DNA damage is a constant source of stress challenging genomic integrity. To ensure faithful duplication of our genomes, mechanisms have evolved to deal with damage encountered during replication. One such mechanism is referred to as DNA damage tolera...
This paper presents a contribution to reviewing the most common seismic design procedures of CLT buildings and their implications on structural features and technological solutions. Attention is particularly focused on the overall seismic performance...
DNA lesions escaping from repair often block the DNA replicative polymerases required for DNA replication and are handled during the S/G2 phases by the DNA damage tolerance (DDT) mechanisms, which include the error-prone translesion synthesis (TLS) a...
Talcum reinforced polypropylene was enhanced with a soft type of polypropylene in order to increase the impact strength and damage tolerance of the material. The soft phase was incorporated in the form of continuous interlayers, where the numbers of...
The paper addresses the fatigue resistance, fracture behavior, and damage tolerance of a new type of ultrahigh-strength bar for prestressing concrete made of a low-alloy lath martensitic steel. The fracture tests show that the bar steel has a medium-...
The Saccharomyces cerevisiae chromosomal architectural protein Hmo1 is categorized as an HMGB protein, as it contains two HMGB motifs that bind DNA in a structure-specific manner. However, Hmo1 has a basic C-terminal domain (CTD) that promotes DNA be...
Immunotherapy based on two checkpoint inhibitors (ICI), programmed cell death 1 (PD-1, Nivolumab) and cytotoxic T-lymphocyte 4 (CTLA-4, Ipilimumab), has provided a significant improvement in overall survival for malignant mesothelioma (MM). Despite t...
This study proposes a bionic helical configuration design concept, focusing on glass-fiber-reinforced polymer matrix composites. Through a combination of experimental and numerical simulation methods, it systematically investigates the resistance to...
Aircraft structures must be capable of performing their function throughout their design life while meeting safety objectives. Such structures may contain defects and/or damages that can occur for several reasons. Therefore, aircraft structures are i...
This review investigates interlayer hybrid fiber composites for wind turbine blades (WTBs), focusing on their potential to enhance blade damage tolerance and maintain structural integrity. The objectives of this review are: (I) to assess the effect o...
The size of wind turbine blades is increasing rapidly, and they are being installed in remote offshore locations. Consequently, it is essential to focus on improving the design and maintenance procedures in the blade industry to meet the growing dema...
The DNA damage tolerance (DDT) response is aimed to timely and safely complete DNA replication by facilitating the advance of replication forks through blocking lesions. This process is associated with an accumulation of single-strand DNA (ssDNA), bo...
By means of electron beam powder bed fusion (E-PBF), highly complex lightweight structures can be manufactured within short process times. Due to the increasing complexity of producible components and the entangled interplay of damage mechanisms, com...
The present study aims to investigate the influence of multi-walled carbon nanotubes (MWCNTs) on the damage tolerance after impact (CAI) of the development of Out of Autoclave (OoA) carbon fibre reinforced polymer (CFRP) laminates. The introduction o...
Complex engineering models are typically computationally demanding and defined by a high-dimensional parameter space challenging the comprehensive exploration of parameter effects and design optimization. To overcome this curse of dimensionality and...
This study systematically investigates the synergistic effects of the pre-stretching deformation and aging temperature on the precipitation behavior and mechanical properties of an Al-Cu-Li alloy. The results indicate that increasing the pre-stretchi...
The corrosion module of COMSOL Multiphysics 5.6® software was employed to simulate the influence of the corrosion products and calcareous deposits on the damage tolerance of a Thermally Sprayed Aluminium coating (TSA) in a simulated marine immers...
Cracks and holes are commonly found in wooden components, and ancient Chinese wooden buildings, represented by the Yingxian Wooden Pagoda, demonstrate the ability to work with defects. This study systematically investigated the effects of longitudina...
Single-layer reticulated shell structures are widely used, but their stability performance is not ideal. Moreover, they are sensitive to structural damage and imperfections, while the existing conventional design methods of increasing the cross-secti...
The sliding clamp PCNA is a multifunctional homotrimer mainly linked to DNA replication. During this process, cells must ensure an accurate and complete genome replication when constantly challenged by the presence of DNA lesions. Post-translational...
Water deficit adversely affects apple (Malus domestica) productivity on the Loess Plateau. Autophagy plays a key role in plant responses to unfavorable environmental conditions. Previously, we demonstrated that a core apple autophagy-related protein,...
This paper first presents the results of an experimental study into the damage tolerance of AA7075-T6, which is widely used in both fixed- and rotary-wing aircraft, space structures, and laser bed powder fusion (LBPF) Scalmalloy specimens built by Bo...
In nature, organisms have evolved unique structures that feature low weight, high strength, and damage resistance. The Eurasian eagle-owl serves as a representative example, with specialized feather architectures that enable stable flight in intense...
Helicase-like transcription factor (HLTF) and SNF2, histone-linker, PHD and RING finger domain-containing helicase (SHPRH), the two human homologs of yeast Rad5, are believed to have a vital role in DNA damage tolerance (DDT). Here we show that HLTF,...
To prevent replication fork collapse and genome instability under replicative stress, DNA damage tolerance (DDT) mechanisms have evolved. The RAD5 homologs, HLTF (helicase-like transcription factor) and SHPRH (SNF2, histone-linker, PHD and RING finge...
