Next Article in Journal
Survivin-Based Treatment Strategies for Squamous Cell Carcinoma
Next Article in Special Issue
Chemically-Induced DNA Damage, Mutagenesis, and Cancer
Previous Article in Journal
Preclinical Evaluation of Vemurafenib as Therapy for BRAFV600E Mutated Sarcomas
Previous Article in Special Issue
High NOTCH1 mRNA Expression Is Associated with Better Survival in HNSCC
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessReview

DNA Damage, Mutagenesis and Cancer

Department of Chemistry, University of Connecticut, Storrs, CT 06269-3060, USA
Int. J. Mol. Sci. 2018, 19(4), 970;
Received: 29 January 2018 / Revised: 16 March 2018 / Accepted: 20 March 2018 / Published: 23 March 2018
(This article belongs to the Special Issue Chemically-Induced DNA Damage, Mutagenesis, and Cancer)
PDF [1523 KB, uploaded 3 May 2018]


A large number of chemicals and several physical agents, such as UV light and γ-radiation, have been associated with the etiology of human cancer. Generation of DNA damage (also known as DNA adducts or lesions) induced by these agents is an important first step in the process of carcinogenesis. Evolutionary processes gave rise to DNA repair tools that are efficient in repairing damaged DNA; yet replication of damaged DNA may take place prior to repair, particularly when they are induced at a high frequency. Damaged DNA replication may lead to gene mutations, which in turn may give rise to altered proteins. Mutations in an oncogene, a tumor-suppressor gene, or a gene that controls the cell cycle can generate a clonal cell population with a distinct advantage in proliferation. Many such events, broadly divided into the stages of initiation, promotion, and progression, which may occur over a long period of time and transpire in the context of chronic exposure to carcinogens, can lead to the induction of human cancer. This is exemplified in the long-term use of tobacco being responsible for an increased risk of lung cancer. This mini-review attempts to summarize this wide area that centers on DNA damage as it relates to the development of human cancer. View Full-Text
Keywords: carcinogenesis; carcinogen; mutagen; metabolism; DNA adduct; tumor; chronic exposure; somatic mutation carcinogenesis; carcinogen; mutagen; metabolism; DNA adduct; tumor; chronic exposure; somatic mutation

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
Printed Edition Available!
A printed edition of this Special Issue is available here.

Share & Cite This Article

MDPI and ACS Style

Basu, A.K. DNA Damage, Mutagenesis and Cancer. Int. J. Mol. Sci. 2018, 19, 970.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top