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2,220 Results Found

  • Article
  • Open Access
1,382 Views
14 Pages

Establishing the Physiological Values of Minimally Invasive Biomarkers in Gilthead Sea Bream (Sparus aurata)

  • Rafael Angelakopoulos,
  • Andreas Tsipourlianos,
  • Alexia E. Fytsili and
  • Katerina A. Moutou

28 January 2025

Peripheral blood has been always used as the mirror of physiological status in a minimally invasive manner. In homeothermic vertebrates, different blood parameters have been correlated to a variety of biochemical and physiological processes and the e...

  • Article
  • Open Access
35 Citations
5,093 Views
16 Pages

Quantifying Physiological Biomarkers of a Microwave Brain Stimulation Device

  • Iqram Hussain,
  • Seo Young,
  • Chang Ho Kim,
  • Ho Chee Meng Benjamin and
  • Se Jin Park

8 March 2021

Physiological signals are immediate and sensitive to neural and cardiovascular change resulting from brain stimulation, and are considered as a quantifying tool with which to evaluate the association between brain stimulation and cognitive performanc...

  • Article
  • Open Access
4 Citations
6,214 Views
15 Pages

10 July 2023

Adolescents are a vulnerable population with a high prevalence of depression, yet there is a scarcity of biological markers for diagnosing depression specifically in this age group. In this case–control study, we examined physiological response...

  • Article
  • Open Access
41 Citations
5,169 Views
18 Pages

Identifying Physiological Stress Biomarkers for Prediction of Pork Quality Variation

  • Nikola Čobanović,
  • Sanja Dj Stanković,
  • Mirjana Dimitrijević,
  • Branko Suvajdžić,
  • Nevena Grković,
  • Dragan Vasilev and
  • Nedjeljko Karabasil

2 April 2020

This study assessed the potential use of various physiological stress biomarkers as indicators of carcass and meat quality traits in 240 pigs subjected to the standard marketing conditions and minimal stressful antemortem handling using Pearson corre...

  • Article
  • Open Access
8 Citations
4,273 Views
15 Pages

2 September 2020

This study explored the use of wearable sensor technology to investigate autonomic function in children with autism spectrum disorder (ASD) and Rett syndrome (RTT). We aimed to identify autonomic biomarkers that can correctly differentiate females wi...

  • Opinion
  • Open Access
17 Citations
3,052 Views
6 Pages

13 November 2021

Secreted protein acidic and rich in cysteine (SPARC) is expressed in diverse tissues and plays roles in various biological functions and processes. Increased serum levels of SPARC or its gene overexpression have been reported following numerous physi...

  • Review
  • Open Access
8 Citations
4,467 Views
19 Pages

Physiological Biomarkers of Upper Motor Neuron Dysfunction in ALS

  • Aicee Dawn Calma,
  • Mehdi van den Bos,
  • Nathan Pavey,
  • Cláudia Santos Silva,
  • Parvathi Menon and
  • Steve Vucic

Upper motor neuron (UMN) dysfunction is an important feature of amyotrophic lateral sclerosis (ALS) for the diagnosis and understanding of pathogenesis. The identification of UMN signs forms the basis of ALS diagnosis, although may be difficult to di...

  • Review
  • Open Access
247 Views
18 Pages

The Role of Biomarkers in Personalized Anesthesia: From Physiological Parameters to Molecular Diagnostics

  • Irina Nenadic,
  • Predrag Stevanovic,
  • Marina Bobos,
  • Maja Stojanovic,
  • Nemanja Dimic,
  • Suzana Bojic,
  • Dragica Dekic,
  • Jovana Radovanovic and
  • Marko Djuric

Personalized anesthesia has emerged as a key direction in modern perioperative medicine, driven by advances in molecular biology, analytical technologies, and digital monitoring. Traditional physiological parameters often fail to detect early stages...

  • Article
  • Open Access
17 Citations
4,158 Views
15 Pages

Retinal Vascular Physiology Biomarkers in a 5XFAD Mouse Model of Alzheimer’s Disease

  • Nathanael Matei,
  • Sophie Leahy,
  • Norman P. Blair,
  • James Burford,
  • Mansour Rahimi and
  • Mahnaz Shahidi

4 August 2022

Background: Alzheimer’s disease (AD) is a neurodegenerative disorder that affects the brain and retina and lacks reliable biomarkers for early diagnosis. As amyloid beta (Aβ) manifestations emerge prior to clinical symptoms and plaques of...

