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252 Results Found

  • Review
  • Open Access
14 Citations
5,856 Views
33 Pages

Building an Ethical and Trustworthy Biomedical AI Ecosystem for the Translational and Clinical Integration of Foundation Models

  • Baradwaj Simha Sankar,
  • Destiny Gilliland,
  • Jack Rincon,
  • Henning Hermjakob,
  • Yu Yan,
  • Irsyad Adam,
  • Gwyneth Lemaster,
  • Dean Wang,
  • Karol Watson and
  • Peipei Ping
  • + 2 authors

Foundation Models (FMs) are gaining increasing attention in the biomedical artificial intelligence (AI) ecosystem due to their ability to represent and contextualize multimodal biomedical data. These capabilities make FMs a valuable tool for a variet...

  • Perspective
  • Open Access
41 Citations
7,165 Views
12 Pages

Sharing Biomedical Data: Strengthening AI Development in Healthcare

  • Tania Pereira,
  • Joana Morgado,
  • Francisco Silva,
  • Michele M. Pelter,
  • Vasco Rosa Dias,
  • Rita Barros,
  • Cláudia Freitas,
  • Eduardo Negrão,
  • Beatriz Flor de Lima and
  • Hélder P. Oliveira
  • + 6 authors

Artificial intelligence (AI)-based solutions have revolutionized our world, using extensive datasets and computational resources to create automatic tools for complex tasks that, until now, have been performed by humans. Massive data is a fundamental...

  • Article
  • Open Access
6 Citations
4,023 Views
22 Pages

An Explainable AI System for the Diagnosis of High-Dimensional Biomedical Data

  • Alfred Ultsch,
  • Jörg Hoffmann,
  • Maximilian A. Röhnert,
  • Malte von Bonin,
  • Uta Oelschlägel,
  • Cornelia Brendel and
  • Michael C. Thrun

Typical state-of-the-art flow cytometry data samples typically consist of measures of 10 to 30 features of more than 100,000 cell “events”. Artificial intelligence (AI) systems are able to diagnose such data with almost the same accuracy...

  • Review
  • Open Access
3 Citations
1,798 Views
29 Pages

Enhancing Biomedical Metal 3D Printing with AI and Nanomaterials Integration

  • Jackie Liu,
  • Jaison Jeevanandam and
  • Michael K. Danquah

21 October 2025

The integration of artificial intelligence (AI) with nanomaterials is rapidly transforming metal three-dimensional (3D) printing for biomedical applications due to their unprecedented precision, customization, and functionality. This article discusse...

  • Review
  • Open Access
9 Citations
5,054 Views
20 Pages

Trustworthy AI Guidelines in Biomedical Decision-Making Applications: A Scoping Review

  • Marçal Mora-Cantallops,
  • Elena García-Barriocanal and
  • Miguel-Ángel Sicilia

Recently proposed legal frameworks for Artificial Intelligence (AI) depart from some frameworks of concepts regarding ethical and trustworthy AI that provide the technical grounding for safety and risk. This is especially important in high-risk appli...

  • Review
  • Open Access
19 Citations
3,510 Views
33 Pages

28 July 2025

Biomarkers play a pivotal role in disease diagnosis, therapeutic efficacy evaluation, prognostic assessment, and drug screening. However, the trace concentrations of these markers in complex physiological environments pose significant challenges to e...

  • Perspective
  • Open Access
9 Citations
3,199 Views
17 Pages

Issues and Limitations on the Road to Fair and Inclusive AI Solutions for Biomedical Challenges

  • Oliver Faust,
  • Massimo Salvi,
  • Prabal Datta Barua,
  • Subrata Chakraborty,
  • Filippo Molinari and
  • U. Rajendra Acharya

2 January 2025

Objective: In this paper, we explore the correlation between performance reporting and the development of inclusive AI solutions for biomedical problems. Our study examines the critical aspects of bias and noise in the context of medical decision sup...

  • Review
  • Open Access
545 Citations
40,078 Views
29 Pages

Artificial Intelligence (AI) and Internet of Medical Things (IoMT) Assisted Biomedical Systems for Intelligent Healthcare

  • Pandiaraj Manickam,
  • Siva Ananth Mariappan,
  • Sindhu Monica Murugesan,
  • Shekhar Hansda,
  • Ajeet Kaushik,
  • Ravikumar Shinde and
  • S. P. Thipperudraswamy

25 July 2022

Artificial intelligence (AI) is a modern approach based on computer science that develops programs and algorithms to make devices intelligent and efficient for performing tasks that usually require skilled human intelligence. AI involves various subs...

