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Exploiting the Legacy of the Arbovirus Hunters
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Electron Microscopy in Discovery of Novel and Emerging Viruses from the Collection of the World Reference Center for Emerging Viruses and Arboviruses (WRCEVA)

by Vsevolod L. Popov 1,2,3,4,5,*, Robert B. Tesh 1,2,3,4,5, Scott C. Weaver 2,3,4,5,6 and Nikos Vasilakis 1,2,3,4,5,*
1
Department of Pathology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
2
Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
3
Institute for Human Infection and Immunity, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
4
Center for Tropical Diseases, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
5
World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
6
Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
*
Authors to whom correspondence should be addressed.
Viruses 2019, 11(5), 477; https://doi.org/10.3390/v11050477
Received: 30 April 2019 / Revised: 20 May 2019 / Accepted: 24 May 2019 / Published: 25 May 2019
(This article belongs to the Special Issue 6th Pan-American Dengue Research Network Meeting)
Since the beginning of modern virology in the 1950s, transmission electron microscopy (TEM) has been an important and widely used technique for discovery, identification and characterization of new viruses. Using TEM, viruses can be differentiated by their ultrastructure: shape, size, intracellular location and for some viruses, by the ultrastructural cytopathic effects and/or specific structures forming in the host cell during their replication. Ultrastructural characteristics are usually sufficient for the identification of a virus to the family level. In this review, we summarize 25 years of experience in identification of novel viruses from the collection of the World Reference Center for Emerging Viruses and Arboviruses (WRCEVA). View Full-Text
Keywords: virus ultrastructure; virus discovery; electron microscopy; virus taxonomy virus ultrastructure; virus discovery; electron microscopy; virus taxonomy
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Popov, V.L.; Tesh, R.B.; Weaver, S.C.; Vasilakis, N. Electron Microscopy in Discovery of Novel and Emerging Viruses from the Collection of the World Reference Center for Emerging Viruses and Arboviruses (WRCEVA). Viruses 2019, 11, 477.

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