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Strategies to Discover p53 Activators and a p73 Activator for Neuroblastoma

Department of Chemical Sciences, Laboratory of Organic and Medicinal Chemistry, Faculty of Pharmacy, University of Porto,4050-313 Porto, Portugal
CIIMAR—Interdisciplinary Centre of Marine and Environmental Research, 4450-208 Porto, Portugal
LAQV/REQUIMTE, Laboratório de Microbiologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, Portugal
Laboratory of Tumor Biology, Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic. International Clinical Research Center, St. Anne’s University Hospital, 656 – 91 Brno, Czech Republic
Author to whom correspondence should be addressed.
Presented at the 2nd Molecules Medicinal Chemistry Symposium (MMCS): Facing Novel Challenges in Drug Discovery, Barcelona, Spain, 15–17 May 2019.
Proceedings 2019, 22(1), 56;
Published: 9 August 2019
(This article belongs to the Proceedings of The Molecules Medicinal Chemistry Symposium)
PDF [189 KB, uploaded 9 August 2019]
Note: In lieu of an abstract, this is an excerpt from the first page.


In our quest to discover antitumor agents with novel mechanisms of action, our strategy
concerned multiple molecular modifications in a chemical core. [...]
Keywords: xanthones; antitumor; p53 family xanthones; antitumor; p53 family
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Sousa, E.; Gomes, S.; Raimundo, L.; Soares, J.; Loureiro, J.; Leão, M.; Ramos, H.; Monteiro, M.; Chlapek, P.; Veselská, R.; Lemos, A.; Moreira, J.; Pinto, M.; Saraiva, L. Strategies to Discover p53 Activators and a p73 Activator for Neuroblastoma. Proceedings 2019, 22, 56.

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