Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.4
3.9
Journals
JCM
Special Issues
The Diagnosis, Treatment and Management of Movement Disorders and Dementias
share announcement

The Diagnosis, Treatment and Management of Movement Disorders and Dementias

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: closed (15 September 2022) | Viewed by 9978

Special Issue Editors

Dr. Giovanni Palermo

E-Mail Website
Guest Editor
Center for Neurodegenerative diseases - Parkinson’s disease and Movement disorders Unit of Neurology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
Interests: Parkinson’s disease; dementia with Lewy bodies; Huntington’s disease; atypical Parkinson syndromes; tremor; dystonia; imaging and blood biomarkers in Parkinson’s disease and Lewy body dementias
Dr. Sandy Maria Cartella

E-Mail Website
Guest Editor
Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
Interests: Parkinson’s Disease; Dementia with Lewy Bodies; atypical parkinsonisms; dystonia; tremor; Huntington’s Disease; cognitive impairment in Movement Disorders patients; functional movement disorders

Special Issue Information

Dear Colleagues,

On behalf of the Journal of Clinical Medicine (JCM) Editorial Team, we are delighted to present a new Special Issue on the topic of “The Diagnosis, Treatment and Management of Movement Disorders and Dementias”, Guest Edited by Dr. Giovanni Palermo, from the University of Pisa, and Sandy Maria Cartella from the University of Messina (Italy).

Movement disorders comprise a large group of conditions commonly encountered in the clinic. Although the diagnostic process is frequently perceived as being complex, recent developments have vastly improved our understanding of these disorders, generating a considerable array of tools which can support clinician in the diagnosis. The phenomenology of the clinical syndrome remains what guides the diagnosis but new classification systems and diagnostic criteria have been proposed for several movement disorders with the incorporation of paraclinical investigations and available biomarkers. Similarly, there is an urgent need of disease-modifying therapies and, as understanding of their pathogenesis grows, new therapeutic avenues to prevent disease or restore brain function are likely to emerge.

Therefore, the aim of this special issue is to highlight the progress that has been made in this area, providing an update in the fields of diagnosis and treatment of Movement Disorders, with special emphasis to Parkinson’s Disease which is the second most common neurodegenerative disease, affecting more than 10 million people worldwide.

Dr. Giovanni Palermo
Dr. Sandy Maria Cartella
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Parkinson’s Disease
  • atypical parkinsonisms
  • Lewy body dementias
  • Dystonia, Functional Movement Disorders
  • Movement disorders
  • Treatment
  • Diagnosis
  • Imaging
  • Biomarkers

Published Papers (5 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review, Other

12 pages, 734 KiB  
Article
The Concentration of Fibronectin and MMP-1 in Patients with Alzheimer’s Disease in Relation to the Selected Antioxidant Elements and Eating Habits
by Sylwia Bogdan, Anna Puścion-Jakubik, Katarzyna Klimiuk, Katarzyna Socha, Jan Kochanowicz and Ewa Gorodkiewicz
J. Clin. Med. 2022, 11(21), 6360; https://doi.org/10.3390/jcm11216360 - 27 Oct 2022
Cited by 2 | Viewed by 1558
Abstract
Alzheimer’s disease (AD) is a neurodegenerative disease and the most common form of dementia in the elderly. In recent years, markers of this disease have been researched, with an emphasis on prophylaxis. The aim of this study is to evaluate the concentration of [...] Read more.
Alzheimer’s disease (AD) is a neurodegenerative disease and the most common form of dementia in the elderly. In recent years, markers of this disease have been researched, with an emphasis on prophylaxis. The aim of this study is to evaluate the concentration of fibronectin and MMP-1 in serums in relation to levels of antioxidant elements, as well as eating habits in the group of patients with AD (n = 110). The control group consisted of 60 healthy people. The conducted studies showed that patients with AD are characterized by a significantly higher median concentration of fibronectin compared to healthy subjects (652.06 vs. 268.31 µg/mL), but a significantly lower median of MMP-1 (4.62 vs. 18.09 ng/mL). Significant inverse correlations between MMP-1 and the concentration of antioxidant elements, as well as positive correlations between MMP-1 vs. Total Antioxidant Status (TAS) and MMSE, were observed. Multiple regressions showed that the concentration of fibronectin can be explained in 28% cases by eating habits, and by MMP-1 in 25%. Nutritional modifications to reduce the consumption of fruit, meat and processed products can be part of AD prevention. Full article
(This article belongs to the Special Issue The Diagnosis, Treatment and Management of Movement Disorders and Dementias)
►▼ Show Figures

