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Role of Notch Receptors in Hematologic Malignancies

MASVE Interdepartmental Hepatology Center, Department of Experimental and Clinical Medicine,University of Florence, Center for Research and Innovation CRIA-MASVE, 50134 Firenze, Italy
Author to whom correspondence should be addressed.
Cells 2021, 10(1), 16;
Received: 10 November 2020 / Revised: 18 December 2020 / Accepted: 22 December 2020 / Published: 24 December 2020
(This article belongs to the Special Issue The Roles of Notch Signaling in Cancers)
Notch receptors are single-pass transmembrane proteins that play a critical role in cell fate decisions and have been implicated in the regulation of many developmental processes. The human Notch family comprises of four receptors (Notch 1 to 4) and five ligands. Their signaling can regulate extremely basic cellular processes such as differentiation, proliferation and death. Notch is also involved in hematopoiesis and angiogenesis, and increasing evidence suggests that these genes are involved and frequently deregulated in several human malignancies, contributing to cell autonomous activities that may be either oncogenic or tumor suppressive. It was recently proposed that Notch signaling could play an active role in promoting and sustaining a broad spectrum of lymphoid malignancies as well as mutations in Notch family members that are present in several disorders of T- and B-cells, which could be responsible for altering the related signaling. Therefore, different Notch pathway molecules could be considered as potential therapeutic targets for hematological cancers. In this review, we will summarize and discuss compelling evidence pointing to Notch receptors as pleiotropic regulators of hematologic malignancies biology, first describing the physiological role of their signaling in T- and B-cell development and homeostasis, in order to fully understand the pathological alterations reported. View Full-Text
Keywords: Notch; Notch receptor; Notch signaling; T-cells; B-cells; leukemia; lymphoma; hematological malignancies Notch; Notch receptor; Notch signaling; T-cells; B-cells; leukemia; lymphoma; hematological malignancies
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MDPI and ACS Style

Gragnani, L.; Lorini, S.; Marri, S.; Zignego, A.L. Role of Notch Receptors in Hematologic Malignancies. Cells 2021, 10, 16.

AMA Style

Gragnani L, Lorini S, Marri S, Zignego AL. Role of Notch Receptors in Hematologic Malignancies. Cells. 2021; 10(1):16.

Chicago/Turabian Style

Gragnani, Laura, Serena Lorini, Silvia Marri, and Anna L. Zignego 2021. "Role of Notch Receptors in Hematologic Malignancies" Cells 10, no. 1: 16.

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