During polyomavirus (PyV) infection, host proteins localize to subnuclear domains, termed viral replication centers (VRCs), to mediate viral genome replication. Although the protein composition and spatial organization of VRCs have been described usi...
Human coronavirus 229E (HCoV-229E) is an alpha coronavirus that infects humans and bats. In common with all positive-strand RNA viruses, 229E infection causes rearrangements of the host’s intracellular membranes to form replication organelles,...
Recent years have introduced major shifts in scientific reporting and publishing. The scientific community, publishers, funding agencies, and the public expect research to adhere to principles of openness, reproducibility, replicability, and repeatab...
DNA viruses that replicate in the nucleus encompass a range of ubiquitous and clinically important viruses, from acute pathogens to persistent tumor viruses. These viruses must co-opt nuclear processes for the benefit of the virus, whilst evading hos...
Over the past few years, increasing attention has been given to the health sector and the integration of new technologies into it. Cloud computing and storage clouds have become essentially state of the art solutions for other major areas and have st...
The rapid growth in cloud service demand has led to the establishment of large-scale virtualized data centers in which virtual machines (VMs) are used to handle user requests for service. A user’s request cannot be completed if the VM fails. Replicat...
UL34 is one of the ~50 genes of human cytomegalovirus (HCMV) required for replication in cell culture in human fibroblasts. UL34 encodes highly related early (UL34a) and late (UL34b) proteins that are virtually identical, with the early protein conta...
Explanation of the emergence of primitive cellular structures from a set of chemical reactions is necessary to unveil the origin of life and to experimentally synthesize protocells. By simulating a cellular automaton model with a two-species hypercyc...
Minute Virus of Mice (MVM) is an autonomous parvovirus of the Parvoviridae family that replicates in mouse cells and transformed human cells. MVM genomes localize to cellular sites of DNA damage with the help of their essential non-structural phospho...
The design and management of smart cities and the IoT is a multidimensional problem. One of those dimensions is cloud and edge computing management. Due to the complexity of the problem, resource sharing is one of the vital and major components that...
Viral helicases are conserved nucleic acid-dependent ATPases that drive genome replication, gene expression, and virion assembly, thereby playing a central role in viral replication and pathogenicity. Here, we discuss structural, biochemical, and vir...
The aim of this study was to evaluate the contact pressure distribution of two different nickel-titanium (NiTi) endodontic rotary instruments against the root canal walls and to virtually predict their centering ability during shaping with finite ele...
The objective of this work is to design a rehabilitation mechanism for the index finger that can replicate the finger’s natural movements in the sagittal plane; this mechanism must also be able to adapt to an individual’s anthropometric d...
Removal of RNA/DNA hybrids for the maturation of Okazaki fragments on the lagging strand, or due to misincorporation of ribonucleotides by DNA polymerases, is essential for all types of cells. In prokaryotic cells such as Escherichia coli, DNA polyme...
SARS-CoV-2 infection remains a global burden. Despite intensive research, the mechanism and dynamics of early viral replication are not completely understood, such as the kinetics of the formation of genomic RNA (gRNA), sub-genomic RNA (sgRNA), and r...
Introduction: Cytomegalovirus (CMV) infection is a well-known factor associated with invasive aspergillosis in immunocompromised hosts. However, its association with COVID-19-associated pulmonary aspergillosis (CAPA) has not been described. We aimed...
In light of the COVID-19 global pandemic caused by SARS-CoV-2, ongoing research has centered on minimizing viral spread either by stopping viral entry or inhibiting viral replication. Repurposing antiviral drugs, typically nucleoside analogs, has pro...
Nowadays, considering the urgent issues related to climate change and land consumption as well as the increasing urban population, urban spaces, enhanced by appropriate design solutions, can help reduce risks and improve conditions of environmental w...
A surge of interest in data-intensive computing has led to a drastic increase in the demand for data centers. Given this growing popularity, data centers are becoming a primary contributor to the increased consumption of energy worldwide. To mitigate...
African swine fever virus (ASFV) is a double-stranded DNA virus causing a hemorrhagic fever disease with high mortality rates and severe economic losses in pigs worldwide. ASFV replicates in perinuclear sites called viral factories (VFs) that are mo...
Human adenovirus (HAdV) is extremely common and can rapidly spread in confined populations such as daycare centers, hospitals, and retirement homes. Although HAdV usually causes only minor illness in otherwise healthy patients, HAdV can cause signifi...
DNA Holliday junction (HJ) is a four-way stranded DNA intermediate that formed in replication fork regression, homology-dependent repair and mitosis, performing a significant role in genomic stability. Failure to remove HJ can induce an acceptable re...
Introduction: Stress at work is a factor that has repercussions on both a personal and health level, as well as on productivity at work. Objective: To establish if the wearables are devices capable of determining the level of labor stress of working...
This research paper focuses on the fabrication of a microstructure based on a natural structure pattern of hydrophobic properties using micro-milling technology, followed by an investigation of the dimensional accuracy, roughness, and replication of...
This paper presents a direct contact printing method to obtain arrayed metallic nanostructures on a soft polymer substrate. It utilizes a polydimethylsiloxane (PDMS) mold replicated from silicon molds to transfer metallic nanopatterns onto a polymer...
