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144 Results Found

  • Article
  • Open Access
1,745 Views
16 Pages

8 January 2024

The Graphical User Interface (GUI) is the most promising factor in the Software Development Lifecycle (SDL), which allows the users to interact with the system. To ensure user-friendliness, GUI Testing (GT) is required. The traditional testing techni...

  • Article
  • Open Access
4 Citations
2,114 Views
14 Pages

22 September 2023

To deliver user-friendly experiences, modern software applications rely heavily on graphical user interfaces (GUIs). However, it is paramount to ensure the quality of these GUIs through effective testing. This paper proposes a novel “Finite sta...

  • Article
  • Open Access
6 Citations
3,655 Views
11 Pages

Proof of Concept of a Novel Multiepitope Recombinant Protein for the Serodiagnosis of Patients with Chagas Disease

  • Juliana Martins Machado,
  • Isabela Amorim Gonçalves Pereira,
  • Ana Clara Gontijo Maia,
  • Mariana Ferraz Chaves Francisco,
  • Lais Moreira Nogueira,
  • Isadora Braga Gandra,
  • Anna Julia Ribeiro,
  • Kamila Alves Silva,
  • Carlos Ananias Aparecido Resende and
  • Alexsandro Sobreira Galdino
  • + 10 authors

14 February 2023

Chagas disease remains a neglected disease that is considered to be a public health problem. The early diagnosis of cases is important to improve the prognosis of infected patients and prevent transmission. Serological tests are the method of choice...

  • Article
  • Open Access
10 Citations
4,009 Views
27 Pages

C-Band SAR Winds for Tropical Cyclone Monitoring and Forecast in the South-West Indian Ocean

  • Quoc-Phi Duong,
  • Sébastien Langlade,
  • Christophe Payan,
  • Romain Husson,
  • Alexis Mouche and
  • Sylvie Malardel

29 April 2021

Tropical cyclone (TC) monitoring and forecast in the South West Indian Ocean (SWIO) basin remain challenging, notably because of the lack of direct observations. During the 2018–2019 cyclone season, S-1 Sentinel SAR images were acquired, as part of t...

  • Feature Paper
  • Article
  • Open Access
6 Citations
3,224 Views
17 Pages

30 June 2021

The oxygen diffusion layer (alpha-case) is generally considered to have a negative impact on the mechanical properties and applications of titanium alloys. In this study, TC4 alloy specimens with four types of different oxygen concentrations in alpha...

  • Article
  • Open Access
10 Citations
3,336 Views
11 Pages

16 June 2021

In this study, the general impact of high-resolution moving nesting domains on tropical cyclone (TC) intensity and track forecasts was verified, for a total of 107 forecast cases of 33 TCs, using the Weather Research and Forecasting (WRF) model. The...

  • Article
  • Open Access
7 Citations
3,379 Views
25 Pages

28 January 2023

This study evaluates the ability of a random forest classifier to identify tropical cyclone (TC) intensification or weakening prior to landfall over the western region of the Southwest Pacific Ocean (SWPO) basin. For both Australia mainland and SWPO...

  • Article
  • Open Access
84 Citations
4,346 Views
8 Pages

A Fully Automated Deep Learning Network for Brain Tumor Segmentation

  • Chandan Ganesh Bangalore Yogananda,
  • Bhavya R. Shah,
  • Maryam Vejdani-Jahromi,
  • Sahil S. Nalawade,
  • Gowtham K. Murugesan,
  • Frank F. Yu,
  • Marco C. Pinho,
  • Benjamin C. Wagner,
  • Kyrre E. Emblem and
  • Joseph A. Maldjian
  • + 3 authors

1 June 2020

We developed a fully automated method for brain tumor segmentation using deep learning; 285 brain tumor cases with multiparametric magnetic resonance images from the BraTS2018 data set were used. We designed 3 separate 3D-Dense-UNets to simplify the...

  • Article
  • Open Access
6 Citations
2,835 Views
16 Pages

7 December 2021

Taxol drugs can be extracted from various species of the taxaceae family. It is an alkaloid (metabolic product) used for the treatment of various types of cancer. Since taxol is a metabolic product, multiple aspects such as edaphic, biochemical, topo...

