15,198 Results Found

The reasons initiating insulin resistance are not identified. Various metabolic derailments have been characterized. These are the outcome and not the initiation of insulin resistance. In animal models of type 2 diabetes and hypertension, a decreased...

This work is devoted to the procedure of the construction of an abstract cyclic functional relation, which summarizes and extends the known results for a cyclically correlated random process and a cyclic (cyclically distributed) random process to the...

Metformin is the leading drug for treating type 2 diabetics, but the mechanism of action of metformin, despite some suggested mechanisms such as the activation of the AMP-kinase, is largely unknown. Among its many positive effects are the reduction o...

The damping ratio is essential to conducting dynamic analysis for underground engineering under traffic loading. Variations in the damping ratio are usually studied using cyclic triaxial tests with continuous cyclic loading; however, intermittent loa...

Symmetries in the context of hypergroups and their generalizations are closely related to the algebraic structures and transformations that preserve certain properties of hypergroup operations. Symmetric LA-hypergroups are indeed commutative hypergro...

This work is devoted to the procedure for constructing of a cyclically correlated random process of a continuous argument as a mathematical model of cyclic signals in dynamic systems, which makes it possible to consistently describe cyclic stochastic...

This paper is devoted to the research of the isomorphic multidimensional cyclic structure and multidimensional phase structure of the cyclic random process (CRP) and to its formation method, which enables a rigorous formalization of intuitive ideas c...

The natural cyclic AMP antagonist, prostaglandylinositol cyclic phosphate (cyclic PIP), is biosynthesized from prostaglandin E (PGE) and activated inositol phosphate (n-Ins-P), which is synthesized by a particulate rat-liver-enzyme from GTP and a pre...

Land resources are being depleted due to global climate change, and as a result, infrastructures such as expressways and high-speed railways have no option but to be built in soft soil regions. Hence, the cyclic and post-cyclic behaviors of soft soil...

In this paper, we investigate the structure of double cyclic codes of length $(\alpha ,\beta )$ over $\mathfrak{R}={\mathbb{F}}_4+\varrho {\mathbb{F}}_4,{\varrho }^2=0$ and give a minimal spanning set of double cyclic codes. Moreover, we extend this study to construct DNA codes from $\mathfrak{R}$-double c...

This paper refers to cyclic shear strains (γ_c) and permanent shear strains (γ_p) of a soft cohesive soil, when both monotonic shear stresses (τ_o) and cyclic shear stresses (τ_c) are applied. The research is backed by an extensive ex...

Let G be a group. An automorphism $\alpha$ of G is said to be a cyclic automorphism if the subgroup $⟨x,x^{\alpha }⟩$ is cyclic for every element x of G. In [F. de Giovanni, M.L. Newell, A. Russo: On a class of normal endomorphisms of groups,...

The phosphodiester linkage is found in DNA, RNA and many signaling molecules, such as cyclic mononucleotide, cyclic dinucleotides (CDNs) and cyclic oligonucleotides (cONs). Enzymes that cleave the phosphodiester linkage (nucleases and phosphodiestera...

A resolution of a Steiner triple system of order v (STS(v)) is point-cyclic if it has an automorphism permuting the points in one cycle. An STS(v) is cyclically resolvable if it has at least one point-cyclic resolution. Cyclically resolvable STS(v)s...

In the algebra of single-valued structures, cyclicity is one of the fundamental properties of groups. Therefore, it is natural to study it also in the algebra of multivalued structures (algebraic hyperstructure theory). However, when one considers th...

In offshore engineering, the sand beneath an embankment may be subjected to traffic loads, resulting in a series of engineering issues. The behaviour of the sand beneath the embankment may change under a long-term traffic load. A series of drained cy...

Polymers with cyclic topology have no terminal structure and, therefore, exhibit various unique physical and functional properties compared to those of linear analogs. In this paper, we report an innovative methodology for the synthesis of cyclic pol...

Soft soil is often subjected to cyclic loading such as that imposed during storms, under traffic, or in an earthquake. Furthermore, the cyclic-loading-induced excess pore water pressure can be partially dissipated after cyclic loading. Thus, differen...

This study investigates the tensile properties of granite subjected to cyclic thermal treatment under cyclic loading-unloading conditions, which is of great significance for the modification of hot dry rock reservoirs. Brazilian splitting tests under...

Cyclic triaxial tests are frequently used in the laboratory to assess the liquefaction susceptibility of soils. This paper will serve a two-fold purpose: First, it will serve to explain how the mechanics of the tests represent the stresses that occur...

In the process of cyclic loading, strain development not only presents the strain softening phenomenon, but also a strain hardening phenomenon, depending on the different values of static deflection stress. The strain hardening and strain softening c...

Plant cyclic nucleotide-gated channels (CNGCs) are tetrameric cation channels which may be activated by the cyclic nucleotides (cNMPs) adenosine 3′,5′-cyclic monophosphate (cAMP) and guanosine 3′,5′-cyclic monophosphate (cGMP)...

For more than four decades, the cyclic nucleotides cyclic AMP (cAMP) and cyclic GMP (cGMP) have been recognized as important signaling molecules within cells. Under normal physiological conditions, cyclic nucleotides regulate a myriad of biological p...

The soft decision decoding algorithm for cyclic codes, especially the maximum likelihood (ML) decoding algorithm, can obtain significant performance superior to that of algebraic decoding, but the complexity is much higher. To deal with this problem,...

This study examines the cyclic behavior of calcareous sand obtained from the South China Sea. A series of undrained cyclic triaxial tests were performed on the calcareous sand with various relative densities, cyclic stress ratios, and effective confi...

