Next Article in Journal
Clinically Usable Interleukin 12 Plasmid without an Antibiotic Resistance Gene: Functionality and Toxicity Study in Murine Melanoma Model
Next Article in Special Issue
Selective Inhibition of Histone Deacetylation in Melanoma Increases Targeted Gene Delivery by a Bacteriophage Viral Vector
Previous Article in Journal
Respiratory-Gated Proton Beam Therapy for Hepatocellular Carcinoma Adjacent to the Gastrointestinal Tract without Fiducial Markers
Previous Article in Special Issue
Modification of Epigenetic Histone Acetylation in Hepatocellular Carcinoma
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessReview
Cancers 2018, 10(3), 59; https://doi.org/10.3390/cancers10030059

Post-Translational Modifications of H2A Histone Variants and Their Role in Cancer

1
Josep Carreras Leukaemia Research Institute (IJC), Campus ICO-Germans Trias i Pujol, Universitat Autònoma de Barcelona, 08916 Badalona, Spain
2
PhD Programme of Genetics, Universitat de Barcelona, 08007 Barcelona, Spain
3
Program for Predictive and Personalized Medicine of Cancer, Germans Trias i Pujol Research Institute (PMPPC-IGTP), 08916 Badalona, Spain
*
Author to whom correspondence should be addressed.
Received: 15 January 2018 / Revised: 19 February 2018 / Accepted: 25 February 2018 / Published: 27 February 2018
(This article belongs to the Collection Histone Modification in Cancer)
  |  
PDF [1087 KB, uploaded 27 February 2018]
  |  

Abstract

Histone variants are chromatin components that replace replication-coupled histones in a fraction of nucleosomes and confer particular characteristics to chromatin. H2A variants represent the most numerous and diverse group among histone protein families. In the nucleosomal structure, H2A-H2B dimers can be removed and exchanged more easily than the stable H3-H4 core. The unstructured N-terminal histone tails of all histones, but also the C-terminal tails of H2A histones protrude out of the compact structure of the nucleosome core. These accessible tails are the preferential target sites for a large number of post-translational modifications (PTMs). While some PTMs are shared between replication-coupled H2A and H2A variants, many modifications are limited to a specific histone variant. The present review focuses on the H2A variants H2A.Z, H2A.X, and macroH2A, and summarizes their functions in chromatin and how these are linked to cancer development and progression. H2A.Z primarily acts as an oncogene and macroH2A and H2A.X as tumour suppressors. We further focus on the regulation by PTMs, which helps to understand a degree of context dependency. View Full-Text
Keywords: histone variants; post-translational modifications; cancer; epigenetics; H2A.Z; H2A.X; macroH2A histone variants; post-translational modifications; cancer; epigenetics; H2A.Z; H2A.X; macroH2A
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Corujo, D.; Buschbeck, M. Post-Translational Modifications of H2A Histone Variants and Their Role in Cancer. Cancers 2018, 10, 59.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top