  • Article
  • Open Access
12 Citations
2,324 Views
17 Pages

Fracture Behavior of a Unidirectional Carbon Fiber-Reinforced Plastic under Biaxial Tensile Loads

  • Kosuke Sanai,
  • Sho Nakasaki,
  • Mikiyasu Hashimoto,
  • Arnaud Macadre and
  • Koichi Goda

18 March 2024

In order to clarify the fracture behavior of a unidirectional CFRP under proportional loading along the fiber (0°) and fiber vertical (90°) directions, a biaxial tensile test was carried out using a cruciform specimen with two symmetric flat...

  • Article
  • Open Access
2,880 Views
19 Pages

8 October 2024

Over the last decade, hardware-in-the-loop (HIL) simulation has been established as a safe, efficient, reliable, and flexible method for performing real-time simulation. Furthermore, in the automotive sector, the HIL system has been recommended in th...

  • Article
  • Open Access
2 Citations
2,655 Views
8 Pages

20 October 2020

The purpose of this in vitro study was to evaluate the influence of mechanical load cycling (MLC), which simulated mastication, alone or combined with thermal cycling (TC), on the resin shear bond strength (SBS) to zirconia. Two resin cements (Panavi...

  • Communication
  • Open Access
4 Citations
2,781 Views
10 Pages

Mechanical and Contractile Properties of Knee Joint Muscles after Sports-Related Concussions in Women Footballers

  • Georgios Kakavas,
  • Athanasios Tsiokanos,
  • Michael Potoupnis and
  • Panagiotis V. Tsaklis

The purpose of this study was to determine if women footballers have an increased lack of neuromuscular control of the knee joint after a concussion compared to a healthy cohort tested with tensiomyography (TMG). Forty-one female collegiate footballe...

  • Review
  • Open Access
15 Citations
8,436 Views
34 Pages

Systematic Literature Review on Test Case Selection and Prioritization: A Tertiary Study

  • Shweta Singhal,
  • Nishtha Jatana,
  • Bharti Suri,
  • Sanjay Misra and
  • Luis Fernandez-Sanz

20 December 2021

Software testing is undertaken to ensure that the software meets the expected requirements. The intention is to find bugs, errors, or defects in the developed software so that they can be fixed before deployment. Testing of the software is needed eve...

  • Article
  • Open Access
6 Citations
2,234 Views
16 Pages

4 August 2021

This paper demonstrates that it is possible to characterize the water temperature profile and its temporal trend in a hot water storage tank during the thermal charge process, using a minimum number of thermocouples (TC), with minor differences compa...

  • Review
  • Open Access
2 Citations
1,708 Views
12 Pages

The Unappreciated Value of a Cheap, ‘Good Enough’ Method of Detecting Thyroid Cancer

  • Salvatore Sciacchitano,
  • Massimo Rugge and
  • Armando Bartolazzi

30 November 2024

The advent of advanced molecular diagnostic techniques has revealed plenty of information about signaling pathways and gene regulation in cancer, as well as new inputs for the classification of cancer subtypes, diagnosis, prognosis, and prediction of...

  • Article
  • Open Access
8 Citations
2,993 Views
10 Pages

Telocytes and Lymphatics of the Human Colon

  • Mihai Zurzu,
  • Mihnea Ioan Nicolescu,
  • Laurențiu Mogoantă,
  • Stelian Pantea and
  • Mugurel Constantin Rusu

23 September 2021

Background: Telocytes (TCs) are a peculiar morphological type of stromal cells. They project long and moniliform telopodes, visible on various bidimensional sections. Originally regarded as “interstitial Cajal-like cells”, gastrointestinal TCs were C...

  • Article
  • Open Access
15 Citations
13,056 Views
11 Pages

The underlying reasons for the increasing occurrence of male reproductive diseases (MRD) such as hypospadias, cryptorchidism, and testicular cancer (TC) over the last decades are still unknown. It has been hypothesized that the risk of MRD is determi...

  • Article
  • Open Access
9 Citations
4,900 Views
24 Pages

Background: Studies evaluating the association between the atrial natriuretic peptide (ANP) genetic polymorphism and the risk of essential hypertension (EH) have reported inconsistent results. The aim of this meta-analysis was to provide a more relia...

  • Article
  • Open Access
4 Citations
2,761 Views
13 Pages

21 November 2022

Challenges posed by the retention of radiopharmaceuticals in unintended organs affect the quality of patient procedures when undergoing diagnostics and therapeutics. The aim of this study was to formulate a suitable tracer encapsulated in liposomes u...

