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Diagnostics
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Advances in Eye Imaging
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Advances in Eye Imaging

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: 30 May 2025 | Viewed by 2441

Special Issue Editor

Dr. Antonio Ferreras

E-Mail Website
Guest Editor
Department of Ophthalmology, Miguel Servet University Hospital, 50009 Zaragoza, Spain
Interests: eye
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, different imaging techniques have been adopted as part of the usual examinations in ophthalmology. Optical coherence tomography is one of them, playing a key role in the diagnosis and follow-up of many ocular diseases. Imaging devices are frequently enhanced, providing higher resolution and quality scans obtained from evaluated tissues. Consequently, the assessment of the structures of the eye has become more accurate over time.

Additionally, the upgrades introduced in the built-in analysis tools make it easy to make decisions in real practice. Most clinical guidelines include the outcomes of these tools in the algorithms for the management of eye disorders affecting the anterior pole, retina, or optic nerve head.

We encourage authors to submit manuscripts related to this topic to increase the current knowledge on the anatomy of the eye, the physiopathology of eye diseases, and clinical studies based on imaging technologies.

Dr. Antonio Ferreras
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

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15 pages, 951 KiB  
Article
Utilizing Shear Wave Elastography for the Evaluation of Ocular Involvement in Systemic Sclerosis
by Mehmet Kök, Ayşe Ayan, Mehmet Emin Arayici and Sinan Ülgen
Diagnostics 2025, 15(10), 1227; https://doi.org/10.3390/diagnostics15101227 - 13 May 2025
Viewed by 178
Abstract
Background: Several imaging studies have confirmed ocular involvement in systemic sclerosis (SSc). However, elastography has not yet been used for this purpose in the literature. Thus, this study aimed to evaluate ocular involvement in SSc using shear wave elastography (SWE). Methods: This study [...] Read more.
Background: Several imaging studies have confirmed ocular involvement in systemic sclerosis (SSc). However, elastography has not yet been used for this purpose in the literature. Thus, this study aimed to evaluate ocular involvement in SSc using shear wave elastography (SWE). Methods: This study included 29 SSc patients and 30 age- and sex-matched healthy controls. All participants underwent independent ophthalmological evaluations by two ophthalmologists. Subsequently, SWE was used to evaluate the retina–choroid–sclera (RCS), optic disc (OD), optic nerve (ON), and retrobulbar adipose tissue (RBFT) of the right eye. The median shear wave elasticity (kPa) and velocity (m/s) values were automatically calculated using the ultrasound device’s integrated software. Results: The elasticity and velocity values of RBFT in SSc patients were significantly higher than those in the control group. However, no notable differences were observed in other analyzed areas. A strong association was found between digital ulcers and velocity values of the RCS, while no significant differences were noted for other parameters. Conclusions: This study revealed increased stiffness in the RBFT of SSc patients. To our knowledge, this is the first evidence suggesting that SSc can affect RBFT. Further studies are required to confirm this finding and investigate its link to the disease. Additionally, we found a strong association between digital ulcers and increased RCS stiffness. Using SWE for the first time, we have demonstrated that microcirculatory disruption in SSc extends beyond the skin and can affect multiple tissues simultaneously. Full article
(This article belongs to the Special Issue Advances in Eye Imaging)
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Review

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20 pages, 325 KiB  
Review
The Perspective of Using Optical Coherence Tomography in Ophthalmology: Present and Future Applications
by Mario A. Vasilescu and Mioara L. Macovei
Diagnostics 2025, 15(4), 402; https://doi.org/10.3390/diagnostics15040402 - 7 Feb 2025
Cited by 1 | Viewed by 933
Abstract
Optical coherence tomography (OCT) imaging plays a major role in the field of diagnosing, monitoring, and treating ophthalmological diseases. Since its introduction in the early 1990s, OCT technology has continued to advance both in the direction of acquisition quality and technique. In this [...] Read more.
Optical coherence tomography (OCT) imaging plays a major role in the field of diagnosing, monitoring, and treating ophthalmological diseases. Since its introduction in the early 1990s, OCT technology has continued to advance both in the direction of acquisition quality and technique. In this manuscript, we concentrate on actual and future applications of OCT in the ophthalmology field, reviewing multiple types of OCT techniques and systems, such as visible-light OCT, adaptative optics OCT, intraoperative OCT, wide-field OCT, and more. All of them allow better monitoring of ocular diseases, earlier and broader diagnosis, and a more suitable treatment. Furthermore, overviewing all these technologies could play a pivotal role in research, leading to an advance in understanding the pathophysiology of targeted diseases. Finally, the aim of the present review was to evaluate the technical advances in OCT and their actual and potential clinical applications. Full article
(This article belongs to the Special Issue Advances in Eye Imaging)
13 pages, 1453 KiB  
Review
The Value of MRI and Radiomics for the Diagnostic Evaluation of Thyroid-Associated Ophthalmopathy
by Weiyi Zhou, Yan Song, Jufeng Shi and Tuo Li
Diagnostics 2025, 15(3), 388; https://doi.org/10.3390/diagnostics15030388 - 6 Feb 2025
Viewed by 758
Abstract
Thyroid-associated ophthalmopathy (TAO) is a vision-threatening autoimmune disease that involves the extraocular muscles (EOMs) and periorbital fat. Typical signs of TAO include eyelid recession, proptosis, diplopia, and decreased visual acuity. As a self-limited disease, there is major bipolarity in clinical outcomes in TAO [...] Read more.
Thyroid-associated ophthalmopathy (TAO) is a vision-threatening autoimmune disease that involves the extraocular muscles (EOMs) and periorbital fat. Typical signs of TAO include eyelid recession, proptosis, diplopia, and decreased visual acuity. As a self-limited disease, there is major bipolarity in clinical outcomes in TAO population. The early diagnosis and prediction of these refractory and relapsed patients is essential. Unfortunately, commonly used tools such as CAS/NOSPECTS, are based on clinical symptoms and signs alone, have significant limitations. Some imaging techniques or examinations, such as magnetic resonance imaging (MRI), can be very effective in assisting TAO assessment, from exhaustive whiteboard notes to optimized patient outcomes. Being one of the most commonly used and accurate objective examinations for TAO assessment, MRI boosts no ionizing radiation, high soft tissue contrast, better reflection of tissue water content, and the ability to quantify multiple parameters. In addition, novel MR sequences are becoming increasingly more familiar in TAO and other areas of clinical and scientific research. Moreover, radiomics, a method involving the extraction of a large number of features from medical images through algorithms, is a more recent approach used in the analysis and characterization of TAO data. Thus, this review aims to summarize and compare the value of routine and novel functional MRI sequences and radiomics prediction models in the diagnosis and evaluation of TAO. Full article
(This article belongs to the Special Issue Advances in Eye Imaging)
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