  • Article
  • Open Access
36 Citations
2,154 Views
29 Pages

Hybrid FEM-AI Approach for Thermographic Monitoring of Biomedical Electronic Devices

  • Danilo Pratticò,
  • Domenico De Carlo,
  • Gaetano Silipo and
  • Filippo Laganà

22 August 2025

Prolonged operation of biomedical devices may compromise electronic component integrity due to cyclic thermal stress, thereby impacting both functionality and safety. Regulatory standards require regular inspections, particularly for surgical applica...

  • Review
  • Open Access
1 Citations
2,558 Views
36 Pages

2 December 2025

The integration of artificial intelligence (AI) and micro/nanorobotics is fundamentally reshaping biosensing by enabling autonomous, adaptive, and high-resolution biological analysis. These miniaturized robotic systems fabricated using advanced techn...

  • Review
  • Open Access
1,034 Views
29 Pages

Digital Telecommunications in Medicine and Biomedical Engineering: Applications, Challenges, and Future Directions

  • Nikolaos Karkanis,
  • Andreas Giannakoulas,
  • Kyriakos E. Zoiros,
  • Theodoros N. F. Kaifas and
  • Georgios A. A. Kyriacou

1 January 2026

Digital telecommunications have become the backbone of modern healthcare, transforming how patients and professionals interact, share information, and deliver treatment. The integration of telecommunications with medicine, biomedical engineering and...

  • Review
  • Open Access
1 Citations
6,745 Views
24 Pages

14 October 2025

Large language model (LLM)-based agents are rapidly emerging as transformative tools across biomedical research and clinical applications. By integrating reasoning, planning, memory, and tool use capabilities, these agents go beyond static language m...

  • Review
  • Open Access
1,565 Views
32 Pages

A Survey of the Application of Explainable Artificial Intelligence in Biomedical Informatics

  • Hassan Eshkiki,
  • Farinaz Tanhaei,
  • Fabio Caraffini and
  • Benjamin Mora

8 December 2025

This review investigates the application of Explainable Artificial Intelligence (XAI) in biomedical informatics, encompassing domains such as medical imaging, genomics, and electronic health records. Through a systematic analysis of 43 peer-reviewed...

  • Review
  • Open Access
475 Views
36 Pages

Air-Coupled Ultrasound Systems for Biomedical Applications: Advances in Sensors, Electronic Interfaces and Signal Processing Strategies

  • Filippo Laganà,
  • Riccardo Olivieri,
  • Elena Stuppia,
  • Gianluca Barile,
  • Giuseppe Ferri and
  • Salvatore A. Pullano

7 March 2026

Air-coupled ultrasound (ACU) is emerging as a fully non-contact sensing modality in biomedical applications. ACU applications can be broadly classified into two main domains: (i) contactless monitoring of physiological parameters and (ii) assistive a...

  • Review
  • Open Access
3 Citations
3,584 Views
11 Pages

Organs-on-Chips: Revolutionizing Biomedical Research

  • Ankit Monga,
  • Khush Jain,
  • Harvinder Popli,
  • Prashik Telgote,
  • Ginpreet Kaur,
  • Fariah Rizwani,
  • Ritu Chauhan,
  • Damandeep Kaur,
  • Abhishek Chauhan and
  • Hardeep Singh Tuli

Organs-on-Chips (OoC) technology has begun to be considered a pragmatic tool for drug evaluation, offering researchers an opportunity to move beyond the less physiologically relevant animal models. OoCs are microfluidic structures that imitate the fu...

  • Editorial
  • Open Access
302 Views
6 Pages

The Convergence of Precision and Cognition in Biomedical AI

  • Luis Pinto-Coelho,
  • João Paulo Teixeira and
  • João Paulo Carmo

The historical trajectory of biomedical engineering has been defined by the pursuit of enhanced resolution, whether in the spatial granularity of an MRI scan, the temporal precision of a kinematic sensor, or the spectral clarity of an audio recording...

  • Review
  • Open Access

Language Models and Food–Health Evidence: Challenges, Opportunities, and Implications

  • David Jackson,
  • Athanasios Gousiopoulos and
  • Theodoros G. Soldatos

Scientific evidence is fundamental to uncovering insights about health, including food and nutritional claims. Substantiating such claims requires robust scientific procedures that often include clinical studies, biochemical analyses, and the examina...