  • Article
  • Open Access
4 Citations
1,720 Views
13 Pages

Inflammation and Thyroid Cancer: Deciphering the Role of Blood Immune Indexes

  • Salvatore Sorrenti,
  • Gregorio Scerrino,
  • Eleonora Lori,
  • Fabrizio Vassallo,
  • Stefania Saverino,
  • Calogera Amato,
  • Giuseppina Melfa,
  • Pierina Richiusa,
  • Sergio Mazzola and
  • Giuseppa Graceffa
  • + 2 authors

19 April 2025

Background: Inflammation within tumor microenvironments has been correlated to numerous malignancies. This study aims to explore its significance in thyroid cancer (TC). Methods: Retrospective analysis of 157 thyroid carcinomas and 40 benign cases in...

  • Article
  • Open Access
8 Citations
3,322 Views
14 Pages

Toxicity Assessment and Treatment Options of Diclofenac and Triclosan Dissolved in Water

  • Lenka Wimmerova,
  • Olga Solcova,
  • Marketa Spacilova,
  • Nadija Cehajic,
  • Simona Krejcikova and
  • Petr Marsik

27 July 2022

The presence of pharmaceutical and personal care products in water is increasing tremendously nowadays. Typical representatives are diclofenac (DCF) and triclosan (TCS). Acute toxicity of these substances was experimentally assessed using the freshwa...

  • Proceeding Paper
  • Open Access
1 Citations
1,208 Views
10 Pages

IEC-61108-7 SBAS Standard for Shipborne Receivers: Preliminary Testing Validation Activities

  • Javier Tegedor,
  • Joaquim Fortuny,
  • Guillermo Fernandez,
  • Elisabet Lacarra,
  • Ettore Canestri,
  • Silvia Porfili and
  • Ciro Gioia

The IEC 61108-7 standard focuses on the minimum performance required by shipborne receivers using satellite-based augmentation system (SBAS) L1 signals to be compliant with the performance specified in IMO Resolution A.1046(27). Apart from the minimu...

  • Article
  • Open Access
2 Citations
2,082 Views
14 Pages

26 July 2023

This paper aims to investigate the impact of beam deflection geometry on the structure, surface architecture, and friction coefficient of electron-beam-modified TC4 titanium alloys. During the experiments, the electron beam was deflected in the form...

  • Review
  • Open Access
1 Citations
1,915 Views
19 Pages

Design Principles to Reduce Vehicle Pocketing at Guardrail-to-Concrete Barrier Transitions

  • Desiree Kofler,
  • Ernst Tomasch,
  • Christian Mader,
  • Marco Jiraut,
  • Alexander Barnaš,
  • Olivier Jantscher,
  • Johann Horvatits and
  • Karl Gragger

Road restraint systems (RRSs) on European roads are provided by several manufacturers and, hence, lead to differences in geometry, material, and mode of operation. Focusing on the combination of soft steel RRSs with relatively stiffer concrete RRSs,...

  • Article
  • Open Access
28 Citations
4,384 Views
24 Pages

CCL2 Expression in Tumor Cells and Tumor-Infiltrating Immune Cells Shows Divergent Prognostic Potential for Bladder Cancer Patients Depending on Lymph Node Stage

  • Markus Eckstein,
  • Elena Epple,
  • Rudolf Jung,
  • Katrin Weigelt,
  • Verena Lieb,
  • Danijel Sikic,
  • Robert Stöhr,
  • Carol Geppert,
  • Veronika Weyerer and
  • Sven Wach
  • + 5 authors

15 May 2020

Bladder cancer (BCa) is the ninth most commonly diagnosed cancer worldwide. Although there are several well-established molecular and immunological classifications, markers for tumor cells and immune cells that are associated with prognosis are still...

  • Tutorial
  • Open Access
10 Citations
4,703 Views
26 Pages

20 December 2018

Interoperability is a challenge for the realisation of smart grids. In this work, we first present an interoperability testing methodology, which is substantial to perform interoperability tests for the smart grid. To show its applicability and facil...

  • Review
  • Open Access
1,805 Views
10 Pages

Investigating the Role of B9D1 in Meckel–Gruber Syndrome: A Case Report and Comprehensive Literature Review

  • Gianluca Campobasso,
  • Ludovica Mercuri,
  • Francesca De Razza,
  • Antonella Cosentino,
  • Marta Mele,
  • Antonella Monittola,
  • Carmen Congedo,
  • Maria Chiara Calò,
  • Caterina Scalcione and
  • Serena Lattante
  • + 2 authors

27 May 2025

Meckel–Gruber syndrome (MKS) is a rare autosomal recessive lethal ciliopathy, characterized by occipital encephalocele, cystic kidneys, and postaxial polydactyly, caused by mutations in different genes. Its significant genetic heterogeneity alo...

