The Complex Story of Plant Cyclic Nucleotide-Gated Channels
Department of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, UK
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Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(2), 874; https://doi.org/10.3390/ijms22020874
Received: 11 December 2020
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Revised: 14 January 2021
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Accepted: 15 January 2021
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Published: 16 January 2021
(This article belongs to the Special Issue Cell Signaling in Model Plants 2.0)
Plant cyclic nucleotide-gated channels (CNGCs) are tetrameric cation channels which may be activated by the cyclic nucleotides (cNMPs) adenosine 3′,5′-cyclic monophosphate (cAMP) and guanosine 3′,5′-cyclic monophosphate (cGMP). The genome of Arabidopsis thaliana encodes 20 CNGC subunits associated with aspects of development, stress response and immunity. Recently, it has been demonstrated that CNGC subunits form heterotetrameric complexes which behave differently from the homotetramers produced by their constituent subunits. These findings have widespread implications for future signalling research and may help explain how specificity can be achieved by CNGCs that are known to act in disparate pathways. Regulation of complex formation may involve cyclic nucleotide-gated channel-like proteins.
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Keywords:
calcium signalling; CaM; calmodulin; cAMP; cGMP; CNGC; cyclic nucleotide-gated channel; CNGCL; cyclic nucleotide-gated channel like
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MDPI and ACS Style
Jarratt-Barnham, E.; Wang, L.; Ning, Y.; Davies, J.M. The Complex Story of Plant Cyclic Nucleotide-Gated Channels. Int. J. Mol. Sci. 2021, 22, 874. https://doi.org/10.3390/ijms22020874
AMA Style
Jarratt-Barnham E, Wang L, Ning Y, Davies JM. The Complex Story of Plant Cyclic Nucleotide-Gated Channels. International Journal of Molecular Sciences. 2021; 22(2):874. https://doi.org/10.3390/ijms22020874
Chicago/Turabian StyleJarratt-Barnham, Edwin, Limin Wang, Youzheng Ning, and Julia M. Davies. 2021. "The Complex Story of Plant Cyclic Nucleotide-Gated Channels" International Journal of Molecular Sciences 22, no. 2: 874. https://doi.org/10.3390/ijms22020874
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