  • Review
  • Open Access
369 Views
31 Pages

A Review of Multi-Agent AI Systems for Biological and Clinical Data Analysis

  • Jackson Spieser,
  • Ali Balapour,
  • Jarek Meller,
  • Krushna C. Patra and
  • Behrouz Shamsaei

28 February 2026

This review evaluates the emerging paradigm of multi-agent systems (MASs) for biomedical and clinical data analysis, focusing on their ability to overcome the reasoning and reliability limitations of standalone large language models (LLMs). We synthe...

  • Article
  • Open Access
1 Citations
1,140 Views
24 Pages

1 August 2025

How do regulatory policies, funding structures, and cross-sector coordination shape knowledge flows and institutional transformation? Focusing on the smart medical device sector in Taiwan, this study explores how governance dynamics accelerate system...

  • Systematic Review
  • Open Access
3,249 Views
41 Pages

A Systematic Review of Contrastive Learning in Medical AI: Foundations, Biomedical Modalities, and Future Directions

  • George Obaido,
  • Ibomoiye Domor Mienye,
  • Kehinde Aruleba,
  • Chidozie Williams Chukwu,
  • Ebenezer Esenogho and
  • Cameron Modisane

Medical artificial intelligence (AI) systems depend heavily on high-quality data representations to support accurate prediction, diagnosis, and clinical decision-making. However, the availability of large, well-annotated medical datasets is often con...

  • Article
  • Open Access
12 Citations
5,367 Views
28 Pages

Background: Transforming one-dimensional (1D) biomedical signals into two-dimensional (2D) images enables the application of convolutional neural networks (CNNs) for classification tasks. In this study, we investigated the effectiveness of different...

  • Feature Paper
  • Article
  • Open Access
4,138 Views
27 Pages

As climate change transforms our environment and human intrusion into natural ecosystems escalates, there is a growing demand for disease spread models to forecast and plan for the next zoonotic disease outbreak. Accurate parametrization of these mod...

  • Systematic Review
  • Open Access
12 Citations
20,083 Views
29 Pages

Retrieval-Augmented Generation (RAG) in Healthcare: A Comprehensive Review

  • Fnu Neha,
  • Deepshikha Bhati and
  • Deepak Kumar Shukla

11 September 2025

Retrieval-Augmented Generation (RAG) enhances large language models (LLMs) by integrating external knowledge retrieval to improve factual consistency and reduce hallucinations. Despite growing interest, its use in healthcare remains fragmented. This...

  • Article
  • Open Access
16 Citations
5,382 Views
20 Pages

BioDiffusion: A Versatile Diffusion Model for Biomedical Signal Synthesis

  • Xiaomin Li,
  • Mykhailo Sakevych,
  • Gentry Atkinson and
  • Vangelis Metsis

Machine learning tasks involving biomedical signals frequently grapple with issues such as limited data availability, imbalanced datasets, labeling complexities, and the interference of measurement noise. These challenges often hinder the optimal tra...

  • Review
  • Open Access
115 Citations
12,589 Views
22 Pages

5 October 2022

Modern life quality is strongly supported by the advances made in biosensors, which has been attributed to their crucial and viable contribution in point-of-care (POC) technology developments. POC devices are exploited for the fast tracing of disease...

  • Article
  • Open Access
125 Views
17 Pages

Optimizing Radiographic Diagnosis Through Signal-Balanced Convolutional Models

  • Sakina Juzar Neemuchwala,
  • Raja Hashim Ali,
  • Qamar Abbas,
  • Talha Ali Khan,
  • Ambreen Shahnaz and
  • Iftikhar Ahmed

Accurate interpretation of chest radiographs is central to the early diagnosis and management of pulmonary disorders. This study introduces an explainable deep learning framework that integrates biomedical signal fidelity analysis with transfer learn...

  • Systematic Review
  • Open Access
1 Citations
3,944 Views
19 Pages

27 May 2025

Synthetic medical text generation has emerged as a solution to data scarcity and privacy constraints in clinical NLP. This review systematically evaluates the use of Large Language Models (LLMs) for structured medical text generation, examining techn...

  • Article
  • Open Access
6 Citations
3,642 Views
30 Pages

9 May 2023

Background: Image analysis applications in digital pathology include various methods for segmenting regions of interest. Their identification is one of the most complex steps and therefore of great interest for the study of robust methods that do not...

  • Article
  • Open Access
21 Citations
11,399 Views
12 Pages

Background: Currently, discriminating Iron Deficiency Anemia (IDA) from other anemia requires an expensive test (serum ferritin). Complete Blood Count (CBC) tests are less costly and more widely available. Machine learning models have not yet been ap...