  • Article
  • Open Access
2 Citations
2,389 Views
12 Pages

Role of Arthrospira Platensis in Preventing and Treating High-Fat Diet-Induced Hypercholesterolemia in Adult Rats

  • Nunzio Antonio Cacciola,
  • Paola De Cicco,
  • Maja Milanović,
  • Ivan Milovanović,
  • Aleksandra Mišan,
  • Danijela Kojić,
  • Jelica Simeunović,
  • Dajana Blagojević,
  • Tamara Popović and
  • Nataša Milić
  • + 4 authors

11 June 2024

Hyperlipidaemia is a recognised risk factor for cardiovascular disease. In this study, the antihyperlipidaemic properties of spirulina (Arthrospira platensis, strain S2 from Serbia) were tested in adult Wistar rats before and after induction of hyper...

  • Article
  • Open Access
1 Citations
2,852 Views
15 Pages

Study of Landfalling Typhoon Potential Maximum Gale Forecasting in South China

  • Zhizhong Su,
  • Lifang Li,
  • Fumin Ren,
  • Jing Zhu,
  • Chunxia Liu,
  • Qilin Wan,
  • Qiongbo Sun and
  • Li Jia

Based on historical tropical cyclone (TC) tracking data and wind data from observation stations, four comparison experiments were designed that considered TC translation speed similarity and five new ensemble schemes in an improved Dynamical-Statisti...

  • Article
  • Open Access
3 Citations
2,260 Views
12 Pages

Pregnancy Cholesterol Metabolism Markers and the Risk of Gestational Diabetes Mellitus: A Nested Case-Control Study

  • Yan Li,
  • Yuanjue Wu,
  • Yanyan Ge,
  • Shanshan Huang,
  • Yang Yang,
  • Zhen Zhang,
  • Ningning Cui,
  • Junan Yan,
  • Yonggang Li and
  • Xuefeng Yang
  • + 3 authors

31 August 2023

This study aims to determine the association of pregnancy cholesterol metabolism markers with gestational diabetes mellitus (GDM) risk. We performed a nested case–control study in the Tongji Birth Cohort. GDM was diagnosed according to the 75 g...

  • Article
  • Open Access
3 Citations
2,590 Views
16 Pages

Evolution of Microstructure and Hardness of TC11 Titanium Alloy under Different Electroshocking Treatment Directions

  • Chang Liu,
  • Yongjian Wu,
  • Haoxing Wang,
  • Fei Yin,
  • Dongsheng Qian,
  • Liqiang Wang,
  • Lechun Xie and
  • Lin Hua

4 August 2023

The effects of electroshocking treatment (EST) direction on microstructure and hardness of TC11 alloy (Ti-6.5Al-3.5Mo-1.5Zr-0.3Si) were investigated. The results indicated that the temperature of specimens under EST along the transverse direction (T-...

  • Article
  • Open Access
16 Citations
4,251 Views
22 Pages

A Hydrodynamical Atmosphere/Ocean Coupled Modeling System for Multiple Tropical Cyclones

  • Ghassan J. Alaka,
  • Dmitry Sheinin,
  • Biju Thomas,
  • Lew Gramer,
  • Zhan Zhang,
  • Bin Liu,
  • Hyun-Sook Kim and
  • Avichal Mehra

16 August 2020

The goal of this paper is to introduce a new multi-storm atmosphere/ocean coupling scheme that was implemented and tested in the Basin-Scale Hurricane Weather Research and Forecasting (HWRF-B) model. HWRF-B, an experimental model developed at the Nat...

  • Article
  • Open Access
26 Citations
3,919 Views
12 Pages

Hydroxyapatite and Titanium Dioxide Nanoparticles: Radiolabelling and In Vitro Stability of Prospective Theranostic Nanocarriers for 223Ra and 99mTc

  • Petra Suchánková,
  • Ekaterina Kukleva,
  • Eva Nykl,
  • Pavel Nykl,
  • Michal Sakmár,
  • Martin Vlk and
  • Ján Kozempel

20 August 2020

Hydroxyapatite and titanium dioxide are widely used materials in a broad spectrum of branches. Due to their appropriate properties such as a large specific surface area, radiation stability or relatively low toxicity, they could be potentially used a...