Figure 1

8 pages, 249 KiB  
Article
Relationship between Lower Limbs Performance and Spinal Alignment in Parkinson’s Disease Patients: An Observational Study with Cross Sectional Design
by Luciano Bissolotti, Matteo Rota, Stefano Calza, Eleuterio A. Sanchez Romero, Andrea Battaglino and Jorge H. Villafañe
J. Clin. Med. 2022, 11(13), 3775; https://doi.org/10.3390/jcm11133775 - 29 Jun 2022
Cited by 4 | Viewed by 1711
Abstract
Parkinson’s disease (PD) is a progressive neurodegenerative disease determining spinal deformities and muscle rigidity, weakness and dystonia that can be related to a change in muscular output during sit-to-stand tasks (STS). Purpose: The aim of this study was to determine the impacts of [...] Read more.
Parkinson’s disease (PD) is a progressive neurodegenerative disease determining spinal deformities and muscle rigidity, weakness and dystonia that can be related to a change in muscular output during sit-to-stand tasks (STS). Purpose: The aim of this study was to determine the impacts of spinal alignment on lower limbs performance during STS tasks in Parkinson’s disease (PD) patients and healthy controls. Methods: In total, 43 consecutive PD patients (“PD” Group, 25 males and 18 females; age 73.7 ± 7.1) and 42 people not affected by any type of neurological disease (“CON” Group, 22 males, 20 females; age 69.8 ± 6.0) participated in the observational study. The clinical assessment included: IPAQ (International Physical Activity Questionnaire), Hoehn Yahr score, plumb-line distance from the spinous process of C7, kyphosis apex and the spinous process of L3 and S1. We used the Muscle Quality Index test (MQI) to assess muscle power output during STS in both groups. Results: The MQI test measurements of absolute and relative lower limb power was significantly lower in the PD group, in addition to a negative correlation with age and a positive correlation with PL-L3 in that group of patients. Conclusions: A final consideration regarding our results leads to the possibility that the preservation of lumbar lordosis may be one of the factors for maintaining efficient biomechanics of the lower limb muscles, with the preservation of the physiological contractile characteristics of these muscles being the objective for a multidisciplinary rehabilitation based on postural exercises of the spine and a program of training exercises for the lower limb muscles. Full article
(This article belongs to the Special Issue The Diagnosis, Treatment and Management of Movement Disorders and Dementias)
9 pages, 238 KiB  
Article
The Effects of COVID-19-Related Restrictions on Parkinson’s Disease Patients in Italy: Results of a Structured Survey
by Stefano Martini, Luca Magistrelli, Francesca Vignaroli, Federico Colombatto, Cristoforo Comi and Marco Cosentino
J. Clin. Med. 2022, 11(11), 3007; https://doi.org/10.3390/jcm11113007 - 26 May 2022
Cited by 3 | Viewed by 1635
Abstract
COVID-19 was first identified in China in late 2019 and spread globally, originating a pandemic. To limit the spreading of the virus, many countries, including Italy, introduced social distancing measures and limited human movement. The Italian government declared a lockdown of the whole [...] Read more.
COVID-19 was first identified in China in late 2019 and spread globally, originating a pandemic. To limit the spreading of the virus, many countries, including Italy, introduced social distancing measures and limited human movement. The Italian government declared a lockdown of the whole country lasting about two months, and the introduced restrictive rules heavily impacted patients with chronic neurological diseases because of the reduced access to healthcare and community support services. In Parkinson’s disease, studies confirmed lockdown restrictions increase levels of psychological distress, impose limitations on physical activities, and cause a lack of clinical assistance. This study aims at investigating the impact of the pandemic during and beyond the lockdown period in such patients using an online survey. A total of 387 total patients accessed the survey and were asked about their personal experiences during and after lockdown. The results show a significant impact on people’s lives even months after lockdown restrictions were lifted, with a substantial and durable worsening in different aspects of daily life, heavily influenced by impaired access to health services—particularly physical therapies, including personal physical activity—and readily available clinical counselling, with an overall observation of worsening symptoms control. These aspects should be carefully considered in the assessment of global health care strategies to overcome the current pandemic and its broader effects. Full article
(This article belongs to the Special Issue The Diagnosis, Treatment and Management of Movement Disorders and Dementias)

