386 Results Found

Cardiomyocyte progenitor cells play essential roles in early heart development, which requires highly controlled cellular organization. microRNAs (miRs) are involved in various cell behaviors by post-transcriptional regulation of target genes. Howeve...

Recently MEIS1 emerged as a major determinant of the MLL-r leukemic phenotype. The latest and most efficient drugs effectively decrease the levels of MEIS1 in cancer cells. Together with an overview of the latest drugs developed to target MEIS1 in ML...

In this article, the formulation of first-order approximate Mei symmetries and Mei invariants of the corresponding Lagrangian is presented. Theorems and determining equations are given to evaluate approximate Mei symmetries, as well as approximate fi...

In this paper, the Mei symmetries for the Lagrangians corresponding to the spherically and axially symmetric metrics are investigated. For this purpose, the Schwarzschild and Kerr black hole metrics are considered. Using the Mei symmetries criterion,...

Background: Normal spermatogenesis in Mongolian horses depends on the mitotic division of spermatogonia, two successive meiotic divisions, and the morphological transformation of spermatids into mature spermatozoa. The MEI1 gene is involved in the me...

The function of retinoic acid (RA) during limb development is still debated, as loss and gain of function studies led to opposite conclusions. With regard to limb initiation, genetic studies demonstrated that activation of FGF10 signaling is required...

The Mei-Yu front is a significantly important summer precipitation system in eastern Asia. In recent years, anthropogenic air pollution over the Yangtze-Huaihe region of China has been aggravating continuously. A cloud-resolving model coupled with an...

Background: We intended to explore the potential immunological functions and prognostic value of Myeloid Ecotropic Viral Integration Site 1 (MEIS1) across 33 cancer types. Methods: The data were acquired from The Cancer Genome Atlas (TCGA), Genotype-...

MicroRNA-23a (miR-23a) is an endogenous small activating RNA (saRNA) involved in ovarian granulosa cell (GC) apoptosis and sow fertility by activating lncRNA NORHA transcription. Here, we reported that both miR-23a and NORHA were repressed by a commo...

As a member of TALE family, Meis1 has been proven to regulate cell proliferation and differentiation during cell fate commitment; however, the mechanism is still not fully understood. The planarian, which has an abundance of stem cells (neoblasts) re...

Meis1 is a transcription factor involved in numerous functions including development and proliferation and has been previously shown to harness cell cycle progression. In this study, we used in silico analysis to predict that miR-499-5p targets Meis1...

Hydrological calibration of raw weather radar rainfall estimation relies on in situ rainfall measurements. Raindrop size distribution (DSD) was collected during three typical Mei-Yu rainstorms in July 2014 using three particle size velocity (Parsivel...

Non-standard Lagrangians play an important role in the systems of non-conservative dynamics or nonlinear differential equations, quantum field theories, etc. This paper deals with quasi-fractional dynamical systems from exponential non-standard Lagra...

Understanding the influence of the morphological mechanisms of Mei Gui chairs on the emotional preferences of female users is crucial for achieving perceptual resonance in design. This study aims to investigate/explore the relationship between user p...

During 6–7 June 2003, a Mei-Yu jet/front system over Southern China is characterized by appreciable horizontal temperature contrast below the 850 hPa level (>8 K), where the cold, dry, postfrontal northeasterlies converge with the warm, mois...

Recurrence and metastasis remain major obstacles in colorectal cancer (CRC) treatment. Recent studies suggest that a small subpopulation of cells with a self-renewal ability, called cancer stem-like cells (CSCs), promotes recurrence and metastasis in...

The necrotrophic fungus Botrytis cinerea causes devastating pre- and post-harvest yield losses in grapevine (Vitis vinifera L.). Although B. cinerea has been well-studied in different plant species, there is limited information related to the resista...

HOXA9 and MEIS1 are frequently upregulated in acute myeloid leukemia (AML), including those with MLL-rearrangement. Because of their pivotal role in hemostasis, HOXA9 and MEIS1 appear non-druggable. We, thus, interrogated gene expression data of pre-...

Catalpa bungei C. A. Mey is a unique and precious multi-purpose tree species that possesses great timber-related, ornamental and medicinal values. In this study, MS, N6 and DKW were used as basic media, and different concentrations of 6-BA and NAA we...

Background: To investigate the potential anti-obesity properties of an innovative functional formula (called the Mei-Gin formula: MGF) consisting of bainiku-ekisu, Prunus mume (70% ethanol extract), black garlic (water extract), and Mesona procumbens...

As a traditional Chinese medicinal herb, ginseng (Panax ginseng C. A. Mey.) is commonly used to treat common diseases, for example, esophageal cancer and myasthenia gravis. Furthermore, ginseng is also processed into a functional food additive that i...

In this study, the performances of Mei-yu (May–June) quantitative precipitation forecasts (QPFs) in Taiwan by three mesoscale models: the Cloud-Resolving Storm Simulator (CReSS), the Central Weather Bureau (CWB) Weather Research and Forecasting...

The human genome is covered by 8% of candidate cis-regulatory elements. The identification of distal acting regulatory elements and an understanding of their action are crucial to determining their key role in gene expression. Disruptions of such reg...

This study examines a Mei-Yu rainfall event using rain gauges (RG) and OTT Parsivel disdrometers to observe precipitation characteristics and raindrop size distributions (RSD), with comparisons made against Weather Research and Forecasting (WRF) mode...