  • Review
  • Open Access
44 Citations
8,083 Views
29 Pages

Current Advances in Thyroid Cancer Management. Are We Ready for the Epidemic Rise of Diagnoses?

  • Dagmara Rusinek,
  • Ewa Chmielik,
  • Jolanta Krajewska,
  • Michal Jarzab,
  • Malgorzata Oczko-Wojciechowska,
  • Agnieszka Czarniecka and
  • Barbara Jarzab

A rising incidence of thyroid cancers (TCs) mainly small tumors, observed during recent years, lead to many controversies regarding treatment strategies. TCs represent a distinct molecular background and clinical outcome. Although in most cases TCs a...

  • Article
  • Open Access
11 Citations
4,855 Views
18 Pages

3 February 2022

Reversed micelles are helpful to solubilize otherwise insoluble membranotropic or membrane-bound enzymes in their functional form, thus enabling activity assay and inhibition analysis. However, in the case of redox enzymes, this task is further compl...

  • Article
  • Open Access
4 Citations
2,792 Views
14 Pages

Analysis of the Effects of IL-6 -572 C/G, CRP -757 A/G, and CRP -717 T/C Gene Polymorphisms; IL-6 Levels; and CRP Levels on Chronic Periodontitis in Coronary Artery Disease in Indonesia

  • Sanggap Indra Sitompul,
  • Budi Susetyo Pikir,
  • Aryati,
  • Citrawati Dyah Kencono Wungu,
  • Shafira Kurnia Supandi and
  • Monika Estherlita Sinta

12 May 2023

Interleukin 6 (IL-6) and C-Reactive Protein (CRP) play an important role in chronic periodontitis with coronary artery disease (CAD). Genetic factors can affect a person’s risk of CAD, which affects one-third of the population. This study inves...

  • Article
  • Open Access
606 Views
20 Pages

Nanocatalytic Enhancement of Local Heat Transfer in Continuous-Flow Thermal Reactors

  • Nasser Zouli,
  • Nujud Maslamani,
  • Ayman Yousef and
  • Muthanna Al-Dahhan

19 February 2026

An experimental investigation was conducted to evaluate the thermal conductivity (TC) and local heat-transfer coefficients (LHTCs) of nanofluids containing alumina (Al2O3), hematite (Fe2O3), and copper oxide (CuO) nanoparticles dispersed in deionized...

  • Article
  • Open Access
33 Citations
6,374 Views
9 Pages

Efficacy and Accuracy of Maxillary Arch Expansion with Clear Aligner Treatment

  • Gabriella Galluccio,
  • Adriana A. De Stefano,
  • Martina Horodynski,
  • Alessandra Impellizzeri,
  • Rosanna Guarnieri,
  • Ersilia Barbato,
  • Stefano Di Carlo and
  • Francesca De Angelis

The aim of this work was to evaluate the efficacy and accuracy of maxillary arch transverse expansion using the Invisalign® clear aligner system without auxiliaries other than Invisalign attachments. Knowing the accuracy of a movement through a c...

  • Technical Note
  • Open Access
1,064 Views
13 Pages

Semi-Automated Training of AI Vision Models

  • Mathew G. Pelletier,
  • John D. Wanjura and
  • Greg A. Holt

The adoption of AI vision models in specialized industries is often hindered by the substantial requirement for extensive, manually annotated image datasets. Even when employing transfer learning, robust model development typically necessitates tens...

  • Article
  • Open Access
22 Citations
8,513 Views
20 Pages

13 March 2015

Based on the operational regional ensemble prediction system (REPS) in China Meteorological Administration (CMA), this paper carried out comparison of two initial condition perturbation methods: an ensemble transform Kalman filter (ETKF) and a dynam...

  • Article
  • Open Access
1 Citations
2,904 Views
14 Pages

Phenotypes, Genotypes, Treatment, and Outcomes of 14 Children with Sitosterolemia at Vietnam National Children’s Hospital

  • Thi Thanh Mai Do,
  • Chi Dung Vu,
  • Tran Minh Dien,
  • Thi Bich Ngoc Can,
  • Thi Thanh Ngan Nguyen,
  • Huy Hoang Nguyen,
  • Van Khanh Tran,
  • Ngoc Lan Nguyen,
  • Huy Thinh Tran and
  • Khanh Ngoc Nguyen
  • + 1 author

7 January 2025

Background: Sitosterolemia is a rare autosomal recessive disorder characterized by diverse clinical manifestations ranging from asymptomatic cases to the development of xanthomas, hypercholesterolemia, premature atherosclerosis, or even sudden death...

