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Open AccessFeature PaperReview

meiRNA, A Polyvalent Player in Fission Yeast Meiosis

by Akira Yamashita 1,2,3
1
National Institute for Basic Biology, Nishigonaka 38, Myodaiji, Okazaki 444-8585, Japan
2
Center for Novel Science Initiatives, National Institutes of Natural Sciences, Nishigonaka 38, Myodaiji, Okazaki 444-8585, Japan
3
Department of Basic Biology, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies), Nishigonaka 38, Myodaiji, Okazaki 444-8585, Japan
Non-Coding RNA 2019, 5(3), 45; https://doi.org/10.3390/ncrna5030045
Received: 21 August 2019 / Revised: 12 September 2019 / Accepted: 16 September 2019 / Published: 17 September 2019
(This article belongs to the Special Issue Non-Coding RNA and Intracellular Structures)
A growing number of recent studies have revealed that non-coding RNAs play a wide variety of roles beyond expectation. A lot of non-coding RNAs have been shown to function by forming intracellular structures either in the nucleus or the cytoplasm. In the fission yeast Schizosaccharomyces pombe, a non-coding RNA termed meiRNA has been shown to play multiple vital roles in the course of meiosis. meiRNA is tethered to its genetic locus after transcription and forms a peculiar intranuclear dot structure. It ensures stable expression of meiotic genes in cooperation with an RNA-binding protein Mei2. Chromosome-associated meiRNA also facilitates recognition of homologous chromosome loci and induces robust pairing. In this review, the quarter-century history of meiRNA, from its identification to functional characterization, will be outlined. View Full-Text
Keywords: non-coding RNA; nuclear body; meiosis; fission yeast; gene expression; chromosome pairing non-coding RNA; nuclear body; meiosis; fission yeast; gene expression; chromosome pairing
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Yamashita, A. meiRNA, A Polyvalent Player in Fission Yeast Meiosis. Non-Coding RNA 2019, 5, 45.

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