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192 Results Found

  • Article
  • Open Access
13 Citations
4,724 Views
22 Pages

CsgI (YccT) Is a Novel Inhibitor of Curli Fimbriae Formation in Escherichia coli Preventing CsgA Polymerization and Curli Gene Expression

  • Kotaro Sano,
  • Hiroaki Kobayashi,
  • Hirotaka Chuta,
  • Nozomi Matsuyoshi,
  • Yuki Kato and
  • Hiroshi Ogasawara

22 February 2023

Curli fimbriae are amyloids—found in bacteria (Escherichia coli)—that are involved in solid-surface adhesion and bacterial aggregation during biofilm formation. The curli protein CsgA is coded by a csgBAC operon gene, and the transcriptio...

  • Article
  • Open Access
27 Citations
6,292 Views
25 Pages

Metabolic Activation of CsgD in the Regulation of Salmonella Biofilms

  • Akosiererem S. Sokaribo,
  • Elizabeth G. Hansen,
  • Madeline McCarthy,
  • Taseen S. Desin,
  • Landon L. Waldner,
  • Keith D. MacKenzie,
  • George Mutwiri,
  • Nancy J. Herman,
  • Dakoda J. Herman and
  • Aaron P. White
  • + 1 author

Among human food-borne pathogens, gastroenteritis-causing Salmonella strains have the most real-world impact. Like all pathogens, their success relies on efficient transmission. Biofilm formation, a specialized physiology characterized by multicellul...

  • Article
  • Open Access
8 Citations
3,342 Views
12 Pages

Gre Factors Are Required for Biofilm Formation in Salmonella enterica Serovar Typhimurium by Targeting Transcription of the csgD Gene

  • Tania Gaviria-Cantin,
  • Andrés Felipe Vargas,
  • Youssef El Mouali,
  • Carlos Jonay Jiménez,
  • Annika Cimdins-Ahne,
  • Cristina Madrid,
  • Ute Römling and
  • Carlos Balsalobre

Rdar biofilm formation of Salmonella typhimurium and Escherichia coli is a common ancient multicellular behavior relevant in cell–cell and inter-organism interactions equally, as in interaction with biotic and abiotic surfaces. With the express...

  • Article
  • Open Access
17 Citations
4,343 Views
15 Pages

The Transcription Factor CsgD Contributes to Engineered Escherichia coli Resistance by Regulating Biofilm Formation and Stress Responses

  • Cheng-Hai Yan,
  • Fang-Hui Chen,
  • Yu-Lu Yang,
  • Yu-Fan Zhan,
  • Richard A. Herman,
  • Lu-Chan Gong,
  • Sheng Sheng and
  • Jun Wang

5 September 2023

The high cell density, immobilization and stability of biofilms are ideal characteristics for bacteria in resisting antibiotic therapy. CsgD is a transcription activating factor that regulates the synthesis of curly fimbriae and cellulose in Escheric...

  • Article
  • Open Access
2 Citations
1,697 Views
25 Pages

18 April 2024

In order to predict the settlement and compressive stress of the cemented sand and gravel (CSG) dam, and optimize its section design, relying on a CSG dam in the design phase, using finite element software ANSYS, the influence of the dam’s own...

  • Article
  • Open Access
4 Citations
1,853 Views
16 Pages

Pathogenic Salmonella strains causing gastroenteritis typically can colonize and proliferate in the intestines of multiple host species. They retain the ability to form red dry and rough (rdar) biofilms, as seen in Salmonella enterica serovar Typhimu...

  • Article
  • Open Access
17 Citations
4,157 Views
25 Pages

This paper uses hydrochemical and multi-isotope analysis to investigate geological controls on coal seam gas (CSG) saturation domains and gas well production performance in a high-rank (vitrinite reflectance (Rv) > 1.1) CSG field in the north-west...

  • Article
  • Open Access
8 Citations
5,816 Views
23 Pages

4 May 2020

The preference of three-dimensional representation of underground cable wells from two-dimensional symbols is a developing trend, and three-dimensional (3D) point cloud data is widely used due to its high precision. In this study, we utilize the char...

  • Article
  • Open Access
14 Citations
2,474 Views
24 Pages

5 January 2023

Cemented sand and gravel (CSG) has a wide range of applications in dam construction, and its properties are between rockfill and roller compacted concrete (RCC). A difference in gel content will result in a variance in CSG’s structure and mecha...

  • Article
  • Open Access
16 Citations
4,349 Views
12 Pages

Gut Microbiota Is the Key to the Antidepressant Effect of Chaihu-Shu-Gan-San

  • Meng Yu,
  • Hong-Mei Jia,
  • Tao Zhang,
  • Hai Shang,
  • Hong-Wu Zhang,
  • Li-Yan Ma and
  • Zhong-Mei Zou

10 February 2020

Accumulating evidence highlights the link between gut microbiota and depression. As an antidepressant herbal drug in clinic, Chaihu-Shu-Gan-San (CSGS) has also been used in China for the treatment of various gastrointestinal disorders. Therefore, we...

  • Article
  • Open Access
8 Citations
3,376 Views
16 Pages

Enhanced Detection of Desmoplasia by Targeted Delivery of Iron Oxide Nanoparticles to the Tumour-Specific Extracellular Matrix

  • Meenu Chopra,
  • Jiansha Wu,
  • Yen Ling Yeow,
  • Louise Winteringham,
  • Tristan D. Clemons,
  • Martin Saunders,
  • Venkata Ramana Kotamraju,
  • Ruth Ganss,
  • Kirk W. Feindel and
  • Juliana Hamzah

Diagnostic imaging of aggressive cancer with a high stroma content may benefit from the use of imaging contrast agents targeted with peptides that have high binding affinity to the extracellular matrix (ECM). In this study, we report the use of super...

  • Article
  • Open Access
1 Citations
1,355 Views
21 Pages

23 December 2024

In order to explore the influence of different layer treatment methods on the macro- and meso-mechanical properties of cemented sand and gravel (CSG), in this paper, the shear behavior of CSG material was simulated by a three-dimensional particle flo...

  • Article
  • Open Access
65 Citations
14,973 Views
26 Pages

The Production of Curli Amyloid Fibers Is Deeply Integrated into the Biology of Escherichia coli

  • Daniel R. Smith,
  • Janet E. Price,
  • Peter E. Burby,
  • Luz P. Blanco,
  • Justin Chamberlain and
  • Matthew R. Chapman

31 October 2017

Curli amyloid fibers are the major protein component of the extracellular matrix produced by Enterobacteriaceae during biofilm formation. Curli are required for proper biofilm development and environmental persistence by Escherichia coli. Here, we pr...

  • Article
  • Open Access
6 Citations
4,244 Views
18 Pages

25 December 2019

The area covered by Chinese-style solar greenhouses (CSGs) has been increasing rapidly. However, only a few pyranometers, which are fundamental for solar radiation sensing, have been installed inside CSGs. The lack of solar radiation sensing will bri...

  • Article
  • Open Access
1 Citations
891 Views
15 Pages

GPU-Optimized Implementation for Accelerating CSAR Imaging

  • Mengting Cui,
  • Ping Li,
  • Zhaohui Bu,
  • Meng Xun and
  • Li Ding

The direct porting of the Range Migration Algorithm to GPUs for three-dimensional (3D) cylindrical synthetic aperture radar (CSAR) imaging faces difficulties in achieving real-time performance while the architecture and programming models of GPUs sig...

  • Article
  • Open Access
27 Citations
6,239 Views
30 Pages

1 January 2021

The complexity and variety of buildings and the defects of point cloud data are the main challenges faced by 3D urban reconstruction from point clouds, especially in metropolitan areas. In this paper, we developed a method that embeds multiple relati...