  • Article
  • Open Access
81 Citations
9,958 Views
27 Pages

14 April 2015

The integration of Global Navigation Satellite Systems (GNSS) carrier phases with Inertial Navigation System (INS) measurements is essential to provide accurate and continuous position, velocity and attitude information, however it is necessary to fi...

  • Article
  • Open Access
7 Citations
4,003 Views
11 Pages

20 May 2020

(Sc,Ti)Fe2 Laves phases present a relatively unique case of first-order ferro-ferromagnetic transition originating from an instability of the Fe moment. In addition to large magnetoelastic effects making them potential negative thermal expansion mate...

  • Article
  • Open Access
7 Citations
6,753 Views
9 Pages

Experiences with Diagnosis and Treatment of Chagas Disease at a United States Teaching Hospital—Clinical Features of Patients with Positive Screening Serologic Testing

  • Peter Hyson,
  • Lilian Vargas Barahona,
  • Laura C. Pedraza-Arévalo,
  • Jonathan Schultz,
  • Luisa Mestroni,
  • Maria da Consolação Moreira,
  • Matthew Taylor,
  • Carlos Franco-Paredes,
  • Esther Benamu and
  • Andrés F. Henao-Martínez
  • + 3 authors

Chagas disease (CD) is the third most common parasitic infection globally and can cause cardiac and gastrointestinal complications. Around 300,000 carriers of CD live in the U.S., with about 3000 of those in Colorado. We described our experience in d...

  • Article
  • Open Access
2 Citations
3,059 Views
12 Pages

Prevalent Variants in the LDLR Gene Impair Responsiveness to Rosuvastatin among Family Members of Patients with Premature Myocardial Infarction

  • Nguyen Trung Kien,
  • Tran Tin Nghia,
  • Nguyen Minh Hoang,
  • Tran Nguyen Trong Phu,
  • Pham Thi Ngoc Nga,
  • Ha Thi Thao Mai and
  • J. Luis Espinoza

18 December 2023

Background: Familial hypercholesterolemia (FH) is an inherited metabolic disorder characterized by high levels of low-density lipoprotein cholesterol (LDL-c) from birth. About 85% of all FH cases are caused by pathogenic variants in the LDLR gene. In...

  • Article
  • Open Access
3 Citations
4,523 Views
25 Pages

Compression Behavior of Sheets Metals of Pure Titanium 2 and Ti6Al4V Alloy under High Temperature: Evaluation of the Tension–Compression Asymmetry

  • Jorge Ayllón,
  • Valentín Miguel,
  • Alberto Martínez-Martínez,
  • Juana Coello,
  • Jesús Andrés Naranjo and
  • Francisco García-Sevilla

18 January 2021

Determining the intrinsic indices of sheet metals under compression states at high temperatures is vital to accurately predict the behavior of the material in warm/hot forming processes. Nevertheless, the literature contains little previous experimen...

  • Article
  • Open Access
7 Citations
5,539 Views
28 Pages

In this paper, the authors examined the change in track gauges in curves for several railway lines with low and high traffic in Hungary (i.e., secondary lines and main lines). They covered the processing of raw data as well as statistical calculation...

  • Article
  • Open Access
7 Citations
3,580 Views
16 Pages

8 August 2023

Hotspots pose a significant long-term reliability challenge in photovoltaic (PV) modules that can have a detrimental impact on the efficiency, safety, and financial viability of a PV system. This paper aims to evaluate the endurance of hotspot stress...

  • Review
  • Open Access
3 Citations
7,090 Views
25 Pages

Systemic Therapeutic Options in Radioiodine-Refractory Differentiated Thyroid Cancer: Current Indications and Optimal Timing

  • Tamara Díaz Vico,
  • Brezo Martínez-Amores Martínez,
  • Luka Mihic Góngora,
  • Paula Jiménez-Fonseca,
  • Paloma Peinado Martín,
  • Irene Grao Torrente,
  • Alejandro García Muñoz-Nájar and
  • Manuel Durán-Poveda

28 May 2025

Thyroid cancer (TC) remains a prevalent malignancy, with over 820,000 global cases diagnosed in 2022. Differentiated thyroid carcinoma (DTC), primarily papillary and follicular types, accounts for most cases and has a favorable prognosis with total t...

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