. In complex systems, the scalin...

  • Article
  • Open Access
30 Citations
9,105 Views
29 Pages

27 April 2011

We consider a problem of high-resolution array radar/SAR imaging formalized in terms of a nonlinear ill-posed inverse problem of nonparametric estimation of the power spatial spectrum pattern (SSP) of the random wavefield scattered from a remotely se...

  • Article
  • Open Access
18 Citations
5,601 Views
17 Pages

Calcium Phosphate Nanoparticle Precipitation by a Continuous Flow Process: A Design of Experiment Approach

  • Lorenzo Degli Esposti,
  • Alessandro Dotti,
  • Alessio Adamiano,
  • Claudia Fabbi,
  • Eride Quarta,
  • Paolo Colombo,
  • Daniele Catalucci,
  • Claudio De Luca and
  • Michele Iafisco

19 October 2020

Calcium phosphate nanoparticles (CaP NPs) are an efficient class of nanomaterials mainly used for biomedical applications but also very promising in other sectors such as cosmetics, catalysis, water remediation, and agriculture. Unfortunately, as in...

  • Article
  • Open Access
2 Citations
2,508 Views
27 Pages

Physiologically based pharmacokinetic (PBPK) models of skin absorption are a powerful resource for estimating drug delivery and chemical risk of dermatological products. This paper presents a PBPK workflow for the quantification of the mechanistic de...

  • Article
  • Open Access
1 Citations
2,104 Views
15 Pages

Numerical Experiment and Design of a Two-Rod Crank Knee Press with an Internal Layout of the Motor Drive

  • Amandyk Tuleshov,
  • Balzhan Akhmetova,
  • Moldir Kuatova,
  • Bakhyt Merkibayeva and
  • Gulama-Garip Alisher Ibrayev

3 October 2023

In crank presses, an important role is played by the presence of actuators with dwell, in which, with continuous movement of the input links, the output working link remains stationary at some part of the work. The use of a high-class structural grou...

  • Article
  • Open Access
28 Citations
14,466 Views
11 Pages

21 January 2008

Micro drilled holes are utilized in many of today’s fabrication processes.Precision production processes in industries are trending toward the use of smaller holeswith higher aspect ratios, and higher speed operation for micro deep hole drilling. How...

  • Article
  • Open Access
2 Citations
2,304 Views
15 Pages

25 October 2023

The internal electric field distribution is a key factor to characterize the partial discharge and voltage resistance of current transformers (CTs), and the conical current transformer has a special structure with complex electric field distribution....

  • Article
  • Open Access
34 Citations
6,278 Views
13 Pages

This study aimed to develop a novel oral drug delivery system for gastroretentive sustained drug release by using a capsular device. A capsular device that can control drug release rates from the inner immediate release (IR) tablet while floating in...

  • Article
  • Open Access
4 Citations
1,893 Views
15 Pages

26 August 2023

Engineering education is critical for the creation of a more sustainable world, and engineering education accreditation has become the current trend for reform in higher education worldwide. Traditional replication experiment-based teaching cannot me...

  • Article
  • Open Access
17 Citations
7,153 Views
17 Pages

27 July 2020

This study aims to develop an optimization model for obtaining the maximum benefit from wind power plants (WPPs) to help with reducing external dependence in terms of energy. In this sense, design of experiment and optimization methods are comprehens...

  • Article
  • Open Access
12 Citations
3,251 Views
19 Pages

Material Extrusion Filament Width and Height Prediction via Design of Experiment and Machine Learning

  • Xiaoquan Shi,
  • Yazhou Sun,
  • Haiying Tian,
  • Puthanveettil Madathil Abhilash,
  • Xichun Luo and
  • Haitao Liu

12 November 2023

The dimensions of material extrusion 3D printing filaments play a pivotal role in determining processing resolution and efficiency and are influenced by processing parameters. This study focuses on four key process parameters, namely, nozzle diameter...

  • Article
  • Open Access
15 Citations
5,371 Views
23 Pages

The targeted delivery of a hydrophilic Tripeptide-3 to the skin using microemulsions or nanoemulsions for facial oil reduction was the focus of this study. The impact factors affecting oil/water transparent dispersion formation, such as the surfactan...

  • Article
  • Open Access
15 Citations
4,538 Views
18 Pages

Silk/Fibroin Microcarriers for Mesenchymal Stem Cell Delivery: Optimization of Cell Seeding by the Design of Experiment

  • Carlotta Perucca Orfei,
  • Giuseppe Talò,
  • Marco Viganò,
  • Sara Perteghella,
  • Gaia Lugano,
  • Francesca Fabro Fontana,
  • Enrico Ragni,
  • Alessandra Colombini,
  • Paola De Luca and
  • Laura De Girolamo
  • + 2 authors

In this methodological paper, lyophilized fibroin-coated alginate microcarriers (LFAMs) proposed as mesenchymal stem cells (MSCs) delivery systems and optimal MSCs seeding conditions for cell adhesion rate and cell arrangement, was defined by a Desig...

  • Article
  • Open Access
28 Citations
6,463 Views
10 Pages

19 October 2021

This paper presents the application of Taguchi design of experiment and Autodesk Moldflow® simulation in finding the optimal processing parameters for the manufacturing of natural fiber–polymer composite products. The material used in the study is a...

