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3,241 Results Found

  • Article
  • Open Access
14 Citations
7,849 Views
29 Pages

Malware Detection Based on API Call Sequence Analysis: A Gated Recurrent Unit–Generative Adversarial Network Model Approach

  • Nsikak Owoh,
  • John Adejoh,
  • Salaheddin Hosseinzadeh,
  • Moses Ashawa,
  • Jude Osamor and
  • Ayyaz Qureshi

13 October 2024

Malware remains a major threat to computer systems, with a vast number of new samples being identified and documented regularly. Windows systems are particularly vulnerable to malicious programs like viruses, worms, and trojans. Dynamic analysis, whi...

  • Article
  • Open Access
2 Citations
3,001 Views
18 Pages

19 November 2021

A classic and fundamental result about the decomposition of random sequences into a mixture of simpler ones is de Finetti’s Theorem. In its original form, it applies to infinite 0–1 valued sequences with the special property that the distribution is...

  • Article
  • Open Access
22 Citations
6,853 Views
15 Pages

Network Entropy for the Sequence Analysis of Functional Connectivity Graphs of the Brain

  • Chi Zhang,
  • Fengyu Cong,
  • Tuomo Kujala,
  • Wenya Liu,
  • Jia Liu,
  • Tiina Parviainen and
  • Tapani Ristaniemi

25 April 2018

Dynamic representation of functional brain networks involved in the sequence analysis of functional connectivity graphs of the brain (FCGB) gains advances in uncovering evolved interaction mechanisms. However, most of the networks, even the event-rel...

  • Article
  • Open Access
11 Citations
3,970 Views
15 Pages

Source Attribution of Human Campylobacteriosis Using Whole-Genome Sequencing Data and Network Analysis

  • Lynda Wainaina,
  • Alessandra Merlotti,
  • Daniel Remondini,
  • Clementine Henri,
  • Tine Hald and
  • Patrick Murigu Kamau Njage

Campylobacter spp. are a leading and increasing cause of gastrointestinal infections worldwide. Source attribution, which apportions human infection cases to different animal species and food reservoirs, has been instrumental in control- and evidence...

  • Article
  • Open Access
267 Views
21 Pages

Protists represent a vast yet underexplored reservoir of enzymatic diversity across the eukaryotic tree of life. In this study, we established axenic strains of diverse protists from four major eukaryotic supergroups using single-cell isolation and g...

  • Article
  • Open Access
5 Citations
2,843 Views
9 Pages

Protein–protein interactions (PPIs) are fundamental to many biological processes. The coevolution-based prediction of interacting residues has made great strides in protein complexes that are known to interact. A multiple sequence alignment (MS...

  • Article
  • Open Access
116 Views
30 Pages

Path-Dependent Infrastructure Planning: A Network Science-Driven Decision Support System with Iterative TOPSIS

  • Senbin Yu,
  • Haichen Chen,
  • Nina Xu,
  • Xinxin Yu,
  • Zeling Fang,
  • Gehui Liu and
  • Jun Yang

30 January 2026

Expressway networks represent evolving complex systems whose topological properties significantly impact regional development. This paper presents a decision support framework for addressing the expressway infrastructure sequencing problem using comp...

  • Article
  • Open Access
12 Citations
3,476 Views
18 Pages

Evolutionary Analyses of Sequence and Structure Space Unravel the Structural Facets of SOD1

  • Sourav Chowdhury,
  • Dwipanjan Sanyal,
  • Sagnik Sen,
  • Vladimir N. Uversky,
  • Ujjwal Maulik and
  • Krishnananda Chattopadhyay

4 December 2019

Superoxide dismutase (SOD) is the primary enzyme of the cellular antioxidant defense cascade. Misfolding, concomitant oligomerization, and higher order aggregation of human cytosolic SOD are linked to amyotrophic lateral sclerosis (ALS). Although, wi...

  • Article
  • Open Access
1 Citations
2,136 Views
22 Pages

16 October 2024

RNA-sequencing enables the comprehensive detection of gene expression levels at specific time points and facilitates the identification of stress-related genes through co-expression network analysis. Understanding the molecular mechanisms and identif...

