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721 Results Found

  • Article
  • Open Access
1,033 Views
29 Pages

Initiating Event Frequencies for Internal Flooding and High-Energy Line Break PRAs

  • Karl N. Fleming,
  • Bengt O. Y. Lydell,
  • Mary Presley,
  • Ali Mosleh and
  • Wadie Chalgham

16 September 2025

Utilities that operate nuclear power plants are increasingly using probabilistic risk assessments (PRAs) to make day-to-day decisions on design, operations, and maintenance and to support risk-informed applications. These applications require high-qu...

  • Article
  • Open Access
19 Citations
778 Views
22 Pages

There is a discrepancy between professional subtitling guidelines and how they are implemented in real life. One example of such discrepancy are line breaks: the way the text is divided between the two lines in a subtitl...

  • Article
  • Open Access
8 Citations
5,130 Views
19 Pages

In last decades, Mobile Light Detection And Ranging (LiDAR) systems were revealed to be an efficient and reliable method to collect dense and precise point clouds. The challenge now faced by researchers is the automatic object extraction from those p...

  • Article
  • Open Access
28 Citations
6,234 Views
15 Pages

The railway structures need constant monitoring and maintenance to ensure the train circulation safety. Quality information concerning the infrastructure geometry, namely the three-dimensional linear elements, are crucial for that processes. Along wi...

  • Article
  • Open Access
31 Citations
9,677 Views
17 Pages

Flood Damage Analysis: First Floor Elevation Uncertainty Resulting from LiDAR-Derived Digital Surface Models

  • José María Bodoque,
  • Carolina Guardiola-Albert,
  • Estefanía Aroca-Jiménez,
  • Miguel Ángel Eguibar and
  • María Lorena Martínez-Chenoll

19 July 2016

The use of high resolution ground-based light detection and ranging (LiDAR) datasets provides spatial density and vertical precision for obtaining highly accurate Digital Surface Models (DSMs). As a result, the reliability of flood damage analysis ha...

  • Article
  • Open Access
7 Citations
5,041 Views
24 Pages

Statistical Dependence of Pipe Breaks on Explanatory Variables

  • Patricia Gómez-Martínez,
  • Francisco Cubillo,
  • Francisco J. Martín-Carrasco and
  • Luis Garrote

24 February 2017

Aging infrastructure is the main challenge currently faced by water suppliers. Estimation of assets lifetime requires reliable criteria to plan assets repair and renewal strategies. To do so, pipe break prediction is one of the most important inputs....

  • Article
  • Open Access
11 Citations
5,226 Views
15 Pages

The Antiviral Agent Cidofovir Induces DNA Damage and Mitotic Catastrophe in HPV-Positive and -Negative Head and Neck Squamous Cell Carcinomas In Vitro

  • Femke Verhees,
  • Dion Legemaate,
  • Imke Demers,
  • Robin Jacobs,
  • Wisse Evert Haakma,
  • Mat Rousch,
  • Bernd Kremer and
  • Ernst Jan Speel

30 June 2019

Cidofovir (CDV) is an antiviral agent with antiproliferative properties. The aim of our study was to investigate the efficacy of CDV in HPV-positive and -negative head and neck squamous cell carcinoma (HNSCC) cell lines and whether it is caused by a...

  • Article
  • Open Access
9 Citations
2,309 Views
14 Pages

19 January 2023

The atomic structure and electronic and magnetic properties of two zig-zag-edged hexagonal nanohelicenes of the second type [1.2] and [2.2] were studied by the density functional theory. These objects possess a helical periodicity and belong to the f...

  • Article
  • Open Access
5 Citations
3,243 Views
11 Pages

Methotrexate (MTX)-mediated gene amplification has been widely used in Chinese hamster ovary (CHO) cells for the biomanufacturing of therapeutic proteins. Although many studies have reported chromosomal instability and extensive chromosomal rearrange...

  • Article
  • Open Access
15 Citations
766 Views
18 Pages

The Impact of Text Segmentation on Subtitle Reading

  • Olivia Gerber-Morón,
  • Agnieszka Szarkowska and
  • Bencie Woll

Understanding the way people watch subtitled films has become a central concern for subtitling researchers in recent years. Both subtitling scholars and professionals generally believe that in order to reduce cognitive load and enhance readability, l...

  • Article
  • Open Access
8 Citations
2,411 Views
28 Pages

13 November 2023

The integration of distributed generation (DG) into the decentralized access of the distribution network transforms the existing structure into an active distribution network. The alteration in fault characteristics poses significant challenges to th...

