3,137 Results Found

Increased uterine artery Doppler indices have been shown to be associated with preeclampsia and adverse pregnancy outcomes in singleton and twin pregnancies. At 20–22 weeks of gestation, we assessed the use of notching, the highest, lowest, and...

This paper presents the design and realization of a compact printed ultra-wideband (UWB) antenna with notching characteristics for compact devices using a genetic algorithm. The antenna is capable of mitigating an adjacent sub-band ranging from 3.75...

Background: Scapular notching following reverse shoulder arthroplasty (RSA) is caused by both biological and mechanical mechanisms. Some authors postulated that osteolysis that extends over the inferior screw is caused mainly by biological notching....

A novel ultra-wideband (UWB) KAYI-shaped and common KITE-shaped ground plane tri-port antenna is proposed. The proposed research work has a small size of (30 × 30 × 1.6 mm${}^3$). The MIMO antenna elements are placed in a KAYI-shaped (Y-shaped...

Torque ripple and radial electromagnetic (EM) vibration can lead to motor vibration and noise, which are crucial to the motor’s NVH (Noise, Vibration, and Harshness) performance. Researchers focus on two main aspects: motor body design and cont...

Interior permanent magnet (IPM) synchronous motors have gained widespread adoption in electric vehicles (EVs) owing to their durable rotor configurations, expansive operational speed range, and superior efficiency. Nonetheless, typical IPM motor desi...

Bud-notching in pear varieties with weak-branches enhances branch development, hormone distribution, and germination, promoting healthier growth and improving early yield. To examine the regulatory mechanisms of endogenous hormones on lateral bud ger...

This paper compares two types of interior permanent magnet synchronous motors (IPMSMs) to determine the most effective arrangement for electric vehicle (EV) applications. The comparison is based on torque ripple, power, efficiency, and mechanical obj...

The Notch signaling pathway is pivotal to cellular differentiation. Activation of this pathway involves proteolysis of the Notch receptor and the release of the biologically active Notch intracellular domain, acting as a transcriptional co-activator...

NOTCH signaling represents a promising therapeutic target in chronic lymphocytic leukemia (CLL). We compared the anti-neoplastic effects of the nuclear NOTCH2 inhibitor gliotoxin and the pan-NOTCH γ-secretase inhibitor RO4929097 in primary CLL...

Background and objective: Notch signaling is a conserved developmental pathway, which plays an important role in the regulation of cell proliferation, differentiation and death. Deregulation of Notch pathway has been connected with the carcinogenesis...

This paper presents the design and realization of a compact ultra-wideband (UWB) antenna with a rectangular notch wireless area network (WLAN) band that has controllable notched bandwidth and center frequency. The UWB characteristics of the antenna a...

Notch receptors are single-pass transmembrane proteins that play a critical role in cell fate decisions and have been implicated in the regulation of many developmental processes. The human Notch family comprises of four receptors (Notch 1 to 4) and...

Biochemical and genetic studies have indicated that O-linked glycosylation such as O-glucose (Glc), fucose (Fuc), and N-acetylglucosamine (GlcNAc) is critical for Notch signaling; however, it is not fully understood how O-glycans regulate the Notch r...

Notch signaling plays various roles in cell-fate specification through direct cell–cell interactions. Notch receptors are evolutionarily conserved transmembrane proteins with multiple epidermal growth factor (EGF)-like repeats. Drosophila Notch...

There is accumulating evidence that deregulated Notch signaling affects cancer development, and specifically pancreatic cancer (PC) progression. Notch canonical and non-canonical signaling has diverse impact on PC. Moreover, the actions of RBP-Jk (nu...

A numerical approach based on plastic crack tip opening displacement (CTOD) was followed to study fatigue crack growth (FCG) from notches. The identification of fundamental mechanisms was made considering notched and unnotched models, with and withou...

The 100th anniversary of Notch discovery in Drosophila has recently passed. The Notch is evolutionarily conserved from Drosophila to humans. The discovery of human-specific Notch genes has led to a better understanding of Notch signaling in developme...

This study focused on the effects of the notch angle, notch length, and injection rate on hydraulic fracturing. True triaxial hydraulic fracturing experiments were conducted with 300 × 300 × 300 mm cement mortar blocks. The test results s...

Notch signaling is critical for controlling a variety of cell fate decisions during metazoan development and homeostasis. This unique, highly conserved signaling pathway relies on cell-to-cell contact, which triggers the proteolytic release of the cy...

NOTCH3 receptor signaling has been linked to the regulation of smooth muscle cell proliferation and the maintenance of smooth muscle cells in an undifferentiated state. Pulmonary arterial hypertension (World Health Organization Group 1 idiopathic dis...

Aberrant Notch signaling has been found in a broad range of human malignancies. Consequently, small molecule inhibitors and antibodies targeting Notch signaling in human cancers have been developed and tested; however, these have failed due to limite...

The notch sensitivity of additively manufactured IN 625 superalloy produces by laser powder bed fusion (LPBF) has been investigated by tensile testing of cylindrical test pieces. Smooth and V-notched test pieces with four different radii were tested...

The effect of the notch structure and bottom diameter of a GH4169 notch bolt for an explosive separation device used for longitudinal separation of the fairing, and GH4169 strength range on the tensile load was studied by combing simulations with tes...