  • Article
  • Open Access
2 Citations
2,673 Views
17 Pages

The Landscapes of Gluten Regulatory Network in Elite Wheat Cultivars Contrasting in Gluten Strength

  • Jiajun Liu,
  • Dongsheng Li,
  • Peng Zhu,
  • Shi Qiu,
  • Kebing Yao,
  • Yiqing Zhuang,
  • Chen Chen,
  • Guanqing Liu,
  • Mingxing Wen and
  • Tao Li
  • + 4 authors

Yangmai-13 (YM13) is a wheat cultivar with weak gluten fractions. In contrast, Zhenmai-168 (ZM168) is an elite wheat cultivar known for its strong gluten fractions and has been widely used in a number of breeding programs. However, the genetic mechan...

  • Article
  • Open Access
2 Citations
1,855 Views
13 Pages

26 July 2024

Equine rhinitis A (ERAV) and B (ERBV) viruses are respiratory pathogens with worldwide distribution. The current study aimed to determine the frequency of infection of ERAV and ERBV among horses and foals at Polish national studs, and to determine ge...

  • Article
  • Open Access
10 Citations
3,728 Views
20 Pages

Transcriptomic Sequencing and Co-Expression Network Analysis on Key Genes and Pathways Regulating Nitrogen Use Efficiency in Myriophyllum aquaticum

  • Rui Wang,
  • Shengjun Xu,
  • Cancan Jiang,
  • Haishu Sun,
  • Shugeng Feng,
  • Sining Zhou,
  • Guoqiang Zhuang,
  • Zhihui Bai and
  • Xuliang Zhuang

Massively input and accumulated ammonium is one of the main causes of eutrophication in aquatic ecosystems, which severely deteriorates water quality. Previous studies showed that one of the commonly used macrophytes, Myriophyllum aquaticum, was capa...

  • Article
  • Open Access
1,394 Views
20 Pages

9 July 2025

As China’s economy grows and travel demand increases, its aviation market has evolved to become the second-largest in the world. This study presents a pioneering analysis of China’s aviation network evolution (1990–2024) by integrat...

  • Article
  • Open Access
42 Citations
13,514 Views
34 Pages

Information Theory in Computational Biology: Where We Stand Today

  • Pritam Chanda,
  • Eduardo Costa,
  • Jie Hu,
  • Shravan Sukumar,
  • John Van Hemert and
  • Rasna Walia

6 June 2020

“A Mathematical Theory of Communication” was published in 1948 by Claude Shannon to address the problems in the field of data compression and communication over (noisy) communication channels. Since then, the concepts and ideas developed...

  • Article
  • Open Access
1 Citations
1,810 Views
27 Pages

Research on User Behavior Based on Higher-Order Dependency Network

  • Liwei Qian,
  • Yajie Dou,
  • Chang Gong,
  • Xiangqian Xu and
  • Yuejin Tan

26 July 2023

In the era of the popularization of the Internet of Things (IOT), analyzing people’s daily life behavior through the data collected by devices is an important method to mine potential daily requirements. The network method is an important means to an...

  • Article
  • Open Access
6 Citations
3,568 Views
14 Pages

Integrating Single-Cell Transcriptome and Network Analysis to Characterize the Therapeutic Response of Chronic Myeloid Leukemia

  • Jialu Ma,
  • Nathan Pettit,
  • John Talburt,
  • Shanzhi Wang,
  • Sherman M. Weissman and
  • Mary Qu Yang

18 November 2022

Chronic myeloid leukemia (CML) is a myeloproliferative disease characterized by a unique BCR-ABL fusion gene. Tyrosine kinase inhibitors (TKIs) were developed to target the BCR-ABL oncoprotein, inhibiting its abnormal kinase activity. TKI treatments...

  • Article
  • Open Access
8 Citations
3,896 Views
19 Pages

A Malware Detection Framework Based on Semantic Information of Behavioral Features

  • Yuxin Zhang,
  • Shumian Yang,
  • Lijuan Xu,
  • Xin Li and
  • Dawei Zhao

20 November 2023

As the amount of malware has grown rapidly in recent years, it has become the most dominant attack method in network security. Learning execution behavior, especially Application Programming Interface (API) call sequences, has been shown to be effect...