The cyclic nucleotides 3′,5′-adenosine monophosphate (cyclic AMP) signalling system underlies the control of many biological events and disease processes in man. Cyclic AMP is synthesised by adenylate cyclase (AC) enzymes in order to acti...

Some properties on large contractions in metric spaces are proven. In particular, such contractions are proven to be asymptotically regular. In addition, if the metric space is complete, then the sequences that they generate are bounded, Cauchy, and...

The expression is obtained for determination of cyclic tensile strength for asphalt concrete, which considers damage accumulation and history of loading, using the long-term strength curve for asphalt concrete obtained according to the test results o...

Polydimethylsiloxane (PDMS) is widely utilised as a substrate for wearable (stretchable) electronics where high fatigue resistance is required. Cyclic loadings cause the rearrangement of the basic molecular structure of polymer chains, which leads to...

Let $R={\mathbb{F}}_4+u{\mathbb{F}}_4,\mathrm{with}{u}^2=u$ and $S={\mathbb{F}}_4+u{\mathbb{F}}_4+v{\mathbb{F}}_4,with{u}^2=u,v^2=v,uv=vu=0$. In this paper, we study ${\mathbb{F}}_{4}RS$-cyclic codes of block length $(\alpha ,\beta ,\gamma )$ and construct cyclic DNA codes from them. ${\mathbb{F}}_{4}RS$-cyclic codes can be viewed as $S[x]$-submodules of $\frac{{\mathbb{F}}_q[x]}{\&lan}$...

Kidney fibrosis is an important factor for the progression of kidney diseases, e.g., diabetes mellitus induced kidney failure, glomerulosclerosis and nephritis resulting in chronic kidney disease or end-stage renal disease. Cyclic adenosine monophos...

We investigate fixed points for p cyclic maps by introducing a new notion of p–cyclic infimum summing maps and a generalized best proximity point for p–cyclic maps. The idea generalizes some results about best proximity points in order to...

During the service period, the offshore wind turbine foundation mainly bears the wind load from the upper structure and the periodic loads such as wave load and sea currents from the lower structure. Long-term cyclic loads have an important impact on...

Cyclic nucleotides are important second messengers involved in cellular events, and analogues of this type of molecules are promising drug candidates. Some cyclic nucleotide analogues have become standard tools for the investigation of biochemical an...

Helical anchors have been widely used in geotechnical engineering due to their large uplift resistance. However, the current knowledge of the cyclic performance of helical anchors is still insufficient. Consequently, a series of small-scale model tes...

Oceans are a rich source of structurally unique bioactive compounds from the perspective of potential therapeutic agents. Marine peptides are a particularly interesting group of secondary metabolites because of their chemistry and wide range of biolo...

Cyclic peptides have been widely reported to have therapeutic abilities in the treatment of cancer. This has been proven through in vitro and in vivo studies against breast, lung, liver, colon, and prostate cancers, among others. The multitude of dat...

Recent material science advances have resulted in the use of High-Performance Concrete (HPC) and Ultra-High-Performance Concrete (UHPC) in superstructures, which were chosen for their superior strength. However, under cyclic loads, these materials fr...

For positive integers s and t, the Ramsey number $R(s,t)$ is the smallest positive integer n such that every graph of order n contains either a clique of order s or an independent set of order t. The triangle-free process begins with an em...

This paper focuses on dealing with several types of enriched cyclic contractions defined in the union of a set of non-empty closed subsets of normed or metric spaces. In general, any finite number $p\ge 2$ of subsets is permitted in the cyclic arrangem...

The cyclic stress response behavior of Ti-3Al-8V-6Cr-4Mo-4Zr alloy with three different microstructures has been systematically studied. The cyclic stress response was highly related to the applied strain amplitude and precipitated phase. At low stra...

A deeper understanding of the mechanical behavior of ultra-fine (UF) and nanocrystalline (NC) grained metals is necessary with the growing interest in using UF and NC grained metals for structural applications. The cyclic deformation response and beh...

The reservoir landslide in the Three Gorges Reservoir Area (TGRA) often suffers from local cyclic loading scenarios produced by surge waves, groundwater level fluctuation, traffic loading, and seismic activity. However, the effects of local cyclic lo...

Cyclic peptides are molecules that are already used as drugs in therapies approved for various pharmacological activities, for example, as antibiotics, antifungals, anticancer, and immunosuppressants. Interest in these molecules has been growing due...

A modified numerical procedure for the shakedown analysis of structures under dual cyclic loadings, based on the Abdalla method, is proposed in this paper. Based on the proposed numerical procedure, the shakedown analysis of the thick cylindrical ves...

In this study, the cyclic responses of an offshore wind turbine with a tripod foundation installed on an actual site were evaluated in a centrifuge. To understand the behavior of the turbine at the site, the site soil conditions, environmental loads,...

We study cyclic codes over the ring H of order 4 and characteristic 2 defined by generators and relations as $H=⟨a,b\mid 2a=2b=0,a^2=0,b^2=b,ab=ba=0⟩.$ This is the first time that cyclic codes over a non-unitary ring are studied. Every cy...

The field of indices has been explored and advanced by various researchers for different purposes. One purpose is the optimization of indices in various problems. In this work, the general power-sum connectivity index is considered. The general power...

Based on the twin bridge shear specimen, the cyclic shear experiments were performed on 1.2 mm thin plates of 316L metastable austenitic stainless steel with different strain amplitudes from 1 to 5% at ambient temperature. The fatigue behavior of 316...

Since the discovery of cyclic dimeric guanosine 3',5'-monophosphate (c-di-GMP) in 1987, the role of cyclic dinucleotides in signal pathways has been extensively studied. Many receptors and effectors of cyclic dinucleotides have been identified which...