  • Article
  • Open Access
13 Citations
3,051 Views
13 Pages

Evaluation of the Properties of PHB Composite Filled with Kaolin Particles for 3D Printing Applications Using the Design of Experiment

  • Přemysl Menčík,
  • Radek Přikryl,
  • Štěpán Krobot,
  • Veronika Melčová,
  • Soňa Kontárová,
  • Roderik Plavec,
  • Jan Bočkaj,
  • Vojtech Horváth and
  • Pavol Alexy

19 November 2022

In the presented work, poly(3-hydroxybutyrate)-PHB-based composites for 3D printing as bio-sourced and biodegradable alternatives to synthetic plastics are characterized. The PHB matrix was modified by polylactide (PLA) and plasticized by tributyl ci...

  • Article
  • Open Access
16 Citations
3,835 Views
24 Pages

19 January 2020

The wind energy pump system is a new green energy technology. The wide high efficiency region of pump is of great significance for energy conservation of wind power pumping system. In this study, factorial experiment design (FED) and computational fl...

  • Article
  • Open Access
423 Views
19 Pages

27 December 2025

This study evaluates the influence of repeated processing, γ-irradiation (25 kGy), and additive formulation including Irgafos 168 (I168), Tinuvin 622 (T622), and Calcium Stearate (CaSt) on a polypropylene copolymer (PP-C). Motivated by medical...

  • Article
  • Open Access
4 Citations
2,262 Views
29 Pages

Design and Experiment of a Film-Drilling Potato Seeder with Eccentric Coupling

  • Liangqi Pei,
  • Wei Sun,
  • Juanling Wang and
  • Petru A. Simionescu

The new technique of filming in autumn and planting directly through the plastic film in spring is an effective method for water-saving and drought-resistant commercial potato production. However, there are currently no supporting film-drilling seede...

  • Article
  • Open Access
1 Citations
4,792 Views
12 Pages

Surface and Morphological Investigation of Synthesized Nanostructured Ridges from Electrospun Polyvinyl Alcohol-Albumin Blend—A Taguchi Design of Experiment Approach

  • Jopeth Ramis,
  • Bryan Pajarito,
  • Crisneil Natividad,
  • Mark Jared Van Ocampo,
  • Crizaldy Tugade,
  • John Adrian Santos and
  • Robert Delfin

2 May 2020

We report the synthesis of presumably a “nanoridge” from the electrospinning of a hydrophilic polymer–protein blend. The material exhibits vertical elevation from the substrate, distinct from the morphologies seen in electrospinning...

  • Article
  • Open Access
7 Citations
3,450 Views
24 Pages

22 December 2023

This study aims to assess the impact of the water ratio and nanoparticle concentration of neat diesel fuel on the performance characteristics of and exhaust gas emissions from diesel engines. The experimental tests were conducted in two stages. In th...

  • Article
  • Open Access
57 Citations
7,618 Views
18 Pages

Optimization of Mesoporous Silica Nanoparticles through Statistical Design of Experiment and the Application for the Anticancer Drug

  • Min-Ki Kim,
  • Do-Hyung Ki,
  • Young-Guk Na,
  • Hae-Soo Lee,
  • Jong-Suep Baek,
  • Jae-Young Lee,
  • Hong-Ki Lee and
  • Cheong-Weon Cho

The synthesis process or composition of mesoporous silica nanoparticles (MSNs) affects the physicochemical properties. Using these properties, MSNs were synthesized through the Box–Behnken design (BBD) among statistical experimental methods. The effe...

  • Article
  • Open Access
16 Citations
2,334 Views
23 Pages

A Hybrid Design of Experiment Approach in Analyzing the Electrical Discharge Machining Influence on Stir Cast Al7075/B4C Metal Matrix Composites

  • Velusamy Mohankumar,
  • Sunderraj Kapilan,
  • Aruchamy Karthik,
  • Mylsamy Bhuvaneshwaran,
  • Carlo Santulli,
  • Durairaj Thresh Kumar,
  • Sivasubramanian Palanisamy and
  • Cristiano Fragassa

7 February 2024

The present work centers on aluminum-based metal matrix composites (AMCs), synthesized via stir casting and then processed by electrical discharge machining (EDM) in the case of Al7075 as a matrix and 6 wt.% boron carbide (B4C) as reinforcement. A de...

  • Article
  • Open Access
3,248 Views
39 Pages

19 December 2024

This paper explores a recently proposed scalable z-pinch-based space propulsion engine in greater detail. This concept involves a “modified plasma focus with a tapered anode that transports current from a pulsed power source to a consumable por...

  • Article
  • Open Access
2 Citations
2,479 Views
19 Pages

Solubility is a critical parameter controlling drug absorption after oral administration. For poorly soluble drugs, solubility is influenced by the complex composition of intestinal media and the influence of dosage form excipients, which can cause b...

  • Article
  • Open Access
11 Citations
4,074 Views
14 Pages

30 December 2022

Data about customer experiences are important in smart product-service systems. It is desired to establish a framework for customer experience data so that smart customer experiences can be designed based on customer data. Particularly such a framewo...

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