  • Article
  • Open Access
39 Citations
5,329 Views
14 Pages

Responses of Microbial Communities and Interaction Networks to Different Management Practices in Tea Plantation Soils

  • Lin Tan,
  • Songsong Gu,
  • Shi Li,
  • Zuohua Ren,
  • Ye Deng,
  • Zhonghua Liu,
  • Zhihua Gong,
  • Wenjun Xiao and
  • Qiulong Hu

16 August 2019

Soil microorganisms play important roles in the plant health and agricultural production. However, little is known about the complex responses of microbial communities and interaction networks to different agricultural management practices in tea pla...

  • Article
  • Open Access
8 Citations
3,693 Views
14 Pages

Rapid SARS-CoV-2 Intra-Host and Within-Household Emergence of Novel Haplotypes

  • Laura Manuto,
  • Marco Grazioli,
  • Andrea Spitaleri,
  • Paolo Fontana,
  • Luca Bianco,
  • Luigi Bertolotti,
  • Martina Bado,
  • Giorgia Mazzotti,
  • Federico Bianca and
  • Stefano Toppo
  • + 11 authors

15 February 2022

In February 2020, the municipality of Vo’, a small town near Padua (Italy) was quarantined due to the first coronavirus disease 19 (COVID-19)-related death detected in Italy. To investigate the viral prevalence and clinical features, the entire...

  • Protocol
  • Open Access
5 Citations
6,467 Views
18 Pages

The reduction in costs associated with performing RNA-sequencing has driven an increase in the application of this analytical technique; however, restrictive factors associated with this tool have now shifted from budgetary constraints to time requir...

  • Article
  • Open Access
12 Citations
3,080 Views
13 Pages

Comparison of Source Attribution Methodologies for Human Campylobacteriosis

  • Maja Lykke Brinch,
  • Tine Hald,
  • Lynda Wainaina,
  • Alessandra Merlotti,
  • Daniel Remondini,
  • Clementine Henri and
  • Patrick Murigu Kamau Njage

Campylobacter spp. are the most common cause of bacterial gastrointestinal infection in humans both in Denmark and worldwide. Studies have found microbial subtyping to be a powerful tool for source attribution, but comparisons of different methodolog...

  • Article
  • Open Access
22 Citations
5,434 Views
21 Pages

12 May 2020

Improved reproductive efficiency could lead to economic benefits for the beef industry, once the intensive selection pressure has led to a decreased fertility. However, several factors limit our understanding of fertility traits, including genetic di...

  • Article
  • Open Access
4 Citations
5,871 Views
21 Pages

11 August 2016

Extracting opinion expressions from text is an essential task of sentiment analysis, which is usually treated as one of the word-level sequence labeling problems. In such problems, compositional models with multiplicative gating operations provide ef...

  • Article
  • Open Access
17 Citations
4,628 Views
17 Pages

Characterization of Peptaibols Produced by a Marine Strain of the Fungus Trichoderma endophyticum via Mass Spectrometry, Genome Mining and Phylogeny-Based Prediction

  • Gleucinei S. Castro,
  • Thiago F. Sousa,
  • Gilvan F. da Silva,
  • Rita C. N. Pedroso,
  • Kelly S. Menezes,
  • Marcos A. Soares,
  • Gustavo M. Dias,
  • Aline O. Santos,
  • Michel E. B. Yamagishi and
  • Hector H. F. Koolen
  • + 2 authors

3 February 2023

Trichoderma is recognized as a prolific producer of nonribosomal peptides (NRPs) known as peptaibols, which have remarkable biological properties, such as antimicrobial and anticancer activities, as well as the ability to promote systemic resistance...

  • Article
  • Open Access
15 Citations
4,606 Views
30 Pages

Transcriptome Profiling of the Dorsomedial Prefrontal Cortex in Suicide Victims

  • Fanni Dóra,
  • Éva Renner,
  • Dávid Keller,
  • Miklós Palkovits and
  • Árpád Dobolyi

The default mode network (DMN) plays an outstanding role in psychiatric disorders. Still, gene expressional changes in its major component, the dorsomedial prefrontal cortex (DMPFC), have not been characterized. We used RNA sequencing in postmortem D...