  • Article
  • Open Access
9 Citations
3,573 Views
12 Pages

Diagnostic Performance of a Deep Learning-Powered Application for Aortic Dissection Triage Prioritization and Classification

  • Vladimir Laletin,
  • Angela Ayobi,
  • Peter D. Chang,
  • Daniel S. Chow,
  • Jennifer E. Soun,
  • Jacqueline C. Junn,
  • Marlene Scudeler,
  • Sarah Quenet,
  • Maxime Tassy and
  • Yasmina Chaibi
  • + 2 authors

27 August 2024

This multicenter retrospective study evaluated the diagnostic performance of a deep learning (DL)-based application for detecting, classifying, and highlighting suspected aortic dissections (ADs) on chest and thoraco-abdominal CT angiography (CTA) sc...

  • Article
  • Open Access
5 Citations
7,610 Views
28 Pages

Leveraging Large Language Models for Enhancing Literature-Based Discovery

  • Ikbal Taleb,
  • Alramzana Nujum Navaz and
  • Mohamed Adel Serhani

The exponential growth of biomedical literature necessitates advanced methods for Literature-Based Discovery (LBD) to uncover hidden, meaningful relationships and generate novel hypotheses. This research integrates Large Language Models (LLMs), parti...

  • Article
  • Open Access
2 Citations
2,138 Views
18 Pages

The fusion of machine learning and biomedical research offers novel ways to understand, diagnose, and treat various health conditions. However, the complexities of biomedical data, coupled with the intricate process of developing and deploying machin...

  • Article
  • Open Access
1 Citations
1,495 Views
33 Pages

A Hybrid MCDM and Machine Learning Framework for Thalassemia Risk Assessment in Pregnant Women

  • Shefayatuj Johara Chowdhury,
  • Tanjim Mahmud,
  • Farzana Tasnim,
  • Sanjida Sharmin,
  • Saida Nawal,
  • Umme Habiba Papri,
  • Samia Afreen Dolon,
  • Md. Eftekhar Alam,
  • Mohammad Shahadat Hossain and
  • Karl Andersson

8 November 2025

Background: Thalassemia has been recognized as a critical public health issue in Bangladesh, especially among pregnant women, due to its hereditary nature and the lack of early screening infrastructure. Early identification of at-risk individuals is...

  • Article
  • Open Access
3 Citations
808 Views
36 Pages

Fair and Explainable Multitask Deep Learning on Synthetic Endocrine Trajectories for Real-Time Prediction of Stress, Performance, and Neuroendocrine States

  • Abdullah,
  • Zulaikha Fatima,
  • Carlos Guzman Sánchez Mejorada,
  • Muhammad Ateeb Ather,
  • José Luis Oropeza Rodríguez and
  • Grigori Sidorov

25 November 2025

Cortisol and testosterone are key digital biomarkers reflecting neuroendocrine activity across the hypothalamic–pituitary–adrenal (HPA) and hypothalamic–pituitary–gonadal (HPG) axes, encoding stress adaptation and behavioral r...

  • Article
  • Open Access
6 Citations
3,166 Views
14 Pages

Biomedical Image Classification via Dynamically Early Stopped Artificial Neural Network

  • Giorgia Franchini,
  • Micaela Verucchi,
  • Ambra Catozzi,
  • Federica Porta and
  • Marco Prato

20 October 2022

It is well known that biomedical imaging analysis plays a crucial role in the healthcare sector and produces a huge quantity of data. These data can be exploited to study diseases and their evolution in a deeper way or to predict their onsets. In par...

  • Perspective
  • Open Access
1 Citations
2,535 Views
36 Pages

13 December 2024

During the last decade, artificial intelligence (AI) was applied to nearly all domains of human activity, including scientific research. It is thus warranted to ask whether AI thinking should be durably involved in biomedical research. This problem w...

  • Review
  • Open Access
11 Citations
5,063 Views
13 Pages

Integrating Artificial Intelligence into Biomedical Science Curricula: Advancing Healthcare Education

  • Aarti Sharma,
  • Amal Al-Haidose,
  • Maha Al-Asmakh and
  • Atiyeh M. Abdallah

11 July 2024

The integration of artificial intelligence (AI) into healthcare practice has improved patient management and care. Many clinical laboratory specialties have already integrated AI in diagnostic specialties such as radiology and pathology, where it can...