  • Article
  • Open Access
5 Citations
3,095 Views
9 Pages

Stress and anxiety significantly impact the hypothalamic–pituitary axis, and in pregnancy, the subsequent maternal–fetal response can lead to poor outcomes. The objective of this study was to assess the association between psychosocial measures of pr...

  • Article
  • Open Access
4 Citations
2,640 Views
18 Pages

Assessing individual aging has always been an important topic in aging research. Caenorhabditis elegans (C. elegans) has a short lifespan and is a popular model organism widely utilized in aging research. Studying the differences in C. elegans life s...

  • Feature Paper
  • Article
  • Open Access
4 Citations
2,985 Views
23 Pages

Assessment of Phthalate Esters and Physiological Biomarkers in Bottlenose Dolphins (Tursiops truncatus) and Killer Whales (Orcinus orca)

  • Leila S. Lemos,
  • Amanda C. Di Perna,
  • Karen J. Steinman,
  • Todd R. Robeck and
  • Natalia S. Quinete

17 May 2024

There is growing concern about the potential adverse health effects of phthalates (PAEs) on human health and the environment due to their extensive use as plasticizers and additives in commercial and consumer products. In this study, we assessed PAE...

  • Article
  • Open Access
447 Views
22 Pages

Three Years Later: Landfill Proximity Alters Biomarker Dynamics in White Stork (Ciconia ciconia) Nestlings

  • Dora Bjedov,
  • Ivona Levak,
  • Mirna Velki,
  • Sabina Alić,
  • Luka Jurinović,
  • Biljana Ječmenica,
  • Sandra Ečimović and
  • Alma Mikuška

Landfills represent increasingly common anthropogenic habitats that provide food resources but also expose wildlife to complex chemical mixtures. White Storks (Ciconia ciconia) have recently expanded breeding near such sites, yet little is known abou...

  • Case Report
  • Open Access
1,292 Views
13 Pages

6 December 2025

Previous studies suggest that the cortisol awakening response (CAR) shows a biphasic pattern—either an increase or a blunting—in response to exercise involving overload, potentially reflecting physiological adaptation. However, its respon...

  • Review
  • Open Access
1,028 Views
24 Pages

Multidomain Molecular Sensor Devices, Systems, and Algorithms for Improved Physiological Monitoring

  • Lianna D. Soriano,
  • Shao-Xiang Go,
  • Lunna Li,
  • Natasa Bajalovic and
  • Desmond K. Loke

31 July 2025

Molecular sensor systems, e.g., implantables and wearables, provide extensive health-related monitoring. Glucose sensor systems have historically prevailed in wearable bioanalysis applications due to their continuous and reliable glucose monitoring,...

  • Systematic Review
  • Open Access
5,665 Views
19 Pages

Exploring Sex Activity Impact on Biological Biomarkers and Athletic Parameters in Sexually and Physically Active Healthy Adults: A Systematic Review of Clinical Trials

  • Diego Fernández-Lázaro,
  • Jesús Seco-Calvo,
  • José María Izquierdo,
  • Juan Mielgo-Ayuso,
  • Enrique Roche and
  • Gema Santamaría

Background: A sexually active lifestyle is generally associated with positive effects on physical condition and health. However, engaging in sexual activity prior to a sports competition could affect athletic performance. This systematic review exami...

  • Article
  • Open Access
18 Citations
8,799 Views
16 Pages

16 December 2022

Burnout is becoming a global pandemic jeopardizing brain health, with a huge impact on quality of life, available workforce, and the economy. Knowledge of the impact of burnout on cognition, physiology, and physical activity (PA) in daily life allows...

  • Article
  • Open Access
17 Citations
3,589 Views
22 Pages

Physiological Responses of the Bivalves Mytilus galloprovincialis and Ruditapes decussatus Following Exposure to Phenanthrene: Toxicokinetics, Dynamics and Biomarkers Study

  • Mohamed Dellali,
  • Khadija Mardassi,
  • Abdel Halim Harrath,
  • Lamjed Mansour,
  • Octavian Pacioglu,
  • Waleed Aldahmash,
  • Saber Nahdi,
  • Riadh Badraoui,
  • Abdulwahed Fahad Alrefaei and
  • Fehmi Boufahja

30 December 2022

The aim of the current study was to assess the multifaceted effects of the polycylic aromatic hydrocarbon phenanthrene, mainly used in the colouring, explosive, and pharmaceutical industries, on the physiology of two bivalve species with economic val...

