269,899 Results Found

The members of the p53 family comprise p53, p63, and p73, and full-length isoforms of the p53 family have a tumor suppressor function. However, p53, but not p63 or p73, has a high mutation rate in cancers causing it to lose its tumor suppressor funct...

The p53 tumor suppressor protein is crucial for cell growth control and the maintenance of genomic stability. Later discovered, p63 and p73 share structural and functional similarity with p53. To understand the p53 pathways more profoundly, all famil...

(1) Background: TP53 deficiency remains a major adverse event in Multiple Myeloma (MM) despite therapeutic progresses. As it is not possible to target TP53 deficiency with pharmacological agents, we explored the possibility of activating another p53...

Small proline-rich protein 2A and 2D (SPRR2A and SPRR2D) provide barrier function in terminally differentiated stratified squamous epithelia through the epidermal differentiation complex. However, little is known how SPRR2A/2D expression is controlle...

Understanding the mechanisms that regulate cancer progression is pivotal for the development of new therapies. Although p53 is mutated in half of human cancers, its family member p73 is not. At the same time, isoforms of p73 are often overexpressed i...

Epithelial organs are the first barrier against microorganisms and genotoxic stress, in which the p53 family members p63 and p73 have both overlapping and distinct functions. Intriguingly, p73 displays a very specific localization to basal epithelial...

The p53 family has the following three members: p53, p63 and p73. p53 is a tumor suppressor gene that frequently exhibits mutation in head and neck cancer. Most p53 mutants are loss-of-function (LoF) mutants, but some acquire some oncogenic function,...

TP53 (TP53), p73 (TP73), and p63 (TP63) are members of the p53 transcription factor family, which has many activities spanning from embryonic development through to tumor suppression. The utilization of two promoters and alternative mRNA splicing has...

Resistance to platinum-based chemotherapy is a major clinical problem in ovarian cancers. The development of predictive biomarkers and therapeutic approaches is an area of unmet need. p73, a member of the p53 family of transcription factors, has esse...

Gastric cancer (GC) remains a health issue due to the low efficiency of therapies, such as cisplatin. This unsatisfactory situation highlights the necessity of finding factors impacting GC sensibility to therapies. We analyzed the cisplatin pangenomi...

In our quest to discover antitumor agents with novel mechanisms of action, our strategy
concerned multiple molecular modifications in a chemical core. [...]

The tumor suppressor p73 is a member of the p53 family and is expressed as different isoforms with opposing properties. The TAp73 isoforms act as tumor suppressors and have pro-apoptotic effects, whereas the ΔNp73 isoforms lack the N-terminus transac...

Altered lipid metabolism is a hallmark of cancer. p73, a p53 family member, regulates cellular processes and is expressed as multiple isoforms. However, the role of p73 in regulating lipid metabolism is not well-characterized. Previously, we found th...

Mechanisms governing tumor progression differ from those of initiation. One enigmatic prometastatic process is the recapitulation of pathways of neural plasticity in aggressive stages. Cancer and neuronal cells develop reciprocal interactions via mut...

Feline oral squamous cell carcinoma (FOSCC) is a highly aggressive head and neck cancer in cats, but the molecular pathogenesis of this cancer is still uncertain. In this study, p16, p53, and pRb proteins were detected and quantified by immunohistoch...

A graph G is said to be perfect if $\omega \left(H\right)=\chi \left(H\right)$ for every induced subgraph H of G, where $\omega \left(H\right)$ and $\chi \left(H\right)$ denote the clique number and the chromatic number of H. We say that a graph G admits a perfect division if its vertex set can be p...

In recent years, $(p,q)$-special polynomials, such as $\left(p,q\right)$-Euler, $\left(p,q\right)$-Genocchi, $\left(p,q\right)$-Bernoulli, and $\left(p,q\right)$-Frobenius-Euler, have been studied and investigated by many mathematicians, as well physicists. It is important that any polynomial have explicit form...

