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Int. J. Mol. Sci. 2016, 17(1), 48;

Notch Signaling in Pancreatic Development

College of Life Science, Northeast Forestry University, Harbin 150040, China
College of Life Sciences, Agriculture and Forestry, Qiqihar University, Qiqihar 161006, China
Author to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Received: 22 November 2015 / Revised: 22 December 2015 / Accepted: 24 December 2015 / Published: 30 December 2015
(This article belongs to the Special Issue Molecular Classification of Human Cancer: Diagnosis and Treatment)
Full-Text   |   PDF [1620 KB, uploaded 30 December 2015]   |  


The Notch signaling pathway plays a significant role in embryonic cell fate determination and adult tissue homeostasis. Various studies have demonstrated the deep involvement of Notch signaling in the development of the pancreas and the lateral inhibition of Notch signaling in pancreatic progenitor differentiation and maintenance. The targeted inactivation of the Notch pathway components promotes premature differentiation of the endocrine pancreas. However, there is still the contrary opinion that Notch signaling specifies the endocrine lineage. Here, we review the current knowledge of the Notch signaling pathway in pancreatic development and its crosstalk with the Wingless and INT-1 (Wnt) and fibroblast growth factor (FGF) pathways. View Full-Text
Keywords: pancreatic progenitor; Notch signaling; differentiation; maintenance pancreatic progenitor; Notch signaling; differentiation; maintenance

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Li, X.-Y.; Zhai, W.-J.; Teng, C.-B. Notch Signaling in Pancreatic Development. Int. J. Mol. Sci. 2016, 17, 48.

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