HOXA9 and MEIS1 are frequently upregulated in acute myeloid leukemia (AML), including those with MLL-rearrangement. Because of their pivotal role in hemostasis, HOXA9 and MEIS1 appear non-druggable. We, thus, interrogated gene expression data of pre-...
The group X secreted phospholipase A2 (PLA2G10) is present at high levels in mouse sperm acrosome. The enzyme is secreted during capacitation and amplifies the acrosome reaction and its own secretion via an autocrine loop. PLA2G10 also improves the r...
Wheat straw/poly(lactic acid) (WS/PLA) biocomposites provide a promising route for agricultural residue valorization, but poor interfacial compatibility limits their performance. This study investigated the effect of maleic-anhydride-grafted PLA (PLA...
The melt-free radical grafting of glycidyl methacrylate (GMA) onto poly (lactic acid) (PLA) with styrene (St), α-methylstyrene (AMS), and epoxy resin (EP) as comonomers in a twin-screw extruder was used to prepare PLA-g-GMA graft copolymers. Th...
Phospholipase A2 group VI (PLA2G6) regulates phospholipid remodeling and cellular homeostasis, and its mutations cause neurodegenerative disorders, including neurodegeneration with brain iron accumulation and PLA2G6-associated parkinsonism (PARK14)....
PLA2G16 is a member of the phospholipase A2 family that catalyzes the generation of lysophosphatidic acids (LPAs) and free fatty acids (FFAs) from phosphatidic acid. Previously, PLA2G16 was found to be a host factor for picornaviruses. Here, we disco...
Background: Macrophages play an important role in eliminating diseased and damaged cells through programmed cell death. Signal regulatory protein alpha (SIRPα) is a crucial immune checkpoint primarily expressed on myeloid cells and macrophages....
Metastasis is the leading cause of colorectal cancer (CRC)-related deaths. Therefore, the identification of accurate biomarkers predictive of metastasis is needed to better stratify high-risk patients to provide preferred management and reduce mortal...
A couple presented to the office with an apparently healthy infant for a thorough clinical assessment, as they had previously lost two male children to a neurodegenerative disorder. They also reported the death of a male cousin abroad with a comparab...
Brain tumors are a significant medical problem. This study aimed to assess the potential significance of DPYSL2, 8-OHdG, and LP-PLA2 in the oncological diagnosis of patients with brain tumors who have a vitamin D deficiency. To this end, we measured...
Platelet-activating factor (PAF) is a potent inflammatory mediator that activates the PAF receptor, which induces additional PAF production. Animal studies have shown that PAF induces inflammatory and neuropathic pain, including dysesthesia, a prodro...
Oncogenic K-ras is often activated in pancreatic ductal adenocarcinoma (PDAC) due to frequent mutation (>90%), which drives multiple cellular processes, including alterations in lipid metabolism associated with a malignant phenotype. However, the...
Fused deposition modeling (FDM) is one of the most accessible additive manufacturing (AM) technologies for processing polymeric materials. It allows processing most of thermoplastic polymers, with polyethylene terephthalate glycol-modified (PET-G) an...
The Movement Disorders Society recommends the DYT/PARK prefix for genes where dystonia and parkinsonism are prominent in approximately half or more of patients. This systematic review explores the genotype–phenotype correlations of GLB1, SLC6A3...
Objective. To determine how bamboo loadings (2.5–5 wt%) and compatibilization with PBAT-g-MAH (BP-1, 10 wt%) affect melt flow and early-time mineralization of PLA biocomposites under near-ambient soil–compost conditions (ASTM D5988), whil...
Past studies have confirmed that aberrant activation of the Wnt/β-catenin signaling is associated with tumorigenesis and metastasis in breast cancer, while the role of platelet-activating factor acetylhydrolase (PLA2G7/PAF-AH) in this signaling...
PLA2G6-dystonia-parkinsonism (PLAN-DP) is characterized by levodopa responsive parkinsonism and dystonia. While neuropsychiatric symptoms and early cognitive decline are also common in this entity there is little information regarding other non-motor...
Given the global challenge of plastic pollution, the development of new bioplastics to replace conventional polymers has become a priority. It is therefore essential to achieve a balance in the performances of biopolymers in order to improve their co...
Clutch persistence, defined as the ability to sustain consecutive egg-laying cycles, is a pivotal determinant of profitability in the poultry industry, particularly for aging laying hens (≥65 weeks). However, the molecular mechanisms governing thi...
PLA2G6-associated neurodegeneration (PLAN) is a rare autosomal recessive disorder caused by PLA2G6 mutations. This study aimed to investigate the clinical characteristics and mutation spectrum of PLAN and to investigate the founder effects in Chinese...
Background: To elucidate the role of iPLA2/PLA2G6 in gingivobuccal squamous cell carcinoma (GB-SCC) and to ascertain the synthetic lethality-based chemoprevention role of aspirin in arachidonic acid metabolism (AAM) pathway down-regulated GB-SCC. Met...
Τhe effect of docosahexaenoic acid (DHA, an omega-3 polyunsaturated fatty acid) upon the proliferation of EoL-1 (Eosinophilic leukemia) cell line was assessed, while additional cellular events during the antiproliferative action were recorded. DH...
Serious diseases caused by Streptococcus suis serotype 2 (S. suis 2) include septicaemia and meningitis, which are associated with high morbidity and mortality. Proliferation in the blood can result in a breach of the blood–brain barrier (BBB)...
Polymorphisms of group VIA calcium-independent phospholipase A2 (iPLA2β or PLA2G6) are positively associated with adiposity, blood lipids, and Type-2 diabetes. The ubiquitously expressed iPLA2β catalyzes the hydrolysis of phospholipids (PLs...