  • Article
  • Open Access
2,715 Views
15 Pages

Overarm Training Tolerance: A Pilot Study on the Use of Muscle Oxygen Saturation as a Biomarker

  • Bhargav Gorti,
  • Connor Stephenson,
  • Maia Sethi,
  • KaiLi Gross,
  • Mikaela Ramos,
  • Dhruv Seshadri and
  • Colin K. Drummond

20 July 2024

Ulnar collateral ligament (UCL) tears occur due to the prolonged exposure and overworking of joint stresses, resulting in decreased strength in the flexion and extension of the elbow. Current rehabilitation approaches for UCL tears involve subjective...

  • Review
  • Open Access
9 Citations
4,684 Views
20 Pages

14 January 2023

The knowledge of how diet choices, dietary supplements, and feed intake influence molecular mechanisms in ruminant nutrition and physiology to maintain ruminant health, is essential to attain. In the present review, we focus on the role of microRNAs...

  • Review
  • Open Access
141 Citations
10,151 Views
24 Pages

Extracellular Vesicles in Blood: Sources, Effects, and Applications

  • Ainhoa Alberro,
  • Leire Iparraguirre,
  • Adelaide Fernandes and
  • David Otaegui

Extracellular vesicles (EVs) are important players for intercellular communication. EVs are secreted by almost all cell types; they can transfer information between nearby or distant cells, and they are highly abundant in body fluids. In this review,...

  • Article
  • Open Access
3 Citations
2,305 Views
19 Pages

4 February 2024

A honeybee colony, as a super-organism, is regulated through age-polyethism. A honeybee worker’s age is considered by means of a chronological and biological approach. The biological age is estimated with physiologically related biological mark...

  • Article
  • Open Access
2,957 Views
16 Pages

Biochemical and Perceptual Markers of Physiological Stress During Acute Exercise Overload in U20 Elite Basketball Players

  • Juan M. López-Cuervo,
  • Andrés Rojas-Jaramillo,
  • Andrés García-Caro,
  • Jhonatan González-Santamaria,
  • Gustavo Humeres,
  • Jeffrey R. Stout,
  • Adrián Odriozola-Martínez and
  • Diego A. Bonilla

18 August 2025

The allostatic load index (ALindex) measures the cumulative physiological burden on the body due to stress. This prospective cohort study examined the relationships between certain molecular biomarkers, physical variables, and psychometric variables...

  • Article
  • Open Access
1 Citations
2,306 Views
17 Pages

6 July 2024

This study examines the phenotypic differences between wild-derived F2 Central Valley mosquitoes and the insecticide-susceptible Rockefeller (Rock) lab strain of Ae. aegypti. Given the rarity of wild pyrethroid-susceptible populations, the focus of t...

  • Review
  • Open Access
14 Citations
5,897 Views
25 Pages

Extracellular Vesicles in Veterinary Medicine

  • Valentina Moccia,
  • Alessandro Sammarco,
  • Laura Cavicchioli,
  • Massimo Castagnaro,
  • Laura Bongiovanni and
  • Valentina Zappulli

10 October 2022

Extracellular vesicles (EVs) are cell-derived membrane-bound vesicles involved in many physiological and pathological processes not only in humans but also in all the organisms of the eukaryotic and prokaryotic kingdoms. EV shedding constitutes a fun...

  • Article
  • Open Access
91 Citations
12,991 Views
15 Pages

Quantitative Evaluation of EEG-Biomarkers for Prediction of Sleep Stages

  • Iqram Hussain,
  • Md Azam Hossain,
  • Rafsan Jany,
  • Md Abdul Bari,
  • Musfik Uddin,
  • Abu Raihan Mostafa Kamal,
  • Yunseo Ku and
  • Jik-Soo Kim

17 April 2022

Electroencephalography (EEG) is immediate and sensitive to neurological changes resulting from sleep stages and is considered a computing tool for understanding the association between neurological outcomes and sleep stages. EEG is expected to be an...

