Next Article in Journal
Pleiotropic Immune Functions of Chemokine Receptor 6 in Health and Disease
Previous Article in Journal
Plant-Based Cannabinoids for the Treatment of Chronic Neuropathic Pain
Open AccessReview

The Role of Notch Signaling and Leptin-Notch Crosstalk in Pancreatic Cancer

Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA
Department of Pathology, Emory University, Atlanta, GA 30322, USA
Author to whom correspondence should be addressed.
Medicines 2018, 5(3), 68;
Received: 6 June 2018 / Revised: 27 June 2018 / Accepted: 29 June 2018 / Published: 2 July 2018
There is accumulating evidence that deregulated Notch signaling affects cancer development, and specifically pancreatic cancer (PC) progression. Notch canonical and non-canonical signaling has diverse impact on PC. Moreover, the actions of RBP-Jk (nuclear partner of activated Notch) independent of Notch signaling pathway seem to affect differently cancer progression. Recent data show that in PC and other cancer types the adipokine leptin can modulate Notch/RBP-Jk signaling, thereby, linking the pandemic obesity with cancer and chemoresistance. The potential pivotal role of leptin on PC, and its connection with Notch signaling and chemoresistance are still not completely understood. In this review, we will describe the most important aspects of Notch-RBP-Jk signaling in PC. Further, we will discuss on studies related to RBP-Jk-independent Notch and Notch-independent RPB-Jk signaling. We will also discuss on the novel crosstalk between leptin and Notch in PC and its implications in chemoresistance. The effects of leptin-Notch/RBP-Jk signaling on cancer cell proliferation, apoptosis, and drug resistance require more investigation. Data from these investigations could help to open unexplored ways to improve PC treatment success that has shown little progress for many years. View Full-Text
Keywords: pancreatic cancer; Notch; RBP-Jk; leptin; chemoresistance pancreatic cancer; Notch; RBP-Jk; leptin; chemoresistance
Show Figures

Figure 1

MDPI and ACS Style

Harbuzariu, A.; Oprea-Ilies, G.M.; Gonzalez-Perez, R.R. The Role of Notch Signaling and Leptin-Notch Crosstalk in Pancreatic Cancer. Medicines 2018, 5, 68.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop