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Diagnostics, Volume 15, Issue 24

2025 December-2 - 157 articles

Cover Story: Malignant transformation of bone lesions, though uncommon, poses significant diagnostic challenges in musculoskeletal imaging. Benign tumors, non-tumorous conditions, and low-grade malignancies may progress to malignant transformation or dedifferentiation through diverse genetic and molecular pathways. This review highlights key imaging red flags—such as cortical destruction, loss of internal matrix, heterogeneous enhancement, and soft tissue extension—that warrant further pathologic evaluation. By integrating radiologic findings with histopathologic mechanisms and clinical risk factors, this article emphasizes the importance of imaging–pathology correlation in the early detection of malignant transformation of bone lesions and improved decision-making in orthopedic oncology. View this paper
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Articles (157)

  • Case Report
  • Open Access
418 Views
21 Pages

Functional and Hemodynamic Restoration After Microsurgical Resection of Compact High-Flow Temporo-Parieto-Occipital Arteriovenous Malformation

  • Adrian Tulin,
  • Cosmin Pantu,
  • Alexandru Breazu,
  • Octavian Munteanu,
  • Mugurel Petrinel Rădoi,
  • Catalina-Ioana Tataru,
  • Nicolaie Dobrin,
  • Alexandru Vlad Ciurea and
  • Adrian Vasile Dumitru

18 December 2025

Background/Objectives: Arteriovenous malformations (AVMs) in the dominant temporo-parieto-occipital (TPO) junction of the brain are extremely rare and very difficult to remove surgically because this area includes multiple sensory and language networ...

  • Article
  • Open Access
576 Views
16 Pages

Shape-Sensing Robotic-Assisted Bronchoscopic Microwave Ablation for Primary and Metastatic Pulmonary Nodules: Retrospective Case Series

  • Liqin Xu,
  • Russell Miller,
  • Mitchell Zhao,
  • Grace Lin,
  • Wenduo Gu,
  • Niral Patel,
  • Keriann Van Nostrand,
  • Jorge A. Munoz Pineda,
  • Bryce Duchman and
  • George Cheng
  • + 1 author

18 December 2025

Background: Bronchoscopic thermal ablation has emerged as a minimally invasive therapeutic option for managing pulmonary nodules in patients unsuitable for surgery or radiotherapy. Robotic-assisted bronchoscopy (RAB) offers enhanced stability and pre...

  • Systematic Review
  • Open Access
621 Views
32 Pages

The Application and Performance of Artificial Intelligence (AI) Models in the Diagnosis, Classification, and Prediction of Periodontal Diseases: A Systematic Review

  • Mohammed Jafer,
  • Wael Ibraheem,
  • Tazeen Dawood,
  • Ali Abbas,
  • Khalid Hakami,
  • Turki Khurayzi,
  • Abdullah J. Hakami,
  • Shahd Alqahtani,
  • Mubarak Aldosari and
  • Prabhadevi C. Maganur
  • + 3 authors

18 December 2025

Background/Objectives: Artificial intelligence is revolutionizing healthcare across multiple areas, and periodontology is no exception to this emerging trend. This systematic study sought to rigorously assess the applicability and efficacy of artific...

  • Article
  • Open Access
446 Views
30 Pages

18 December 2025

Background/Objectives: Skin cancer is one of the most common diseases in the world, whose early and accurate detection can have a survival rate more than 90% while the chance of mortality is almost 80% in case of late diagnostics. Methods: A modified...

  • Article
  • Open Access
420 Views
33 Pages

Characteristics of the Fatty Acid Composition in Elderly Patients with Occupational Pathology from Organophosphate Exposure

  • Nikolay V. Goncharov,
  • Elena I. Savelieva,
  • Tatiana A. Koneva,
  • Lyudmila K. Gustyleva,
  • Irina A. Vasilieva,
  • Mikhail V. Belyakov,
  • Natalia G. Voitenko,
  • Daria A. Belinskaia,
  • Ekaterina A. Korf and
  • Richard O. Jenkins

18 December 2025

Background/Objectives: The delayed effects of organophosphate poisoning may manifest years after exposure, often masked by age-related diseases. The aim of this retrospective cohort study was to identify the biochemical “trace” that could...

  • Article
  • Open Access
1,295 Views
20 Pages

Longitudinal Monitoring of Brain Volume Changes After COVID-19 Infection Using Artificial Intelligence-Based MRI Volumetry

  • Zeynep Bendella,
  • Catherine Nichols Widmann,
  • Christine Kindler,
  • Robert Haase,
  • Malte Sauer,
  • Michael T. Heneka,
  • Alexander Radbruch and
  • Frederic Carsten Schmeel

18 December 2025

Background/Objectives: SARS-CoV-2 infection has been linked to long-term neurological sequelae and structural brain alterations. Previous analyses, including baseline results from the COVIMMUNE-Clin study, showed brain volume reductions in COVID-19 p...

  • Article
  • Open Access
448 Views
15 Pages

A Pre-Trained Model Customization Framework for Accelerated PET/MR Segmentation of Abdominal Fat in Obstructive Sleep Apnea

  • Valentin Fauveau,
  • Heli Patel,
  • Jennifer Prevot,
  • Bolong Xu,
  • Oren Cohen,
  • Samira Khan,
  • Philip M. Robson,
  • Zahi A. Fayad,
  • Christoph Lippert and
  • Vaishnavi Kundel
  • + 2 authors

18 December 2025

Background: Accurate quantification of visceral (VAT) and subcutaneous adipose tissue (SAT) is critical for understanding the cardiometabolic consequences of obstructive sleep apnea (OSA) and other chronic diseases. This study validates a customizati...

  • Article
  • Open Access
315 Views
21 Pages

Metabolomics of Prostate Cancer and Clinical Profiles Following Radiotherapy: Need for a Precision Phylometabolomics Approach

  • Hakima Amri,
  • Charles Sturgeon,
  • David Posawatz,
  • Mones Abu-Asab,
  • Ryan R. Collins,
  • Simeng Suy and
  • Sean P. Collins

18 December 2025

Introduction: Metabolomics-based phylogenetic profiling of prostate cancer (PCa) patients before and after stereotactic body radiation therapy (SBRT) can provide insight into the way in which treatment outcomes relate to the underlying physiology and...

  • Article
  • Open Access
346 Views
22 Pages

18 December 2025

Background/Objectives: Autism Spectrum Disorder (ASD) is a multifaceted neuropsychiatric condition characterized by early behavioral irregularities that often precede formal diagnosis. Timely and precise detection remains a major clinical challenge d...

  • Article
  • Open Access
277 Views
20 Pages

Pericardial Fat Radiomics to Predict Left Ventricular Involvement and Provide Incremental Prognostic Value in ARVC

  • Mengqi Guo,
  • Jinyu Zheng,
  • Weihui Xie,
  • Binghua Chen,
  • Dongaolei An,
  • Ruoyang Shi,
  • Jinyi Xiang and
  • Lianming Wu

18 December 2025

Background/Objectives: To explore the predictive value of pericardial fat tissue (PFT) radiomics for left ventricular (LV) involvement and major adverse cardiac events (MACE) in arrhythmogenic right ventricular cardiomyopathy (ARVC). Methods: In this...

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Diagnostics - ISSN 2075-4418