Review

Jump to: Research, Other

14 pages, 673 KiB  
Review
Effectiveness of Therapies Based on Mirror Neuron System to Treat Gait in Patients with Parkinson’s Disease—A Systematic Review
by Silvia Lahuerta-Martín, Rocío Llamas-Ramos and Inés Llamas-Ramos
J. Clin. Med. 2022, 11(14), 4236; https://doi.org/10.3390/jcm11144236 - 21 Jul 2022
Cited by 8 | Viewed by 2419
Abstract
Parkinson’s disease (PD) is a neurodegenerative disease that alters gait patterns from early stages. The visuo-motor training strategies such as action observation (AO) and motor imagery (MI) that are based on the activity of the mirror neuron system (MNS) facilitate motor re-learning. The [...] Read more.
Parkinson’s disease (PD) is a neurodegenerative disease that alters gait patterns from early stages. The visuo-motor training strategies such as action observation (AO) and motor imagery (MI) that are based on the activity of the mirror neuron system (MNS) facilitate motor re-learning. The main purpose of this systematic review was to analyze the current scientific evidence about the effectiveness of MNS’s treatments (AO and MI) to treat gait in patients with PD. Searches were completed from the databases PubMed, Web of Science, and PEDro between November and December 2021. The following keywords were used: “Parkinson disease”, “mirror neurons”, “gait”, “action observation”, and “motor imagery”. Randomized control trials of the last 5 years written in English or Spanish were included. Two independent reviewers screened the articles and applied the eligibility criteria, and a third reviewer assisted in this process. A total of six articles were included for final revision. The risk of bias was assessed with the PEDro Scale. The effects of AO and MI using different outcome measures were referenced in terms of disease severity, quality of life, balance, and gait. Training with AO and MI are effective in improving disease severity, quality of life, balance, and gait in patients with PD. Full article
(This article belongs to the Special Issue The Diagnosis, Treatment and Management of Movement Disorders and Dementias)
►▼ Show Figures

Figure 1

Other

Jump to: Research, Review

8 pages, 281 KiB  
Case Report
Non-Motor Symptoms in PLA2G6-Associated Dystonia-Parkinsonism: A Case Report and Literature Review
by Lydia Vela-Desojo, Daniele Urso, Mireia Osuna-López and Janet Hoenicka
J. Clin. Med. 2022, 11(6), 1590; https://doi.org/10.3390/jcm11061590 - 13 Mar 2022
Cited by 1 | Viewed by 1977
Abstract
PLA2G6-dystonia-parkinsonism (PLAN-DP) is characterized by levodopa responsive parkinsonism and dystonia. While neuropsychiatric symptoms and early cognitive decline are also common in this entity there is little information regarding other non-motor symptoms (NMS). Here, we describe a 26-year-old patient with PLAN-DP whose motor [...] Read more.
PLA2G6-dystonia-parkinsonism (PLAN-DP) is characterized by levodopa responsive parkinsonism and dystonia. While neuropsychiatric symptoms and early cognitive decline are also common in this entity there is little information regarding other non-motor symptoms (NMS). Here, we describe a 26-year-old patient with PLAN-DP whose motor symptoms were preceded by mild cognitive impairment and anxiety, and who developed many other NMS as the disease evolved. Furthermore, we reviewed the NMS described in all the PLAN-DP patients published to date. A total of 50 patients with PLAN-DP were identified, 42 of whom developed NMS and in 23 of these cases, NMS preceded the motor symptoms of the disease. Neuropsychiatric symptoms dominated the premotor phase of this condition and cognitive impairment/dementia was the most prevalent NMS. Other NMS were reported infrequently like sleep disorders, autonomic symptoms, pain and hyposmia, and mostly as the disease evolved. NMS are very frequent in PLAN-DP and they may appear before diagnosis or during the course of the disease. Neuropsychiatric symptoms and cognitive decline are the most frequent NMS. The appearance of neuropsychiatric symptoms like depression, anxiety or personality changes prior to a diagnosis of parkinsonism in younger individuals might suggest the presence of PLA2G6 gene mutations. Full article
(This article belongs to the Special Issue The Diagnosis, Treatment and Management of Movement Disorders and Dementias)
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-5
Back to TopTop