Proprotein convertases activate various envelope glycoproteins and participate in cellular entry of many viruses. We recently showed that the convertase furin is critical for the infectivity of SARS-CoV-2, which requires cleavage of its spike protein...
Arenaviruses include lethal human pathogens which pose serious public health threats. So far, no FDA approved vaccines are available against arenavirus infections, and therapeutic options are limited, making the identification of novel drug targets f...
Inhibition of the binding of enveloped viruses surface glycoproteins to host cell receptor(s) is a major target of vaccines and constitutes an efficient strategy to block viral entry and infection of various host cells and tissues. Cellular entry usu...
In winter sports, the equipment often comes into contact with snow or ice, and this contact generates a force that resists motion. In some sports, such as cross-country skiing, this resistive force can significantly affect the outcome of a race, as a...
A comprehensive analysis of cross-country skiing races is a pivotal step in establishing effective training objectives and tactical strategies. This study aimed to develop a method of classifying sub-techniques and analyzing skiing characteristics du...
13 October 2022
Eleven world elite ski-mountaineering (Ski-Mo) athletes were evaluated for pronounced echocardiographic physiological remodeling as the primary aim of our feasibility speckle tracking study. In this context, sports-related cardiac remodeling was anal...
Background: Older adults have the highest rates of a sedentary lifestyle. Alpine skiing could be considered a suitable activity to encourage continued sports practice and improve the health of this population in winter. The aim of this study was to a...
We have previously shown that treatment of androgen-sensitive LNCaP cells with the sphingosine kinase (SK) inhibitor SKi (2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole) induces the proteasomal degradation of two N-terminal variants of SK1 (SK1a and...
The purpose of this study is to find a way to maintain the sustainability of YouTube quality by identifying the relationship between user satisfaction, perceived achievement, and continuous use intention of YouTube content quality that provides ski t...
6 May 2019
Background: Total knee arthroplasty (TKA) is socially relevant due to its high prevalence, high incidence and the affected population. A subpopulation of TKA patients exists that strives to be active and also return to sports after total joint replac...
This study investigated gender differences in performance and participation and the role of nationality during one century in one of the largest cross-country (XC) skiing events in the world, the ‘Vasaloppet‘ in Sweden. The total number o...
Background: Great physical requirements are necessary to maintain the entire body in a streamlined and aerodynamic position during downhill skiing. Balance control has an important role in alpine skiing and depends on muscle endurance and strength. T...
18 October 2021
Monitoring the training of amateur long-distance cross-country skiers (XCS) can help athletes’ achieve a higher exercise capacity and protect their health. The aim of this study was to assess body composition changes and lipid profiles in middle-aged...
26 October 2019
Background: Whilst the ergogenic effects of carbohydrate intake during prolonged exercise are well-documented, few investigations have studied the effects of carbohydrate ingestion during cross-country skiing, a mode of exercise that presents unique...
Background/Objectives: Sagittal skeletal patterns are associated with upper airway dimensions, which may influence breathing during sleep and potentially relate to sleep quality. We hypothesized that global Thai-Pittsburgh Sleep Quality Index (Thai-P...
Background: Wearable sensors and global positioning systems (GPS) can enable objective monitoring of training loads in outdoor endurance sports. In biathlons, comparing training characteristics across developmental stages can help identify structural...
In competitive alpine skiing, a superior antirotation and rear-chain stabilization capacity is essential to constantly remain in dynamic equilibrium while skiing and to counteract the ski-specific adverse loading patterns of the back. As such, skiers...
The aims of this case study are to assess water quality in a small, forested mountain catchment in the Black Forest, forming part of a National Park and Natura 2000 zone. Field work was carried out in the catchment of the Seebächle torrent, a sm...
This study aimed to analyze the effect of 12 weeks of polarized training on body composition, cardiorespiratory function, and upper-body power of male and female cross-country skiers during the general preparation period. A total of 16 national cross...
1 June 2021
Study Design: Retrospective, observational, cross-sectional study. Objective: To determine the incidence of skiing-related facial trauma and to identify their patterns in terms of potential risk factors, mechanism of injury, anatomical location, and...
Cervical cancer is an important issue globally because it is the second most common gynecological malignant tumor and conventional treatment effects have been shown to be limited. Lut and AsA are plant-derived natural flavonoid and triterpenoid produ...