  • Review
  • Open Access
27 Citations
7,415 Views
17 Pages

Synthetic Post-Contrast Imaging through Artificial Intelligence: Clinical Applications of Virtual and Augmented Contrast Media

  • Luca Pasquini,
  • Antonio Napolitano,
  • Matteo Pignatelli,
  • Emanuela Tagliente,
  • Chiara Parrillo,
  • Francesco Nasta,
  • Andrea Romano,
  • Alessandro Bozzao and
  • Alberto Di Napoli

Contrast media are widely diffused in biomedical imaging, due to their relevance in the diagnosis of numerous disorders. However, the risk of adverse reactions, the concern of potential damage to sensitive organs, and the recently described brain dep...

  • Review
  • Open Access
692 Views
32 Pages

Combined Use of Microwave Sensing Technologies and Artificial Intelligence for Biomedical Monitoring and Imaging

  • Andrea Martínez-Lozano,
  • Alejandro Buitrago-Bernal,
  • Langis Roy,
  • José María Vicente-Samper and
  • Carlos G. Juan

22 January 2026

Microwave sensing technology is rapidly advancing and increasingly finding its way into biomedical applications, promising significant improvements for medical care. Concurrently, the rise of artificial intelligence (AI) is enabling significant enhan...

  • Review
  • Open Access
63 Citations
19,666 Views
18 Pages

Artificial Intelligence: The Milestone in Modern Biomedical Research

  • Konstantina Athanasopoulou,
  • Glykeria N. Daneva,
  • Panagiotis G. Adamopoulos and
  • Andreas Scorilas

In recent years, the advent of new experimental methodologies for studying the high complexity of the human genome and proteome has led to the generation of an increasing amount of digital information, hence bioinformatics, which harnesses computer s...

  • Systematic Review
  • Open Access
11 Citations
5,996 Views
31 Pages

eXplainable Artificial Intelligence (XAI): A Systematic Review for Unveiling the Black Box Models and Their Relevance to Biomedical Imaging and Sensing

  • Nadeesha Hettikankanamage,
  • Niusha Shafiabady,
  • Fiona Chatteur,
  • Robert M. X. Wu,
  • Fareed Ud Din and
  • Jianlong Zhou

30 October 2025

Artificial Intelligence (AI) has achieved immense progress in recent years across a wide array of application domains, with biomedical imaging and sensing emerging as particularly impactful areas. However, the integration of AI in safety-critical fie...

  • Editorial
  • Open Access
331 Views
13 Pages

BioMedInformatics is an international, peer-reviewed, open access journal that covers all areas of biomedical informatics, computational biology, and medicine. Established in 2021, the journal is now five years old and reflects the evolution of the f...

  • Review
  • Open Access
9 Citations
12,879 Views
18 Pages

Artificial intelligence (AI) is a growing area of computer science that combines technologies with data science to develop intelligent, highly computation-able systems. Its ability to automatically analyze and query huge sets of data has rendered it...

  • Editorial
  • Open Access
2 Citations
2,681 Views
4 Pages

This Special Issue of Bioengineering is dedicated to the profound impact of big data and artificial intelligence (AI) in the fields of biomedical research and healthcare. In an age defined by the rapid evolution of technology, this Issue explores the...

  • Article
  • Open Access

12 March 2026

Generative Artificial Intelligence (GenAI) has been a viable technology for decades, yet widespread adoption in healthcare and academic settings has remained limited to research. One possible explanation for this is limited understanding about the be...

  • Review
  • Open Access
99 Citations
13,810 Views
17 Pages

22 January 2021

Artificial intelligence (AI) as a branch of computer science, the purpose of which is to imitate thought processes, learning abilities and knowledge management, finds more and more applications in experimental and clinical medicine. In recent decades...

  • Systematic Review
  • Open Access
1 Citations
1,351 Views
31 Pages

Artificial Intelligence in Biomedicine: A Systematic Review from Nanomedicine to Neurology and Hepatology

  • Diana-Maria Trasca,
  • Pluta Ion Dorin,
  • Sirbulet Carmen,
  • Renata-Maria Varut,
  • Cristina Elena Singer,
  • Kristina Radivojevic and
  • George Alin Stoica

Background/Objectives: This review evaluates the expanding contributions of artificial intelligence (AI) across biomedicine, focusing on cancer therapy and nanomedicine, cardiology and medical imaging, neurodegenerative disorders, and liver disease....

  • Review
  • Open Access
13 Citations
4,998 Views
22 Pages

Given advancements in large-scale data and AI, integrating multimodal artificial intelligence into cancer research can enhance our understanding of tumor behavior by simultaneously processing diverse biomedical data types. In this review, we explore...

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