Special Issue "Phospholipases: From Structure to Biological Function"
Deadline for manuscript submissions: closed (31 August 2020).
Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), 28029 Madrid, Spain
Interests: inflammation; innate immunity; lipid mediators; phospholipases; lipins
Interests: Lipid Biochemistry; Phospholipase A2; Eicosanoids; Lipidomics; Inflammation
Special Issues and Collections in MDPI journals
It is now widely recognized that, in addition to their roles as membrane building blocks and energy sources, lipids play key roles in intracellular signalling and extracellular cell communication. When deregulated, lipid signalling contributes to a wide range of diseases, including cardiovascular and degenerative diseases, and cancer. Many bioactive lipids are generated by phospholipases, which are enzymes that hydrolyze the esther bonds present in phospholipids. As there are four different ester bonds in phospholipids, four major classes of phospholipases enzymes exist, termed A, B, C, and D, which are distinguished by the type of reaction that they catalyse.
Phospholipases of the A-type, which include A1 and A2 forms, are acyl hydrolases, which release fatty acids such as arachidonic acid, and lysophospholipids. Each of these products is implicated in the signal transduction process itself, but also serve as a precursor for eicosanoids, including prostaglandins, leukotrienes, and lipoxins or platelet activating factor. These compounds are implicated in numerous inflammatory diseases, such as rheumatoid arthritis, sepsis, intestinal bowel disease, and asthma, as well as playing a role in cancer, atherosclerosis, and premature parturition. Other important phospholipases include phospholipase C, which controls the production of inositol-1,4,5-trisphosphate, which induces cytosolic Ca2+ release, and diacylglycerol, which activates a myriad of intracellular effectors. Phospholipase D generates phosphatidic acid, which subsequently can either be metabolized to lysophosphophatidic acid, a potent cellular mitogen, or by phosphatidate phosphohydrolase, yielding diacylglycerol. The family of type-2 phosphatidate phosphatases, collectively called lipins, are Mg2+-dependent phospholipase C-type enzymes that act specifically on phosphatidic acid, and have recently gained much attention because of their involvement in a number of pathologies, including rhadomyolisis, atherosclerosis, and colon cancer. Sphingomyelinase, another phospholipase C-type enzyme, and related enzymes of the sphingolipid metabolism are implicated in apoptosis and other signalling processes.
In summary, the phospholipases generate numerous lipid products, which control much of cellular signalling. The aim of this Special Issue aims to bring together international experts to provide a comprehensive view of the recent advances related to the subject of "phospholipases". Both original research articles or focused reviews are acceptable. Articles with mechanistic and functional insights at a cellular or molecular level, as well as animal models of disease are particularly welcome.
Prof. María A. Balboa
Prof. Jesús Balsinde
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Bioactive lipids and lipid signaling
- Membrane remodeling
- Phospholipase A2
- Phospholipase C
- Phospholipase D
- Lipins and lipinopathies
- Animal models of disease