Applications of PET/CT in Clinical Diagnostics
A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".
Deadline for manuscript submissions: 1 May 2025 | Viewed by 237
Special Issue Editors
Interests: F-18; fluorodeoxyglucose; PET/CT imaging; oncology; radiotracers beyond F-18 fluorodeoxyglucose; clinical diagnostics
Special Issue Information
Dear Colleagues,
Positron emission tomography/computed tomography (PET/CT), a fused imaging tool, efficiently combines functional (metabolic) and anatomical (morphologic) information simultaneously. The most frequently used radiotracer for PET/CT imaging is deoxy-2-[18 F] fluoro-D-glucose (F-18 FDG), a glucose analog with a fluorine isotope (F-18) replacing the hydroxyl group. This radiotracer shows increased uptake in tumor cells due to increased anaerobic glycolysis (Warburg effect). The F-18 FDG PET/CT, with its unique ability to highlight tumor cells, plays a pivotal role in clinical diagnostics in oncology. It is a milestone of neoplasm diagnostic algorithms for detection, staging, treatment response evaluation, restaging, and prognosis.
In addition to PET CT using 18-F FDG, which is the workhorse in day-to-day practice, multiple other tracers have been developed and are used routinely. A few examples of these tracers are F-18 Fluoroestradiol (FES) which is used to image ER +ve breast cancer, Ga-68 DOTANOC/DOTATOC, used to image SSTR receptors, Ga-68/F-18 PSMA used in prostate cancer, and the most recent example, -68 FAPI, which images the tumour microenvironment. Unlike 18-F FDG, which looks into the glucose utilisation in various tumours, each of these above-mentioned radiopharmaceuticals look into the specific aspects in various tumours and can be used in detection, staging, response evaluation, restaging and prognostication.
Prof. Dr. Jasna M. Mihailovic
Dr. Partha S Choudhury
Guest Editors
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Keywords
- F-18
- fluorodeoxyglucose
- PET/CT imaging
- oncology
- radiotracers beyond F-18 fluorodeoxyglucose
- clinical diagnostics
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