  • Article
  • Open Access
6 Citations
3,081 Views
23 Pages

Tracing the Evolutionary Pathways of Serogroup O78 Avian Pathogenic Escherichia coli

  • Eun-Jin Ha,
  • Seung-Min Hong,
  • Seung-Ji Kim,
  • Sun-Min Ahn,
  • Ho-Won Kim,
  • Kang-Seuk Choi and
  • Hyuk-Joon Kwon

9 December 2023

Avian pathogenic E. coli (APEC) causes severe economic losses in the poultry industry, and O78 serogroup APEC strains are prevalent in chickens. In this study, we aimed to understand the evolutionary pathways and relationships between O78 APEC and ot...

  • Article
  • Open Access
6 Citations
3,586 Views
23 Pages

1 September 2022

Eukaryotes exist widely in aquatic ecosystems. It is of great importance to study their species composition, diversity, and relationship with environmental factors to protect and maintain ecosystem balance. Salt lakes are essential lakes rich in biol...

  • Article
  • Open Access
7 Citations
3,518 Views
15 Pages

29 November 2022

The molecular mechanisms and gene regulatory networks sustaining cell proliferation in neuroblastoma (NBL) cells are still not fully understood. In this tumor context, it has been proposed that anti-proliferative drugs, such as the pan-HDAC inhibitor...

  • Article
  • Open Access
4 Citations
6,876 Views
19 Pages

DIscBIO: A User-Friendly Pipeline for Biomarker Discovery in Single-Cell Transcriptomics

  • Salim Ghannoum,
  • Waldir Leoncio Netto,
  • Damiano Fantini,
  • Benjamin Ragan-Kelley,
  • Amirabbas Parizadeh,
  • Emma Jonasson,
  • Anders Ståhlberg,
  • Hesso Farhan and
  • Alvaro Köhn-Luque

30 January 2021

The growing attention toward the benefits of single-cell RNA sequencing (scRNA-seq) is leading to a myriad of computational packages for the analysis of different aspects of scRNA-seq data. For researchers without advanced programing skills, it is ve...

  • Article
  • Open Access
8 Citations
2,243 Views
19 Pages

Voltage Regulation Using Recurrent Wavelet Fuzzy Neural Network-Based Dynamic Voltage Restorer

  • Cheng-I Chen,
  • Yeong-Chin Chen,
  • Chung-Hsien Chen and
  • Yung-Ruei Chang

26 November 2020

Dynamic voltage restorers (DVRs) are one of the effective solutions to regulate the voltage of power systems and protect sensitive loads against voltage disturbances, such as voltage sags, voltage fluctuations, et cetera. The performance of voltage c...

  • Article
  • Open Access
7 Citations
2,727 Views
16 Pages

Soil Geochemical Properties Influencing the Diversity of Bacteria and Archaea in Soils of the Kitezh Lake Area, Antarctica

  • Qinxin Li,
  • Nengfei Wang,
  • Wenbing Han,
  • Botao Zhang,
  • Jiaye Zang,
  • Yiling Qin,
  • Long Wang,
  • Jie Liu and
  • Tao Zhang

19 December 2022

It is believed that polar regions are influenced by global warming more significantly, and because polar regions are less affected by human activities, they have certain reference values for future predictions. This study aimed to investigate the eff...

  • Article
  • Open Access
27 Citations
3,787 Views
15 Pages

Here, the ion-exchangeable form of nitrogen (IEF-N), weak-acid extractable form of nitrogen (WAEF-N), strong-alkali extractable form of nitrogen (SAEF-N), strong-oxidant extractable form of nitrogen (SOEF-N), residue nitrogen (Res-N), and total nitro...

  • Article
  • Open Access
22 Citations
4,882 Views
14 Pages

Grape Cultivar Features Differentiate the Grape Rhizosphere Microbiota

  • Lijun Bao,
  • Bo Sun,
  • Yingxue Wei,
  • Nan Xu,
  • Shiwei Zhang,
  • Likun Gu and
  • Zhihui Bai

20 April 2022

Rhizosphere microflora are key determinants that contribute to plant growth and productivity, which are involved in improving the uptake of nutrients, regulation of plants’ metabolisms and activation of plants’ responses against both biot...

