3,728 Results Found

Even though validation is an important concept in safety research, there is comparatively little empirical research on validating specific safety assessment, assurance, and ensurance activities. Focusing on model-based safety analysis, scant work exi...

Taekwondo is a martial art and combat sport that originated in medieval or similar cultures, but today it is primarily a combat activity conditioned by safety rules. The kick technique is called “chagi” (Korean language). “Eyeballin...

During COVID19 pandemic, SARS-CoV-2 rapid antigen tests (RATs) were marketed with minimal or no performance data. We aimed at closing this gap by determining technical sensitivities and specificities of 30 RATs prior to market release. We developed a...

Neurological disorders such as Parkinson’s and Alzheimer’s diseases often involve overlapping motor and cognitive impairments that motivate integrated rehabilitation approaches. This study presents the technical validation of a dual-modal...

Innovative Model-Based Systems Engineering (MBSE) applies function-oriented hierarchical system architecture and utilizes Systems Modeling Language (SysML) for virtual testing. However, for complex systems, the relevant virtual tests are scattered at...

For years, combining the immutability associated with blockchain technology with the European Union’s General Data Protection Regulation (GDPR) has been considered a practically unsolvable conflict due to the very nature of blockchain and the G...

Artificial intelligence (AI) is increasingly positioned as a transformative force in healthcare. The translation of AI from technical validation to real-world clinical impact remains a critical challenge. This systematic review aims to synthesize the...

The biochemical measurement of the CoQ status in different tissues can be performed using HPLC with electrochemical detection (ED). Because the production of the electrochemical cells used with the Coulochem series detectors was discontinued, we aime...

Background: A variety of techniques for measuring lower limb loading exists, each with their own limitations. A new ambulatory biofeedback system was developed to overcome these limitations. In this study, we described the technical aspects and valid...

The ratio of amyloid precursor protein (APP)_669–711 (Aβ_−3–40)/Aβ_1–42 in blood plasma was reported to represent a novel Alzheimer’s disease biomarker. Here, we describe the characterization of two antibodies aga...

Aims: To date, precision medicine has played a pivotal role in the clinical administration of solid-tumor patients. In this scenario, a rapidly increasing number of predictive biomarkers have been approved in diagnostic practice or are currently bein...

In this work, we propose the first study of a technical validation of an assistive robotic platform, which has been designed to assist people with neurodevelopmental disorders. The platform is called LOLA2 and it is equipped with an artificial intell...

Numerous studies have sought to demonstrate the utility of digital measures of motor function in Parkinson’s disease. Frameworks, such as V3, document digital measure development: technical verification, analytical and clinical validation. We p...

Comprehensive next-generation sequencing (NGS) assays enable the identification of clinically relevant mutations, enhancing the capability for targeted therapeutic interventions. In addition, genomic alterations driving the oncogenic roadmap and lead...

Across five studies, we present the preliminary technical validation of an infant-wearable platform, LittleBeats™, that integrates electrocardiogram (ECG), inertial measurement unit (IMU), and audio sensors. Each sensor modality is validated ag...

The Ecuadorian electricity sector, until April 2024, presented losses of 15.64% (6.6% technical and 9.04% non-technical), so it is important to detect the areas that potentially sub-register energy in order to reduce Non-Technical Losses (NTLs). The...

Background/Objectives: Assessing non-technical skills (NTSs) in prehospital care is susceptible to rater subjectivity. While Artificial Intelligence (AI) can be used to score conversation transcripts, it emphasizes formal linguistic features, whereas...

There is increasing interest in the development and deployment of digital solutions to improve patient care and facilitate monitoring in medical practice, e.g., by remote observation of disease symptoms in the patients’ home environment. Digital heal...

Current challenges, such as climate change or military conflicts, show the great importance of urban supply infrastructures. In this context, an open question is how different scenarios and crises can be studied in silico to assess the interaction be...

Validation is mandatory to quantify the reliability of remote sensing products (RSPs). However, this process is not straightforward and usually presents formidable challenges in terms of both theory and real-world operations. In this context, a dedic...

Little is known about thyroid diseases in ruminants, probably due to the lack of diagnosis techniques developed in this species. However, thyroid ultrasound (TU) is widely used in human and in companion animal’s medicine. It is a cheap and non-...

Pipeline bridges are structures characterized by their triangular truss designs, which provide support and stability for pipelines. They have been used for centuries to span gaps and are still widely employed today in various forms and applications....

Detecting fraudulent behaviors in electricity consumption is a significant challenge for electric utility companies due to the lack of information and the complexity of both constructing patterns and distinguishing between regular and fraudulent cons...

In pretreatment tumor samples of EGFR-mutated non-small cell lung cancer (NSCLC) patients, EGFR-Thr790Met mutation has been detected in a variable prevalence by different ultrasensitive assays with controversial prognostic value. Furthermore, its det...

