200 Results Found

Nerve injury is a feared complication of peripheral nerve blockade. The aim of this study was to test the effectiveness of a triple monitoring (TM), i.e., a combination of ultrasound (US), nerve stimulation (NS) and opening injection pressure (OIP) d...

Injectable hydrogels have attracted growing interests as promising biomaterials for clinical applications, due to their minimum invasive implanting approach and easy-handling performance. Nevertheless, natural biomaterials-based injectable hydrogels...

Wet ethanol is a biofuel that can be rapidly integrated into the existing transportation sector infrastructure and have an immediate impact on decarbonization. Compared to conventional hydrocarbon fuels, wet ethanol has unique fuel properties (e.g.,...

Thin films and coatings which have a high demand in a variety of industries—such as manufacturing, optics, and photonics—need regular improvement to sustain industrial productivity. Thus, the present work examined the problem of the Carre...

Purpose: To prospectively compare the efficacy and safety of intra-articular injections of platelet-rich plasma (PRP) with hyaluronic acid (HA) and glucocorticosteroid (CS) control groups for knee osteoarthritis (KOA) in a randomized, triple-parallel...

Background: Femoral neck fractures are effectively treated with bipolar hemiarthroplasty (BHA) surgery, yet postoperative pain management remains a challenge. This study explores the efficacy of multimodal pain management in minimizing opioid use and...

Introduction: Knee osteoarthritis (OA) is defined by articular cartilage loss, increased discomfort, and functional restrictions. Changes in lifestyle, painkillers, intra-articular injections, and, as a last resort, surgery are all part of clinical t...

In injection molding, cooling channels are usually manufactured with a straight shape, and thus have low cooling efficiency for a curved mold. Recently, additive manufacturing (AM) was used to fabricate conformal cooling channels that could maintain...

The paper presents a new design of a triple hook-shaped conformal cooling channels for application in optical parts of great thickness, deep cores, and high dimensional and optical requirements. In these cases, the small dimensions of the core and th...

Purpose: Acute submacular hemorrhage (SMH) is a vision-threatening complication common in patients affected by age-related macular degeneration (AMD). This study evaluates safety, long-term clinical outcomes and associated treatment factors following...

In this study, to reduce the amount of pollutant PAH and soot in the flame, we examined the burner system equipped with a center air injection. For this purpose, by using PAH-LIF and soot LII, we evaluated relative PAH and soot amounts in both the tr...

This study aimed to investigate the transduction efficiency of triple adeno-associated virus (AAV) vectors in the cochleae of adult mice, focusing on large-gene-associated hearing loss (HL). Additionally, we sought to evaluate the feasibility of coch...

In this case series, we describe a novel ultrasound (US)-guided cervical interlaminar epidural steroid injections (CILESIs) procedure that does not depend on the loss-of-resistance method for epidural space identification. A needle is introduced into...

Locating undiagnosed HIV infections is important for limiting transmission. However, there is limited evidence about how best to do so. In South Africa, men have been particularly challenging to reach for HIV testing due, in part, to stigma. We pilot...

Due to transistor shrinking, intermittent faults are a major concern in current digital systems. This work presents an adaptive fault tolerance mechanism based on error correction codes (ECC), able to modify its behavior when the error conditions cha...

In a triple-hole system comprising a primary hole and two sister holes, when the sister holes are positioned slightly downstream of the main hole under steady flow conditions, their jets generate an anti-counter-rotating vortex pair. Vortex interacti...

Gas and downhole water sink-assisted gravity drainage (GDWS-AGD) is a new process of enhanced oil recovery (EOR) in oil reservoirs underlain by large bottom aquifers. The process is capital intensive as it requires the construction of dual-completed...

Intratumoral human epidermal growth factor receptor 2 (HER2) heterogeneity has been reported in 16–36% of HER2-positive breast cancer and its clinical impact is under discussion. We examined the biological effects of HER2-heterogeneity on mouse...

Targeted magnetic resonance imaging (MRI) contrast agents offer platforms for the specific detection of many diseases, including cancer. This study explores the applicability of luteinizing hormone-releasing hormone-conjugated PEG-coated magnetite na...

This study focuses on an analysis of the spray behavior, combustion, and emission characteristics of jet propellant-5 (JP-5) and biodiesel fuels with single-injection timing and multiple split injection strategies in a common rail direct injection (C...

We previously reported an artificial collagen gel that can be used as a cell-culture substrate by end-to-end cross-linking of collagen-like triple-helical peptides via disulfide bonds. However, the gel had to be formed a priori by polymerizing the pe...

Metabolomics based on two-dimensional gas chromatography coupled with mass spectrometry is making high demands on accuracy at all stages of sample preparation, up to the storage and injection into the analytical system. In high sample flow conditions...

Although medicinal mushroom extracts have been proposed as promising anti-cancer agents, their precise impacts on metastatic breast cancer are still to be clarified. For this purpose, the present study exploited the effect of a novel medicinal mushro...

Infectious bovine rhinotracheitis (IBR), caused by bovine alphaherpesvirus 1 (BoHV-1), is an important disease affecting cattle worldwide resulting in great economic losses. Marker vaccines are effective in controlling infectious diseases including I...

Direct-injection in spark-ignition engines has long been recognized as a valid option for improving fuel economy, reducing CO₂ emissions and avoiding knock occurrence due to higher flexibility in control strategies. However, problems associated with...