Psychological preparation has taken on a crucial role in today’s sports practice. Effective resolutions to the challenges inherent in athletes’ psychological preparation require a comprehensive understanding of the key components that con...
Autism spectrum disorder (ASD) is a neurodevelopmental disorder. Abnormal lipid metabolism has been suggested to contribute to its pathogenesis. Further exploration of its underlying biochemical mechanisms is needed. In a search for reliable biomarke...
High-risk human papillomavirus strain 16 (HPV16) causes oral and anogenital cancers through the activities of two viral oncoproteins, E6 and E7, that dysregulate the host p53 and pRb tumor suppressor pathways, respectively. The maintenance of HPV16-p...
Nine ski mountaineering (Ski-Mo), ten Nordic-cross country (NCC), and twelve world elite biathlon (Bia) athletes were evaluated for cardiopulmonary exercise test (CPET) performance and pronounced echocardiographic physiological cardiac remodeling as...
Vitamin D has displayed anti-cancer actions in numerous in vitro studies. Here, we investigated the anti-cancer actions of cholecalciferol, a vitamin D precursor, on a metastatic cervical cancer cell line, namely, CaSki. Experimental cultures were in...
The sphingolipid metabolic pathway, an important signaling pathway, plays a crucial role in various physiological processes including cell proliferation, survival, apoptosis, and immune regulation. The liver has the unique ability to regenerate using...
Plant growth is directly related to levels of photosynthetic photon flux density,
Background: Pulmonary fibrosis (PF) is a progressive interstitial lung disease characterized by chronic inflammation and excessive extracellular matrix deposition, with fibrocytes playing a pivotal role in fibrotic remodeling. This study aimed to ide...
28 October 2022
This paper aims to investigate the differences in standing balance control ability between freestyle skiing aerials athletes and ordinary graduate students by means of wavelet transform (WT) and the overall stability index (OSI) and to discover the c...
Bioactive sphingolipids are a lipid family including ceramide, sphingosine-1-phosphate (S1P) and glucosyl ceramide (GC). Ceramide produced through de novo synthesis pathway (Serine Palmitoyl Transferase (SPT) is a key enzyme subjected to regulation)...
On-slope pilot testing of snow tubes was conducted at two ski areas in the United States to examine the effects of deceleration mats. Snow tube and rider kinematics were measured using an instrumented bodysuit and a GPS system worn by the rider. For...
Background: The aim of the study was to investigate the effects of a novel two-week dynamic high-intensity interval training (HIIT) protocol, characterized by fixed-load and variable-time intervals (“two times up to ten minutes”), on perf...
Research on heart rate (HR), mean arterial pressure (MAP) and blood pressure (BP) during specific training stages is less common in endurance athletes, whereas resting BP and HR are less studied in relationship to HRmax. In the current study, the obj...
22 August 2022
Background: Although the importance of physical fitness for injury prevention is recognized in sports medicine and rehabilitation, few studies have investigated this factor among recreational alpine skiers. Objective: To determine the effect of lower...
Sphingolipids are important signaling lipids which play crucial roles to determine the cell fate. Ceramide, apoptotic central molecule of sphingolipid metabolism, which is produced through de novo pathway by serine palmitoyl transferase (SPT) and can...
Interior space quality in certified office buildings is key in supporting the health and well-being of occupants. Daylight, which regulates the human circadian rhythm and affects physiological processes and productivity, is crucial. This study’...
Background and Objectives: Distal upper limb injuries are frequent in winter sports, but their functional impact is often underestimated. This study aimed to describe the epidemiology, mechanisms, and risk factors for injuries involving the forearm,...
Endothelial dysfunction is a major clinical problem affecting virtually every patient requiring critical care. Volatile anesthetics are frequently used during the perioperative period and protect the heart and kidney against ischemia and reperfusion...
Frequent changes in altitude and oxygen levels limit the practical application of traditionally derived exercise thresholds or training zones based on heart rate (HR) or blood lactate concentration (bLa). We investigated the transferability of a musc...
Rheum tataricum L.fil., known for its high tolerance to drought, salinity, and nutritional deficiency, is the least studied species of wild rhubarb. Extract of roots and rhizomes of R. tataricum has been traditionally used for the treatment of differ...