Background: p73, a member of the p53 family of transcription factors, plays important roles in DNA repair, cell proliferation, angiogenesis, invasion, metastasis, immune evasion, and cytotoxic therapy response. The clinicopathological significance of...

Glioblastoma (GBM), the most common primary brain tumor, is a complex and extremely aggressive disease. Despite recent advances in molecular biology, there is a lack of biomarkers, which would improve GBM’s diagnosis, prognosis, and therapy. He...

After the observation of the strong near-threshold enhancement of proton-antiproton mass spectrum in $J/\psi \to \gamma p$...

Rising awareness and emergence of smart technologies have inspired new thinking in energy system management. Whilst integration of distributed energy resources in micro-grids (MGs) has become the technique of choice for consumers to generate their en...

The TP53 gene is a critical tumor suppressor and key determinant of cell fate which regulates numerous cellular functions including DNA repair, cell cycle arrest, cellular senescence, apoptosis, autophagy and metabolism. In the last 15 years, the p53...

Given a positive integer n, a finite group G is called quasi-core-n if $⟨x⟩/{⟨x⟩}_G$ has order at most n for any element x in G, where ${⟨x⟩}_G$ is the normal core of $⟨x⟩$ in G....

Applications running over peer-to-peer (P2P) networks have exploded since the late 1990s. Research is needed into many aspects of P2P. These include architecture, application functionality, and the categories of digital works that are shared using P2...

In this paper, we introduce the $\left(\rho ,q\right)$ -analog of the p-adic factorial function. By utilizing some properties of $\left(\rho ,q\right)$ -numbers, we obtain several new and interesting identities and formulas. We then construct the p-adic $\left(\mathrm{\&rho}\right)$...

Let G be a graph. We denote the chromatic (clique) number of G by $\chi \left(G\right)\left(\omega \right(G\left)\right)$. In this paper, we prove that (i) $\chi \left(G\right)\le 2\omega \left(G\right)$ if G is ($P_3\cup P_2$, kite)-free, (ii) $\chi \left(G\right)\le {\omega }^2\left(G\right)$ if G is ($P_3\cup P_2$, hammer)-free, (iii) $\mathrm{\&chi}$...

The classical tests for combining p-values use suitable statistics $T(P_1,\dots ,P_n)$, which are based on the assumption that the observed p-values are genuine, i.e., under null hypotheses, are observations from independent and identically distributed...

Wind turbines (WTs) are exposed to a dynamic/cyclic load environment, and are subjected to 1P/3P loads under operational conditions. Recent studies introduced the Sommerfeld Effect to explain the dynamic response amplification induced by 1P/3P loads....

Background: This study aimed to investigate the role of ROS/MAPK signaling pathways and the effects of baicalin in LPS-induced inflammatory responses in mice and porcine intestinal epithelial cells (IPEC-J2). Methods: In vivo, 18 male C57BL/6J mice w...

In this review we focus on the major isoforms of the tumor-suppressor protein p53, dysfunction of which often leads to cancer. Mutations of the TP53 gene, particularly in the DNA binding domain, have been regarded as the main cause for p53 inactivati...

This study aimed to investigate the expression of microRNAs (miRNAs) -146b-3p, -221-5p, -222-3p, and -21a-3p and the methylation pattern of the thyroid-stimulating hormone receptor (TSHR) gene in blood plasma samples from papillary thyroid cancer (PT...

Microglia cells represent the immune system of the central nervous system. They become activated by ATP released from damaged and inflamed tissue via purinergic receptors. Ionotropic purinergic P2X4 and P2X7 receptors have been shown to be involved i...

In this article, the $(p,q)$-analogs of the $\alpha$-th fractional Fourier transform are provided, along with a discussion of their characteristics in specific classes of $(p,q)$-generalized functions. Two spaces of infinitely $(p,q)$-differentiable functio...