Gene therapy for hemophilia B offers the advantage of a single administration with sustained therapeutic effects. This study evaluated the systemic safety, efficacy, biodistribution, and immunogenicity of AAV8-FIX-TripleL, a recombinant adeno-associa...

Intramedullary spinal cord tumors are a rare and understudied cancer with poor treatment options and prognosis. Our prior study used a combination of PDGF-B, HRAS, and p53 knockdown to induce the development of high-grade glioma in the spinal cords o...

Practice shows that CO₂/N₂-ECBM is an effective technology to enhance coalbed methane. However, there are few field tests in which the technology is applied to enhance the gas drainage in underground coal mines, and the effect is uncertain. In this s...

Current intra-articular therapies with hyaluronic acid (HA) provide symptomatic relief in joint diseases, but have limited efficacy in counteracting oxidative stress and inflammation, key drivers of cartilage degradation in rheumatoid arthritis (RA)....

A triple negative breast cancer model using the murine 4T1 tumor cell line was used to explore the efficacy of an adjuvanted survivin peptide microparticle vaccine using tumor growth as the outcome metric. We first performed tumor cell dose titration...

This paper presents a numerical investigation of the ignition and combustion process of a primary reference fuel in a partially premixed light-duty internal combustion (PPC) engine. Partially pre-mixed combustion is achieved by employing a multiple i...

Conflict resolution for knowledge graphs (KGs) is a critical technique in knowledge fusion, ensuring the resolution of conflicts between existing KGs and external knowledge while maintaining post-fusion accuracy. However, current approaches often enc...

Communication systems that work in jeopardized environments such as space are affected by soft errors that can cause malfunctions in the behavior of the circuits such as, for example, single event upsets (SEUs) or multiple bit upsets (MBUs). In order...

Previous studies have shown that volatile organic compounds (VOCs) are potential biomarkers of breast cancer. An unanswered question is how urinary VOCs change over time as tumors progress. To explore this, BALB/c mice were injected with 4T1.2 triple...

To satisfy the increasing demands for more word-line (WL) layers, the dual-deck even triple-deck architecture has emerged in 3D NAND Flash. However, the new reliability issues that occurred at the joint region of two decks became a severe challenge f...

In fully developed turbulence, there is a flux of energy from large to small scales in the inertial range until the dissipation at small scales. It is associated with irreversibility, i.e., a breaking of the time reversal symmetry. Such turbulent flo...

IL-1α is a dual function cytokine that affects inflammatory and immune responses and plays a pivotal role in cancer. The effects of intracellular IL-1α on the development of triple negative breast cancer (TNBC) in mice were assessed using...

This study examines the process of using injection moulding to join two different materials to manufacture bi-component moulded products with improved performance characteristics. The two-component process, which combines the advantages of two differ...

This study investigated the effect of adding two sister holes placed downstream the main hole on film cooling by employing large eddy simulation. Here, film-cooling flow fields from a triple-hole system inclined by 35° to a flat plate at blowing...

We investigated the growth of vertically coupled In_0.75Ga_0.25As quantum dots (QDs) by varying the GaAs spacer thickness (d). Vertically-aligned triple-layer QDs of uniform size and highest accumulated strain are formed with d = 5 nm. The electrolumin...

This paper proposes a single-phase, transformer-less, seven-level inverter that utilizes eight switches, three capacitors, and two diodes to produce seven voltage levels with triple boosting ability. The availability of the common-ground point elimin...

Breast cancer (BC) brain metastases (BCBM) is a severe condition frequently occurring in the triple-negative subtype. The study of BCBM pathogenesis and treatment has been hampered by the difficulty in establishing a reliable animal model that faithf...

Dual adhesives are mainly used to increase the strength of single lap joints (SLJs) by reducing the stress concentration at its ends. However, they can also be used to design the characteristics of the joint so that its operation and failure occur in...

Thick-lipped grey mullet (Chelon labrosus) has important characteristics that make it a promising candidate species for diversifying Mediterranean aquaculture. However, spontaneous spawning in captivity has not been documented, mainly due to failure...

Single Event Upsets (SEUs) are most likely to cause bit flips within the trained parameters of a convolutional neural network (CNN). Therefore, it is crucial to analyze and implement hardening techniques to enhance their reliability under radiation....

Windows in new buildings in Korea are equipped with double or triple glazing, a low-E coating, and gas injection between the panes of glass, in accordance with the regulations for the reinforced insulation of windows. However, these windows have cert...

Pancreatic Cancer (PC) is recognized as a highly thrombogenic tumor; thus, low-molecular-weight heparin (LMWH) such as tinzaparin is routinely used for PC patients. On the basis of combinatorial therapy approaches to treat highly malignant and refrac...

The urokinase plasminogen activator and its receptor (uPA/uPAR) are biomarkers for metastasis, especially in triple-negative breast cancer. We prepared anti-mitotic N-alkylisatin (N-AI)-loaded liposomes functionalized with the uPA/uPAR targeting liga...

Inflammatory breast cancer (IBC) is highly metastatic at the onset of the disease with no IBC-specific treatments, resulting in dismal patient survival. IBC treatment is a clear unmet clinical need. This commentary highlights findings from a recent s...

Triple-negative breast cancer (TNBC) accounts for approximately 10–15% of all breast cancer cases and is characterized by high invasiveness, high metastatic potential, relapse proneness, and poor prognosis. M2-like tumor-associated macrophages...