  • Article
  • Open Access
5 Citations
3,482 Views
12 Pages

A Novel Algorithm for CAD to CSG Conversion in McCAD

  • Moataz Harb,
  • Dieter Leichtle and
  • Ulrich Fischer

15 June 2023

Modeling and simulation lie at the heart of the design process of any nuclear application. An accurate representation of the radiation environment ensures not only the feasibility of new technologies, but it also aids in operation, maintenance, and e...

  • Article
  • Open Access
2 Citations
5,337 Views
17 Pages

16 February 2024

For cost-sensitive Chinese solar greenhouses (CSGs) with an uneven spatial distribution in temperature and humidity, there is a lack of effective strategies for sensor configuration that can reduce sensor usage while monitoring the microclimate preci...

  • Article
  • Open Access
2 Citations
938 Views
17 Pages

Curli fimbriae are a major component of biofilm formation in Escherichia coli, and their expression is regulated by numerous transcription factors and small regulatory RNAs (sRNAs). The RcsD-RcsC-RcsB phosphorelay system, which is involved in the env...

  • Article
  • Open Access
5 Citations
2,733 Views
15 Pages

13 November 2020

The production of coalbed methane, or coal seam gas (CSG) in Australia increased 250-fold since the 1990s to around 1502 petajoules in 2019 and continues to expand. Groundwater flow in the aquifers intersected by gas wells could potentially facilitat...

  • Article
  • Open Access
8 Citations
6,323 Views
23 Pages

Three-dimensional (3D), city models have been applied in a variety of fields. One of the main problems in 3D city model utilization, however, is the large volume of data. In this paper, a method is proposed to generalize the 3D building objects in 3D...

  • Review
  • Open Access
132 Citations
16,279 Views
20 Pages

26 February 2013

Biofilm formation in Escherichia coli and other enteric bacteria involves the inverse regulation of the synthesis of flagella and biofilm matrix components such as amyloid curli fibres, cellulose, colanic acid and poly-N-acetylglucosamine (PGA). Phys...

  • Article
  • Open Access
1 Citations
955 Views
21 Pages

Revealing the Enhancement Mechanism of Alkali-Activated Rice Husk Ash on High Mud Content CSG Materials from the Fractal Perspective

  • Hu Huang,
  • Ruihang Li,
  • Xiancai Zhang,
  • Kelei Cao,
  • Lixia Guo,
  • Qingming Qiu and
  • Changbo Song

To address the detrimental effects of high mud content on cemented sand and gravel (CSG) materials, this study focuses on CSG materials with different contents of alkali-activated rice husk ash (RHA). The microscopic enhancement mechanism of mechanic...

  • Article
  • Open Access
4 Citations
2,658 Views
24 Pages

(1) This paper, based on the characteristics of complex steel structures as well as difficult points in the process of their detailed design, introduces the product design concept of DfMA (Design for Manufacturing and Assembly) from the manufacturing...

  • Article
  • Open Access
12 Citations
4,977 Views
20 Pages

Variability of Amyloid Propensity in Imperfect Repeats of CsgA Protein of Salmonella enterica and Escherichia coli

  • Natalia Szulc,
  • Marlena Gąsior-Głogowska,
  • Jakub W. Wojciechowski,
  • Monika Szefczyk,
  • Andrzej M. Żak,
  • Michał Burdukiewicz and
  • Malgorzata Kotulska

CsgA is an aggregating protein from bacterial biofilms, representing a class of functional amyloids. Its amyloid propensity is defined by five fragments (R1–R5) of the sequence, representing non-perfect repeats. Gate-keeper amino acid residues, speci...

  • Article
  • Open Access
15 Citations
7,102 Views
10 Pages

Short Chain N-Acylhomoserine Lactone Production by Clinical Multidrug Resistant Klebsiella pneumoniae Strain CSG20

  • Yun Fong Ngeow,
  • Huey Jia Cheng,
  • Jian Woon Chen,
  • Wai-Fong Yin and
  • Kok-Gan Chan

7 November 2013

Klebsiella pneumoniae is one of the most common Gram-negative bacterial pathogens in clinical practice. It is associated with a wide range of disorders, ranging from superficial skin and soft tissue infections to potentially fatal sepsis in the lungs...