Snow has an important impact on forest ecosystems in mountainous areas. In this study, we developed 14 tree-ring-width chronologies of Schrenk spruce (Picea schrenkiana Fisch. et Mey.) for the Ili-Balkhash Basin (IBB), Central Asia. We analyzed the r...

Panax ginseng C. A. Mey., a perennial herb belonging to the family Araliaceae, is a valuable medicinal plant with distinctive biological characteristics. However, comprehensive analyses of the mitochondrial genome (mitogenome) are lacking. In this st...

The Chu River is one of the most important rivers in arid Central Asia. Its discharge is affected by climate change. Here, we establish a tree-ring chronology for the upper Chu River Basin and analyze the relationships between radial growth, climate,...

Obesity is a metabolic dysfunction characterized by excessive body fat deposition as a consequence of an energy imbalance. Novel therapeutic strategies have emerged that are safe and have comparatively low side effects for obesity treatment. Function...

This study selected three heavy-rainfall events of different types in Taiwan’s Mei-yu season for high-resolution simulations at a grid size of 1 km and assessed the model’s capability to reproduce their morphology and characteristics. The...

Gout is a common rheumatic disease, resulting from hyperuricemia. Prunus mume fruit extract, after being heat-concentrated named mei extract, was empirically found to reduce the risk of gout. While neochlorogenic acid was found as the predominant phe...

Global warming and the sharp rise in atmospheric CO2 concentrations have a profound impact on forest ecosystems. To better manage these changes, a comprehensive understanding of forest ecosystem responses to global change is essential. There is a lac...

This article addresses the challenge of simulating rainstorm waterlogging in urban-scale areas where reliable drainage pipe network data are often lacking. Although methods have been developed to tackle this issue, there remains a gap in their effect...

During early development, the heart tube grows by progressive addition of progenitor cells to the arterial and venous poles. These cardiac progenitor cells, originally identified in 2001, are located in the splanchnic mesoderm in a region termed the...

Roughly half of all high-risk neuroblastoma patients present with MYCN amplification. The molecular consequences of MYCN overexpression in this aggressive pediatric tumor have been studied for decades, but thus far, our understanding of the early ini...

Centrosome-containing cells assemble their spindles exploiting three main classes of microtubules (MTs): MTs nucleated by the centrosomes, MTs generated near the chromosomes/kinetochores, and MTs nucleated within the spindle by the augmin-dependent p...

Oceanic mesoscale events such as eddies, coastal upwelling, filaments and fronts created by water mass intrusion present properties allowing them to concentrate, transport and disperse salt, nutrients and plankton, among other important constituents...

It is known that corresponding to each Noether symmetry there is a conserved quantity. Another class of symmetries that corresponds to conserved quantities is the class of Mei symmetries. However, the two sets of symmetries may give different conserv...

Hair loss is a disorder in which the hair falls out from skin areas such as the scalp and the body. Several studies suggest the use of herbal medicine to treat related disorders, including alopecia. Dermal microcirculation is essential for hair maint...

Dinoflagellates are unicellular organisms that are crucial components of aquatic ecosystems, known as important primary producers and causes of harmful blooms. They have complex life cycles, including immotile stages, which contribute to their distri...

Platy-1 retroposons are short interspersed elements (SINEs) unique to platyrrhine primates. Discovered in the common marmoset (Callithrix jacchus) genome in 2016, these 100 bp mobile element insertions (MEIs) appeared to be novel drivers of platyrrhi...

Wind erosion is a major cause of soil losses in China’s drylands which is further stimulated by climate variability and fragile ecological conditions. Climatic erosivity is an important index of wind erosion, therefore, evaluation of its spatio...

A growing number of recent studies have revealed that non-coding RNAs play a wide variety of roles beyond expectation. A lot of non-coding RNAs have been shown to function by forming intracellular structures either in the nucleus or the cytoplasm. In...

The irradiation effects of carbon and nitrogen medium energy ions (MEI) on charge transport, structural and optical properties of Ni/Pd/n-GaN Schottky barrier diodes are reported. The devices are exposed to 600 keV C2+ and 650 keV N2+ ions in the flu...

Background and objectives: Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide and is caused by multiple factors. To explore novel targets for HCC treatment, we comprehensively analyzed the expression of HomeoboxB13 (HOXB1...

During 10–12 June 2012, heavy rainfall occurred three days in a row in southern and central Taiwan, with daily rainfall maxima exceeding 500 mm on each day. In the Mei-yu season (May–June) during 1993–2000, only two other rainfall events had a compar...

Panacis Japonici Rhizoma (Zhu-Jie-Shen in Chinese), the root of P. japonicus C.A. Mey., is commonly used in traditional Chinese Medicine. Saponins are the major bioactive compounds in this herb. The similarity of polarity and structure of the natural...

Deploying Large Language Models (LLMs) in edge environments faces two major challenges: (i) the conflict between limited device resources and high computational demands, and (ii) the dynamic impact of user mobility on model partitioning and task offl...

In the current work, stable prenucleated PbS quantum dots (QDs) with a sub-nanometer (0.8 nm) size have been successfully synthesized via a systematically designed experiment. A detailed analysis of critical nucleation, growth, and stability for such...

Background: Adenomyosis is a benign uterine disorder defined by the invagination of ectopic endometrial-like tissue into the myometrium, causing heavy menstrual bleeding and pain. While its pathogenesis remains unclear, shared-symptomology with endom...

MeiShan and Large White pigs differ in their female fecundity. However, the mechanisms behind the gene expression and regulation that cause these differences remain unclear. In this study, we profiled circRNAs and identified 5,879 circRNAs from the o...