  • Article
  • Open Access
1 Citations
3,350 Views
11 Pages

Proteinuria and Significant Dehydration in a Short-Steep Triathlon: Preliminary Observational Report

  • Daniel Rojas-Valverde,
  • Cindy Castro,
  • Diego A. Bonilla,
  • Luis A. Cardozo and
  • Carlos D. Gómez-Carmona

6 November 2024

Background/Objectives: Endurance triathlons impose substantial physiological stress, yet the effects of short-course formats remain relatively unexplored. This preliminary study presents novel findings on proteinuria and hydration levels in well-trai...

  • Article
  • Open Access
11 Citations
3,327 Views
13 Pages

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by memory decline and cognitive impairment. Research on biomarkers can aid in early diagnosis, monitoring disease progression, evaluating treatment efficacy, and advancing f...

  • Article
  • Open Access
1 Citations
1,710 Views
16 Pages

Exploring Salivary Thiocyanate as a Novel Biomarker of Physical Activity Response

  • Christoforos Chrimatopoulos,
  • Kalliopi Papadopoulou,
  • Theodora Tsilouli and
  • Vasilios Sakkas

Salivary thiocyanate (SCN) has long been recognized for its role in mucosal defense and antioxidant function, yet its behavior during physical activity remains unexplored. This study aimed to investigate salivary thiocyanate as a novel salivar...

  • Article
  • Open Access
970 Views
16 Pages

Association of Inflammatory and Oxidative Stress Biomarkers Adjusted by Personal, Psychological, Biochemical, Anthropometric, and Physiological Variables with Global DNA Methylation in a Sample of Mexican Individuals

  • Heriberto Jacobo-Cuevas,
  • Jorge Ivan Gamez-Nava,
  • Saúl Ramírez-De los Santos,
  • Carlos Alfonso Mercado-Calderón,
  • Blanca Estela Ríos-González,
  • Juan Manuel Ponce-Guarneros and
  • Aniel Jessica Leticia Brambila-Tapia

2 September 2025

Global DNA methylation has been associated with numerous traits and conditions; however, its relationship with inflammation and oxidative stress biomarkers has not been fully elucidated. The objective of this study is to determine the correlation bet...

  • Article
  • Open Access
6 Citations
1,776 Views
16 Pages

Bone Adaptations to a Whole Body Vibration Protocol in Murine Models of Different Ages: A Preliminary Study on Structural Changes and Biomarker Evaluation

  • Ida Cariati,
  • Roberto Bonanni,
  • Cristian Romagnoli,
  • Lucio Caprioli,
  • Giovanna D’Arcangelo,
  • Virginia Tancredi and
  • Giuseppe Annino

Background/Objectives: Whole body vibration (WBV) is a valuable tool to mitigate physiological adaptations related to age and inactivity. Although significant benefits have been found at the musculoskeletal level, including increased bone mass and re...

  • Review
  • Open Access
1,989 Views
19 Pages

Multi-Omics Profiling of Individuals Sustaining Extreme Physical Stressors

  • Anurag Sakharkar,
  • Robert Chen,
  • Erik LeRoy,
  • Theodore M. Nelson,
  • Jacqueline Proszynski,
  • JangKeun Kim,
  • Jiwoon Park,
  • Mohith Reddy Arikatla,
  • Begum Mathyk and
  • Christopher E. Mason

1 September 2025

Human engagement in extreme activities, from spaceflight to deep-sea diving and extreme sports, presents unique physiological challenges. Understanding the molecular mechanisms underlying adaptations to these demands is crucial for developing strateg...

  • Article
  • Open Access
13 Citations
2,695 Views
12 Pages

19 July 2022

The effects of heat stress on broiler performance and immunological response were explored using lighting-program manipulation as a potential tool. The study included 200 Cobb500 broiler chicks that were one day old at the time of recruitment. The bi...

