Next Article in Journal
Genotype-Epigenotype Interaction at the IGF2 DMR
Next Article in Special Issue
Chromatin Insulators and Topological Domains: Adding New Dimensions to 3D Genome Architecture
Previous Article in Journal / Special Issue
Contribution of Topological Domains and Loop Formation to 3D Chromatin Organization
Open AccessReview

Chromatin Dynamics in Vivo: A Game of Musical Chairs

Chromatin Structure and Epigenetics Mechanisms Unit, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 41 Library Drive, Bethesda, MD 20892, USA
Biophysics Graduate Program, University of Maryland, College Park, MD 20742, USA
Author to whom correspondence should be addressed.
Academic Editor: Jessica Tyler
Genes 2015, 6(3), 751-776;
Received: 5 June 2015 / Revised: 17 July 2015 / Accepted: 28 July 2015 / Published: 7 August 2015
(This article belongs to the Special Issue Chromatin Dynamics)
Histones are a major component of chromatin, the nucleoprotein complex fundamental to regulating transcription, facilitating cell division, and maintaining genome integrity in almost all eukaryotes. In addition to canonical, replication-dependent histones, replication-independent histone variants exist in most eukaryotes. In recent years, steady progress has been made in understanding how histone variants assemble, their involvement in development, mitosis, transcription, and genome repair. In this review, we will focus on the localization of the major histone variants H3.3, CENP-A, H2A.Z, and macroH2A, as well as how these variants have evolved, their structural differences, and their functional significance in vivo. View Full-Text
Keywords: histones; chromatin; CENP-A; H3.3; H2A.Z; macroH2A; chaperones histones; chromatin; CENP-A; H3.3; H2A.Z; macroH2A; chaperones
Show Figures

Figure 1

MDPI and ACS Style

Melters, D.P.; Nye, J.; Zhao, H.; Dalal, Y. Chromatin Dynamics in Vivo: A Game of Musical Chairs. Genes 2015, 6, 751-776.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Back to TopTop