The global proliferation of plastic waste has made the search for sustainable chemical recycling strategies imperative to transition toward a circular bioeconomy. This study presents a dual-valorization approach for polylactic acid (PLA) waste, utili...
Background: Triple-negative breast cancer (TNBC), defined by the absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER-2) expression, is associated with increased BRCA1/2 mutation rates. Extr...
Aberrantly activated Wnt/β-catenin signaling pathway, as well as platelet-activating factor (PAF), contribute to cancer progression and metastasis of many cancer entities. Nonetheless, the role of the degradation enzyme named platelet-activating fact...
Lung endothelial dysfunction is a key feature of acute lung injury (ALI) and clinical acute respiratory distress syndrome (ARDS). Previous studies have identified the lipid-generating enzyme, group V phospholipase A2 (gVPLA2), as a mediator of lung e...
PLA2G6-associated neurodegeneration (PLAN) is an autosomal recessive neurodegenerative spectrum encompassing infantile, juvenile/atypical and adult-onset phenotypes. Juvenile PLAN may initially resemble autism spectrum disorder or nonspecific develop...
In the past several years a number of alterations in the PAFAH/PLA2G7/LpPLA2 gene have been described. These include inactivating mutations, polymorphisms in the coding region, and other genetic changes located in promoter and intronic regions of the...
3D printing is more and more often used for the development and manufacturing of electronic devices and components. These applications require knowledge about the dielectric properties of the used materials—in particular minimal and stable valu...
While interleukin-1β (IL-1β) is a potent pro-inflammatory cytokine essential for host defense, high systemic levels cause life-threatening inflammatory syndromes. ATP, a stimulus of IL-1β maturation, is released from damaged cells along with β-nicoti...
Although benign hepatocellular adenomas (HCA) are very rare, recent observations have shown their occurrence in patients with diabetes mellitus. Consequently, most of these cases are treated by resection due to concerns regarding their potential prog...
Snakebite is a critical global public health issue, causing substantial mortality and morbidity, particularly in tropical and subtropical regions. The development of innovative antivenoms targeting snake venom toxins is therefore of paramount importa...
Background/Objectives: PLGA/PLA microspheres are attractive candidates for depot delivery of protein therapeutics, but formulation development for antibodies remains challenging because protein encapsulation, burst release, stability, and polymer com...
The use of polymer materials in various fields has increased significantly due to their ease of thermoforming and relatively low production costs. The production volume of these materials is extremely high, and according to forecasts from global stat...
This study presents the results of experimental studies on the thermal conductivity of specimens made from selected pure polymer filaments manufactured with the use of FFF 3D-printing technology. The tested samples were made of polylactic acid (PLA),...
A polyurethane coating represents the conventional solution for protecting and finishing visible wooden furniture surfaces. However, the increasing use of additive manufacturing has introduced visible 3D-printed polymer components whose surface mecha...
Slip risk on surfaces used by humans or active in mechanisms is studied to mitigate its effects or harness its beneficial outcomes. This article presents pioneering research on the risk of surfaces created using 3D printing technology. The study exam...
Poly(ethylene-octene) grafted with glycidyl methacrylate (POE-g-GMA) and ethylene elastomeric grafted with glycidyl methacrylate (EE-g-GMA) were used as impact modifiers, aiming for tailoring poly(lactic acid) (PLA) properties. POE-g-GMA and EE-g-GMA...
Maleic anhydride (MAH) was used as the grafting monomer, which was prepared by melt grafting reaction in the twin screw extruder with dicumyl peroxide (DCP) as the initiator, polylactic acid grafted with maleic anhydride (MAH-g-PLA) was successfully...
Extracellular vesicles (EVs) mediate intercellular communication, yet whether extracellular phospholipid metabolism on EV membranes regulates immune activation remains incompletely understood. Through comparative phenotypic analyses of multiple secre...
Polylactide (PLA) polymer, polypropylene (PP) polymer, and a PLA/PP (70:30 wt%) blend, with liquid natural rubber−graft−methy methacrylate (LNR−g−MMA) of 0.0, 2.5, 5.0, and 10.0 phr as compatibilizers, were prepared by interna...
In this work, blends based on poly (lactic acid) (PLA)/acrylonitrile-butadiene-styrene (ABS) compatibilized with maleic anhydride-grafted (SEBS-g-MA) were prepared in a co-rotational twin-screw extruder by varying the concentrations of the compatibil...
Fused deposition modeling (FDM) is one of the most widely adopted additive manufacturing (AM) technologies due to its accessibility and versatility; however, ensuring process reliability and product quality remains a significant challenge. This work...
The high cost of biofabricated titanium mesh plates can make them out of reach for hospitals in low-income countries. To increase the availability of cranioplasty, the authors of this work investigated the production of polymer-based endoprostheses....
Polylactic acid (PLA) is a biodegradable polymer with good processability, but its poor flame retardancy limits its wider practical use. In this work, an ethanol-assisted pre-assembled g-C3N4/fumed silica hybrid (gCNFS) was introduced into a PLA/ammo...
As energy and environmental issues become more prominent, people must find sustainable, green development paths. Bio-based polymeric phase change energy storage materials provide solutions to cope with these problems. Therefore, in this paper, a full...
Global navigation satellite systems (GNSS) provide a great data source about the ionosphere state. These data can be used for testing ionosphere models. We studied the performance of nine ionospheric models (Klobuchar, NeQuickG, BDGIM, GLONASS, IRI-2...
Snake venom phospholipases A2 (PLA2s) have sequences and structures very similar to those of mammalian group I and II secretory PLA2s, but they possess many toxic properties, ranging from the inhibition of coagulation to the blockage of nerve transmi...
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