612 Results Found

Background: Gene expression in eukaryotic cells can be governed by histone variants, which replace replication-coupled histones, conferring unique chromatin properties. MacroH2A1 is a histone H2A variant containing a domain highly similar to H2A and...

Histone variants confer chromatin unique properties. They have specific genomic distribution, regulated by specific deposition and removal machineries. Histone variants, mostly of canonical histones H2A, H2B and H3, have important roles in early embr...

MacroH2A histone variants have functions in differentiation, somatic cell reprogramming and cancer. However, at present, it is not clear how macroH2As affect gene regulation to exert these functions. We have parted from the initial observation that l...

Heterochromatin formation plays a pivotal role in regulating chromatin organization and influences nuclear architecture and genome stability and expression. Amongst the locations where heterochromatin is found, the pericentric regions have the capabi...

The epigenome regulates gene expression and provides a molecular memory of cellular events. A growing body of evidence has highlighted the importance of epigenetic regulation in physiological tissue homeostasis and malignant transformation. Among epi...

Histone variant macroH2A1 (mH2A1) has been widely recognized as a suppressor of gene expression. Recently, a cell cycle-dependent deposition of mH2A1 was discovered in mouse cells, but whether this process exists in human chromatin is unclear, which...

Despite the importance of radiation therapy, there are few radiation-related markers available for use in clinical practice. A larger catalog of such biomarkers is required to help clinicians decide when radiotherapy should be replaced with a patient...

MacroH2A is a histone variant whose expression has been studied in several neoplasms, including cutaneous melanomas (CMs). In the literature, it has been demonstrated that macroH2A.1 levels gradually decrease during CM progression, and a high express...

Histone variants are chromatin components that replace replication-coupled histones in a fraction of nucleosomes and confer particular characteristics to chromatin. H2A variants represent the most numerous and diverse group among histone protein fami...

Epigenetic regulation, which is characterized by reversible and heritable genetic alterations without changing DNA sequences, has recently been increasingly studied in diseases. Histone variant regulation is an essential component of epigenetic regul...

Lipid catabolism and anabolism changes play a role in stemness acquisition by cancer cells, and cancer stem cells (CSCs) are particularly dependent on the activity of the enzymes involved in these processes. Lipidomic changes could play a role in CSC...

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide. A foremost risk factor for HCC is obesity/metabolic syndrome-related non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH), which is pro...

Histones are a major component of chromatin, the nucleoprotein complex fundamental to regulating transcription, facilitating cell division, and maintaining genome integrity in almost all eukaryotes. In addition to canonical, replication-dependent his...

Gastrointestinal cancers (GC) are malignancies involving the gastrointestinal (GI) tract and accessory organs of the digestive system, including the pancreas, liver, and gall bladder. GC is one of the most common cancers and contributes to more cance...

Skeletal muscle development and regeneration rely on the successive activation of specific transcription factors that engage cellular fate, promote commitment, and drive differentiation. Emerging evidence demonstrates that epigenetic regulation of ge...

The aim of this study is to evaluate salivary remineralisation versus chemical remineralisation/infiltration of enamel, using different dentistry materials. The enamel changes were studied using confocal laser scanning microscopy (CLSM), and the dept...

Due to the feeding system (high-concentrate diet) during the early lactation stage, ruminal pH in dairy cows follows a diurnal pattern and can remain below the critical level of 5.5 for extended periods of the day. This study aimed to evaluate the ef...

Although there has been an increase in the cultivation of highbush blueberry (Vaccinium corymbosum L.) worldwide for several years now, the availability of suitable soils for this species remains a problem. Highbush blueberry is a plant that requires...

Traditional airag (fermented mare’s milk) is a sour, slightly alcoholic drink handmade by Mongolian nomads. As airag is not heated after production, the fermentation continues to proceed and the taste changes rapidly. The objective of this stud...

Soil health and fertility are essential components of sustainable land management. In Bhutan, where agricultural practices range from organic to conventional systems, and natural vegetation areas persist across varied elevations. Understanding how th...

The effects of pH and chloride concentration on the electrochemical corrosion of copper in aqueous sodium chloride (NaCl) media were studied at the micro scale using a microcapillary droplet cell and at the macro scale using a conventional large scal...

We report here an investigation on the preferential oxidation of carbon monoxide in an H2-rich stream (CO-PROX reaction) over mono and bimetallic Au-Ag samples supported on macro-mesoporous CeO2. The highly porous structure of ceria and the synergist...

SPOP (Speckle-type POZ protein) is an E3 ubiquitin ligase adaptor protein that mediates the ubiquitination of several substrates. Furthermore, SPOP is responsible for the regulation of both degradable and nondegradable polyubiquitination of a number...

Protein–protein interactions play crucial roles in a wide range of biological processes, including metabolic pathways, cell cycle progression, signal transduction, and the proteasomal system. For PPIs to fulfill their biological functions, they...

The continuously rising interest in chemical sensors’ applications in environmental monitoring, for soil analysis in particular, is owed to the sufficient sensitivity and selectivity of these analytical devices, their low costs, their simple me...