  • Feature Paper
  • Article
  • Open Access
3 Citations
2,764 Views
31 Pages

In the case of huge tsunamis, such as the 2004 Great Indian Ocean Tsunami and 2011 Great East Japan Tsunami, the damage caused by ground scour is serious. Therefore, it is important to improve prediction models for the topographical change of huge ts...

  • Article
  • Open Access
5 Citations
2,587 Views
14 Pages

Background: Sepsis is a serious worldwide health concern, and Escherichia coli (E. coli) is the main cause. This study investigates the co-expression of blaCTX-M1 and iutA, csgA, and kpsMII genes in E. coli isolated from septicemic patients, aiming t...

  • Article
  • Open Access
7 Citations
4,427 Views
15 Pages

Gelation and Consolidation Characteristics of Cement-Sodium Silicate Grout within Water

  • Rongfeng Lin,
  • Qing Jin,
  • Yaolei Zhang,
  • Guangming Pan,
  • Jianwen Qin and
  • Zejing Huang

7 March 2022

Cement-sodium silicate grout (CSG) is now widely adopted in water plugging engineering to prevent water inrush disasters, and the gelation and consolidation characteristics of CSG in water environment significantly affect the grouting effect. To obta...

  • Article
  • Open Access
10 Citations
2,592 Views
20 Pages

Spatial, Temporal, and Vertical Variability of Ambient Environmental Conditions in Chinese Solar Greenhouses during Winter

  • Md Nasim Reza,
  • Md Nafiul Islam,
  • Md Zafar Iqbal,
  • Md Shaha Nur Kabir,
  • Milon Chowdhury,
  • Md Ashrafuzzaman Gulandaz,
  • Mohammod Ali,
  • Moon-Ki Jang and
  • Sun-Ok Chung

30 August 2023

The monitoring and control of environmental conditions are crucial as they influence crop quality and yield in Chinese solar greenhouses (CSGs). The objectives of this study were to assess the spatial, temporal, and vertical variability of major envi...

  • Review
  • Open Access
11 Citations
5,914 Views
35 Pages

Applications of Serious Games as Affective Disorder Therapies in Autistic and Neurotypical Individuals: A Literature Review

  • Fahad Ahmed,
  • Jesús Requena Carrión,
  • Francesco Bellotti,
  • Giacinto Barresi,
  • Federica Floris and
  • Riccardo Berta

8 April 2023

Affective disorders can greatly influence the everyday lives of neurotypical and autistic individuals. As platforms that promote engagement, computer-based serious games (CSGs) have been previously proposed as therapies to treat affective disorders f...

  • Commentary
  • Open Access
50 Citations
5,289 Views
6 Pages

28 February 2020

Despite the enormous literature documenting the importance of amyloid beta (Ab) protein in Alzheimer's disease, we do not know how Ab aggregation is initiated and why it has its unique distribution in the brain. In vivo and in vitro evidence has been...

  • Article
  • Open Access
1 Citations
1,729 Views
18 Pages

19 November 2024

The main objective of a machine learning (ML) system is to obtain a trained model from input data in such a way that it allows predictions to be made on new i.i.d. (Independently and Identically Distributed) data with the lowest possible error. Howev...

  • Article
  • Open Access
12 Citations
4,192 Views
17 Pages

Flavonoids as Potential Drugs for VPS13-Dependent Rare Neurodegenerative Diseases

  • Piotr Soczewka,
  • Krzysztof Flis,
  • Déborah Tribouillard-Tanvier,
  • Jean-Paul di Rago,
  • Cláudia N. Santos,
  • Regina Menezes,
  • Joanna Kaminska and
  • Teresa Zoladek

21 July 2020

Several rare neurodegenerative diseases, including chorea acanthocytosis, are caused by mutations in the VPS13A–D genes. Only symptomatic treatments for these diseases are available. Saccharomyces cerevisiae contains a unique VPS13 gene and the...