  • Proceeding Paper
  • Open Access
8 Citations
2,232 Views
4 Pages

24 November 2021

In this work, we introduce a new algorithm for effectual crack detection using flying line laser thermography, based on the well-known Canny approach. The algorithm transforms the input thermographic sequence into an edge map. Experimental measuremen...

  • Article
  • Open Access
2 Citations
3,079 Views
16 Pages

11 July 2022

Cancer genomes are characterized by the accumulation of small-scale somatic mutations as well as large-scale chromosomal deletions, amplifications, and complex structural rearrangements. This characteristic is at least partially dependent on the abil...

  • Article
  • Open Access
2 Citations
3,056 Views
14 Pages

10 January 2024

The RSA (Rivest–Shamir–Adleman) cryptosystem is an asymmetric public key cryptosystem popular for its use in encryptions and digital signatures. However, the Wiener’s attack on the RSA cryptosystem utilizes continued fractions, whic...

  • Article
  • Open Access
35 Citations
6,765 Views
19 Pages

26 October 2018

Deep-seated gravitational slope deformations (DSGSDs) endanger settlements and infrastructure in mountain areas all over the world. To prevent disastrous events, their activity needs to be continuously monitored. In this paper, the movement of the Re...

  • Article
  • Open Access
12 Citations
3,048 Views
14 Pages

This paper proposes an external breaking vibration identification method of transmission line tower based on a radio frequency identification (RFID) sensor and deep learning. The RFID sensor is designed to obtain the vibration signal of the transmiss...

  • Article
  • Open Access
5 Citations
3,155 Views
17 Pages

Even though interest in developing the Arctic region is increasing continuously, the standard procedure to be used to analyze the station-keeping performance of a floater considering ice loads has not been established yet. In this paper, the effectiv...

  • Article
  • Open Access
6 Citations
4,871 Views
10 Pages

24 April 2017

Remote sensing images could provide us with tremendous quantities of large-scale information. Noise artifacts (stripes), however, made the images inappropriate for vitalization and batch process. An effective restoration method would make images read...

  • Article
  • Open Access
24 Citations
11,019 Views
5 Pages

Induction of Cell Death, DNA Strand Breaks, and Cell Cycle Arrest in DU145 Human Prostate Carcinoma Cell Line by Benzo[a]pyrene and Benzo[a]pyrene-7,8-diol-9,10-epoxide

  • Onyinye Nwagbara,
  • Selina F. Darling-Reed,
  • Alicia Tucker,
  • Cynthia Harris,
  • Michael Abazinge,
  • Ronald D. Thomas and
  • Richard D. Gragg

Benzo[a]pyrene (B[a]P), a polycyclic aromatic hydrocarbon, is a major environmental pollutant. In this study, the effects of this carcinogen/mutagen and one of its metabolites, benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE), on human prostate carcinoma...

  • Article
  • Open Access
30 Citations
8,849 Views
15 Pages

Chromatin structure affects the extent of DNA damage and repair. Thus, it has been shown that heterochromatin is more protective against DNA double strand breaks (DSB) formation by ionizing radiation (IR); and that DNA DSB repair may proceed differen...

  • Article
  • Open Access
36 Citations
4,442 Views
15 Pages

Dual PI3K/mTOR Inhibitor NVP-BEZ235 Enhances Radiosensitivity of Head and Neck Squamous Cell Carcinoma (HNSCC) Cell Lines Due to Suppressed Double-Strand Break (DSB) Repair by Non-Homologous End Joining

  • Ulrike Schötz,
  • Viola Balzer,
  • Friedrich-Wilhelm Brandt,
  • Frank Ziemann,
  • Florentine S.B. Subtil,
  • Thorsten Rieckmann,
  • Sabrina Köcher,
  • Rita Engenhart-Cabillic,
  • Ekkehard Dikomey and
  • Andrea Arenz
  • + 1 author

18 February 2020

The PI3K/Akt/mTOR pathway is frequently altered in human papillomavirus (HPV)-positive and negative squamous cell carcinoma of the head and neck (HNSCC) and overstimulation is associated with poor prognosis. PI3K drives Akt activation and constitutiv...

  • Article
  • Open Access
110 Citations
14,454 Views
20 Pages

Application of HEC-RAS (2D) for Flood Hazard Maps Generation for Yesil (Ishim) River in Kazakhstan

  • Nurlan Ongdas,
  • Farida Akiyanova,
  • Yergali Karakulov,
  • Altynay Muratbayeva and
  • Nurlybek Zinabdin

24 September 2020

The use of hydraulic models for carrying out flood simulations is a common practice globally. The current study used HEC-RAS (2D) in order to simulate different flood scenarios on the River Yesil (Ishim). Comparison of different mesh sizes (25, 50 an...