Inflammatory breast cancer (IBC) is a rare yet aggressive breast cancer variant, associated with a poor prognosis. The major challenge for IBC is misdiagnosis due to the lack of molecular biomarkers. We profiled dysregulated expression of microRNAs (...

Early hepatocellular carcinoma (HCC) diagnosis is challenging. Moreover, for patients with alpha-fetoprotein (AFP)-negative HCC, this challenge is augmented. MicroRNAs (miRs) profiles may serve as potential HCC molecular markers. We aimed to assess p...

S100P, a small calcium-binding protein, associates with the p53 protein with micromolar affinity. It has been hypothesized that the oncogenic function of S100P may involve binding-induced inactivation of p53. We used ¹H-¹⁵N HSQC experiments and molec...

This paper summarizes the results of investigations into heterogeneous P23/P91 welds after long-term creep exposure at temperatures of 500, 550 and 600 °C. Two variants of welds were studied: In Weld A, the filler material corresponded to P91 ste...

Transactivation of p21 (cyclin-dependent kinase inhibitor 1A, CDKN1A) is closely related to the recruitment of transcription cofactors at the p53 responsive elements (p53REs) in its promoter region. Human chromatin remodeling enzyme INO80 can be recr...

Peer-to-peer (P2P) systems are widely used to exchange content over the Internet. Knowledge of pedophile activity in such networks remains limited, despite having important social consequences. Moreover, though there are different P2P systems in use,...

Cyclin-dependent kinase inhibitor p16 (CDKN2A) primarily functions as a negative regulator of the retinoblastoma protein (pRb) pathway to prevent pRb phosphorylation, thus playing a critical role in cell cycle arrest. In canine lymphoma cells, methyl...

T-2 mycotoxins are known to induce toxic effects in animals. The kidneys are particularly vulnerable to oxidative stress induced by toxins, resulting in cellular damage, apoptosis, and disruptions to cell cycle regulation. Cyclin-dependent kinase inh...

The regularity of the n-P-V-rings and n-P-V’-rings is systematically investigated in this paper. Employing the notions of quasi-ideals, weakly left (or right) ideals, and generalized weak ideals, we focus on investigating the strong $\pi$-regula...

Multidrug resistance (MDR) is regarded as one of the bottlenecks of successful clinical treatment for numerous chemotherapeutic agents. Multiple key regulators are alleged to be responsible for MDR and making the treatment regimens ineffective. In th...

In this paper, we study asymptotic semicircular laws induced both by arbitrarily fixed $C^{*}$ -probability spaces, and p-adic number fields ${\left\{{\mathbb{Q}}_p\right\}}_{p\in \mathcal{P}}$ , as p→ ∞ in the set $\mathcal{P}$ of all primes.

Moyamoya angiopathy (MA) is a rare cerebrovascular disorder characterised by the progressive occlusion of the internal carotid artery. Its aetiology is uncertain, but a genetic background seems likely, given the high MA familial rate. To investigate...

Peer-to-peer (P2P) applications have been popular among users for more than a decade. They consume a lot of network bandwidth, due to the fact that network administrators face several issues such as congestion, security, managing resources, etc. Henc...

The rapid development of online lending in the past decade, while providing convenience and efficiency, also generates large hidden credit risk for the financial system. Will removing financial intermediaries really provide more efficiency to the len...

We establish a theory whose structure is based on a fixed variable and an algebraic inequality and which improves the well-known least squares theory. The mentioned fixed variable plays a basic role in creating such a theory. In this direction, some...

Background: The current treatment of gastroesophageal reflux disease (GERD) is focused on decreasing gastric acid secretion. However, there is still a group of patients that do not respond to conventional therapy. Proteinase-activated receptors and p...

The P2X7 receptor for extracellular ATP is a well-established mediator of tumoral development and progression both in solid cancers and hematological malignancies. The human P2X7 gene is highly polymorphic, and several splice variants of the receptor...