  • Review
  • Open Access
20 Citations
6,872 Views
17 Pages

Gene Regulation of Biofilm-Associated Functional Amyloids

  • Khushal Khambhati,
  • Jaykumar Patel,
  • Vijaylaxmi Saxena,
  • Parvathy A and
  • Neha Jain

Biofilms are bacterial communities encased in a rigid yet dynamic extracellular matrix. The sociobiology of bacterial communities within a biofilm is astonishing, with environmental factors playing a crucial role in determining the switch from plankt...

  • Article
  • Open Access
1 Citations
3,322 Views
16 Pages

Silicon–Gold Nanoparticles Affect Wharton’s Jelly Phenotype and Secretome during Tri-Lineage Differentiation

  • Elena V. Svirshchevskaya,
  • Nina V. Sharonova,
  • Rimma A. Poltavtseva,
  • Mariya V. Konovalova,
  • Anton E. Efimov,
  • Anton A. Popov,
  • Svetlana V. Sizova,
  • Daria O. Solovyeva,
  • Ivan V. Bogdanov and
  • Vladimir A. Oleinikov

15 February 2022

Multiple studies have demonstrated that various nanoparticles (NPs) stimulate osteogenic differentiation of mesenchymal stem cells (MSCs) and inhibit adipogenic ones. The mechanisms of these effects are not determined. The aim of this paper was to es...

  • Review
  • Open Access
1,579 Views
22 Pages

Bacterial Amyloids as Hubs for Nucleic Acid Interactions: Implications and Mechanisms

  • Sylwia Bloch,
  • Gaelle Loutfi,
  • Gautier Moroy,
  • Richard R. Sinden,
  • Grzegorz Węgrzyn and
  • Véronique Arluison

Amyloids are protein aggregates having a cross-β structure, and they reveal some unusual properties, like interactions with specific dyes and resistance to actions of detergents and proteases, as well as the capability to force some proteins to...

  • Article
  • Open Access
9 Citations
4,555 Views
21 Pages

Pickering Emulsion Stabilized by Different Concentrations of Whey Protein–Cress Seed Gum Nanoparticles

  • Maryam Davtalab,
  • Sara Naji-Tabasi,
  • Mostafa Shahidi-Noghabi,
  • Artur J. Martins,
  • Ana I. Bourbon and
  • Miguel A. Cerqueira

25 November 2024

Nanoparticles based on food-grade materials are promising materials to develop Pickering emulsions for food applications. Initially, this study focuses on the development of nanoparticles through the utilization of a soluble complex of whey protein c...

  • Article
  • Open Access
24 Citations
8,445 Views
14 Pages

Comparative Pharmacokinetics of Naringin in Rat after Oral Administration of Chaihu-Shu-Gan-San Aqueous Extract and Naringin Alone

  • Shu-Qi Li,
  • Shu Dong,
  • Zhi-Heng Su,
  • Hong-Wu Zhang,
  • Jing-Bo Peng,
  • Chang-Yuan Yu and
  • Zhong-Mei Zou

30 September 2013

Chaihu-Shu-Gan-San (CSGS), a traditional Chinese medicine (TCM) formula containing seven herbal medicines, has been used in the clinical treatment of gastritis, peptic ulcer, irritable bowel syndrome and depression in China. In order to explore the i...

  • Article
  • Open Access
22 Citations
4,061 Views
16 Pages

10 June 2019

Knowing the deformation properties of cemented sand and gravel (CSG) material can help construct reasonable constitutive models for the material, which can be used to simulate the structural performance of various practical projects including CSG dam...

  • Article
  • Open Access
12 Citations
4,671 Views
17 Pages

Complex System Governance as a Framework for Asset Management

  • Polinpapilinho F. Katina,
  • James C. Pyne,
  • Charles B. Keating and
  • Dragan Komljenovic

29 July 2021

Complex system governance (CSG) is an emerging field encompassing a framework for system performance improvement through the purposeful design, execution, and evolution of essential metasystem functions. The goal of this study was to understand how t...

