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The Role of Notch Signaling and Leptin-Notch Crosstalk in Pancreatic Cancer

1
Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA
2
Department of Pathology, Emory University, Atlanta, GA 30322, USA
*
Author to whom correspondence should be addressed.
Medicines 2018, 5(3), 68; https://doi.org/10.3390/medicines5030068
Received: 6 June 2018 / Revised: 27 June 2018 / Accepted: 29 June 2018 / Published: 2 July 2018
There is accumulating evidence that deregulated Notch signaling affects cancer development, and specifically pancreatic cancer (PC) progression. Notch canonical and non-canonical signaling has diverse impact on PC. Moreover, the actions of RBP-Jk (nuclear partner of activated Notch) independent of Notch signaling pathway seem to affect differently cancer progression. Recent data show that in PC and other cancer types the adipokine leptin can modulate Notch/RBP-Jk signaling, thereby, linking the pandemic obesity with cancer and chemoresistance. The potential pivotal role of leptin on PC, and its connection with Notch signaling and chemoresistance are still not completely understood. In this review, we will describe the most important aspects of Notch-RBP-Jk signaling in PC. Further, we will discuss on studies related to RBP-Jk-independent Notch and Notch-independent RPB-Jk signaling. We will also discuss on the novel crosstalk between leptin and Notch in PC and its implications in chemoresistance. The effects of leptin-Notch/RBP-Jk signaling on cancer cell proliferation, apoptosis, and drug resistance require more investigation. Data from these investigations could help to open unexplored ways to improve PC treatment success that has shown little progress for many years. View Full-Text
Keywords: pancreatic cancer; Notch; RBP-Jk; leptin; chemoresistance pancreatic cancer; Notch; RBP-Jk; leptin; chemoresistance
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Harbuzariu, A.; Oprea-Ilies, G.M.; Gonzalez-Perez, R.R. The Role of Notch Signaling and Leptin-Notch Crosstalk in Pancreatic Cancer. Medicines 2018, 5, 68.

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