  • Review
  • Open Access
8 Citations
3,236 Views
23 Pages

Exosomes in Ocular Health: Recent Insights into Pathology, Diagnostic Applications and Therapeutic Functions

  • Noelia Blanco-Agudín,
  • Suhui Ye,
  • Sara González-Fernández,
  • Ignacio Alcalde,
  • Jesús Merayo-Lloves and
  • Luis M. Quirós

Exosomes are extracellular vesicles ranging from 30 to 150 nm in diameter that contain proteins, nucleic acids and other molecules. Produced by virtually all cell types, they travel throughout the body until they reach their target, where they can tr...

  • Review
  • Open Access
1 Citations
3,401 Views
22 Pages

4 August 2025

The eye, a complex organ essential for visual perception, is composed of diverse cell populations with specialized functions; however, the complex interplay between these cellular components and their underlying molecular mechanisms remains largely e...

  • Article
  • Open Access
482 Views
22 Pages

The purpose of this study was to develop a model capable of predicting stress levels and interpreting the underlying physiological patterns using large-scale, real-life biosignal data. To achieve this, we utilized approximately 137,000 longitudinal m...

  • Review
  • Open Access
1,221 Views
33 Pages

HRV in Stress Monitoring by AI: A Scoping Review

  • Giovanna Zimatore,
  • Samuele Russo,
  • Maria Chiara Gallotta,
  • Giordano Passalacqua,
  • Victoria Zaborova,
  • Matteo Campanella,
  • Francesca Fiani,
  • Carlo Baldari,
  • Christian Napoli and
  • Cristian Randieri

19 December 2025

Despite the growing interest in physiological stress monitoring, an objective measure of stress is currently lacking, especially in clinical and rehabilitation contexts. With the emerging integration of artificial intelligence (AI) in data analytics,...

  • Article
  • Open Access
1 Citations
1,203 Views
16 Pages

Physiological and Oxidative Stress in General and Spinal Anesthesia for Elective Cesarean Section in Women: Is There Any Difference?

  • Nemanja D. Dimic,
  • Gorica D. Maric,
  • Zorana S. Orescanin Dusic,
  • Tanja M. Grahovac,
  • Teodora F. Vidonja Uzelac,
  • Marko D. Djuric,
  • Irina B. Nenadic,
  • Marina M. Bobos,
  • Predrag D. Stevanovic and
  • Marina M. Stojanovic
  • + 1 author

22 July 2025

This study evaluates the influence of general anesthesia (GA) and spinal anesthesia (SA) on physiological and oxidative stress in parturients undergoing elective cesarean section, one of the most frequently performed surgical procedures worldwide. A...

  • Article
  • Open Access
62 Citations
6,186 Views
25 Pages

21 October 2021

Physiological signals are immediate and sensitive to neurological changes resulting from the mental workload induced by various driving environments and are considered a quantifying tool for understanding the association between neurological outcomes...

  • Article
  • Open Access
3 Citations
4,452 Views
16 Pages

Berry Consumption in Relation to Allostatic Load in US Adults: The National Health and Nutrition Examination Survey, 2003–2010

  • Li Zhang,
  • Joshua E. Muscat,
  • Vernon M. Chinchilli,
  • Penny M. Kris-Etherton,
  • Laila Al-Shaar and
  • John P. Richie

30 January 2024

Introduction: Berries are a rich source of antioxidant polyphenols and other nutrients that are associated with good health. Allostatic load (AL) is an aggregate measure of chronic stress-induced physiological dysregulations across cardiovascular, me...

  • Article
  • Open Access
7 Citations
3,295 Views
22 Pages

Surface Immune Checkpoints as Potential Biomarkers in Physiological Pregnancy and Recurrent Pregnancy Loss

  • Michał Zych,
  • Monika Kniotek,
  • Aleksander Roszczyk,
  • Filip Dąbrowski,
  • Robert Jędra and
  • Radosław Zagożdżon

29 August 2024

Due to the genetic diversity between the mother and the fetus, heightened control over the immune system during pregnancy is crucial. Immunological parameters determined by clinicians in women with idiopathic recurrent spontaneous abortion (RSA) incl...

  • Systematic Review
  • Open Access
1 Citations
5,676 Views
19 Pages

The Early Detection of Cardiac Fatigue: Could the HRV Be Used as a Physiological Biomarker by AI?