Endometriosis is a complicated condition characterized by inflammation, low oocyte quality, and decreased uterus receptivity, associated with fertility issues. This study aims to better understand the reduced pregnancy outcome in endometriosis by ana...
Background: In this essay, we address an important issue in the logistics education discourse relating to student-centered curriculum design and evaluation. Methods: We adopt an integrative approach based on conceptual development and guided by const...
The Meat Animal Research Center-145 (MARC-145) cell line has been proven to be valuable for viral attenuation regarding vaccine development and production. Cell-adaptation is necessary for the efficient replication of porcine reproductive and respira...
Antimony is a toxic metalloid with poorly understood mechanisms of toxicity and uncertain carcinogenic properties. By using a combination of genetic, biochemical and DNA damage assays, we investigated the genotoxic potential of trivalent antimony in...
Optimization of coagulant dosage and pH to reduce the turbidity and chemical oxygen demand (COD) of synthetic dairy wastewater (SDW) was investigated using a full factorial design (FFD) and full factorial design with center point (FFDCP). Two organic...
In contemporary times, bike sharing programs are gaining importance as an influential transportation mode in both urban and rural areas. They are also used as a vital transportation mode on university campuses which serve as a healthy and environment...
Based on the assumption that the process of understanding is partly narrative, this study explores the potential benefits and limitations of using narrative writing in biology education. We investigate what contribution a student-centered narrative i...
Protein kinase CK2 is a pleiotropic protein kinase, which phosphorylates a number of cellular and viral proteins. Thereby, this kinase is implicated in the regulation of cellular signaling, controlling of cell proliferation, apoptosis, angiogenesis,...
This study evaluated the historical precipitation simulations of 49 global climate models (GCMs) of the Coupled Model Intercomparison Project Phase 6 (CMIP6) in reproducing annual and seasonal precipitation climatology, linear trends, and their spati...
High-valent cobalt–oxo complexes are reactive transient intermediates in a number of oxidative transformation processes e.g., water oxidation and oxygen atom transfer reactions. Studies of cobalt–oxo complexes are very important for under...
Since the beginning of modern virology in the 1950s, transmission electron microscopy (TEM) has been an important and widely used technique for discovery, identification and characterization of new viruses. Using TEM, viruses can be differentiated by...
This paper is a report on the year-long MOVING GROUND project (MG), initiated by the Isadora and Raymond Duncan Dance Research Center (DDRC). The Duncan Dance Research Center sets out to address climate change issues interweaving the social, physical...
The SARS-CoV-2 virus invades and replicates within host cells by “hijacking” biomolecular machinery, gaining control of the microtubule cytoskeleton. After attaching to membrane receptors and entering cells, the SARS-CoV-2 virus co-opts t...
Systematic tendencies such as the center and horizontal bias are known to have a large influence on how and where we move our eyes during static onscreen free scene viewing. However, it is unknown whether these tendencies are learned viewing strategi...
This paper presents the development of an electronic system that converts an electrically assisted bicycle into an intelligent health monitoring system, allowing people who are not athletic or who have a history of health issues to progressively star...
16 December 2022
Background: Dementia is a priority for global public health. The management of behavioral and psychological symptoms of dementia (BPSD) is one of the highest ongoing challenges and needs new approaches. The special care unit for people with dementia...
Cognitive abilities and interests both play an important role in guiding knowledge acquisition, but most previous studies have examined them separately. The current study used a large and representative dataset to integrate interests and abilities us...
The human primosome is a 340-kilodalton complex of primase (DNA-dependent RNA polymerase) and DNA polymerase α, which initiates genome replication by synthesizing chimeric RNA-DNA primers for DNA polymerases δ and ϵ. Accumulated biochemical and struc...
Changes in the cellular microRNA (miRNA) expression profile in response to HIV infection, replication or latency have been reported. Nevertheless, little is known concerning the abundance of miRNA in extracellular vesicles (EVs). In the search for a...
Transcription elongation is regulated at several different levels, including control by various accessory transcription elongation factors. A distinct group of these factors interacts with the RNA polymerase secondary channel, an opening at the enzym...
The University of Texas MD Anderson Cancer Center, a comprehensive cancer center designated by the National Cancer Institute (NCI), defines its service population area as the State of Texas (29.1 M), the second most populous state in the country and...
Sustainable rural development depends on a multidimensional process based on the interaction of the economic, cultural, social, environmental, and political subsystems. Many studies have ascribed the extensive livestock systems a potential role in su...
Background: Enterovirus (EV) infections are associated with a broad range of diseases. Since the first experimental infection of primates with poliovirus (PV), tonsils and the Peyer’s patches (PPs) have been believed to be the primary replicati...
A large number of chemicals and several physical agents, such as UV light and γ-radiation, have been associated with the etiology of human cancer. Generation of DNA damage (also known as DNA adducts or lesions) induced by these agents is an important...
The impact of small-stature alkali bulrush (Bolboschoenus maritimus) and two hydroperiod treatments (early season raised water level or ambient water level) on mosquito production and water quality was studied in replicate 0.09 ha free water surface...
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