Skin is the largest organ of many animals. Its protective function against hostile environments and predatorial attack makes high mechanical strength a vital characteristic. Here, we measured the mechanical properties of bass fish skins and found tha...
Individual tissues have significantly different resistance to ischemia–reperfusion damage. There is still no adequate treatment for the consequences of ischemia–reperfusion damage. By utilizing ischemic tolerance, it is possible to achiev...
Metal Additive Manufacturing (AM) allows the fabrication of intricate shaped parts that cannot be produced with conventional manufacturing techniques. Despite the advantages of this novel manufacturing technology, the main drawback is the inferior fa...
Phase-specific damage tolerance was investigated for the AlCoCrFeNi2.1 high entropy alloy with a lamellar microstructure of L12 and B2 phases. A microcantilever bending technique was utilized with notches milled in each of the two phases as well as a...
PrimPol is a human deoxyribonucleic acid (DNA) polymerase that also possesses primase activity and is involved in DNA damage tolerance, the prevention of genome instability and mitochondrial DNA maintenance. In this review, we focus on recent advance...
Oxidative stress causes severe tissue injury of the central nervous system in ischemic brain damage (IBD), traumatic brain injury (TBI) and neurodegenerative disorders. In this study, we used hydrogen peroxide (H2O2) to induce oxidative stress in org...
The leading edges of wind turbine blades are adhesively bonded composite sections that are susceptible to impact loads during offshore installation. The impact loads can cause localized damages at the leading edges that necessitate damage tolerance a...
Biodiversity-friendly farming is a growing area of discussion among farmers, as well as in government departments and non-government organizations interested in conservation on private land. Those seeking to encourage biodiversity on farms must under...
The 22 wt.% Cr, fully ferritic stainless steel Crofer®22 H has higher thermomechanical fatigue (TMF)- lifetime compared to advanced ferritic-martensitic P91, which is assumed to be caused by different damage tolerance, leading to differences in c...
DNA replication is an essential biochemical reaction in dividing cells that frequently stalls at damaged sites. Homologous/homeologous recombination (HR)-mediated template switch and translesion DNA synthesis (TLS)-mediated bypass processes release a...
Composite structures are particularly vulnerable to impact, which drastically reduces their residual strength, in particular, at high temperatures. The glass-transition temperature (Tg) of a polymer is a critical factor that can modify the mechanical...
The behavior of impact damaged composite laminates under cyclic load is crucial to achieve a damage tolerant design of composite structures. A sufficient residual strength has to be ensured throughout the entire structural service life. In this study...
The USAF requirements for the durability and damage tolerance certification for additively manufactured (AM) aircraft structural parts, which are detailed in Structures Bulletin EZ-19-01, raise a number of new and, as yet, unanswered questions. The p...
Accurate DNA replication is crucial for cell survival and the maintenance of genome stability. Cells have developed mechanisms to cope with the frequent genotoxic injuries that arise from both endogenous and environmental sources. Lesions encountered...
In the present study, the layout structure of an n-MOSFET, which is vulnerable to radiation, was designed in a different way to enhance its tolerance to radiation. Radiation damage assessment was conducted using modeling and simulation (M&S) tech...
The low delamination tendency and high damage tolerance of three-dimensional (3D) braided composites highlight their significant potential in handling defects. To enhance the engineering potential of three-dimensional four-directional (3D4d) braided...
Fungi play irreplaceable roles in the functioning of natural ecosystems, but global warming poses a significant threat to them. However, the mechanisms underlying fungal tolerance to thermal and UV-B stresses remain largely unknown. Dual-specificity...
In the current work, an analysis method for obtaining post-impact damage propagation under cyclic compressive load in flat carbon fiber reinforced plastic (CFRP) panels is presented. The solution for damage growth life is given based on the introduce...
An experimental analysis of mechanical behaviour for aluminium-based fibre metal laminates under compression after impact was conducted. Damage initiation and propagation were evaluated for critical state and force thresholds. Parametrization of lami...
Cisplatin (CDDP)-based chemotherapy is the standard of care in patients with muscle-invasive bladder cancer. However, in a large number of cases, the disease becomes resistant or does not respond to CDDP, and thus progresses and disseminates. In such...
The plant-specific transcription factors TEOSINTE BRANCHED1/CYCLO IDEA/PROLIFERATING CELL FACTOR1 (TCP) act as developmental regulators that have many roles in the growth and development processes throughout the entire life span of plants. TCP transc...
Natural materials are generally damage adaptive through their multilevel architectures, with the characteristics of compositional and mechanical gradients. This study demonstrated that the desired elastic gradient can be in-situ stress-induced in a t...
A widely used coating system for corrosion mitigation of offshore steel structures is thermally sprayed aluminium (TSA). Even though these coatings have been used for decades, it is not always clear how they perform in service over long periods, part...
The sustainment of replication and transcription of damaged DNA is essential for cell survival under genotoxic stress; however, the damage tolerance of these key cellular functions comes at the expense of fidelity. Thus, translesion DNA synthesis (TL...
The usage of high-strength steels for structural components and reinforcement parts is inevitable for modern car-body manufacture in reaching lightweight design as well as increasing passive safety. Depending on their microstructure these steels show...
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