  • Article
  • Open Access
1 Citations
2,409 Views
12 Pages

Identification of Genes Associated with Crest Cushion Development in the Chinese Crested Duck

  • Qixin Guo,
  • Lan Huang,
  • Yong Jiang,
  • Zhixiu Wang,
  • Guohong Chen,
  • Hao Bai and
  • Guobin Chang

22 August 2022

The crest trait is a specific and widely distributed phenotype in birds. However, the shape and function vary in different species of birds. To understand the mechanism of crest formation, the present study used RNA sequencing and weighted gene co-ex...

  • Review
  • Open Access
7 Citations
7,080 Views
50 Pages

25 February 2022

Retinal neurogenesis is driven by concerted actions of transcription factors, some of which are expressed in a continuum and across several cell subtypes throughout development. While seemingly redundant, many factors diversify their regulatory outco...

  • Article
  • Open Access
46 Citations
5,567 Views
23 Pages

22 February 2020

Nitrogen (N) is the most important limiting factor for cotton production worldwide. Genotype-dependent ability to cope with N shortage has been only partially explored in cotton, and in this context, the comparison of molecular responses of cotton ge...

  • Article
  • Open Access
1 Citations
1,574 Views
23 Pages

Ex Vivo Drug Sensitivity of Pleural Effusion-Derived Cells from Lung Cancer and Pleural Mesothelioma Patients Is Linked to Clinical Response

  • Rita Hutyra-Gram Ötvös,
  • Hanna Krynska,
  • Greta Gudoityte,
  • Marcus Skribek,
  • Anca Oniscu,
  • Olena Berkovska,
  • Katharina Strauß,
  • Jenny Zipprick,
  • David Tamborero and
  • Katalin Dobra
  • + 3 authors

16 July 2025

Background: Tumors of the pleura, such as metastatic lung cancer and mesothelioma, are amongst the most lethal and therapy-resistant tumors. The first manifestation of the disease is often pleural effusion, the first available material for diagnosis....

  • Article
  • Open Access
11 Citations
2,538 Views
17 Pages

30 June 2024

Combined organic and inorganic fertilization can improve soil fertility in coal mine reclamation areas. However, the contribution of the bacterial community (especially its occurrence patterns) to soil physicochemical properties and enzyme activity n...

  • Article
  • Open Access
13 Citations
7,021 Views
18 Pages

Comparative Transcriptomic Analysis of the Hematopoietic System between Human and Mouse by Single Cell RNA Sequencing

  • Shouguo Gao,
  • Zhijie Wu,
  • Jeerthi Kannan,
  • Liza Mathews,
  • Xingmin Feng,
  • Sachiko Kajigaya and
  • Neal S. Young

21 April 2021

(1) Background: mouse models are fundamental to the study of hematopoiesis, but comparisons between mouse and human in single cells have been limited in depth. (2) Methods: we constructed a single-cell resolution transcriptomic atlas of hematopoietic...

  • Article
  • Open Access
29 Citations
6,435 Views
27 Pages

29 December 2020

The basic region-leucine zipper (bZIP) transcription factors (TFs) form homodimers and heterodimers via the coil–coil region. The bZIP dimerization network influences gene expression across plant development and in response to a range of enviro...

  • Article
  • Open Access
7 Citations
5,122 Views
18 Pages

The prevalence of vancomycin resistant enterococcus (VRE) carrier-state has been increasing in patients of intensive care unit and it would be a public health threat. Different research groups conducted decolonizing VRE with probiotic and the results...

  • Article
  • Open Access
6 Citations
3,091 Views
16 Pages

Analysis of Sequence Divergence in Mammalian ABCGs Predicts a Structural Network of Residues That Underlies Functional Divergence

  • James I. Mitchell-White,
  • Thomas Stockner,
  • Nicholas Holliday,
  • Stephen J. Briddon and
  • Ian D. Kerr

The five members of the mammalian G subfamily of ATP-binding cassette transporters differ greatly in their substrate specificity. Four members of the subfamily are important in lipid transport and the wide substrate specificity of one of the members,...

  • Article
  • Open Access
11 Citations
3,609 Views
15 Pages

ML-DTD: Machine Learning-Based Drug Target Discovery for the Potential Treatment of COVID-19

  • Sovan Saha,
  • Piyali Chatterjee,
  • Anup Kumar Halder,
  • Mita Nasipuri,
  • Subhadip Basu and
  • Dariusz Plewczynski

30 September 2022

Recent research has highlighted that a large section of druggable protein targets in the Human interactome remains unexplored for various diseases. It might lead to the drug repurposing study and help in the in-silico prediction of new drug-human pro...