As a core element of China’s housing security system, public rental housing (PRH) has gradually become an effective means of providing low- and moderately low-income groups with viable housing options and is regarded as the embodiment of housin...

Research efforts are placing an ever increasing emphasis on identifying signal transduction pathways related to the chemopreventive activity of curcumin. Its anticarcinogenic effects are presumably mediated by the regulation of signaling cascades, in...

The impact of key classes of compounds found in wine on protein removal by the ion-exchange resin, Macro-Prep® High S, was examined by adsorption isotherm experiments. A model wine system, which contained a prototypical protein Bovine Serum Albumin (...

This study aimed to evaluate the micro-mechanical and macro-mechanical properties of self-cured and light-cured alkasite and to investigate how accelerated degradation in acidic, alkaline, and ethanol solutions affects the macro-mechanical properties...

Microscopic characteristics greatly affect mechanical and physical properties as they exert vital impact on the stability and durability of materials. In this paper, widely distributed sandstone was chosen as the research object. Sandstone was treate...

The storage enclosures are vital for stabilizing the micro-environment within, facilitating preventive conservation efforts, and enabling energy savings by reducing the need for extensive macro-environmental control within the room. However, real-tim...

Bee venom is a complex natural beekeeping product, traditionally used in apitherapy, with a wide spectrum of pharmacological properties. Research on the mineral content of bee venom is limited and challenging to compare across studies due to the vary...

Water-level fluctuation (WLF) can destroy soil aggregates and induce soil organic carbon (SOC) loss, potentially triggering impacts on the concentration of atmospheric carbon dioxide. However, responses of soil aggregate content and aggregate-associa...

Recently, the production of macro-fungi (mushrooms) has steadily increased, and so has their economic value, in global terms. The use of functional foods, dietary supplements, and traditional medicines derived from macro-fungi is increasing as they h...

Water management in sandy soils (Typic Torripsamments) is crucial in sustaining agricultural production. The main goal of this research was to assess the impact of date palm biochar on the physical properties of sandy soil with different particle siz...

Titanium dioxide (TiO2) is an antimicrobial agent which is considered of potential value in inhibiting the growth of multiple bacteria. Klebsiella pneumonia and Haemophilus influenza are two of the most common respiratory infection pathogens, and are...

Structural lightweight concrete (SLWC) is crucial for reducing building weight, reducing structural loads, and enhancing energy efficiency through lower thermal conductivity. This study explores the effects of incorporating silica fume (SF), micro-po...

This study investigates the possibility of replacing the minimum web reinforcement in deep beams with discrete fibers. Additionally, the equivalent dosage of fibers required to obtain similar performance of the deep beam with minimum web reinforcemen...

Exposure to high acute doses of ionizing radiation (IR) can induce cutaneous radiation syndrome. Weeks after such radiation insults, keratinocyte nuclei of the epidermis exhibit persisting genomic lesions that present as focal accumulations of DNA do...

In this study, computational models of heat and mass exchange through textile structures with additional ventilation at the micro- and macro-scale were investigated. The finite element analysis of advanced textile materials provides a better understa...

Pavement surface texture evaluation is mainly analyzed based on elevation data in previous research, and attention also need to be paid to wavelength information. Furthermore, a well-established relationship model between surface texture and skid res...

Light therapy is used to treat sleep and circadian rhythm disorders, yet there are limited studies on whether light therapy impacts electroencephalographic (EEG) activity during sleep. Therefore, we aimed to provide an overview of research studies th...

Acute Myeloid Leukemia (AML) is a heterogeneous disease with several recurrent cytogenetic abnormalities. Despite genomics and transcriptomics profiling efforts to understand AML’s heterogeneity, studies focused on the proteomic profiles associated w...

Exploring and modifying the C-S-H structure at a micro–nano level is an effective solution to improve the performance of Portland cement. Compared with organics inserting C-S-H, the research on the performance of a polymer-binding C-S-H structu...

CO2 enrichment in the marine environment caused by leakages from carbon capture and storage technologies may occur over operational procedures. An integrated approach using weight-of-evidence was applied to assess the environmental risk associated wi...

A novel methodology combining the macro- and micro-creep techniques was employed to study the effect of S′/S precipitate growth on the creep mechanism of an Al–Cu–Mg alloy. An AA2524 alloy was pre-aged at 180 °C to obtain S&prim...

Dual thermo- and pH-responsive comb-type grafted hydrogels of poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA) and poly(N-isopropylacrylamide) (PNIPAM) with reversed network-graft architectures were synthesized by the combination of atom transfer...

In this paper, in order to accurately detect Domain Name System (DNS) covert channels based on DNS over HTTPS (DoH) encryption and to solve the problems of weak single-feature differentiation and poor performance in the existing detection methods, we...

Global energy demand escalates the interest in effective and durable catalytic systems for the dry reforming of methane (DRM), a process that converts CO2/CH4 into H2/CO syngas. Porous silica-supported nickel (Ni) catalysts are recognized as a promis...

Macro-benthos is commonly considered an indicator for evaluating the health of an aquatic ecosystem. Earlier research from sub-tropical mangrove estuaries, however, has primarily relied on conventional taxonomic methods to determine the pattern of ma...