  • Technical Note
  • Open Access
2 Citations
9,043 Views
11 Pages

Comparative Analysis of Triangulation Libraries for Modeling Large Point Clouds from Land and Their Infrastructures

  • Luis Lopez-Fernandez,
  • Pablo Rodriguez-Gonzalvez,
  • David Hernandez-Lopez,
  • Damian Ortega-Terol and
  • Diego Gonzalez-Aguilera

Although the generation of large points clouds from geomatic techniques allows us to realize the topography and appearance of the terrain and its infrastructures (e.g., roads, bridges, buildings, etc.), all these 3D point clouds require an unavoidabl...

  • Article
  • Open Access
371 Views
18 Pages

17 November 2025

Transmission lines may experience significant ice loads during service, which can cause damage or even destruction to transmission tower components and transmission lines. Under the traditional design concept, when the load exceeds the safety thresho...

  • Feature Paper
  • Article
  • Open Access
9 Citations
5,445 Views
14 Pages

Quasar Black Hole Mass Estimates from High-Ionization Lines: Breaking a Taboo?

  • Paola Marziani,
  • Ascensión Del Olmo,
  • Mary Loli Martínez-Aldama,
  • Deborah Dultzin,
  • Alenka Negrete,
  • Edi Bon,
  • Natasa Bon and
  • Mauro D’Onofrio

20 September 2017

Can high ionization lines such as CIV λ 1549 provide useful virial broadening estimators for computing the mass of the supermassive black holes that power the quasar phenomenon? The question has been dismissed by several workers as a rhetorical o...

  • Article
  • Open Access
18 Citations
4,415 Views
16 Pages

RAD51 Is Implicated in DNA Damage, Chemoresistance and Immune Dysregulation in Solid Tumors

  • Chengcheng Liao,
  • Srikanth Talluri,
  • Jiangning Zhao,
  • Shidai Mu,
  • Subodh Kumar,
  • Jialan Shi,
  • Leutz Buon,
  • Nikhil C. Munshi and
  • Masood A. Shammas

20 November 2022

Background: In normal cells, homologous recombination (HR) is tightly regulated and plays an important role in the maintenance of genomic integrity and stability through precise repair of DNA damage. RAD51 is a recombinase that mediates homologous ba...

  • Article
  • Open Access
15 Citations
3,500 Views
23 Pages

Dynamic Analysis of a Barge-Type Floating Wind Turbine Subjected to Failure of the Mooring System

  • Mingsheng Chen,
  • Lenan Yang,
  • Xinghan Sun,
  • Jin Pan,
  • Kai Zhang,
  • Lin Lin,
  • Qihao Yun and
  • Ziwen Chen

Evidence points to increasing the development of floating wind turbines to unlock the full potential of worldwide wind-energy generation. Barge-type floating wind turbines are of interest because of their shallow draft, structural simplicity, and moo...

  • Article
  • Open Access
27 Citations
7,622 Views
14 Pages

23 July 2018

Transmission lines are affected by Aeolian vibration, which causes strands to break and eventually causes an entire line to break. In this paper, a method for monitoring strand breaking based on modal identification is proposed. First, the natural fr...

  • Article
  • Open Access
1 Citations
2,438 Views
11 Pages

Hauling Snow Crab Traps in Eastern Canada: A Study Documenting Tension in Ropes

  • Genevieve Peck,
  • Tomas Araya-Schmidt and
  • Paul D. Winger

26 April 2024

Entanglement in commercial fishing gear is one of the main factors inhibiting the recovery of critically endangered North Atlantic right whales. Installing low-breaking-strength (LBS) components in the buoy lines and main lines of stationary fishing...

  • Article
  • Open Access
1 Citations
1,934 Views
19 Pages

A New Source and Large Quantity of Resveratrol in Cratoxylum Species and Their Activities on Normal Human and Cancer Cells

  • Sanit Kaewdaungdee,
  • Tankun Banlue,
  • Napatsakon Youngsanbhu,
  • Mallika Naeklang,
  • Shiou Yih Lee,
  • Arnold Ang,
  • Runglawan Sudmoon,
  • Tawatchai Tanee,
  • Sakda Daduang and
  • Arunrat Chaveerach

1 June 2024

Cratoxylum formosum ssp. formosum (Cff), C. formosum ssp. pruniflorum (Cfp), and C. sumatranum (Cs) were investigated for phytochemical analysis. Toxicity testing, programmed cell death, and cell cycle arrest were tested on CHL-1, HCT-116, and HepG2...