  • Article
  • Open Access
13 Citations
3,446 Views
23 Pages

Integrated QTL Mapping, Meta-Analysis, and RNA-Sequencing Reveal Candidate Genes for Maize Deep-Sowing Tolerance

  • Xiaoqiang Zhao,
  • Yining Niu,
  • Zakir Hossain,
  • Jing Shi,
  • Taotao Mao and
  • Xiaodong Bai

Synergetic elongation of mesocotyl and coleoptile are crucial in governing maize seedlings emergence, especially for the maize sown in deep soil. Studying the genomic regions controlling maize deep-sowing tolerance would aid the development of new va...

  • Article
  • Open Access
1 Citations
2,959 Views
19 Pages

Sequence Similarity Network Analysis Provides Insight into the Temporal and Geographical Distribution of Mutations in SARS-CoV-2 Spike Protein

  • Shruti S. Patil,
  • Helen N. Catanese,
  • Kelly A. Brayton,
  • Eric T. Lofgren and
  • Assefaw H. Gebremedhin

29 July 2022

Severe acute respiratory syndrome-related coronavirus (SARS-CoV-2), which still infects hundreds of thousands of people globally each day despite various countermeasures, has been mutating rapidly. Mutations in the spike (S) protein seem to play a vi...

  • Article
  • Open Access
35 Citations
6,782 Views
22 Pages

Co-Expression Network Analysis and Hub Gene Selection for High-Quality Fiber in Upland Cotton (Gossypium hirsutum) Using RNA Sequencing Analysis

  • Xianyan Zou,
  • Aiying Liu,
  • Zhen Zhang,
  • Qun Ge,
  • Senmiao Fan,
  • Wankui Gong,
  • Junwen Li,
  • Juwu Gong,
  • Yuzhen Shi and
  • Haihong Shang
  • + 11 authors

6 February 2019

Upland cotton (Gossypium hirsutum) is grown for its elite fiber. Understanding differential gene expression patterns during fiber development will help to identify genes associated with fiber quality. In this study, we used two recombinant inbred lin...

  • Article
  • Open Access
16 Citations
5,194 Views
20 Pages

9 December 2022

A phenotype is the composite of an observable expression of a genome for traits in a given environment. The trajectories of phenotypes computed from an image sequence and timing of important events in a plant’s life cycle can be viewed as tempo...

  • Article
  • Open Access
12 Citations
5,917 Views
21 Pages

Two-State Co-Expression Network Analysis to Identify Genes Related to Salt Tolerance in Thai Rice

  • Apichat Suratanee,
  • Chidchanok Chokrathok,
  • Panita Chutimanukul,
  • Nopphawitchayaphong Khrueasan,
  • Teerapong Buaboocha,
  • Supachitra Chadchawan and
  • Kitiporn Plaimas

29 November 2018

Khao Dawk Mali 105 (KDML105) rice is one of the most important crops of Thailand. It is a challenging task to identify the genes responding to salinity in KDML105 rice. The analysis of the gene co-expression network has been widely performed to prior...

  • Article
  • Open Access
13 Citations
3,172 Views
16 Pages

29 July 2022

The white wax secreted by the male insects of the Chinese white wax scale (CWWS) is a natural high-molecular-weight compound with important economic value. However, its regulatory mechanism of wax biosynthesis is still unclear. In this study, a weigh...

  • Article
  • Open Access
7 Citations
5,453 Views
15 Pages

Comparative Analysis and Ancestral Sequence Reconstruction of Bacterial Sortase Family Proteins Generates Functional Ancestral Mutants with Different Sequence Specificities

  • Jordan D. Valgardson,
  • Sarah A. Struyvenberg,
  • Zachary R. Sailer,
  • Isabel M. Piper,
  • Justin E. Svendsen,
  • D. Alex Johnson,
  • Brandon A. Vogel,
  • John M. Antos,
  • Michael J. Harms and
  • Jeanine F. Amacher

9 June 2022

Gram-positive bacteria are some of the earliest known life forms, diverging from gram-negative bacteria 2 billion years ago. These organisms utilize sortase enzymes to attach proteins to their peptidoglycan cell wall, a structural feature that distin...

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