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P2X7 Variants in Oncogenesis

Department of Medical Sciences, Section of Experimental Medicine, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy
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Author to whom correspondence should be addressed.
Cells 2021, 10(1), 189; https://doi.org/10.3390/cells10010189
Received: 15 December 2020 / Revised: 14 January 2021 / Accepted: 15 January 2021 / Published: 19 January 2021
(This article belongs to the Special Issue Purine Signaling and Metabolism in Tumors)
The P2X7 receptor for extracellular ATP is a well-established mediator of tumoral development and progression both in solid cancers and hematological malignancies. The human P2X7 gene is highly polymorphic, and several splice variants of the receptor have been identified in time. P2X7 single-nucleotide polymorphisms (SNPs) have been broadly analyzed by studies relating them to pathologies as different as infectious, inflammatory, nervous, and bone diseases, among which cancer is included. Moreover, in the last years, an increasing number of reports concentrated on P2X7 splice variants’ different roles and their implications in pathological conditions, including oncogenesis. Here, we give an overview of established and recent literature demonstrating a role for human P2X7 gene products in oncological conditions, mainly focusing on current data emerging on P2X7 isoform B and nfP2X7. We explored the role of these and other genetic variants of P2X7 in cancer insurgence, dissemination, and progression, as well as the effect of chemotherapy on isoforms expression. The described literature strongly suggests that P2X7 variants are potential new biomarkers and therapeutical targets in oncological conditions and that their study in carcinogenesis deserves to be further pursued. View Full-Text
Keywords: P2X7; P2X7 splice variants; P2X7 SNPs; cancer; leukemia; P2X7B P2X7; P2X7 splice variants; P2X7 SNPs; cancer; leukemia; P2X7B
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MDPI and ACS Style

Pegoraro, A.; De Marchi, E.; Adinolfi, E. P2X7 Variants in Oncogenesis. Cells 2021, 10, 189. https://doi.org/10.3390/cells10010189

AMA Style

Pegoraro A, De Marchi E, Adinolfi E. P2X7 Variants in Oncogenesis. Cells. 2021; 10(1):189. https://doi.org/10.3390/cells10010189

Chicago/Turabian Style

Pegoraro, Anna; De Marchi, Elena; Adinolfi, Elena. 2021. "P2X7 Variants in Oncogenesis" Cells 10, no. 1: 189. https://doi.org/10.3390/cells10010189

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