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  • Article
  • Open Access
Diagnostics2025, 15(21), 2685;https://doi.org/10.3390/diagnostics15212685 
(registering DOI)

23 October 2025

Objective: This study aimed to evaluate the diagnostic value of logistic regression and nomogram models based on multimodal ultrasound in predicting sarcopenia in patients with peritoneal dialysis (PD). Methods: A total of 178 patients with PD admitt...

  • Article
  • Open Access

Intratumoral SPP1+BCL2A1+ Tumor-Associated Macrophages Predict Poor Response to PD1 Blockade

  • Chun-Hao Lai,
  • Yu-Ping Hung,
  • Po-Chun Tseng,
  • Rahmat Dani Satria and
  • Chiou-Feng Lin
Diagnostics2025, 15(21), 2680;https://doi.org/10.3390/diagnostics15212680 
(registering DOI)

23 October 2025

Background/Objectives: Immune checkpoint blockade (ICB) has emerged as a promising therapeutic option for hepatocellular carcinoma (HCC), yet reliable biomarkers to predict clinical outcomes remain limited. Tumor-associated macrophages (TAMs) are inc...

  • Interesting Images
  • Open Access

A Multi-Modality Approach to the Assessment of a Right Atrium Mass in a Female Patient with Breast Cancer Undergoing Neoadjuvant Chemotherapy

  • Małgorzata Chlabicz,
  • Paweł Muszyński,
  • Joanna Kruszyńska,
  • Piotr Kazberuk,
  • Magdalena Róg-Makal,
  • Magdalena Lipowicz,
  • Urszula Matys,
  • Anna Tomaszuk-Kazberuk,
  • Marcin Kożuch and
  • Sławomir Dobrzycki
Diagnostics2025, 15(21), 2683;https://doi.org/10.3390/diagnostics15212683 
(registering DOI)

23 October 2025

Echocardiography remains a vital part of the initial assessment and monitoring of oncological patients. It allows for proper treatment selection but can also reveal life-threatening complications, including impaired left ventricular function or throm...

  • Systematic Review
  • Open Access

Efficacy of Percutaneous Vertebroplasty Versus Placebo and Conservative Treatment in Osteoporotic Vertebral Fractures: An Updated Systematic Review and Meta-Analysis of Randomized Clinical Trials

  • Antonio Jesús Láinez Ramos-Bossini,
  • Francisco Garrido Sanz,
  • Marina Gea Becerra,
  • Consolación Melguizo Alonso,
  • José Prados,
  • Fernando Ruiz Santiago and
  • José Manuel Benítez
Diagnostics2025, 15(21), 2684;https://doi.org/10.3390/diagnostics15212684 
(registering DOI)

23 October 2025

Introduction: The efficacy of percutaneous vertebroplasty (PV) versus placebo and conservative treatment (CT) in patients with osteoporotic vertebral fractures (OVFs) has been debated in recent years. The aim of this study was to conduct an updated s...

  • Article
  • Open Access

Diagnostic Performance of the Triglyceride-Glucose Index in Screening for Gestational Diabetes Mellitus at 24–28 Weeks of Gestation

  • Saliha Sağnıç,
  • Tuğba Gül Yılmaz,
  • Addule Serhanoğlu Seçen,
  • Mustafa Bağcı,
  • Selin Güney,
  • Mert Cenker Güney and
  • Ayşegül Atalay
Diagnostics2025, 15(21), 2682;https://doi.org/10.3390/diagnostics15212682 
(registering DOI)

23 October 2025

Background/Objectives: The objective of this study was to assess the diagnostic accuracy of the Triglyceride-Glucose (TyG) index for screening gestational diabetes mellitus (GDM) at 24–28 weeks of gestation, to determine its optimal diagnostic...

  • Article
  • Open Access

Placental Pathological Findings and Clinical Outcomes in Triplet Pregnancies Conceived via Oocyte Donation and Non-Oocyte Donation: A Case–Control Study

  • Eva Manuela Pena-Burgos,
  • Maria De la Calle,
  • Jose Juan Pozo-Kreilinger,
  • Cecilia García-Díaz and
  • Rita María Regojo-Zapata
Diagnostics2025, 15(21), 2681;https://doi.org/10.3390/diagnostics15212681 
(registering DOI)

23 October 2025

Objective: This study aimed to assess whether oocyte donation in triplet pregnancies is associated with increased risk of placental abnormalities and pregnancy complications compared to triplet pregnancies conceived through assisted reproductive tech...

  • Article
  • Open Access

Spatial Distribution of Senescent Cells and Their Proximity to Immune Subsets in the Human Endometrium During the Implantation Window

  • Dimitar Parvanov,
  • Rumiana Ganeva,
  • Margarita Ruseva,
  • Maria Handzhiyska,
  • Jinahn Safir,
  • Lachezar Jelezarsky,
  • Nina Vidolova,
  • Dimitar Metodiev,
  • Georgi Stamenov and
  • Savina Hadjidekova
Diagnostics2025, 15(21), 2679;https://doi.org/10.3390/diagnostics15212679 
(registering DOI)

23 October 2025

Background/Objectives: Senescent cells contribute to endometrial remodeling during the implantation window, but their spatial organization within the stroma remains poorly understood. This study aimed to characterize the distribution of senescent (p1...

  • Article
  • Open Access
Diagnostics2025, 15(21), 2676;https://doi.org/10.3390/diagnostics15212676 
(registering DOI)

23 October 2025

Background/Objectives: Transferrin is a multi-task protein commonly known for binding iron; however, it is involved in multiple crucial processes, including antimicrobial activity, the growth of different cell types, differentiation, chemotaxis, the...

  • Case Report
  • Open Access
Diagnostics2025, 15(21), 2678;https://doi.org/10.3390/diagnostics15212678 
(registering DOI)

23 October 2025

Background and Clinical Significance: Tandem pathology at the dominant-hemisphere middle cerebral artery (MCA)—combining a wide-neck bifurcation aneurysm that shares the neck with both M2 origins and a short dorsal M1 fusiform dilation embedded...

  • Article
  • Open Access
Diagnostics2025, 15(21), 2677;https://doi.org/10.3390/diagnostics15212677 
(registering DOI)

23 October 2025

Background/Objectives: This study investigated clinical value of galectin-9 (Gal-9), a soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), and soluble CD25 (sCD25) among critically ill patients with organ failure in the emergency depa...

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Diagnostics - ISSN 2075-4418Creative Common CC BY license