  • Article
  • Open Access
12 Citations
4,297 Views
17 Pages

Determination of the Optimal Orientation of Chinese Solar Greenhouses Using 3D Light Environment Simulations

  • Anhua Liu,
  • Demin Xu,
  • Michael Henke,
  • Yue Zhang,
  • Yiming Li,
  • Xingan Liu and
  • Tianlai Li

14 February 2022

With the continuous use of resources, solar energy is expected to be the most used sustainable energy. To improve the solar energy efficiency in Chinese Solar Greenhouses (CSG), the effect of CSG orientation on intercepted solar radiation was systema...

  • Article
  • Open Access
42 Citations
6,671 Views
20 Pages

27 January 2022

This study involves the modeling of rheological behavior of the gum solution obtained from cold-pressed chia seed (CSG), flaxseed (FSG), and rocket seed (RSG) oil by-products and the application of these gums in a low-fat vegan mayonnaise formulation...

  • Article
  • Open Access
5 Citations
5,921 Views
13 Pages

The majority of Australia’s coal seam gas (CSG) reserves are in Queensland, where the industry has expanded rapidly in recent years. Despite concerns, health data have not been examined alongside CSG development. This study examined hospitalisation r...

  • Article
  • Open Access
10 Citations
2,771 Views
9 Pages

21 November 2021

Cemented sand and gravel (CSG) material is a new type of dam material developed on the basis of roller compacted concrete, hardfill, and ultra-poor cementing materials. Its main feature is a wide range of sources of aggregate (aggregate is not screen...

  • Article
  • Open Access
1 Citations
1,994 Views
16 Pages

Identification and Functional Analysis of E3 Ubiquitin Ligase g2e3 in Chinese Tongue Sole, Cynoglossus semilaevis

  • Zhongkai Cui,
  • Jun Luo,
  • Fangzhou Cheng,
  • Wenteng Xu,
  • Jialin Wang,
  • Mengjiao Lin,
  • Yuqi Sun and
  • Songlin Chen

5 September 2024

Gametogenesis, the intricate developmental process responsible for the generation of germ cells (gametes), serves as a fundamental prerequisite for the perpetuation of the reproductive cycle across diverse organisms. The g2e3 enzyme is a putative ubi...

  • Review
  • Open Access
48 Citations
8,876 Views
20 Pages

29 August 2019

The California serogroup (CSG) comprises 18 serologically and genetically related mosquito-borne orthobunyaviruses. Of these viruses, at least seven have been shown to cause neurological disease in humans, including the leading cause of pediatric arb...

  • Article
  • Open Access
19 Citations
3,570 Views
19 Pages

19 September 2021

Most greenhouses in the Canadian Prairies shut down during the coldest months (November to February) because of the hefty heating cost. Chinese mono-slope solar greenhouses do not primarily rely on supplemental heating; instead, they mostly rely on s...

  • Article
  • Open Access
14 Citations
3,673 Views
23 Pages

Simulation of Thermal Performance in a Typical Chinese Solar Greenhouse

  • Jian Ma,
  • Xuejing Du,
  • Sida Meng,
  • Juanjuan Ding,
  • Xuan Gu,
  • Yuxue Zhang,
  • Tianlai Li and
  • Rui Wang

21 September 2022

A Chinese solar greenhouse (CSG) is used as a horticultural facility that provides high efficiency thermal storage performance to produce vegetables in winter. Quantifying the thermal performance of the surrounding structure including the back roof,...

  • Feature Paper
  • Review
  • Open Access
10 Citations
2,697 Views
29 Pages

26 September 2023

A Chinese solar greenhouse (CSG) is an agricultural facility type with Chinese characteristics. It can effectively utilize solar energy during low-temperature seasons in alpine regions. The low construction and operation costs make it a main facility...

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