  • Giovanna Zimatore,
  • Maria Chiara Gallotta,
  • Marco Alessandria,
  • Matteo Campanella,
  • Marta Ricci and
  • Leonarda Galiuto

14 May 2025

Background: Physical activity is vital for promoting health and rehabilitation, and ensuring cardiovascular safety during such activities is paramount. Electrocardiography (ECG) and its longitudinal monitoring remain crucial for the early detection o...

  • Review
  • Open Access
909 Views
19 Pages

16 November 2025

This review synthesizes current knowledge on chemical biomarker panels in the honeybee in a tissue-specific and factor-oriented framework. We show that these panels undergo predictable shifts under endogenous factors (age, caste) and environmental st...

  • Article
  • Open Access
15 Citations
3,569 Views
11 Pages

Nutritional Status Associated with Molecular Biomarkers, Physiological Indices, and Clinical Severity in Parkinson’s Disease Patients

  • Tsu-Kung Lin,
  • Yung-Yee Chang,
  • Nai-Ching Chen,
  • Chia-Wei Liou,
  • Min-Yu Lan,
  • Ying-Fa Chen and
  • Chia-Liang Tsai

This study is intended to explore the associations between nutritional status and molecular biomarkers and the clinical severity of Parkinson’s disease (PD), as well as to examine the differences in related factors between PD patients with norm...

  • Communication
  • Open Access
55 Citations
7,838 Views
13 Pages

7 October 2019

Polyphenols are secondary metabolites involved in a myriad of critical processes in plants. Over recent decades, special attention has been paid to the anti-oxidative role of fruit-derived polyphenols in the human diet, with evidence supporting the c...

  • Article
  • Open Access
4 Citations
3,925 Views
27 Pages

28 January 2022

Analysis of volatile organic compound (VOC) emissions using electronic-nose (e-nose) devices has shown promise for early detection of white-nose syndrome (WNS) in bats. Tricolored bats, Perimyotis subflavus, from three separate sampling groups define...

  • Article
  • Open Access
4 Citations
1,745 Views
18 Pages

7 May 2025

The traditional horse industry has undergone a remarkable evolution, with horse racing emerging as a prominent and pivotal economic driver within the sector. Among the various breeds, Mongolian horses, renowned for their exceptional endurance and spe...

  • Article
  • Open Access
19 Citations
4,702 Views
16 Pages

Physiological, Developmental, and Biomarker Responses of Zebrafish Embryos to Sub-Lethal Exposure of Bendiocarb

  • Gyöngyi Gazsi,
  • Zsolt Czimmerer,
  • Bence Ivánovics,
  • Izabella Roberta Berta,
  • Béla Urbányi,
  • Zsolt Csenki-Bakos and
  • András Ács

16 January 2021

Bendiocarb is a broad-spectrum insecticide recommended for malaria control by the World Health Organization (WHO). Still, bendiocarb poses a toxic risk to populations of nontargeted aquatic organisms. Thus, our study was aimed to evaluate the sub-let...

  • Article
  • Open Access
10 Citations
2,679 Views
11 Pages

Physiological Biomarkers Assessed by Low-Tech Exercise Tests Predict Complications and Overall Survival in Patients Undergoing Pneumonectomy Due to Lung Cancer

  • Tomasz Marjanski,
  • Damian Wnuk,
  • Robert Dziedzic,
  • Marcin Ostrowski,
  • Wioletta Sawicka,
  • Ewa Marjanska and
  • Witold Rzyman

10 February 2021

Due to its debilitating character pneumonectomy this is last-resort procedure. Preoperative results of the 6-min walking test (6MWT) help to identify high risk of postoperative complications and increased mortality in patients undergoing lobectomy fo...

  • Article
  • Open Access
18 Citations
5,043 Views
12 Pages

A Novel Approach to Assess Balneotherapy Effects on Musculoskeletal Diseases—An Open Interventional Trial Combining Physiological Indicators, Biomarkers, and Patients’ Health Perception

  • Jani Silva,
  • José Martins,
  • Cristina Nicomédio,
  • Catarina Gonçalves,
  • Cátia Palito,
  • Ramiro Gonçalves,
  • Paula Odete Fernandes,
  • Alcina Nunes and
  • Maria José Alves

The present study aimed to evaluate whether a 14-day period of balneotherapy influences the inflammatory status, health-related quality of life (QoL) and quality of sleep, underlying overall health state, and clinically relevant benefits of patients...

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