  • Article
  • Open Access
26 Citations
4,717 Views
18 Pages

Auger Emitter Conjugated PARP Inhibitor for Therapy in Triple Negative Breast Cancers: A Comparative In-Vitro Study

  • Ramya Ambur Sankaranarayanan,
  • Jennifer Peil,
  • Andreas T. J. Vogg,
  • Carsten Bolm,
  • Steven Terhorst,
  • Arno Classen,
  • Matthias Bauwens,
  • Jochen Maurer,
  • Felix Mottaghy and
  • Agnieszka Morgenroth

4 January 2022

PARP1 inhibitors (PARPi) are currently approved for BRCAmut metastatic breast cancer, but they have shown limited response in triple negative breast cancer (TNBC) patients. Combination of an Auger emitter with PARPis enables PARP inhibition and DNA s...

  • Article
  • Open Access
2,121 Views
13 Pages

The high-speed railway project and the ultra-high-voltage transmission project represent two crucial components of China’s “new infrastructure”. As the construction of these two projects progresses rapidly, it is inevitable that ins...

  • Article
  • Open Access
4 Citations
4,776 Views
8 Pages

Use of a Spinal Traction Device during Work Shift in Assembly Line Workers

  • Juan Rabal-Pelay,
  • Cristina Cimarras-Otal,
  • Mónica Macia-Calvo,
  • Carmen Laguna-Miranda and
  • Ana Vanessa Bataller-Cervero

Increasing back discomfort and spinal shrinkage during the workday is a problem that affects assembly line workers. The aim of this research was to analyze the effect of a spinal traction system on discomfort, spinal shrinkage, and spinal sagittal al...

  • Article
  • Open Access
32 Citations
7,838 Views
24 Pages

22 October 2015

Highly-dynamic floating bodies such as wave energy convertors require mooring lines with particular mechanical properties; the mooring system must achieve adequate station keeping whilst controlling mooring tensions within acceptable limits. Optimise...

  • Article
  • Open Access
19 Citations
14,213 Views
11 Pages

5 May 2019

In this article, we apply an integrable nonautonomous Lotka–Volterra model to study the relationship between oil and renewable energy stock prices between 2006 and 2016. The advantage of this innovative approach is that it allows us to study th...

  • Article
  • Open Access
2 Citations
3,869 Views
15 Pages

Effect of Two Transport Options on the Welfare of Two Genetic Lines of Organic Free Range Pullets in Switzerland

  • Helena Sprafke,
  • Rupert Palme,
  • Paul Schmidt,
  • Michael Erhard and
  • Shana Bergmann

19 October 2018

The welfare of two genetic lines of organic layer hen pullets—H&N Super Nick (HNS) and H&N Brown Nick (HNB)—was compared during two commercial transport variants of 15 flocks of mixed-reared birds. Birds were either transported ov...

  • Article
  • Open Access
22 Citations
6,540 Views
14 Pages

The Effectiveness of Distributed Acoustic Sensing (DAS) for Broken Rail Detection

  • Adrian Wagner,
  • Andrew Nash,
  • Frank Michelberger,
  • Hirut Grossberger and
  • Gavin Lancaster

3 January 2023

Broken rails remain one of the main causes of railway accidents despite improved rail quality and inspections. Today, signalling system with track circuits are often used to detect broken rails, however new signalling systems such as the European Tra...

  • Abstract
  • Open Access
1,653 Views
1 Page

Genetically Encoded Photosensitizer Targeted to Methylated DNA

  • Anastasiia Gorshkova,
  • Dmitry Gorbachev,
  • Mariia Moshareva,
  • Lidiya Putlyaeva and
  • Konstantin Lukyanov

Genetically encoded photosensitizers are widely used in fundamental research and translational medicine due to their ability to generate reactive oxygen species (ROS) after photosensitizing. Previously, it was shown in mice that red dimeric fluoresce...

  • Article
  • Open Access
5 Citations
2,279 Views
21 Pages

Tunneling projects face several risks during the execution stage that affect the execution objectives (cost, time, quality, and safety). This study aimed to define the main execution activities of machinery tunnels with the associated risk factors an...