In this paper, stress intensity factor (SIF) solutions are numerically obtained for notched bars subjected to tensile loading containing an eccentric circular inner crack located in the cross-section corresponding to the notch root. The finite elemen...

This study was completed in effort to characterize the notch sensitivity of additively manufactured (AM) Inconel 718 produced by laser powder bed fusion (L-PBF). Three different root radii on V-notched test specimens and smooth specimens were evaluat...

The Notch signaling pathway plays a fundamental role for the terminal differentiation of multiple cell types, including B and T lymphocytes. The Notch receptors are transmembrane proteins that, upon ligand engagement, undergo multiple processing step...

The combination of neoadjuvant chemotherapy and surgery has been promoted for the treatment of osteosarcoma; however, the local recurrence and lung metastasis rates remain high. Therefore, it is crucial to explore new therapeutic targets and strategi...

Notch3 is one of four mammalian Notch proteins, which act as signalling receptors to control cell fate in many developmental and adult tissue contexts. Notch signalling continues to be important in the adult organism for tissue maintenance and renewa...

The issues of the high-cycle fatigue resistance of notches and the role of non-propagating short cracks in defining the fatigue notch sensitivity and fatigue limit of the configuration are addressed. A fracture mechanics approach is employed to deter...

Members of the Notch family and chronic inflammation were each separately demonstrated to have prominent malignancy-supporting roles in breast cancer. Recent investigations indicate that bi-directional interactions that exist between these two pathwa...

The results of experimental research on the pullout properties of circumferentially notched z-pins with various notch designs are presented in this paper. Investigations on notched z-pins with four different notch designs—rectangular, circular,...

The Notch signaling pathway is a critical regulator of embryonic brain development. Among its four mammalian receptors, Notch1 and Notch2 are particularly significant in the developing cortex, yet their roles in human neurodevelopment are not well un...

Background: The Notch signal transduction pathway is pivotal for various physiological processes, including immune responses, and has been implicated in the pathogenesis of many diseases. The effectiveness of various targeted Notch pathway inhibitors...

NOTCH1 PEST domain mutations are often seen in hematopoietic malignancies, including T-cell acute lymphoblastic leukemia (T-ALL), chronic lymphocytic leukemia (CLL), splenic marginal zone lymphoma (SMZL), mantle cell lymphoma (MCL), and diffuse large...

The Notch signaling pathway plays a significant role in embryonic cell fate determination and adult tissue homeostasis. Various studies have demonstrated the deep involvement of Notch signaling in the development of the pancreas and the lateral inhib...

Despite major progress in mantle cell lymphoma (MCL) therapeutics, MCL remains a deadly disease with a median survival not exceeding four years. No single driver genetic lesion has been described to solely give rise to MCL. The hallmark translocation...

The evolutionarily conserved Notch signalling pathway regulates the fate, proliferation and differentiation of cells in most developing organs, thus affecting their morphogenesis and function. Here, we investigated the role of the Notch2 receptor in...

Notch signaling is conserved in C. elegans, Drosophila, and mammals. Among the four NOTCH genes in humans, NOTCH1, NOTCH2, and NOTCH3 are known to cause monogenic hereditary disorders. Most NOTCH-related disorders are congenital and caused by a gain...

Colorectal cancer (CRC) has one of the highest mortality rates despite the advancement of treatment options. Aggressive CRC remains difficult to treat owing to the activation of oncogenic signaling pathways such as the Notch signaling pathway. The ro...

The Notch signaling pathway is an evolutionary conserved signal transduction cascade present in almost all tissues and is required for embryonic and postnatal development, as well as for stem cell maintenance, but it is also implicated in tumorigenes...

The notch effect of semicrystalline PVDF was investigated using U- and V-notch geometries with different depths, and tensile tests were performed at 23 °C using the DIC technique and FEA. Both unnotched and notched dumbbell-shaped specimens were...

This study focuses on predicting the fatigue life of notched specimens with geometries and microstructure representative of welded joints. It employs 26 series of fatigue tests on welded and non-welded specimens containing notches located in differen...

Notch family members are generally recognized as signaling molecules that control various cellular responses in metazoan organisms. Early fly studies and our mammalian studies demonstrated that Notch family members are also cell adhesion molecules; h...

Bladder cancer (BCa) is one of the most diagnosed cancers worldwide. It is classified as non-muscle-invasive (NMIB), confined to the mucosa, and muscle-invasive (MIB), extended to deeper layers or formed metastases. The poor outcomes associated with...

The very conserved Notch pathway is used iteratively during development and adulthood to regulate cell fates. Notch activation relies on interactions between neighboring cells, through the binding of Notch receptors to their ligands, both transmembr...

Notch pathway is a highly conserved intracellular signaling route that modulates a vast variety of cellular processes including proliferation, differentiation, migration, cell fate and death. Recently, the presence of a strict crosstalk between Notch...

The symmetry of a human organism’s structure is an expression of the general law of development regarding organic life. Assessing the symmetry of the face and its individual components is one of the most important factors when it comes to the o...

In this paper, a notch bandpass filter based on spoof surface plasmon polaritons (SSPPs) is presented and systematically analyzed. The bandpass response is realized by a momentum-matched SSPP transition section and two SSPP resonant units. An annular...

Notch1 signalling plays a multifaceted role in tissue development and homeostasis. Currently, due to the pivotal role of Notch1 signalling, the relationship between NOTCH1 expression and the development of health disorders is being intensively studie...