Biportal endoscopic spinal surgery (BESS) is a minimally invasive technique that is widely used in human spinal procedures; however, its standardized methodology and anatomical adaptation for veterinary applications have not yet been established. Thi...

It has been demonstrated that needle guidance systems can enhance the precision and safety of ultrasound-guided punctures in human medicine. Systems that permit the utilization of commercially available standard needles, instead of those that necessi...

Imaging biomarkers (IBs) have been proposed in medical literature that exploit images in a quantitative way, going beyond the visual assessment by an imaging physician. These IBs can be used in the diagnosis, prognosis, and response assessment of sev...

Bite force measuring devices that are generally suitable for edentulous patients or patients undergoing mandibular reconstruction are missing. This study assesses the validity of a new bite force measuring device (prototype of loadpad^®, novel Gmb...

Falls are the primary contributors of accidents in elderly people. An important factor of fall severity is the amount of time that people lie on the ground. To minimize consequences through a short reaction time, the motion sensor “AIDE-MOI&rdq...

The rapid pace of invention in technology and the evolution of network communication has produced a new lifestyle with variety of opportunities and challenges. Remotely Piloted Aerial Systems (RPAS) technology, which includes drones, is one example o...

Reaction time and decision-making (DMA) in football have usually been evaluated using edited images or videos of game situations. The purpose of this research is to design and validate a test that simultaneously evaluates execution time (ET) and deci...

This research is aimed at developing a questionnaire for the self-assessment of non-technical skills (NTS) leading to safety in the chemical sector and at analysing the properties of its scales in terms of construct validity. The research involved 26...

Step width is an important clinical motor marker for gait stability assessment. While laboratory-based systems can measure it with high accuracy, wearable solutions based on inertial measurement units do not directly provide spatial information such...

Clinical motion analysis plays an important role in the diagnosis and treatment of mobility-limiting diseases. Within this assessment, relative (point-to-point) tracking of extremities could benefit from increased accuracy. Given the limitations of c...

microcirculation; conjunctiva; jejunum; rectum; pigs

In this study, we compared a monocular computer vision (MCV)-based approach with the golden standard for collecting kinematic data on ski tracks (i.e., video-based stereophotogrammetry) and assessed its deployment readiness for answering applied rese...

Quantitative assessment of parkinsonian tremor based on inertial sensors can provide reliable feedback on the effect of medication. In this regard, the features of parkinsonian tremor and its unique properties such as motor fluctuations and dyskinesi...

In alpine ski racing the relationships between skier kinetics and kinematics and their effect on performance and injury-related aspects are not well understood. There is currently no validated system to determine all external forces simultaneously ac...

The study aimed to explore the sensitivity and specificity of a new methodological approach related to the musical rhythm for discriminating a competitive Cuban dancer’s (CDCs) level. Thirty CDCs (Age 23.87 ± 1.76 years, body mass 60.33...

This paper deals with the occurrence of construction defects, particularly those due to water penetration in buildings. The considered defects mainly originated from improper management of validation checks during the design or execution phases. From...

The assessment of tactical-technical knowledge of football is essential to develop optimal and integral teaching processes for students. Therefore, the aim of this study was to design and validate an instrument so that teachers, coaches, and research...

Translational research is aimed at turning discoveries from basic science into results that advance patient treatment. The translation of technical solutions into clinical use is a complex, iterative process that involves different stages of design,...

Background: The SARS-CoV-2 virus has assumed considerable importance during the COVID-19 pandemic. Its mutation rate is high, involving the spike (S) gene and thus there has been a rapid spread of new variants. Herein, we describe a rapid, easy, adap...

To foster the implementation of Industrial Symbiosis, several support tools have been developed to facilitate the dissemination of Industrial Symbiosis (IS) and the engagement of stakeholders; the establishment of exchanges between companies, the so-...

Wearable technologies for health monitoring have become a reality in the last few years. So far, most research studies have focused on assessments of the technical performance of these systems, as well as the validation of the clinical outcomes. Neve...

Developing the empathy of a technical team for target users has been a practice to innovate solutions centered on the experience they can provide to their users. However, there are few studies focused on the impact of empathy practices on solution de...

One of the technical issues for enabling in situ sensors is to energize them through a battery pack which is often obtrusive and compromises the ecological validity of the system performance. [...]

Demand response and distributed generation are key components of power systems. Several challenges are raised at both technical and business model levels for integration of those resources in smart grids and microgrids. The implementation of a distri...

Human beings must develop many skills to cope with the large amount of challenges that currently exist in the world: media empowerment for an active and democratic citizenship, knowledge acquisition and conversion for lifelong and life-wide learning,...

The TSTOF stands for the time-shift time-of-flight measurement method, which is used to characterize individual dynamic particles—such as droplets in droplet clouds or particles in flows—in various industrial applications. Over the past 1...