  • Article
  • Open Access
10 Citations
3,295 Views
22 Pages

2 October 2021

One of the fundamental challenges in L-PBF of filigree geometries, such as aortic stents used in biomedical applications, is the requirement for a robust yet easily removable support structure that allows each component to be successfully fabricated...

  • Article
  • Open Access
100 Citations
3,485 Views
16 Pages

30 August 2017

With the increasing occurrence of extreme weather events, the short circuit and line-breaking faults in transmission lines caused by line galloping have been threatening the security operation of power systems. These faults are also hard to be simula...

  • Article
  • Open Access
2 Citations
1,816 Views
13 Pages

7 September 2022

The setting is a system containing achiral reactants which form a chiral compound. In 1983, Kondepudi and Nelson proposed a model for the breaking of chiral symmetry. The present article reduces the conditions for bifurcation to a single condition wh...

  • Article
  • Open Access
12 Citations
3,932 Views
12 Pages

Detecting Broken Strands in Transmission Lines Based on Pulsed Eddy Current

  • Chunhui Liao,
  • Yinghu Yi,
  • Tao Chen,
  • Chen Cai,
  • Zhiyang Deng,
  • Xiaochun Song and
  • Cheng Lv

15 June 2022

High-voltage transmission lines are the main facilities for power transmission, and they are mainly composed of aluminum conductor steel-reinforced (ACSR). Over long-term outdoor use, overhead transmission lines will encounter lightning strikes, chem...

  • Article
  • Open Access
11 Citations
9,462 Views
11 Pages

Characteristics and Utility of Fluorescein Breakup Patterns among Dry Eyes in Clinic-Based Settings

  • Chika Shigeyasu,
  • Masakazu Yamada,
  • Norihiko Yokoi,
  • Motoko Kawashima,
  • Kazuhisa Suwaki,
  • Miki Uchino,
  • Yoshimune Hiratsuka,
  • Kazuo Tsubota and
  • on behalf of the DECS-J Study Group

17 September 2020

(1) Background: To evaluate the characteristics of fluorescein breakup patterns (FBUPs) among patients with dry eye disease (DED) and efficacy of FBUPs as a diagnostic test for DED subgroups. (2) Methods: The study enrolled 449 patients with DED. FBU...

  • Article
  • Open Access
3 Citations
2,984 Views
33 Pages

One risk posed by hurricanes and typhoons is local inundation as ocean swell and storm surge bring a tremendous amount of energy and water flux to the shore. Numerical wave tanks are developed to understand the dynamics computationally. The three-dim...

  • Article
  • Open Access
699 Views
21 Pages

2 September 2025

To address the challenge of determining the borehole layout scheme in the practical application of high-pressure gas expansion rock breaking, this study takes the excavation of the safety passage at Kaixuan Road Station on the North Extension Line 2...

  • Article
  • Open Access
13 Citations
4,110 Views
13 Pages

Specific Targeting of Antiapoptotic Bcl-2 Proteins as a Radiosensitizing Approach in Solid Tumors

  • Benjamin Sobol,
  • Osama Azzam Nieto,
  • Emily Lara Eberlein,
  • Anna-Lena Scherr,
  • Lars Ismail,
  • Annika Kessler,
  • Luisa Nader,
  • Maximilian Schwab,
  • Paula Hoffmeister and
  • Bruno Christian Köhler
  • + 10 authors

Avoidance of therapy-induced apoptosis is a hallmark of acquired resistance towards radiotherapy. Thus, breaking resistance still challenges modern cancer therapy. The Bcl-2 protein family is known for its regulatory role in apoptosis signaling, maki...

  • Article
  • Open Access
12 Citations
4,049 Views
38 Pages

Comprehensive Evaluation of Biological Effects of Pentathiepins on Various Human Cancer Cell Lines and Insights into Their Mode of Action

  • Lisa Wolff,
  • Siva Sankar Murthy Bandaru,
  • Elias Eger,
  • Hoai-Nhi Lam,
  • Martin Napierkowski,
  • Daniel Baecker,
  • Carola Schulzke and
  • Patrick J. Bednarski

Pentathiepins are polysulfur-containing compounds that exert antiproliferative and cytotoxic activity in cancer cells, induce oxidative stress and apoptosis, and inhibit glutathione peroxidase (GPx1). This renders them promising candidates for antica...

  • Article
  • Open Access
4 Citations
2,162 Views
11 Pages

17 August 2021

The article presents problems occurring during remote temperature measurement of lashing clamps of bridge connections on high voltage poles using thermal imaging cameras. The basic metrological parameters of thermal imaging cameras are described. On...

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